-
1
-
-
0035687018
-
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
-
Abraham R., Myers A., Wavrant-DeVrieze F., Hamshere M.L., Thomas H.V., Marshall H., Compton D., Spurlock G., Turic D., Hoogendoorn B., Kwon J.M., Petersen R.C., Tangalos E., Norton J., Morris J.C., Bullock R., Liolitsa D., Lovestone S., Hardy J., Goate A., O'Donovan M., Williams J., Owen M.J., Jones L. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Hum. Genet. 2001, 109:646-652.
-
(2001)
Hum. Genet.
, vol.109
, pp. 646-652
-
-
Abraham, R.1
Myers, A.2
Wavrant-DeVrieze, F.3
Hamshere, M.L.4
Thomas, H.V.5
Marshall, H.6
Compton, D.7
Spurlock, G.8
Turic, D.9
Hoogendoorn, B.10
Kwon, J.M.11
Petersen, R.C.12
Tangalos, E.13
Norton, J.14
Morris, J.C.15
Bullock, R.16
Liolitsa, D.17
Lovestone, S.18
Hardy, J.19
Goate, A.20
O'Donovan, M.21
Williams, J.22
Owen, M.J.23
Jones, L.24
more..
-
2
-
-
3242777669
-
Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese
-
Bian L., Yang J.D., Guo T.W., Sun Y., Duan S.W., Chen W.Y., Pan Y.X., Feng G.Y., He L. Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese. Neurology 2004, 63:241-245.
-
(2004)
Neurology
, vol.63
, pp. 241-245
-
-
Bian, L.1
Yang, J.D.2
Guo, T.W.3
Sun, Y.4
Duan, S.W.5
Chen, W.Y.6
Pan, Y.X.7
Feng, G.Y.8
He, L.9
-
3
-
-
34447556836
-
Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE
-
Bjork B.F., Katzov H., Kehoe P., Fratiglioni L., Winblad B., Prince J.A., Graff C. Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE. Neurobiol. Aging 2007, 28:1374-1380.
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1374-1380
-
-
Bjork, B.F.1
Katzov, H.2
Kehoe, P.3
Fratiglioni, L.4
Winblad, B.5
Prince, J.A.6
Graff, C.7
-
4
-
-
0037162647
-
Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease
-
Boussaha M., Hannequin D., Verpillat P., Brice A., Frebourg T., Campion D. Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease. Neurosci. Lett. 2002, 329:121-123.
-
(2002)
Neurosci. Lett.
, vol.329
, pp. 121-123
-
-
Boussaha, M.1
Hannequin, D.2
Verpillat, P.3
Brice, A.4
Frebourg, T.5
Campion, D.6
-
6
-
-
33644968179
-
Insulin degrading enzyme and alpha-3 catenin polymorphisms in Italian patients with Alzheimer disease
-
Cellini E., Bagnoli S., Tedde A., Nacmias B., Piacentini S., Sorbi S. Insulin degrading enzyme and alpha-3 catenin polymorphisms in Italian patients with Alzheimer disease. Alzheimer Dis. Assoc. Disord. 2005, 19:246-247.
-
(2005)
Alzheimer Dis. Assoc. Disord.
, vol.19
, pp. 246-247
-
-
Cellini, E.1
Bagnoli, S.2
Tedde, A.3
Nacmias, B.4
Piacentini, S.5
Sorbi, S.6
-
7
-
-
33845571913
-
Random-effects model for meta-analysis of clinical trials: an update
-
DerSimonian R., Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp. Clin. Trials 2007, 28:105-114.
-
(2007)
Contemp. Clin. Trials
, vol.28
, pp. 105-114
-
-
DerSimonian, R.1
Kacker, R.2
-
8
-
-
0038519618
-
Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE)
-
Edland S.D., Wavrant-De Vriese F., Compton D., Smith G.E., Ivnik R., Boeve B.F., Tangalos E.G., Petersen R.C. Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE). Neurosci. Lett. 2003, 345:21-24.
-
(2003)
Neurosci. Lett.
, vol.345
, pp. 21-24
-
-
Edland, S.D.1
Wavrant-De Vriese, F.2
Compton, D.3
Smith, G.E.4
Ivnik, R.5
Boeve, B.F.6
Tangalos, E.G.7
Petersen, R.C.8
-
9
-
-
1842765688
-
Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease
-
Ertekin-Taner N., Allen M., Fadale D., Scanlin L., Younkin L., Petersen R.C., Graff-Radford N., Younkin S.G. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. Hum. Mutat. 2004, 23:334-342.
-
(2004)
Hum. Mutat.
, vol.23
, pp. 334-342
-
-
Ertekin-Taner, N.1
Allen, M.2
Fadale, D.3
Scanlin, L.4
Younkin, L.5
Petersen, R.C.6
Graff-Radford, N.7
Younkin, S.G.8
-
10
-
-
17844382678
-
Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein
-
Farris W., Leissring M.A., Hemming M.L., Chang A.Y., Selkoe D.J. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry 2005, 44:6513-6525.
