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Volumn 3, Issue NOV, 2012, Pages

The intersection of aging, longevity pathways, and learning and memory in C. elegans

Author keywords

Aging; Behavior; C. elegans; Insulin signaling; Learning; Longevity; Memory; Neurons

Indexed keywords

CAENORHABDITIS ELEGANS;

EID: 84876126388     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2012.00259     Document Type: Article
Times cited : (37)

References (170)
  • 1
    • 0031904566 scopus 로고    scopus 로고
    • Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans
    • Adachi, H., Fujiwara, Y., and Ishii, N. (1998). Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans. J. Gerontol. A Biol. Sci. Med. Sci. 53, B240-B244.
    • (1998) J. Gerontol. A Biol. Sci. Med. Sci. , vol.53
    • Adachi, H.1    Fujiwara, Y.2    Ishii, N.3
  • 2
    • 0347854376 scopus 로고    scopus 로고
    • Regulation of C. elegans longevity by specific gustatory and olfactory neurons
    • Alcedo, J., and Kenyon, C. (2004). Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41, 45-55.
    • (2004) Neuron , vol.41 , pp. 45-55
    • Alcedo, J.1    Kenyon, C.2
  • 3
    • 62749196605 scopus 로고    scopus 로고
    • Caloric restriction and aging: studies in mice and monkeys
    • Anderson, R. M., Shanmuganayagam, D., and Weindruch, R. (2009). Caloric restriction and aging: studies in mice and monkeys. Toxicol. Pathol. 37,47-51.
    • (2009) Toxicol. Pathol. , vol.37 , pp. 47-51
    • Anderson, R.M.1    Shanmuganayagam, D.2    Weindruch, R.3
  • 4
    • 0032538315 scopus 로고    scopus 로고
    • Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span
    • Apfeld, J., and Kenyon, C. (1998). Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell 95, 199-210.
    • (1998) Cell , vol.95 , pp. 199-210
    • Apfeld, J.1    Kenyon, C.2
  • 5
    • 0033576579 scopus 로고    scopus 로고
    • Regulation of lifespan by sensory perception in Caenorhabditis elegans
    • Apfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-809.
    • (1999) Nature , vol.402 , pp. 804-809
    • Apfeld, J.1    Kenyon, C.2
  • 6
    • 77950244850 scopus 로고    scopus 로고
    • An elegant mind: learning and memory in Caenorhabditis elegans
    • Ardiel, E. L., and Rankin, C. H. (2010). An elegant mind: learning and memory in Caenorhabditis elegans. Learn. Mem. 17, 191-201.
    • (2010) Learn. Mem. , vol.17 , pp. 191-201
    • Ardiel, E.L.1    Rankin, C.H.2
  • 7
    • 0030571016 scopus 로고    scopus 로고
    • Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor
    • Asanuma, M., Nishibayashi, S., Iwata, E., Kondo, Y., Nakanishi, T., Vargas, M. G., et al. (1996). Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor. Brain Res. Mol. Brain Res. 41, 210-215.
    • (1996) Brain Res. Mol Brain Res. , vol.41 , pp. 210-215
    • Asanuma, M.1    Nishibayashi, S.2    Iwata, E.3    Kondo, Y.4    Nakanishi, T.5    Vargas, M.G.6
  • 8
    • 0024743467 scopus 로고
    • Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C. elegans
    • Avery, L., and Horvitz, H. R. (1989). Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C. elegans. Neuron 3, 473-485.
    • (1989) Neuron , vol.3 , pp. 473-485
    • Avery, L.1    Horvitz, H.R.2
  • 9
    • 0043270437 scopus 로고    scopus 로고
    • Food transport in the C-elegans pharynx
    • Avery, L., and Shtonda, B. B. (2003). Food transport in the C-elegans pharynx. J. Exp. Biol. 206, 2441-2457.
    • (2003) J. Exp. Biol. , vol.206 , pp. 2441-2457
    • Avery, L.1    Shtonda, B.B.2
  • 10
    • 0033609045 scopus 로고    scopus 로고
    • Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
    • Bach, M. E., Barad, M., Son, H., Zhuo, M., Lu, Y. F., Shih, R., et al. (1999). Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 96,5280-5285.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 5280-5285
    • Bach, M.E.1    Barad, M.2    Son, H.3    Zhuo, M.4    Lu, Y.F.5    Shih, R.6
  • 11
    • 0037040402 scopus 로고    scopus 로고
    • Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture
    • Barco, A., Alarcon, J. M., and Kandel, E. R. (2002). Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108, 689-703.
