메뉴 건너뛰기




Volumn 19, Issue 10, 2012, Pages 1018-1029

Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter

Author keywords

Lentiviral vector; Myeloid expression; Silencing; UCOE; X CGD

Indexed keywords

LENTIVIRUS VECTOR; MYELOID RELATED PROTEIN 8; PROTEIN; UNCLASSIFIED DRUG;

EID: 84867402831     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.167     Document Type: Article
Times cited : (49)

References (58)
  • 5
    • 47149115696 scopus 로고    scopus 로고
    • Recent advances in gene therapy for severe congenital immunodeficiency diseases
    • Sokolic R, Kesserwan C, Candotti F. Recent advances in gene therapy for severe congenital immunodeficiency diseases. CurrOpin Hematol 2008; 15: 375-380.
    • (2008) CurrOpin Hematol , vol.15 , pp. 375-380
    • Sokolic, R.1    Kesserwan, C.2    Candotti, F.3
  • 6
    • 70449127230 scopus 로고    scopus 로고
    • Insertional transformation ofhematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors
    • Modlich U, Navarro S, Zychlinski D, Maetzig T, Knoess S, Brugman MH et al. Insertional transformation ofhematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors. Mol Ther 2009; 17: 1919-1928.
    • (2009) Mol Ther , vol.17 , pp. 1919-1928
    • Modlich, U.1    Navarro, S.2    Zychlinski, D.3    Maetzig, T.4    Knoess, S.5    Brugman, M.H.6
  • 7
    • 76249131912 scopus 로고    scopus 로고
    • Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after genetherapyforchronic granulomatous disease
    • Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, Kinner A et al. Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after genetherapyforchronic granulomatous disease. Nat Med2010; 16:198-204.
    • (2010) Nat Med , vol.16 , pp. 198-204
    • Stein, S.1    Ott, M.G.2    Schultze-Strasser, S.3    Jauch, A.4    Burwinkel, B.5    Kinner, A.6
  • 8
    • 33645734405 scopus 로고    scopus 로고
    • Correction ofX-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
    • Ott MG, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U et al. Correction ofX-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med 2006; 12: 401-409.
    • (2006) Nat Med , vol.12 , pp. 401-409
    • Ott, M.G.1    Schmidt, M.2    Schwarzwaelder, K.3    Stein, S.4    Siler, U.5    Koehl, U.6
  • 10
    • 80855132872 scopus 로고    scopus 로고
    • Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease
    • E-pub Ahead Of Print 5 May 2011; doi:10.1038/gt.2011.65
    • Barde I, Laurenti E, Verp S, Wiznerowicz M, Offner S, Viornery A et al. Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease. Gene Therapy 2011; e-pub ahead of print 5 May 2011; doi:10.1038/gt.2011.65.
    • (2011) Gene Therapy
    • Barde, I.1    Laurenti, E.2    Verp, S.3    Wiznerowicz, M.4    Offner, S.5    Viornery, A.6
  • 11
    • 78650918644 scopus 로고    scopus 로고
    • Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells
    • Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP et al. Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells. Mol Ther 2011; 19: 122-132.
    • (2011) Mol Ther , vol.19 , pp. 122-132
    • Santilli, G.1    Almarza, E.2    Brendel, C.3    Choi, U.4    Beilin, C.5    Blundell, M.P.6
  • 12
    • 27744489220 scopus 로고    scopus 로고
    • Silencing and variegation of gammaretrovirus and lentivirus vectors
    • DOI 10.1089/hum.2005.16.1241
    • Ellis J. Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum Gene Ther2005; 16: 1241 -1246. (Pubitemid 41611651)
    • (2005) Human Gene Therapy , vol.16 , Issue.11 , pp. 1241-1246
    • Ellis, J.1
  • 13
    • 79955852358 scopus 로고    scopus 로고
    • The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors
    • Emery DW. The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors. Hum Gene Ther 2011; 22: 761 -774.
