Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Breda, Laura ^a   Casu, Carla ^a   Gardenghi, Sara ^a   Bianchi, Nicoletta ^b   Cartegni, Luca ^c   Narla, Mohandas ^d   Yazdanbakhsh, Karina ^d   Musso, Marco ^e   Manwani, Deepa ^f   Little, Jane ^g   Gardner, Lawrence B ^h   Kleinert, Dorothy A ^a   Prus, Eugenia ⁱ   Fibach, Eitan ⁱ   Grady, Robert W ^a   Giardina, Patricia J ^a   Gambari, Roberto ^b   Rivella, Stefano ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF FERRARA   (Italy)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d NEW YORK BLOOD CENTER   (United States)

^e GALLIERA HOSPITAL   (Italy)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^g MONTEFIORE MEDICAL CENTER   (United States)

^h NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

ⁱ HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; ANKYRIN; BETA GLOBIN; CD71 ANTIGEN; HEMOGLOBIN; HEMOGLOBIN A; HEMOGLOBIN F; HEMOGLOBIN S; HERMES ANTIGEN; IRON; LENTIVIRUS VECTOR; MESSENGER RNA; CD34 ANTIGEN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANKYRIN INSULATOR ELEMENT; ARTICLE; BETA GLOBIN GENE; BETA THALASSEMIA; BONE MARROW TRANSPLANTATION; CD34 SELECTION; CELL DIFFERENTIATION; CELL ISOLATION; CHIMERA; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROCYTE STRUCTURE; ERYTHROID CELL; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; FEMALE; GENE; GENE DOSAGE; GENE EXPRESSION; GENE INSERTION; GENE MUTATION; HEMATOCRIT; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULATOR ELEMENT; IRON LIVER LEVEL; LIVER LEVEL; MOUSE; NONHUMAN; RED CELL DISTRIBUTION WIDTH; RETICULOCYTE COUNT; RNA TRANSCRIPTION; RNA TRANSLATION; SICKLE CELL ANEMIA; SPLEEN; SPLEEN IRON; SPLEEN SIZE; SPLENOMEGALY; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; ADULT; ANIMAL; BLOOD; CELL CULTURE; CELL STRAIN 3T3; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; LENTIVIRINAE; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; TUMOR CELL LINE;

MUS;

ADULT; ANEMIA, SICKLE CELL; ANIMALS; ANKYRINS; ANTIGENS, CD34; BASE SEQUENCE; BETA-GLOBINS; BETA-THALASSEMIA; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELLS, CULTURED; ERYTHROID PRECURSOR CELLS; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEMOGLOBINS; HUMANS; INSULATOR ELEMENTS; LENTIVIRUS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NIH 3T3 CELLS;

EID: 84858978712     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032345     Document Type: Article

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