-
2
-
-
54249138516
-
Monoclonal antibody pharmacokinetics and pharmacodynamics
-
Wang W., et al. Monoclonal antibody pharmacokinetics and pharmacodynamics. Clin. Pharmacol. Ther. 2008, 84:548-558.
-
(2008)
Clin. Pharmacol. Ther.
, vol.84
, pp. 548-558
-
-
Wang, W.1
-
3
-
-
77957361348
-
Development trends for human monoclonal antibody therapeutics
-
Nelson A.L., et al. Development trends for human monoclonal antibody therapeutics. Nat. Rev. Drug Discov. 2010, 9:767-774.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 767-774
-
-
Nelson, A.L.1
-
4
-
-
0035313635
-
Industrial choices for protein production by large-scale cell culture
-
Chu L., Robinson D.K. Industrial choices for protein production by large-scale cell culture. Curr. Opin. Biotechnol. 2001, 12:180-187.
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 180-187
-
-
Chu, L.1
Robinson, D.K.2
-
5
-
-
70349765751
-
25 years of recombinant proteins from reactor-grown cells - where do we go from here?
-
Hacker D.L., et al. 25 years of recombinant proteins from reactor-grown cells - where do we go from here?. Biotechnol. Adv. 2009, 27:1023-1027.
-
(2009)
Biotechnol. Adv.
, vol.27
, pp. 1023-1027
-
-
Hacker, D.L.1
-
6
-
-
33747362656
-
Optimisation of the cellular metabolism of glycosylation for recombinant proteins produced by Mammalian cell systems
-
Butler M. Optimisation of the cellular metabolism of glycosylation for recombinant proteins produced by Mammalian cell systems. Cytotechnology 2006, 50:57-76.
-
(2006)
Cytotechnology
, vol.50
, pp. 57-76
-
-
Butler, M.1
-
7
-
-
23844547597
-
Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?
-
Dinnis D.M., James D.C. Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?. Biotechnol. Bioeng. 2005, 91:180-189.
-
(2005)
Biotechnol. Bioeng.
, vol.91
, pp. 180-189
-
-
Dinnis, D.M.1
James, D.C.2
-
8
-
-
0029837484
-
Getting the glycosylation right: implications for the biotechnology industry
-
Jenkins N., et al. Getting the glycosylation right: implications for the biotechnology industry. Nat. Biotechnol. 1996, 14:975-981.
-
(1996)
Nat. Biotechnol.
, vol.14
, pp. 975-981
-
-
Jenkins, N.1
-
9
-
-
8344271026
-
Production of recombinant protein therapeutics in cultivated mammalian cells
-
Wurm F.M. Production of recombinant protein therapeutics in cultivated mammalian cells. Nat. Biotechnol. 2004, 22:1393-1398.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1393-1398
-
-
Wurm, F.M.1
-
10
-
-
0020574233
-
Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells
-
Urlaub G., et al. Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells. Cell 1983, 33:405-412.
-
(1983)
Cell
, vol.33
, pp. 405-412
-
-
Urlaub, G.1
-
11
-
-
0032924570
-
Disposable bioreactor for cell culture using wave-induced agitation
-
Singh V. Disposable bioreactor for cell culture using wave-induced agitation. Cytotechnology 1999, 30:149-158.
-
(1999)
Cytotechnology
, vol.30
, pp. 149-158
-
-
Singh, V.1
-
12
-
-
44049095731
-
Shaken helical track bioreactors: providing oxygen to high-density cultures of mammalian cells at volumes up to 1000L by surface aeration with air
-
Zhang X., et al. Shaken helical track bioreactors: providing oxygen to high-density cultures of mammalian cells at volumes up to 1000L by surface aeration with air. Nat. Biotechnol. 2008, 25:68-75.
-
(2008)
Nat. Biotechnol.
, vol.25
, pp. 68-75
-
-
Zhang, X.1
-
13
-
-
74949110521
-
Use of orbital shaken disposable bioreactors for mammalian cell cultures from the milliliter-scale to the 1000-liter scale
-
Zhang X., et al. Use of orbital shaken disposable bioreactors for mammalian cell cultures from the milliliter-scale to the 1000-liter scale. Adv. Biochem. Eng. Biotechnol. 2010, 115:33-53.
-
(2010)
Adv. Biochem. Eng. Biotechnol.
, vol.115
, pp. 33-53
-
-
Zhang, X.1
-
14
-
-
77957962291
-
Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells
-
Zhang X., et al. Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells. Biotechnol. Lett. 2010.
-
(2010)
Biotechnol. Lett.
-
-
Zhang, X.1
-
15
-
-
0036426979
-
S-phase synchronized CHO cells show elevated transfection efficiency and expression using CaPi
-
Grosjean F., et al. S-phase synchronized CHO cells show elevated transfection efficiency and expression using CaPi. Cytotechnology 2002, 38:57-62.
-
(2002)
Cytotechnology
, vol.38
, pp. 57-62
-
-
Grosjean, F.1
-
16
-
-
26944481086
-
CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells
-
Williams S., et al. CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells. BMC Biotechnol. 2005, 5:17.