    • (2011) Hum Gene Ther , vol.22 , pp. 761-774
    • Emery, D.W.1
  • 16
    • 64549124715 scopus 로고    scopus 로고
    • CpG islands: Algorithms and applications in methylation studies
    • Zhao Z, Han L. CpG islands: algorithms and applications in methylation studies. Biochem Biophys Res Commun 2009; 382: 643-645.
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 643-645
    • Zhao, Z.1    Han, L.2
  • 17
    • 79955637702 scopus 로고    scopus 로고
    • The dinucleotide CG as a genomic signalling module
    • Bird A. The dinucleotide CG as a genomic signalling module. J Mol Biol2011; 409: 47-53.
    • (2011) J Mol Biol , vol.409 , pp. 47-53
    • Bird, A.1
  • 18
    • 26944481086 scopus 로고    scopus 로고
    • CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells
    • Williams S, Mustoe T, Mulcahy T, Griffiths M, Simpson D, Antoniou M et al. CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells. BMC Biotechnol 2005; 5: 17.
    • (2005) BMC Biotechnol , vol.5 , pp. 17
    • Williams, S.1    Mustoe, T.2    Mulcahy, T.3    Griffiths, M.4    Simpson, D.5    Antoniou, M.6
  • 19
    • 77956265818 scopus 로고    scopus 로고
    • A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors
    • Zhang F, Frost AR, Blundell MP, Bales O, Antoniou MN, Thrasher AJ. A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors. Mol Ther 2010; 18: 1640-1649.
    • (2010) Mol Ther , vol.18 , pp. 1640-1649
    • Zhang, F.1    Frost, A.R.2    Blundell, M.P.3    Bales, O.4    Antoniou, M.N.5    Thrasher, A.J.6
  • 20
    • 49149091892 scopus 로고    scopus 로고
    • The core element of a CpG island protects avian sarcoma and leukosis virus-derived vectors from transcriptional silencing
    • Senigl F, Plachy J, Hejnar J. The core element of a CpG island protects avian sarcoma and leukosis virus-derived vectors from transcriptional silencing. J Virol 2008; 82: 7818-7827.
    • (2008) J Virol , vol.82 , pp. 7818-7827
    • Senigl, F.1    Plachy, J.2    Hejnar, J.3
  • 21
    • 34548843603 scopus 로고    scopus 로고
    • Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells
    • DOI 10.1182/blood-2006-12-060814
    • Zhang F, Thornhill SI, Howe SJ, Ulaganathan M, Schambach A, Sinclair J et al. Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells. Blood 2007; 110: 1448-1457. (Pubitemid 47443959)
    • (2007) Blood , vol.110 , Issue.5 , pp. 1448-1457
    • Zhang, F.1    Thornhill, S.I.2    Howe, S.J.3    Ulaganathan, M.4    Schambach, A.5    Sinclair, J.6    Kinnon, C.7    Gaspar, H.B.8    Antoniou, M.9    Thrasher, A.J.10
  • 23
    • 39749191443 scopus 로고    scopus 로고
    • Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 Ubiquitously-Acting Chromatin Open Element (UCOE)
    • Lindahl Allen M, Antoniou M. Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 ubiquitously-acting chromatin open element (UCOE). Epigenetics 2007; 2: 227-236. (Pubitemid 351308298)
    • (2007) Epigenetics , vol.2 , Issue.4 , pp. 227-236
    • Allen, M.L.1    Antoniou, M.2
  • 24
    • 43549114589 scopus 로고    scopus 로고
    • Neutrophil-selective CD18 silencing using RNA interference in vivo
    • Cullere X, Lauterbach M, Tsuboi N, Mayadas TN. Neutrophil-selective CD18 silencing using RNA interference in vivo. Blood 2008; 111: 3591 -3598.
    • (2008) Blood , vol.111 , pp. 3591-3598
    • Cullere, X.1    Lauterbach, M.2    Tsuboi, N.3    Mayadas, T.N.4
  • 25
    • 0023944868 scopus 로고
    • Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation
    • Lagasse E, Clerc RG. Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation. Mol Cell Biol 1988; 8: 2402-2410.
    • (1988) Mol Cell Biol , vol.8 , pp. 2402-2410
    • Lagasse, E.1    Clerc, R.G.2
  • 26
    • 0026656719 scopus 로고
    • Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage
    • Lagasse E, Weissman IL. Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood 1992; 79: 1907-1915.
