Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population

Journal of Medical Genetics

Volumn 44, Issue 9, 2007, Pages 606-608

  Vepsäläinen, Saila ^a   Parkinson, Michele ^b   Helisalmi, Seppo ^a   Mannermaa, Arto ^c   Soininen, Hilkka ^a   Tanzi, Rudolph E ^b   Bertram, Lars ^b   Hiltunen, Mikko ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; INSULINASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 10Q; CONTROLLED STUDY; ETHNIC GROUP; FEMALE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RISK; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; COHORT STUDIES; FEMALE; FINLAND; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INSULYSIN; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 34548820461     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: 10.1136/jmg.2006.048470     Document Type: Article

References (10)

1. Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem 1998;273:32730-8.
2. Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am J Pathol 2004;164:1425-34.
3. Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 2000;290:2302-3.
4. Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin SG. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 2000;290:2303-4.
5. Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, DeVrieze FW, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, Lillystone S, Kehoe P, Rudrasingham V, Jones L, Lovestone S, Perez-Tur J, Williams J, Owen MJ, Hardy J, Goate AM. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 2000;290:2304-5.
6. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
7. Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala EL, Hartikainen P, Hanninen T, Ryynanen M, Riekkinen PJ. Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism. Neurology 1996;46:413-19.
8. Bertram L, Saunders AJ, Mullin K, Sampson A, Moscarillo T, Tanzi RE. Further assessment of novel Alzheimer's disease loci on chromosome 10 and 9. Neurobiology of Aging 2002;23:S1206.
9. Prince JA, Feuk L, Gu HF, Johansson B, Gatz M, Blennow K, Brookes AJ. Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. Hum Mutat 2003;22:363-71.
10. Bian L, Yang JD, Guo TW, Sun Y, Duan SW, Chen WY, Pan YX, Feng GY, He L. Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese. Neurology 2004;63:241-5.