    • (2002) Cell , vol.108 , pp. 689-703
    • Barco, A.1    Alarcon, J.M.2    Kandel, E.R.3
  • 12
    • 38449121385 scopus 로고    scopus 로고
    • Chemosen-sation in C. elegans
    • ed The C. elegans Research Community (WormBook) doi/10.1895/wormbook.1.123.1
    • Bargmann, C. I. (2006). "Chemosen-sation in C. elegans," in WormBook, ed. The C. elegans Research Community (WormBook), doi/10.1895/ wormbook.1.123.1. Available at: http://www.wormbook.org
    • (2006) WormBook
    • Bargmann, C.I.1
  • 13
    • 0026002375 scopus 로고
    • Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans
    • Bargmann, C. I., and Horvitz, H. R. (1991). Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Neuron 7, 729-742.
    • (1991) Neuron , vol.7 , pp. 729-742
    • Bargmann, C.I.1    Horvitz, H.R.2
  • 14
    • 0031900020 scopus 로고    scopus 로고
    • Signal transduction in the Caenorhabditis elegans nervous system
    • Bargmann, C. I., and Kaplan, J. M. (1998). Signal transduction in the Caenorhabditis elegans nervous system. Annu. Rev. Neurosci. 21, 279-308.
    • (1998) Annu. Rev. Neurosci. , vol.21 , pp. 279-308
    • Bargmann, C.I.1    Kaplan, J.M.2
  • 15
    • 0025533067 scopus 로고
    • Chemosensory cell function in the behavior and development of Caenorhabditis elegans
    • Bargmann, C. I., Thomas, J. H., and Horvitz, H. R. (1990). Chemosensory cell function in the behavior and development of Caenorhabditis elegans. Cold Spring Harb. Symp. Quant. Biol. 55, 529-538.
    • (1990) Cold Spring Harb. Symp. Quant. Biol. , vol.55 , pp. 529-538
    • Bargmann, C.I.1    Thomas, J.H.2    Horvitz, H.R.3
  • 16
    • 0027408722 scopus 로고
    • Effects of aging on habituation in the nematode Caenorhabditis elegans
    • Beck,C.D.O.,andRankin,C.H. (1993). Effects of aging on habituation in the nematode Caenorhabditis elegans. Behav. Processes 28, 145-163.
    • (1993) Behav. Processes , vol.28 , pp. 145-163
    • Beck, C.D.O.1    Rankin, C.H.2
  • 17
    • 65449145109 scopus 로고    scopus 로고
    • Looking beyond development: maintaining nervous system architecture
    • Benard, C., and Hobert, O. (2009). Looking beyond development: maintaining nervous system architecture. Curr. Top. Dev. Biol. 87, 175-194.
    • (2009) Curr. Top. Dev. Biol. , vol.87 , pp. 175-194
    • Benard, C.1    Hobert, O.2
  • 19
    • 80051560513 scopus 로고    scopus 로고
    • Degeneracy and neuromodulation among thermosensory neurons contribute to robust thermosensory behaviors in Caenorhabditis elegans
    • Beverly, M., Anbil, S., and Sengupta, P. (2011). Degeneracy and neuromodulation among thermosensory neurons contribute to robust thermosensory behaviors in Caenorhabditis elegans. J. Neurosci. 31,11718-11727.
    • (2011) J. Neurosci. , vol.31 , pp. 11718-11727
    • Beverly, M.1    Anbil, S.2    Sengupta, P.3
  • 20
    • 33845266493 scopus 로고    scopus 로고
    • A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans
    • Biron, D., Shibuya, M., Gabel, C., Wasserman, S. M., Clark, D. A., Brown, A., et al. (2006). A diacylglycerol kinase modulates longterm thermotactic behavioral plasticity in C. elegans. Nat. Neurosci. 9,1499-1505.
    • (2006) Nat. Neurosci. , vol.9 , pp. 1499-1505
    • Biron, D.1    Shibuya, M.2    Gabel, C.3    Wasserman, S.M.4    Clark, D.A.5    Brown, A.6
  • 21
    • 49449091354 scopus 로고    scopus 로고
    • An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behavior
    • Biron, D., Wasserman, S., Thomas, J. H., Samuel, A. D., and Sengupta, P. (2008). An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behavior. Proc. Natl. Acad. Sci. U.S.A. 105, 11002-11007.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 11002-11007
    • Biron, D.1    Wasserman, S.2    Thomas, J.H.3    Samuel, A.D.4    Sengupta, P.5
  • 22
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Bluher, M., Kahn, B. B., and Kahn, C. R. (2003). Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574.
    • (2003) Science , vol.299 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 23
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 24
