Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: Evidence of effect modification by apolipoprotein E (APOE)

Neuroscience Letters

Volumn 345, Issue 1, 2003, Pages 21-24

  Edland, S D ^a   Wavrant De Vriese F ^b   Compton, D ^b   Smith, G E ^a   Ivnik, R ^a   Boeve, B F ^a   Tangalos, E G ^a   Petersen, R C ^a  

^a MAYO CLINIC   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Alzheimer's disease; Amyloid beta; Genetic epidemiology; Insulin degrading enzyme; Protease

Indexed keywords

APOLIPOPROTEIN E; INSULINASE;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN DEGRADATION; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROTEIN VARIANT; RISK FACTOR;

EID: 0038519618     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(03)00488-9     Document Type: Article

References (23)

1. Abecasis G.R., Cookson W.O. GOLD - graphical overview of linkage disequilibrium. Bioinformatics. 16:2000;182-183.
2. Abraham R., Myers A., Wavrant-DeVrieze F., Hamshere M.L., Thomas H.V., Marshall H., Compton D., Spurlock G., Turic D., Hoogendoorn B., Kwon J.M., Petersen R.C., Tangalos E., Norton J., Morris J.C., Bullock R., Liolitsa D., Lovestone S., Hardy J., Goate A., O'Donovan M., Williams J., Owen M.J., Jones L. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Hum. Genet. 109:2001;646-652.
3. Ait-Ghezala G., Abdullah L., Crestentini R., Crawford F., Town T., Singh S., Richards D., Duara R., Mullan M. Confirmation of association between D10S583 and Alzheimer's disease in a case-control sample. Neurosci. Lett. 325:2002;87-90.
4. Bertram L., Blacker D., Mullin K., Keeney D., Jones J., Basu S., Yhu S., McInnis M.G., Go R.C., Vekrellis K., Selkoe D.J., Saunders A.J., Tanzi R.E. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 290:2000;2302-2303.
5. Boussaha M., Hannequin D., Verpillat P., Brice A., Frebourg T., Campion D. Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease. Neurosci. Lett. 329:2002;121-123.
6. Cook D.G., Leverenz J.B., McMillan P.J., Kulstad J.J., Ericksen S., Roth R.A., Schellenberg G.D., Jin L.-W., Kovacina K.S., Craft S. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-ε4 allele. Am. J. Pathol. 162:2003;313-319.
7. Craft S., Asthana S., Schellenberg G., Cherrier M., Baker L.D., Newcomer J., Plymate S., Latendresse S., Petrova A., Raskind M., Peskind E., Lofgreen C., Grimwood K. Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender. Neuroendocrinology. 70:1999;146-152.
8. Devlin B., Risch N. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics. 29:1995;311-322.
9. Eckman E.A., Reed D.K., Eckman C.B. Degradation of Alzheimer's amyloid beta peptide by endothelin-converting enzyme. J. Biol. Chem. 276:2001;24540-24548.
10. Ertekin-Taner N., Graff-Radford N., Younkin L.H., Eckman C., Baker M., Adamson J., Ronald J., Blangero J., Hutton M., Younkin S.G. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science. 290:2000;2303-2304.
11. Freidlin B., Zheng G., Zhaohai L., Gastwirth J.L. Trend tests for case-control studies of genetic markers: power, sample size and robustness. Hum. Hered. 53:2002;146-152.
12. Gasparini L., Gouras G.K., Wang R., Gross R.S., Beal M.F., Greengard P., Xu H. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J. Neurosci. 21:2001;2561-2570.
13. Jack C.R. Jr, Petersen R.C., Xu Y.C., Waring S.C., O'Brien P.C., Tangalos E.G., Smith G.E., Ivnik R.J., Kokmen E. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology. 49:1997;786-794.
14. Kurochkin I.V., Goto S. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 345:1994;33-37.
15. Kuusisto J., Koivisto K., Mykkanen L., Helkala E.L., Vanhanen M., Hanninen T., Kervinen K., Kesaniemi Y.A., Riekkinen P.J., Laakso M. Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study. Br. Med. J. 315:1997;1045-1049.
16. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 34:1984;939-944.
17. Myers A., Holmans P., Marshall H., Kwon J., Meyer D., Ramic D., Shears S., Booth J., DeVrieze F.W., Crook R., Hamshere M., Abraham R., Tunstall N., Rice F., Carty S., Lillystone S., Kehoe P., Rudrasingham V., Jones L., Lovestone S., Perez-Tur J., Williams J., Owen M.J., Hardy J., Goate A.M. Susceptibility locus for Alzheimer's disease on chromosome 10. Science. 290:2000;2304-2305.
18. Perez A., Morelli L., Cresto J.C., Castano E.M. Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochem. Res. 25:2000;247-255.
19. Selkoe D.J. Clearing the brain's amyloid cobwebs. Neuron. 32:2001;177-180.
20. Sudoh S., Frosch M.P., Wolf B.A. Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells. Biochemistry. 41:2002;1091-1099.
21. Teare M.D., Dunning A.M., Durocher F., Rennart G., Easton D.F. Sampling distribution of summary linkage disequilibrium measures. Ann. Hum. Genet. 66:2002;223-233.
22. Vekrellis K., Ye Z., Qiu W.Q., Walsh D., Hartley D., Chesneau V., Rosner M.R., Selkoe D.J. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J. Neurosci. 20:2000;1657-1665.
23. Yan Y., Yuan W., Velculescu V.E., Vogelstein B., Kinzler K.W. Allelic variation in human gene expression. Science. 297:2002;1143.