메뉴 건너뛰기




Volumn 119, Issue 4, 2009, Pages 239-245

Glucocorticoids increase CD4 +CD25 high cell percentage and Foxp3 expression in patients with multiple sclerosis

Author keywords

CD25; Cytokines; Foxp3; Glucocorticoids; Methylprednisolone; Multiple sclerosis; Regulatory T cells

Indexed keywords

CD3 ANTIGEN; DEXAMETHASONE; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; METHYLPREDNISOLONE; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; GLUCOCORTICOID; IL10 PROTEIN, HUMAN;

EID: 61849112650     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2008.01090.x     Document Type: Article
Times cited : (83)

References (31)
  • 1
    • 22244462396 scopus 로고    scopus 로고
    • Regulatory T cells in immunologic self-tolerance and autoimmune disease
    • Sakaguchi S, Sakaguchi N. Regulatory T cells in immunologic self-tolerance and autoimmune disease. Int Rev Immunol 2005 24 : 211 26.
    • (2005) Int Rev Immunol , vol.24 , pp. 211-26
    • Sakaguchi, S.1    Sakaguchi, N.2
  • 3
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995 155 : 1151 64.
    • (1995) J Immunol , vol.155 , pp. 1151-64
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 4
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
    • Bettelli E, Dastrange M, Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci USA 2005 102 : 5138 43.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5138-43
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3
  • 5
    • 33847415066 scopus 로고    scopus 로고
    • Natural regulatory T cells: Mechanisms of suppression
    • Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med 2007 13 : 108 16.
    • (2007) Trends Mol Med , vol.13 , pp. 108-16
    • Miyara, M.1    Sakaguchi, S.2
  • 6
    • 0036838536 scopus 로고    scopus 로고
    • Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
    • Kohm AP, Carpentier PA, Anger HA, Miller SD. Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 2002 169 : 4712 6.
    • (2002) J Immunol , vol.169 , pp. 4712-6
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 7
    • 33747414436 scopus 로고    scopus 로고
    • Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE
    • Chen X, Oppenheim JJ, Winkler-Pickett RT, Ortaldo JR, Howard OM. Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE. Eur J Immunol 2006 36 : 2139 49.
    • (2006) Eur J Immunol , vol.36 , pp. 2139-49
    • Chen, X.1    Oppenheim, J.J.2    Winkler-Pickett, R.T.3    Ortaldo, J.R.4    Howard, O.M.5
  • 8
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004 199 : 971 9.
    • (2004) J Exp Med , vol.199 , pp. 971-9
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 9
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003 299 : 1033 6.
    • (2003) Science , vol.299 , pp. 1033-6
    • Pasare, C.1    Medzhitov, R.2
  • 11
    • 20844432359 scopus 로고    scopus 로고
    • Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
    • Karagiannidis C, Akdis M, Holopainen P et al. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol 2004 114 : 1425 33.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 1425-33
    • Karagiannidis, C.1    Akdis, M.2    Holopainen, P.3
  • 12
    • 0027488965 scopus 로고
    • Glucocorticoid hormones upregulate interleukin 2 receptor alpha gene expression
    • Lamas M, Sanz E, Martin-Parras L et al. Glucocorticoid hormones upregulate interleukin 2 receptor alpha gene expression. Cell Immunol 1993 151 : 437 50.
    • (1993) Cell Immunol , vol.151 , pp. 437-50
    • Lamas, M.1    Sanz, E.2    Martin-Parras, L.3
  • 13
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983 33 : 1444 52.
    • (1983) Neurology , vol.33 , pp. 1444-52
    • Kurtzke, J.F.1
  • 14