    • 45849083142 scopus 로고    scopus 로고
    • A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans
    • Bretscher, A. J., Busch, K. E., and De Bono, M. (2008). A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 105, 8044-8049.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 8044-8049
    • Bretscher, A.J.1    Busch, K.E.2    De Bono, M.3
  • 25
    • 0345118873 scopus 로고    scopus 로고
    • Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments
    • Brightwell, J. J., Gallagher, M., and Colombo, P. J. (2004). Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments. Neurobiol. Learn. Mem. 81,19-26.
    • (2004) Neurobiol. Learn. Mem , vol.81 , pp. 19-26
    • Brightwell, J.J.1    Gallagher, M.2    Colombo, P.J.3
  • 26
    • 29244439038 scopus 로고    scopus 로고
    • Neural plasticity in the ageing brain
    • Burke, S. N., and Barnes, C. A. (2006). Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 7, 30-40.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 30-40
    • Burke, S.N.1    Barnes, C.A.2
  • 27
    • 35948982603 scopus 로고    scopus 로고
    • Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans
    • Chalasani, S. H., Chronis, N., Tsunozaki, M., Gray, J. M., Ramot, D., Goodman, M. B., et al. (2007). Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. Nature 450, 63-70.
    • (2007) Nature , vol.450 , pp. 63-70
    • Chalasani, S.H.1    Chronis, N.2    Tsunozaki, M.3    Gray, J.M.4    Ramot, D.5    Goodman, M.B.6
  • 28
    • 77951667323 scopus 로고    scopus 로고
    • Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons
    • Chalasani, S. H., Kato, S., Albrecht, D. R., Nakagawa, T., Abbott, L. F., and Bargmann, C. I. (2010). Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons. Nat. Neurosci. 13, 615-621.
    • (2010) Nat. Neurosci. , vol.13 , pp. 615-621
    • Chalasani, S.H.1    Kato, S.2    Albrecht, D.R.3    Nakagawa, T.4    Abbott, L.F.5    Bargmann, C.I.6
  • 29
    • 0019546209 scopus 로고
    • Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans
    • Chalfie, M., and Sulston, J. (1981). Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans. Dev. Biol. 82,358-370.
    • (1981) Dev. Biol. , vol.82 , pp. 358-370
    • Chalfie, M.1    Sulston, J.2
  • 31
    • 23444431611 scopus 로고
    • Green fluorescent protein as a marker for gene expression
    • Chalfie, M., Tu, Y., Euskirchen, G., Ward, W. W., and Prasher, D. C. (1994). Green fluorescent protein as a marker for gene expression. Science 263, 802-805.
    • (1994) Science , vol.263 , pp. 802-805
    • Chalfie, M.1    Tu, Y.2    Euskirchen, G.3    Ward, W.W.4    Prasher, D.C.5
  • 32
    • 37249073826 scopus 로고    scopus 로고
    • Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans
    • Chi, C. A., Clark, D. A., Lee, S., Biron, D., Luo, L., Gabel, C. V., et al. (2007). Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans. J. Exp. Biol. 210,4043-4052.
    • (2007) J. Exp. Biol. , vol.210 , pp. 4043-4052
    • Chi, C.A.1    Clark, D.A.2    Lee, S.3    Biron, D.4    Luo, L.5    Gabel, C.V.6
  • 33
    • 77957674275 scopus 로고    scopus 로고
    • An automated microfluidic platform for calcium imaging of chemosensory neurons in Caenorhabditis elegans
    • Chokshi, T. V., Bazopoulou, D., and Chronis, N. (2010). An automated microfluidic platform for calcium imaging of chemosensory neurons in Caenorhabditis elegans. Lab. Chip 10,2758-2763.
    • (2010) Lab. Chip , vol.10 , pp. 2758-2763
    • Chokshi, T.V.1    Bazopoulou, D.2    Chronis, N.3
  • 34
    • 34548361558 scopus 로고    scopus 로고
    • Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans
    • Chronis, N., Zimmer, M., and Bargmann, C. I. (2007). Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans. Nat. Methods 4,727-731.
    • (2007) Nat. Methods , vol.4 , pp. 727-731
    • Chronis, N.1    Zimmer, M.2    Bargmann, C.I.3
  • 35
    • 0035815414 scopus 로고    scopus 로고
    • Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    • Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., et al. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106.
    • (2001) Science , vol.292 , pp. 104-106