-
(2005)
Biochemistry
, vol.44
, pp. 6513-6525
-
-
Farris, W.1
Leissring, M.A.2
Hemming, M.L.3
Chang, A.Y.4
Selkoe, D.J.5
-
11
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
-
Farris W., Mansourian S., Chang Y., Lindsley L., Eckman E.A., Frosch M.P., Eckman C.B., Tanzi R.E., Selkoe D.J., Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:4162-4167.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
Lindsley, L.4
Eckman, E.A.5
Frosch, M.P.6
Eckman, C.B.7
Tanzi, R.E.8
Selkoe, D.J.9
Guenette, S.10
-
12
-
-
1642290835
-
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
-
Farris W., Mansourian S., Leissring M.A., Eckman E.A., Bertram L., Eckman C.B., Tanzi R.E., Selkoe D.J. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am. J. Pathol. 2004, 164:1425-1434.
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 1425-1434
-
-
Farris, W.1
Mansourian, S.2
Leissring, M.A.3
Eckman, E.A.4
Bertram, L.5
Eckman, C.B.6
Tanzi, R.E.7
Selkoe, D.J.8
-
13
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
14
-
-
0028176821
-
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
-
Kurochkin I.V., Goto S. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 1994, 345:33-37.
-
(1994)
FEBS Lett.
, vol.345
, pp. 33-37
-
-
Kurochkin, I.V.1
Goto, S.2
-
15
-
-
84959801619
-
Statistical aspects of the analysis of data from retrospective studies of disease
-
Mantel N., Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 1959, 22:719-748.
-
(1959)
J. Natl. Cancer Inst.
, vol.22
, pp. 719-748
-
-
Mantel, N.1
Haenszel, W.2
-
16
-
-
33845935327
-
Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk
-
Marlowe L., Peila R., Benke K.S., Hardy J., White L.R., Launer L.J., Myers A. Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. Neurodegener. Dis. 2006, 3:320-326.
-
(2006)
Neurodegener. Dis.
, vol.3
, pp. 320-326
-
-
Marlowe, L.1
Peila, R.2
Benke, K.S.3
Hardy, J.4
White, L.R.5
Launer, L.J.6
Myers, A.7
-
17
-
-
0031044352
-
Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme
-
McDermott J.R., Gibson A.M. Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme. Neurochem. Res. 1997, 22:49-56.
-
(1997)
Neurochem. Res.
, vol.22
, pp. 49-56
-
-
McDermott, J.R.1
Gibson, A.M.2
-
18
-
-
0037947406
-
Amyloid-beta peptide levels in brain are inversely correlated with insulin activity levels in vivo
-
Miller B.C., Eckman E.A., Sambamurti K., Dobbs N., Chow K.M., Eckman C.B., Hersh L.B., Thiele D.L. Amyloid-beta peptide levels in brain are inversely correlated with insulin activity levels in vivo. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:6221-6226.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 6221-6226
-
-
Miller, B.C.1
Eckman, E.A.2
Sambamurti, K.3
Dobbs, N.4
Chow, K.M.5
Eckman, C.B.6
Hersh, L.B.7
Thiele, D.L.8
-
19
-
-
33847379373
-
Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures
-
Mueller J.C., Riemenschneider M., Schoepfer-Wendels A., Gohlke H., Konta L., Friedrich P., Illig T., Laws S.M., Forstl H., Kurz A. Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures. Neurobiol. Aging 2007, 28:727-734.
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 727-734
-
-
Mueller, J.C.1
Riemenschneider, M.2
Schoepfer-Wendels, A.3
Gohlke, H.4
Konta, L.5
Friedrich, P.6
Illig, T.7
Laws, S.M.8
Forstl, H.9
Kurz, A.10
-
20
-
-
0034551718
-
Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques
-
Mukherjee A., Song E., Kihiko-Ehmann M., Goodman J.P., Pyrek J.S., Estus S., Hersh L.B. Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques. J. Neurosci. 2000, 20:8745-8749.
-
(2000)
J. Neurosci.
, vol.20
, pp. 8745-8749
-
-
Mukherjee, A.1
Song, E.2
Kihiko-Ehmann, M.3
Goodman, J.P.4
Pyrek, J.S.5
Estus, S.6
Hersh, L.B.7
-
21
-
-
21444449693
-
Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme
-
Nowotny P., Hinrichs A.L., Smemo S., Kauwe J.S., Maxwell T., Holmans P., Hamshere M., Turic D., Jehu L., Hollingworth P., Moore P., Bryden L., Myers A., Doil L.M., Tacey K.M., Gibson A.M., McKeith I.G., Perry R.H., Morris C.M., Thal L., Morris J.C., O'Donovan M.C., Lovestone S., Grupe A., Hardy J., Owen M.J., Williams J., Goate A. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2005, 136B:62-68.