-
(2005)
BMC Biotechnol.
, vol.5
, pp. 17
-
-
Williams, S.1
-
17
-
-
59249084751
-
Sustained transgene expression using MAR elements
-
Harraghy N., et al. Sustained transgene expression using MAR elements. Curr. Gene Ther. 2008, 8:353-366.
-
(2008)
Curr. Gene Ther.
, vol.8
, pp. 353-366
-
-
Harraghy, N.1
-
18
-
-
12444283327
-
Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing
-
Antoniou M., et al. Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing. Genomics 2003, 82:269-279.
-
(2003)
Genomics
, vol.82
, pp. 269-279
-
-
Antoniou, M.1
-
19
-
-
39749191443
-
Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 ubiquitously-acting chromatin open element (UCOE)
-
Lindahl Allen M., Antoniou M. Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 ubiquitously-acting chromatin open element (UCOE). Epigenetics 2007, 2:227-236.
-
(2007)
Epigenetics
, vol.2
, pp. 227-236
-
-
Lindahl Allen, M.1
Antoniou, M.2
-
20
-
-
34548843603
-
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells
-
Zhang F., et al. Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells. Blood 2007, 110:1448-1457.
-
(2007)
Blood
, vol.110
, pp. 1448-1457
-
-
Zhang, F.1
-
21
-
-
77956265818
-
A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors
-
Zhang F., et al. A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors. Mol. Ther. 2010, 18:1640-1649.
-
(2010)
Mol. Ther.
, vol.18
, pp. 1640-1649
-
-
Zhang, F.1
-
22
-
-
34548402959
-
Construction of miniantibodies for the in vivo study of human autoimmune diseases in animal models
-
Di Niro R., et al. Construction of miniantibodies for the in vivo study of human autoimmune diseases in animal models. BMC Biotechnol. 2007, 7:46.
-
(2007)
BMC Biotechnol.
, vol.7
, pp. 46
-
-
Di Niro, R.1
-
23
-
-
0035869574
-
Molecular dissection of the tissue transglutaminase autoantibody response in celiac disease
-
Marzari R., et al. Molecular dissection of the tissue transglutaminase autoantibody response in celiac disease. J. Immunol. 2001, 166:4170-4176.
-
(2001)
J. Immunol.
, vol.166
, pp. 4170-4176
-
-
Marzari, R.1
-
24
-
-
62649096816
-
Selection and characterization of a novel agonistic human recombinant anti-TRAIL-R2 minibody with anti-leukemic activity
-
Secchiero P., et al. Selection and characterization of a novel agonistic human recombinant anti-TRAIL-R2 minibody with anti-leukemic activity. Int. J. Immunopathol. Pharmacol. 2009, 22:73-83.
-
(2009)
Int. J. Immunopathol. Pharmacol.
, vol.22
, pp. 73-83
-
-
Secchiero, P.1
-
25
-
-
22544462219
-
Controlling complement resistance in cancer by using human monoclonal antibodies that neutralize complement-regulatory proteins CD55 and CD59
-
Ziller F., et al. Controlling complement resistance in cancer by using human monoclonal antibodies that neutralize complement-regulatory proteins CD55 and CD59. Eur. J. Immunol. 2005, 35:2175-2183.
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 2175-2183
-
-
Ziller, F.1
-
26
-
-
0036772528
-
The cleavage site of C5 from man and animals as a common target for neutralizing human monoclonal antibodies: in vitro and in vivo studies
-
Marzari R., et al. The cleavage site of C5 from man and animals as a common target for neutralizing human monoclonal antibodies: in vitro and in vivo studies. Eur. J. Immunol. 2002, 32:2773-2782.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 2773-2782
-
-
Marzari, R.1
-
27
-
-
0026568735
-
Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen
-
Hanke T., et al. Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen. J. Gen. Virol. 1992, 73(Pt. 3):653-660.
-
(1992)
J. Gen. Virol.
, vol.73
, Issue.PART. 3
, pp. 653-660
-
-
Hanke, T.1
-
28
-
-
0035342590
-
Expression of single-chain Fv-Fc fusions in Pichia pastoris
-
Powers D.B., et al. Expression of single-chain Fv-Fc fusions in Pichia pastoris. J. Immunol. Methods 2001, 251:123-135.
-
(2001)
J. Immunol. Methods
, vol.251
, pp. 123-135
-
-
Powers, D.B.1
-
29
-
-
23844433927
-
Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals
-
Butler M. Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals. Appl. Microbiol. Biotechnol. 2005, 68:283-291.
-
(2005)
Appl. Microbiol. Biotechnol.
, vol.68
, pp. 283-291
-
-
Butler, M.1
-
30
-
-
0036317909
-
Industrial processes with animal cells
-
Kretzmer G. Industrial processes with animal cells. Appl. Microbiol. Biotechnol. 2002, 59:135-142.
-
(2002)
Appl. Microbiol. Biotechnol.
, vol.59
, pp. 135-142
-
-
Kretzmer, G.1
|