Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE

Neurobiology of Aging

Volumn 28, Issue 9, 2007, Pages 1374-1380

  Björk, Behnosh F ^a   Katzov, Hagit ^a   Kehoe, Patrick ^b   Fratiglioni, Laura ^a   Winblad, Bengt ^a   Prince, Jonathan A ^a   Graff, Caroline ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

APOE; Association; IDE; LOAD; SNP

Indexed keywords

AMYLOID BETA PROTEIN; INSULINASE;

AGED; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; DISEASE ASSOCIATION; FEMALE; GENE; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; IDE GENE; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; RISK ASSESSMENT; SENILE PLAQUE; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; CHI-SQUARE DISTRIBUTION; CONFIDENCE INTERVALS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INSULYSIN; LOGISTIC MODELS; MALE; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS;

EID: 34447556836     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2006.06.017     Document Type: Article

References (37)

1. Abraham R., Myers A., Wavrant-DeVrieze F., Hamshere M.L., Thomas H.V., Marshall H., et al. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Hum Genet 109 6 (2001) 646-652
2. Bertram L., Blacker D., Mullin K., Keeney D., Jones J., Basu S., et al. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 290 5500 (2000) 2302-2303
3. Bian L., Yang J., Guo T., Sun Y., Duan S., Chen W., et al. Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese. Neurology 63 2 (2004) 241-245
4. Blomqvist M.E., Chalmers K., Andreasen N., Bogdanovic N., Wilcock G.K., Cairns N.J., et al. Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain. Neurobiol Aging 26 6 (2005) 795-802
5. Blomqvist M.E., Silburn P.A., Buchanan D.D., Andreasen N., Blennow K., Pedersen N.L., et al. Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease. Neurogenetics 5 2 (2004) 115-119
6. Boussaha M., Hannequin D., Verpillat P., Brice A., Frebourg T., and Campion D. Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease. Neurosci Lett 329 1 (2002) 121-123
7. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261 5123 (1993) 921-923
8. Edbauer D., Willem M., Lammich S., Steiner H., and Haass C. Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). J Biol Chem 277 16 (2002) 13389-13393
9. Edland S.D., Wavrant-De Vriese F., Compton D., Smith G.E., Ivnik R., Boeve B.F., et al. Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE). Neurosci Lett 345 1 (2003) 21-24
10. Ertekin-Taner N., Allen M., Fadale D., Scanlin L., Younkin L., Petersen R.C., et al. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. Hum Mutat 23 4 (2004) 334-342
11. Ertekin-Taner N., Graff-Radford N., Younkin L.H., Eckman C., Baker M., Adamson J., et al. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 290 5500 (2000) 2303-2304
12. Farris W., Mansourian S., Chang Y., Lindsley L., Eckman E.A., Frosch M.P., et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 100 7 (2003) 4162-4167
13. Farris W., Mansourian S., Leissring M.A., Eckman E.A., Bertram L., Eckman C.B., et al. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am J Pathol 164 4 (2004) 1425-1434
14. Florez J.C., Wiltshire S., Agapakis C.M., Burtt N.P., de Bakker P.I., Almgren P., et al. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4206 people. Diabetes 55 1 (2006) 128-135
15. Goate A., Chartier-Harlin M.-C., Mullan M., Brown J., Crawford F., Fidani L., et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349 (1991) 704-706
16. Gu H.F., Efendic S., Nordman S., Ostenson C.G., Brismar K., Brookes A.J., et al. Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels. Diabetes 53 8 (2004) 2137-2142
17. Horikawa Y., Oda N., Cox N.J., Li X., Orho-Melander M., Hara M., et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26 2 (2000) 163-175
18. Karamohamed S., Demissie S., Volcjak J., Liu C., Heard-Costa N., Liu J., et al. Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. Diabetes 52 6 (2003) 1562-1567
19. Kurochkin I.V., and Goto S. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett 345 1 (1994) 33-37
20. Lagergren M., Fratiglioni L., Hallberg I.R., Berglund J., Elmstahl S., Hagberg B., et al. A longitudinal study integrating population, care and social services data. The Swedish Narional study on Aging and Care (SNAC). Aging Clin Exp Res 16 2 (2004) 158-168
21. Li Y.J., Scott W.K., Hedges D.J., Zhang F., Gaskell P.C., Nance M.A., et al. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet 70 4 (2002) 985-993
22. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 7 (1984) 939-944
23. Miller B.C., Eckman E.A., Sambamurti K., Dobbs N., Chow K.M., Eckman C.B., et al. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci USA 100 10 (2003) 6221-6226
24. Mirra S.S., Heyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41 4 (1991) 479-486
25. Myers A., Holmans P., Marshall H., Kwon J., Meyer D., Ramic D., et al. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290 5500 (2000) 2304-2305
26. Nowotny P., Hinrichs A.L., Smemo S., Kauwe J.S., Maxwell T., Holmans P., et al. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. Am J Med Genet B Neuropsychiatr Genet 136 1 (2005) 62-68
27. Pericak-Vance M.A., Bass M.P., Yamaoka L.H., Gaskell P.C., Scott W.K., Terwedow H.A., et al. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA 278 15 (1997) 1237-1241
28. Pericak-Vance M.A., Bebout J.L., Gaskell Jr. P.C., Yamaoka L.H., Hung W.Y., Alberts M.J., et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 48 6 (1991) 1034-1050
29. Pericak-Vance M.A., Grubber J., Bailey L.R., Hedges D., West S., Santoro L., et al. Identification of novel genes in late-onset Alzheimer's disease. Exp Gerontol 35 9-10 (2000) 1343-1352
30. Prince J.A., Feuk L., Gu H.F., Johansson B., Gatz M., Blennow K., et al. Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. Hum Mutat 22 5 (2003) 363-371
31. Prince J.A., Feuk L., Howell W.M., Jobs M., Emahazion T., Blennow K., et al. Robust and accurate single nucleotide polymorphism genotyping by dynamic allele-specific hybridization (DASH): design criteria and assay validation. Genome Res 11 1 (2001) 152-162
32. Rogaev E.I., Sherrington R., Rogaeva E.A., Levesque G., Ikeda M., Liang Y., et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376 6543 (1995) 775-778
33. Sakai A., Ujike H., Nakata K., Takehisa Y., Imamura T., Uchida N., et al. No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population. Am J Med Genet B Neuropsychiatr Genet 125 1 (2004) 87-91
34. Scott W.K., Hauser E.R., Schmechel D.E., Welsh-Bohmer K.A., Small G.W., Roses A.D., et al. Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. Am J Hum Genet 73 5 (2003) 1041-1051
35. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375 (1995) 754-760
36. Sillen A., Forsell C., Lilius L., Axelman K., Bjork B.F., Onkamo P., et al. Genome scan on Swedish Alzheimer's disease families. Mol Psychiatry 11 2 (2006) 182-186
37. Stephens M., Smith N.J., and Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68 4 (2001) 978-989