Lentivirus vectors incorporating the immunoglobulin heavy chain enhancer and matrix attachment regions provide position-independent expression in B lymphocytes

Journal of Virology

Volumn 77, Issue 13, 2003, Pages 7341-7351

  Lutzko, Carolyn ^a,b   Senadheera, Dinithi ^a   Skelton, Dianne ^a   Petersen, Denise ^a   Kohn, Donald B ^a,b  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; LENTIVIRUS VECTOR; PHOSPHOGLYCERATE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CANCER CELL CULTURE; CELL DIFFERENTIATION; CHROMATIN; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENHANCER REGION; FIBROBLAST; FLUORESCENCE; GENE EXPRESSION REGULATION; GENE THERAPY; HEMATOPOIETIC STEM CELL; IMMUNE DEFICIENCY; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROVIRUS; TRANSGENE; VIRUS ADSORPTION; VIRUS GENOME;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE; CYTOMEGALOVIRUS; DNA PRIMERS; ENHANCER ELEMENTS (GENETICS); FLOW CYTOMETRY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; LENTIVIRUS; LUMINESCENT PROTEINS; MATRIX ATTACHMENT REGION BINDING PROTEINS; MICE; PROMOTER REGIONS (GENETICS); TRANSGENES;

EID: 0038468406     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.13.7341-7351.2003     Document Type: Article

References (32)

1. Adams, J. M., A. W. Harris, C. A. Pinkert, L. M. Corcoran, W. S. Alexander, S. Cory, R. D. Palmiter, and R. L. Brinster. 1985. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318:533-538.
2. Addison, C. L., M. Hitt, D. Kunsken, and F. L. Graham. 1997. Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors. J. Gen. Virol. 78:1653-1661.
3. Aiuti, A., S. Slavin, M. Aker, F. Ficara, S. Deola, A. Mortellaro, S. Morecki, G. Andolfi, A. Tabucchi, F. Carlucci, E. Marinello, F. Cattaneo, S. Vai, P. Servida, R. Miniero, M. G. Roncarolo, and C. Bordignon. 2002. Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science 296:2410-2413.
4. Alvarez, J. D., D. H. Yasui, H. Niida, T. Joh, D. Y. Loh, and T. Kohwi-Shigematsu. 2000. The MAR-binding protein SATBI orchestrates temporal and spatial expression of multiple genes during T-cell development. Genes Dev. 14:521-535.
5. Banerji, J., L. Olson, and W. Schaffner. 1983. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell 33:729-740.
6. Bowtell, D. D., G. R. Johnson, A. Kelso, and S. Cory. 1987. Expression of genes transferred to haemopoietic stem cells by recombinant retroviruses. Mol. Biol. Med. 4:229-250.
7. Cavazzana-Calvo, M., S. Hacein-Bey, G. de Saint Basile, F. Gross, E. Yvon, P. Nusbaum, F. Selz, C. Hue, S. Certain, J. L. Casanova, P. Bousso, F. L. Deist, and A. Fischer. 2000. Gene therapy of human severe combined immunodeficiency (SCID)-XI disease. Science 288:669-672.
8. Challita, P. M., and D. B. Kohn. 1994. Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo. Proc. Natl. Acad. Sci. USA 91:2567-2571.
9. Challita, P. M., D. Skelton, A. el-Khoueiry, X. J. Yu, K. Weinberg, and D. B. Kohn. 1995. Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells. J. Virol. 69:748-755.
10. Cockerill, P. N., M. H. Yuen, and W. T. Garrard. 1987. The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements. J. Biol. Chem. 262:5394-5397.
11. Cui, Y., J. Golob, E. Kelleher, Z. Ye, D. Pardoll, and L. Cheng. 2002. Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem/progenitor cells. Blood 99:399-408.
12. Dickinson, L. A., T. Joh, Y. Kohwi, and T. Kohwi-Shigematsu. 1992. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell 70:631-645.
13. Ellis, J., and D. Pannell. 2001. The beta-globin locus control region versus gene therapy vectors: a struggle for expression. Clin. Genet. 59:17-24.
14. Fernandez, L. A., M. Winkler, and R. Grosschedl. 2001. Matrix attachment region-dependent function of the immunoglobulin mu enhancer involves histone acetylation at a distance without changes in enhancer occupancy. Mol. Cell. Biol. 21:196-208.
15. + multipotent progenitors to Ig-secreting cells. Blood 92:4509-4520.
16. Forrester, W. C., C. van Genderen, T. Jenuwein, and R. Grosschedl. 1994. Dependence of enhancer-mediated transcription of the immunoglobulin mu gene on nuclear matrix attachment regions. Science 265:1221-1225.
17. Gillies, S. D., S. L. Morrison, V. T. Oi, and S. Tonegawa. 1983. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell 33:717-728.
18. Herrscher, R. F., M. H. Kaplan, D. L. Lelsz, C. Das, R. Scheuermann, and P. W. Tucker. 1995. The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family. Genes Dev. 9:3067-3082.
19. Indraccolo, S., S. Minuzzo, F. Roccaforte, R. Zamarchi, W. Habeler, L. Stievano, V. Tosello, D. Klein, W. H. Gunzburg, G. Basso, L. Chieco-Bianchi, and A. Amadori. 2001. Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors. Blood 98:3607-3617.
20. Jenuwein, T., W. C. Forrester, L. A. Fernandez-Herrero, G. Laible, M. Dull, and R. Grosschedl. 1997. Extension of chromatin accessibility by nuclear matrix attachment regions. Nature 385:269-272.
21. Khan, W. N. 2001. Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase. Immunol. Res. 23:147-156.
22. Kowolik, C. M., J. Hu, and J. K. Yee. 2001. Locus control region of the human CD2 gene in a lentivirus vector confers position-independent transgene expression. J. Virol. 75:4641-4648.
23. Maas, A., and R. W. Hendriks. 2001. Role of Bruton's tyrosine kinase in B cell development. Dev. Immunol. 8:171-181.
24. May, C., S. Rivella, J. Callegari, G. Heller, K. M. Gaensler, L. Luzzatto, and M. Sadelain. 2000. Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin. Nature 406:82-86.
25. May, C., S. Rivella, A. Chadburn, and M. Sadelain. 2002. Successful treatment of murine beta-thalassemia intermedia by transfer of the human betaglobin gene. Blood 99:1902-1908.
26. Miyoshi, H., U. Blomer, M. Takahashi, F. H. Gage, and I. M. Verma. 1998. Development of a self-inactivating lentivirus vector. J. Virol. 72:8150-8157.
27. Naldini, L., U. Blomer, P. Gallay, D. Ory, R. Mulligan, F. H. Gage, I. M. Verma, and D. Trono. 1996. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263-267.
28. Park, F., K. Ohashi, W. Chiu, L. Naldini, and M. A. Kay. 2000. Efficient lentiviral transduction of liver requires cell cycling in vivo. Nat. Genet. 24:49-52.
29. Queen, C., and D. Baltimore. 1983. Immunoglobulin gene transcription is activated by downstream sequence elements. Cell 33:741-748.
30. Ronai, D., M. Berru, and M. J. Shulman. 1999. Variegated expression of the endogenous immunoglobulin heavy-chain gene in the absence of the intronic locus control region. Mol. Cell. Biol. 19:7031-7040.
31. Webb, C. F. 2001. The transcription factor, Bright, and immunoglobulin heavy chain expression. Immunol. Res. 24:149-161.
32. Zufferey, R., T. Dull, R. J. Mandel, A. Bukovsky, D. Quiroz, L. Naldini, and D. Trono. 1998. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J. Virol. 72:9873-9880.