    • (1992) Blood , vol.79 , pp. 1907-1915
    • Lagasse, E.1    Weissman, I.L.2
  • 27
    • 0027958313 scopus 로고
    • Bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages
    • Lagasse E, Weissman IL. Bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med 1994; 179: 1047-1052. (Pubitemid 24065666)
    • (1994) Journal of Experimental Medicine , vol.179 , Issue.3 , pp. 1047-1052
    • Lagasse, E.1    Weissman, I.L.2
  • 28
    • 27144536258 scopus 로고    scopus 로고
    • Dynamic DNA methylation and histone modifications contribute to lentiviral transgene silencing in murine embryonic carcinoma cells
    • DOI 10.1128/JVI.79.21.13497-13508.2005
    • He J, Yang Q, Chang LJ. Dynamic DNA methylation and histone modifications contribute to lentiviral transgene silencing in murine embryonic carcinoma cells. J Virol 2005; 79: 13497-13508. (Pubitemid 41508162)
    • (2005) Journal of Virology , vol.79 , Issue.21 , pp. 13497-13508
    • He, J.1    Yang, Q.2    Chang, L.-J.3
  • 29
    • 77957932941 scopus 로고    scopus 로고
    • Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
    • Harris RA, Wang T, Coarfa C, Nagarajan RP, Hong C, Downey SL et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol 2010; 28: 1097-1105.
    • (2010) Nat Biotechnol , vol.28 , pp. 1097-1105
    • Harris, R.A.1    Wang, T.2    Coarfa, C.3    Nagarajan, R.P.4    Hong, C.5    Downey, S.L.6
  • 30
    • 77953809032 scopus 로고    scopus 로고
    • Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
    • Hawkins RD, Hon GC, Lee LK, Ngo Q, Lister R, Pelizzola M et al. Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell 2010; 6: 479-491.
    • (2010) Cell Stem Cell , vol.6 , pp. 479-491
    • Hawkins, R.D.1    Hon, G.C.2    Lee, L.K.3    Ngo, Q.4    Lister, R.5    Pelizzola, M.6
  • 33
    • 33847205752 scopus 로고    scopus 로고
    • The genetic engineering of hematopoietic stem cells: The rise of lentiviral vectors, the conundrum of the ltr, and the promise of lineage-restricted vectors
    • Chang AH, Sadelain M. The genetic engineering of hematopoietic stem cells: the rise of lentiviral vectors, the conundrum of the ltr, and the promise of lineage-restricted vectors. Mol Ther 2007; 15: 445-456.
    • (2007) Mol Ther , vol.15 , pp. 445-456
    • Chang, A.H.1    Sadelain, M.2
  • 34
    • 69949164575 scopus 로고    scopus 로고
    • Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis
    • Kustikova OS, Schiedlmeier B, Brugman MH, Stahlhut M, Bartels S, Li Z et al. Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis. Mol Ther 2009; 17: 1537-1547.
    • (2009) Mol Ther , vol.17 , pp. 1537-1547
    • Kustikova, O.S.1    Schiedlmeier, B.2    Brugman, M.H.3    Stahlhut, M.4    Bartels, S.5    Li, Z.6
  • 36
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation ofmyeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    • Cheng P, Corzo CA, Luetteke N, Yu B, Nagaraj S, Bui MM et al. Inhibition of dendritic cell differentiation and accumulation ofmyeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008; 205: 2235-2249.
    • (2008) J Exp Med , vol.205 , pp. 2235-2249
    • Cheng, P.1    Corzo, C.A.2    Luetteke, N.3    Yu, B.4    Nagaraj, S.5    Bui, M.M.6
  • 37
    • 61449129154 scopus 로고    scopus 로고
    • IL-10-dependent S100A8 gene induction in monocytes/macrophages by double-stranded RNA
    • Endoh Y, Chung YM, Clark IA, Geczy CL, Hsu K. IL-10-dependent S100A8 gene induction in monocytes/macrophages by double-stranded RNA. J Immunol 2009; 182: 2258-2268.
