Systematic evaluation of 640 FDA drugs for their effect on CD4 +Foxp3+ regulatory T cells using a novel cell-based high throughput screening assay

Biochemical Pharmacology

Volumn 85, Issue 10, 2013, Pages 1513-1524

  Mao, Rui ^a   Xiao, Wei ^a   Liu, Haitao ^a   Chen, Bo ^a   Yi, Bing ^a   Kraj, Piotr ^a   She, Jin Xiong ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Foxp3; High throughput screening; Immune tolerance; Immunosuppressive drugs; Regulatory T cells

Indexed keywords

AMINOGLYCOSIDE; ANGIOTENSIN ANTAGONIST; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIHISTAMINIC AGENT; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; COMPACTIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ESTROGEN RECEPTOR; GLUCOCORTICOID; HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMIDAZOLE; MACROLIDE; MEVINOLIN; NONSTEROID ANTIINFLAMMATORY AGENT; OXICAM DERIVATIVE; PRAVASTATIN; PYRROLE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RAPAMYCIN; RETINOIC ACID; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SEROTONIN UPTAKE INHIBITOR; SIMVASTATIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL CULTURE; CONTROLLED STUDY; DRUG SCREENING; FOOD AND DRUG ADMINISTRATION; HIGH THROUGHPUT SCREENING; IMMUNOTHERAPY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ANIMALS; CELL PROLIFERATION; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GENES, REPORTER; GLUCOCORTICOIDS; GREEN FLUORESCENT PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; MICE, TRANSGENIC; PRESCRIPTION DRUGS; SIROLIMUS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; TRETINOIN;

EID: 84876675357     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.03.013     Document Type: Article

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