    • 12444335268 scopus 로고    scopus 로고
    • Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphoma
    • Kari L, Loboda A, Nebozhyn M et al. Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphoma. J Exp Med 2003 197 : 1477 88.
    • (2003) J Exp Med , vol.197 , pp. 1477-88
    • Kari, L.1    Loboda, A.2    Nebozhyn, M.3
  • 15
    • 8344275995 scopus 로고    scopus 로고
    • Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    • Yagi H, Nomura T, Nakamura K et al. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol 2004 16 : 1643 56.
    • (2004) Int Immunol , vol.16 , pp. 1643-56
    • Yagi, H.1    Nomura, T.2    Nakamura, K.3
  • 16
    • 0035175408 scopus 로고    scopus 로고
    • High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes
    • Leussink VI, Jung S, Merschdorf U, Toyka KV, Gold R. High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes. Arch Neurol 2001 58 : 91 7.
    • (2001) Arch Neurol , vol.58 , pp. 91-7
    • Leussink, V.I.1    Jung, S.2    Merschdorf, U.3    Toyka, K.V.4    Gold, R.5
  • 17
    • 0032524790 scopus 로고    scopus 로고
    • Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse
    • Gayo A, Mozo L, Suarez A, Tunon A, Lahoz C, Gutierrez C. Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse. J Neuroimmunol 1998 85 : 122 30.
    • (1998) J Neuroimmunol , vol.85 , pp. 122-30
    • Gayo, A.1    Mozo, L.2    Suarez, A.3    Tunon, A.4    Lahoz, C.5    Gutierrez, C.6
  • 18
    • 1642308173 scopus 로고    scopus 로고
    • Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death
    • Chen X, Murakami T, Oppenheim JJ, Howard OM. Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death. Eur J Immunol 2004 34 : 859 69.
    • (2004) Eur J Immunol , vol.34 , pp. 859-69
    • Chen, X.1    Murakami, T.2    Oppenheim, J.J.3    Howard, O.M.4
  • 19
    • 33947121146 scopus 로고    scopus 로고
    • Transient regulatory T-cells: A state attained by all activated human T-cells
    • Pillai V, Ortega SB, Wang CK, Karandikar NJ. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 2007 123 : 18 29.
    • (2007) Clin Immunol , vol.123 , pp. 18-29
    • Pillai, V.1    Ortega, S.B.2    Wang, C.K.3    Karandikar, N.J.4
  • 20
    • 33746210026 scopus 로고    scopus 로고
    • Circulating dendritic cells subsets and regulatory T-cells at multiple sclerosis relapse: Differential short-term changes on corticosteroids therapy
    • Navarro J, Aristimuno C, Sanchez-Ramon S et al. Circulating dendritic cells subsets and regulatory T-cells at multiple sclerosis relapse: differential short-term changes on corticosteroids therapy. J Neuroimmunol 2006 176 : 153 61.
    • (2006) J Neuroimmunol , vol.176 , pp. 153-61
    • Navarro, J.1    Aristimuno, C.2    Sanchez-Ramon, S.3
  • 21
    • 0033840032 scopus 로고    scopus 로고
    • Effect of oral glucocorticoid treatment on serum inflammatory markers in acute asthma
    • Sahid El-Radhi A, Hogg CL, Bungre JK, Bush A, Corrigan CJ. Effect of oral glucocorticoid treatment on serum inflammatory markers in acute asthma. Arch Dis Child 2000 83 : 158 62.
    • (2000) Arch Dis Child , vol.83 , pp. 158-62
    • Sahid El-Radhi, A.1    Hogg, C.L.2    Bungre, J.K.3    Bush, A.4    Corrigan, C.J.5
  • 22
    • 34249854029 scopus 로고    scopus 로고
    • A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability
    • Dhawan L, Liu B, Blaxall BC, Taubman MB. A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability. J Biol Chem 2007 282 : 10146 52.
    • (2007) J Biol Chem , vol.282 , pp. 10146-52
    • Dhawan, L.1    Liu, B.2    Blaxall, B.C.3    Taubman, M.B.4
  • 23
    • 22144496795 scopus 로고    scopus 로고
    • The mechanism of action of methylprednisolone in the treatment of multiple sclerosis