    • (2009) J Immunol , vol.182 , pp. 2258-2268
    • Endoh, Y.1    Chung, Y.M.2    Clark, I.A.3    Geczy, C.L.4    Hsu, K.5
  • 38
    • 70350070334 scopus 로고    scopus 로고
    • S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis
    • Nemeth J, Stein I, Haag D, Riehl A, Longerich T, Horwitz E et al. S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis. Hepatology 2009; 50: 1251-1262.
    • (2009) Hepatology , vol.50 , pp. 1251-1262
    • Nemeth, J.1    Stein, I.2    Haag, D.3    Riehl, A.4    Longerich, T.5    Horwitz, E.6
  • 39
    • 77449142258 scopus 로고    scopus 로고
    • Hyperglycemia-induced reactive oxygen species increase expression of the receptorforadvanced glycation end products (RAGE) and RAGE ligands
    • Yao D, Brownlee M. Hyperglycemia-induced reactive oxygen species increase expression of the receptorforadvanced glycation end products (RAGE) and RAGE ligands. Diabetes 2010; 59: 249-255.
    • (2010) Diabetes , vol.59 , pp. 249-255
    • Yao, D.1    Brownlee, M.2
  • 40
    • 33750505883 scopus 로고    scopus 로고
    • S100A8 and S100A9 in inflammation and cancer
    • DOI 10.1016/j.bcp.2006.05.017, PII S0006295206003182, Cell Signalling, Transcription and Translation as Therapeutic Tergets
    • Gebhardt C, Nemeth J, Angel P, Hess J. S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol 2006; 72: 1622-1631. (Pubitemid 44666730)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.11 , pp. 1622-1631
    • Gebhardt, C.1    Nemeth, J.2    Angel, P.3    Hess, J.4
  • 42
    • 0027547066 scopus 로고
    • MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytes
    • Hessian PA, Edgeworth J, Hogg N. MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytes.J Leukoc Biol 1993; 53: 197-204.
    • (1993) J Leukoc Biol , vol.53 , pp. 197-204
    • Hessian, P.A.1    Edgeworth, J.2    Hogg, N.3
  • 43
    • 0033951116 scopus 로고    scopus 로고
    • Variegation of retroviral vector gene expression in myeloid cells
    • Zentilin L, Qin G, Tafuro S, Dinauer MC, Baum C, Giacca M. Variegation of retroviral vector gene expression in myeloid cells. Gene Therapy2000; 7: 153-166. (Pubitemid 30088961)
    • (2000) Gene Therapy , vol.7 , Issue.2 , pp. 153-166
    • Zentilin, L.1    Qin, G.2    Tafuro, S.3    Dinauer, M.C.4    Baum, C.5    Giacca, M.6
  • 46
    • 66449107633 scopus 로고    scopus 로고
    • Potent transcriptional interference by pausing of RNA polymerases over a downstream promoter
    • Palmer AC, Ahlgren-Berg A, Egan JB, Dodd IB, Shearwin KE. Potent transcriptional interference by pausing of RNA polymerases over a downstream promoter. Mol Cell 2009; 34: 545-555.
    • (2009) Mol Cell , vol.34 , pp. 545-555
    • Palmer, A.C.1    Ahlgren-Berg, A.2    Egan, J.B.3    Dodd, I.B.4    Shearwin, K.E.5
  • 47
    • 78149477660 scopus 로고    scopus 로고
    • Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation
    • Gilchrist DA, Dos Santos G, Fargo DC, Xie B, Gao Y, Li L et al. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation.Cell2010; 143:540-551.
    • (2010) Cell , vol.143 , pp. 540-551
    • Gilchrist, D.A.1    Dos Santos, G.2    Fargo, D.C.3    Xie, B.4    Gao, Y.5    Li, L.6
  • 48
    • 67649648237 scopus 로고    scopus 로고
    • Control of inducible gene expression by signal-dependent transcriptional elongation
    • Hargreaves DC, Horng T, Medzhitov R. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 2009; 138: 129-145.