-
(2005)
Am. J. Med. Genet. B: Neuropsychiatr. Genet.
, vol.136 B
, pp. 62-68
-
-
Nowotny, P.1
Hinrichs, A.L.2
Smemo, S.3
Kauwe, J.S.4
Maxwell, T.5
Holmans, P.6
Hamshere, M.7
Turic, D.8
Jehu, L.9
Hollingworth, P.10
Moore, P.11
Bryden, L.12
Myers, A.13
Doil, L.M.14
Tacey, K.M.15
Gibson, A.M.16
McKeith, I.G.17
Perry, R.H.18
Morris, C.M.19
Thal, L.20
Morris, J.C.21
O'Donovan, M.C.22
Lovestone, S.23
Grupe, A.24
Hardy, J.25
Owen, M.J.26
Williams, J.27
Goate, A.28
more..
-
22
-
-
33748194140
-
Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease
-
Ozturk A., DeKosky S.T., Kamboh M.I. Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease. Neurosci. Lett. 2006, 406:265-269.
-
(2006)
Neurosci. Lett.
, vol.406
, pp. 265-269
-
-
Ozturk, A.1
DeKosky, S.T.2
Kamboh, M.I.3
-
23
-
-
0034038036
-
Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains
-
Perez A., Morelli L., Cresto J.C., Castano E.M. Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochem. Res. 2000, 25:247-255.
-
(2000)
Neurochem. Res.
, vol.25
, pp. 247-255
-
-
Perez, A.1
Morelli, L.2
Cresto, J.C.3
Castano, E.M.4
-
24
-
-
29844432266
-
Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis
-
Qiu W.Q., Folstein M.F. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol. Aging 2006, 27:190-198.
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 190-198
-
-
Qiu, W.Q.1
Folstein, M.F.2
-
25
-
-
0000398342
-
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
-
Qiu W.Q., Walsh D.M., Ye Z., Vekrellis K., Zhang J., Podlisny M.B., Rosner M.R., Safavi A., Hersh L.B., Selkoe D.J. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J. Biol. Chem. 1998, 273:32730-32738.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32730-32738
-
-
Qiu, W.Q.1
Walsh, D.M.2
Ye, Z.3
Vekrellis, K.4
Zhang, J.5
Podlisny, M.B.6
Rosner, M.R.7
Safavi, A.8
Hersh, L.B.9
Selkoe, D.J.10
-
26
-
-
0942290670
-
No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population
-
Sakai A., Ujike H., Nakata K., Takehisa Y., Imamura T., Uchida N., Kanzaki A., Yamamoto M., Fujisawa Y., Okumura K., Kuroda S. No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2004, 125B:87-91.
-
(2004)
Am. J. Med. Genet. B: Neuropsychiatr. Genet.
, vol.125 B
, pp. 87-91
-
-
Sakai, A.1
Ujike, H.2
Nakata, K.3
Takehisa, Y.4
Imamura, T.5
Uchida, N.6
Kanzaki, A.7
Yamamoto, M.8
Fujisawa, Y.9
Okumura, K.10
Kuroda, S.11
-
27
-
-
0034161516
-
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
-
Vekrellis K., Ye Z., Qiu W.Q., Walsh D., Hartley D., Chesneau V., Rosner M.R., Selkoe D.J. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J. Neurosci. 2000, 20:1657-1665.
-
(2000)
J. Neurosci.
, vol.20
, pp. 1657-1665
-
-
Vekrellis, K.1
Ye, Z.2
Qiu, W.Q.3
Walsh, D.4
Hartley, D.5
Chesneau, V.6
Rosner, M.R.7
Selkoe, D.J.8
-
28
-
-
34548820461
-
Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population
-
Vepsalainen S., Parkinson M., Helisalmi S., Mannermaa A., Soininen H., Tanzi R.E., Bertram L., Hiltunen M. Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population. J. Med. Genet. 2007, 44:606-608.
-
(2007)
J. Med. Genet.
, vol.44
, pp. 606-608
-
-
Vepsalainen, S.1
Parkinson, M.2
Helisalmi, S.3
Mannermaa, A.4
Soininen, H.5
Tanzi, R.E.6
Bertram, L.7
Hiltunen, M.8
-
29
-
-
5344277556
-
Deciphering the molecular basis of memory failure in Alzheimer's disease
-
Walsh D.M., Selkoe D.J. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 2004, 44:181-193.
-
(2004)
Neuron
, vol.44
, pp. 181-193
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
31
-
-
58149170562
-
Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease
-
Zuo X., Jia J. Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease. Brain Res. 2009, 1249:1-8.
-
(2009)
Brain Res.
, vol.1249
, pp. 1-8
-
-
Zuo, X.1
Jia, J.2
|