Regulatory T cells and tolerance induction

Clinical Transplantation

Volumn 23, Issue SUPPL.21, 2009, Pages 10-14

  Fritzsching, Eva ^a   Kunz, Pierre ^b   Maurer, Birgitta ^a   Pöschl, Johannes ^a   Fritzsching, Benedikt ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

FOXP3; Monitoring; Regulatory T cells; Tolerance; Transplantation

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN; INTERLEUKIN 2 RECEPTOR BETA; L SELECTIN; RAPAMYCIN; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3;

ACUTE GRAFT REJECTION; ANTIGEN SPECIFICITY; APOPTOSIS; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CELL EXPANSION; CELL INTERACTION; CELL LINEAGE; CELL PROLIFERATION; CELLULAR IMMUNITY; CHRONIC ALLOGRAFT NEPHROPATHY; DENDRITIC CELL; DRUG MEGADOSE; GRAFT FAILURE; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION;

FORKHEAD TRANSCRIPTION FACTORS; HUMANS; LYMPHOCYTE COUNT; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION TOLERANCE;

EID: 70649110168     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2009.01103.x     Document Type: Review

References (29)

1. Li L, Boussiotis VA. Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications. J Mol Med 2006, 84:887.
2. Roncarolo MG, Battaglia M. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat Rev Immunol 2007, 7:585.
3. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155:1151.
4. Hall BM, Jelbart ME, Gurley KE, Dorsch SE. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells. J Exp Med 1985, 162:1683.
5. Quigley RL, Wood KJ, Morris PJ. Mediation of the induction of immunologic unresponsiveness following antigen pretreatment by a CD4 (W3/25+) T cell appearing transiently in the splenic compartment and subsequently in the TDL. Transplantation 1989, 47:689.
6. Shevach EM. Regulatory T cells. Introduction. Semin Immunol 2004, 16:69.
7. Fritzsching B, Oberle N, Pauly E. Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death. Blood 2006, 108:3371.
8. Kang SM, Tang Q, Bluestone JA. CD4+ CD25+ regulatory T cells in transplantation: progress, challenges and prospects. Am J Transplant 2007, 7:1457.
9. Seddiki N, Santner-Nanan B, Martinson J. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006, 203:1693.
10. Liu W, Putnam AL, Xu-Yu Z. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006, 203:1701.
11. Watanabe N, Wang YH, Lee HK. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 2005, 436:1181.
12. Suri-Payer E, Fritzsching B. Regulatory T cells in experimental autoimmune disease. Springer Semin Immunopathol 2006, 28:3.
13. Oberle N, Eberhardt N, Falk CS, Krammer PH, Suri-Payer E. Rapid suppression of cytokine transcription in human CD4+ CD25 T cells by CD4+ Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling. J Immunol 2007, 179:3578.
14. Bopp T, Becker C, Klein M. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med 2007, 204:1303.
15. Baecher-Allan C, Hafler DA. Human regulatory T cells and their role in autoimmune disease. Immunol Rev 2006, 212:203.
16. Beyer M, Schultze JL. Regulatory T cells in cancer. Blood 2006, 108:804.
17. Fritzsching B, Oberle N, Eberhardt N. In contrast to effector T cells, CD4+ CD25+ FoxP3+ regulatory T cells are highly susceptible to CD95 ligand-but not to TCR-mediated cell death. J Immunol 2005, 175:32.
18. Vukmanovic-Stejic M, Zhang Y, Cook JE. Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest 2006, 116:2423.
19. Wieers G, Gras J, Bourdeaux C, Truong DQ, Latinne D, Reding R. Monitoring tolerance after human liver transplantation. Transpl Immunol 2007, 17:83.
20. Muthukumar T, Dadhania D, Ding R. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005, 353:2342.
21. Braudeau C, Racape M, Giral M. Variation in numbers of CD4+ CD25highFOXP3+ T cells with normal immuno-regulatory properties in long-term graft outcome. Transpl Int 2007, 20:845.
22. Bestard O, Cruzado JM, Mestre M. Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates. J Immunol 2007, 179:4901.
23. Veronese F, Rotman S, Smith RN. Pathological and clinical correlates of FOXP3+ cells in renal allografts during acute rejection. Am J Transplant 2007, 7:914.
24. Koshiba T, Li Y, Takemura M. Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transpl Immunol 2007, 17:94.
25. Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG. Rapamycin promotes expansion of functional CD4+ CD25+ FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol 2006, 177:8338.
26. He H, Stone JR, Perkins DL. Analysis of robust innate immune response after transplantation in the absence of adaptive immunity. Transplantation 2002, 73:853.
27. Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M. Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells. Blood 2004, 104:895.
28. Trenado A, Charlotte F, Fisson S. Recipient-type specific CD4+ CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest 2003, 112:1688.
29. Golshayan D, Jiang S, Tsang J, Garin MI, Mottet C, Lechler RI. In vitro-expanded donor alloantigen-specific CD4+ CD25+ regulatory T cells promote experimental transplantation tolerance. Blood 2007, 109:827.