    • (2009) Cell , vol.138 , pp. 129-145
    • Hargreaves, D.C.1    Horng, T.2    Medzhitov, R.3
  • 49
    • 0029817964 scopus 로고    scopus 로고
    • High-level reconstitution of respiratory burst activity in a human X- linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91(phox)
    • Ding C, Kume A, Bjorgvinsdottir H, Hawley RG, Pech N, Dinauer MC. High-level reconstitution of respiratory burst activity in a human X-linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox. Blood 1996; 88: 1834-1840. (Pubitemid 26307081)
    • (1996) Blood , vol.88 , Issue.5 , pp. 1834-1840
    • Ding, C.1    Kume, A.2    Bjorgvinsdottir, H.3    Hawley, R.G.4    Pech, N.5    Dinauer, M.C.6
  • 50
    • 0028893203 scopus 로고
    • Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
    • Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J et al. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet 1995; 9: 202-209.
    • (1995) Nat Genet , vol.9 , pp. 202-209
    • Pollock, J.D.1    Williams, D.A.2    Gifford, M.A.3    Li, L.L.4    Du, X.5    Fisherman, J.6
  • 51
    • 19444386119 scopus 로고    scopus 로고
    • Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion
    • DOI 10.1182/blood-2004-11-4418
    • Zhang CC, Lodish HF. Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion. Blood 2005; 105: 4314-4320. (Pubitemid 40723656)
    • (2005) Blood , vol.105 , Issue.11 , pp. 4314-4320
    • Cheng, C.Z.1    Lodish, H.F.2
  • 52
    • 79953072037 scopus 로고    scopus 로고
    • Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells
    • Maetzig T, Brugman MH, Bartels S, Heinz N, Kustikova OS, Modlich U et al. Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells. Blood 2011; 117: 3053 - 3064.
    • (2011) Blood , vol.117 , pp. 3053-3064
    • Maetzig, T.1    Brugman, M.H.2    Bartels, S.3    Heinz, N.4    Kustikova, O.S.5    Modlich, U.6
  • 53
    • 0036252492 scopus 로고    scopus 로고
    • High-level transduction and gene expression in hematopoietic repopulating cells using a human imunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter
    • DOI 10.1089/10430340252898984
    • Demaison C, Parsley K, Brouns G, Scherr M, Battmer K, Kinnon C et al. High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of immnodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Hum Gene Ther 2002; 13: 803-813. (Pubitemid 34493974)
    • (2002) Human Gene Therapy , vol.13 , Issue.7 , pp. 803-813
    • Demaison, C.1    Parsley, K.2    Brouns, G.3    Scherr, M.4    Battmer, K.5    Kinnon, C.6    Grez, M.7    Thrasher, A.J.8
  • 54
    • 33645103149 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression
    • Schambach A, Bohne J, Baum C, Hermann FG, Egerer L, von Laer D et al. Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression. Gene Therapy 2006; 13: 641 -645.
    • (2006) Gene Therapy , vol.13 , pp. 641-645
    • Schambach, A.1    Bohne, J.2    Baum, C.3    Hermann, F.G.4    Egerer, L.5    Von Laer, D.6
  • 55
    • 58149469932 scopus 로고    scopus 로고
    • Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells
    • Moreno-Carranza B, Gentsch M, Stein S, Schambach A, Santilli G, Rudolf E et al. Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells. Gene Therapy 2009; 16: 111-118.
    • (2009) Gene Therapy , vol.16 , pp. 111-118
    • Moreno-Carranza, B.1    Gentsch, M.2    Stein, S.3    Schambach, A.4    Santilli, G.5    Rudolf, E.6
  • 58
    • 36349010744 scopus 로고    scopus 로고
    • Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia
    • DOI 10.1038/sj.leu.2404961, PII 2404961
    • Tonks A, Pearn L, Musson M, Gilkes A, Mills KI, Burnett AK et al. Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia. Leukemia 2007; 21: 2495-2505. (Pubitemid 350148893)
    • (2007) Leukemia , vol.21 , Issue.12 , pp. 2495-2505
    • Tonks, A.1    Pearn, L.2    Musson, M.3    Gilkes, A.4    Mills, K.I.5    Burnett, A.K.6    Darley, R.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.