    • Sloka JS, Stefanelli M. The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler 2005 11 : 425 32.
    • (2005) Mult Scler , vol.11 , pp. 425-32
    • Sloka, J.S.1    Stefanelli, M.2
  • 24
    • 50949102041 scopus 로고    scopus 로고
    • Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis
    • Wust S, Van Den Brandt J, Tischner D et al. Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. J Immunol 2008 180 : 8434 43.
    • (2008) J Immunol , vol.180 , pp. 8434-43
    • Wust, S.1    Van Den Brandt, J.2    Tischner, D.3
  • 25
    • 40449126433 scopus 로고    scopus 로고
    • Glucocorticoids regulate innate immunity in a model of multiple sclerosis: Reciprocal interactions between the A1 adenosine receptor and beta-arrestin-1 in monocytoid cells
    • Tsutsui S, Vergote D, Shariat N, Warren K, Ferguson SS, Power C. Glucocorticoids regulate innate immunity in a model of multiple sclerosis: reciprocal interactions between the A1 adenosine receptor and beta-arrestin-1 in monocytoid cells. FASEB J 2008 22 : 786 96.
    • (2008) FASEB J , vol.22 , pp. 786-96
    • Tsutsui, S.1    Vergote, D.2    Shariat, N.3    Warren, K.4    Ferguson, S.S.5    Power, C.6
  • 26
    • 33745863552 scopus 로고    scopus 로고
    • Effect of the treatment with methylprednisolone on the cerebrospinal fluid and serum levels of CCL2 and CXCL10 chemokines in patients with active multiple sclerosis
    • Moreira MA, Tilbery CP, Monteiro LP, Teixeira MM, Teixeira AL. Effect of the treatment with methylprednisolone on the cerebrospinal fluid and serum levels of CCL2 and CXCL10 chemokines in patients with active multiple sclerosis. Acta Neurol Scand 2006 114 : 109 13.
    • (2006) Acta Neurol Scand , vol.114 , pp. 109-13
    • Moreira, M.A.1    Tilbery, C.P.2    Monteiro, L.P.3    Teixeira, M.M.4    Teixeira, A.L.5
  • 27
    • 33645227147 scopus 로고    scopus 로고
    • Effect of high-dose methylprednisolone treatment on CCR5 expression on blood cells in MS exacerbation
    • Elovaara I, Kuusisto H, Paalavuo R et al. Effect of high-dose methylprednisolone treatment on CCR5 expression on blood cells in MS exacerbation. Acta Neurol Scand 2006 113 : 163 6.
    • (2006) Acta Neurol Scand , vol.113 , pp. 163-6
    • Elovaara, I.1    Kuusisto, H.2    Paalavuo, R.3
  • 28
    • 33845873044 scopus 로고    scopus 로고
    • Interferon beta-1a therapy enhances CD4+ regulatory T-cell function: An ex vivo and in vitro longitudinal study in relapsing-remitting multiple sclerosis
    • De Andres C, Aristimuno C, De Las Heras V et al. Interferon beta-1a therapy enhances CD4+ regulatory T-cell function: an ex vivo and in vitro longitudinal study in relapsing-remitting multiple sclerosis. J Neuroimmunol 2007 182 : 204 11.
    • (2007) J Neuroimmunol , vol.182 , pp. 204-11
    • De Andres, C.1    Aristimuno, C.2    De Las Heras, V.3
  • 29
    • 34848885871 scopus 로고    scopus 로고
    • Mechanism of action of glatiramer acetate in treatment of multiple sclerosis
    • Weber MS, Hohlfeld R, Zamvil SS. Mechanism of action of glatiramer acetate in treatment of multiple sclerosis. Neurotherapeutics 2007 4 : 647 53.
    • (2007) Neurotherapeutics , vol.4 , pp. 647-53
    • Weber, M.S.1    Hohlfeld, R.2    Zamvil, S.S.3
  • 31
    • 43549110503 scopus 로고    scopus 로고
    • Avonex Combination Trial in relapsing-remitting MS: Rationale, design and baseline data
    • Cohen JA, Calabresi PA, Chakraborty S et al. Avonex Combination Trial in relapsing-remitting MS: rationale, design and baseline data. Mult Scler 2008 14 : 370 82.
    • (2008) Mult Scler , vol.14 , pp. 370-82
    • Cohen, J.A.1    Calabresi, P.A.2    Chakraborty, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.