    • Clancy, D.J.1    Gems, D.2    Harshman, L.G.3    Oldham, S.4    Stocker, H.5    Hafen, E.6
  • 36
    • 33748792821 scopus 로고    scopus 로고
    • Opposing activities protect against age-onset proteotoxicity
    • Cohen, E., Bieschke, J., Perciavalle, R. M., Kelly, J. W., and Dillin, A. (2006). Opposing activities protect against age-onset proteotoxicity. Science 313,1604-1610.
    • (2006) Science , vol.313 , pp. 1604-1610
    • Cohen, E.1    Bieschke, J.2    Perciavalle, R.M.3    Kelly, J.W.4    Dillin, A.5
  • 37
    • 0028931470 scopus 로고
    • Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans
    • Colbert, H. A., and Bargmann, C. I. (1995). Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. Neuron 14, 803-812.
    • (1995) Neuron , vol.14 , pp. 803-812
    • Colbert, H.A.1    Bargmann, C.I.2
  • 38
    • 34548645020 scopus 로고    scopus 로고
    • Caenorhabditis elegans integrates food and reproductive signals in lifespan determination
    • Crawford, D., Libina, N., and Kenyon, C. (2007). Caenorhabditis elegans integrates food and reproductive signals in lifespan determination. Aging Cell 6,715-721.
    • (2007) Aging Cell , vol.6 , pp. 715-721
    • Crawford, D.1    Libina, N.2    Kenyon, C.3
  • 39
    • 0032402946 scopus 로고    scopus 로고
    • Oxidative stress causes a general, calcium-dependent degradation of mitochondrial polynucleotides
    • Crawford, D. R., Abramova, N. E., and Davies, K. J. A. (1998). Oxidative stress causes a general, calcium-dependent degradation of mitochondrial polynucleotides. Free Radic. Biol. Med. 25, 1106-1111.
    • (1998) Free Radic. Biol. Med. , vol.25 , pp. 1106-1111
    • Crawford, D.R.1    Abramova, N.E.2    Davies, K.J.A.3
  • 40
    • 0016411692 scopus 로고
    • Behavioural analysis of nematode movement
    • Croll, N. A. (1975). Behavioural analysis of nematode movement. Adv. Parasitol. 13, 71-122.
    • (1975) Adv. Parasitol. , vol.13 , pp. 71-122
    • Croll, N.A.1
  • 41
    • 0018143864 scopus 로고
    • Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans
    • Culotti, J. G., and Russell, R. L. (1978). Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans. Genetics 90, 243-256.
    • (1978) Genetics , vol.90 , pp. 243-256
    • Culotti, J.G.1    Russell, R.L.2
  • 42
    • 23244432182 scopus 로고    scopus 로고
    • Neuronal substrates of complex behaviors in C. elegans
    • de Bono, M., and Maricq, A. V. (2005). Neuronal substrates of complex behaviors in C. elegans. Annu. Rev. Neurosci. 28,451-501.
    • (2005) Annu. Rev. Neurosci. , vol.28 , pp. 451-501
    • de Bono, M.1    Maricq, A.V.2
  • 43
    • 0037147103 scopus 로고    scopus 로고
    • Rates of behavior and aging specified by mitochondrial function during development
    • Dillin, A., Hsu, A. L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., et al. (2002). Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-2401.
    • (2002) Science , vol.298 , pp. 2398-2401
    • Dillin, A.1    Hsu, A.L.2    Arantes-Oliveira, N.3    Lehrer-Graiwer, J.4    Hsin, H.5    Fraser, A.G.6
  • 44
    • 0028807085 scopus 로고
    • The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
    • Dorman, J. B., Albinder, B., Shroyer, T., and Kenyon, C. (1995). The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141, 1399-1406.
    • (1995) Genetics , vol.141 , pp. 1399-1406
    • Dorman, J.B.1    Albinder, B.2    Shroyer, T.3    Kenyon, C.4
  • 45
    • 63049132176 scopus 로고    scopus 로고
    • The olfactory system and its disorders
    • Doty, R. L. (2009). The olfactory system and its disorders. Semin. Neurol. 29, 74-81.
    • (2009) Semin. Neurol. , vol.29 , pp. 74-81
    • Doty, R.L.1
  • 46
  • 47
    • 0016256879 scopus 로고
    • Analysis of chemotaxis in the nematode Caenorhabditis elegans by counter-current separation
    • Dusenbery, D. B. (1974). Analysis of chemotaxis in the nematode Caenorhabditis elegans by counter-current separation. J. Exp. Zool. 188, 41-47.
    • (1974) J. Exp. Zool. , vol.188 , pp. 41-47
    • Dusenbery, D.B.1
  • 48
    • 0001789916 scopus 로고
    • Olfactory responses and adaptation in the human neonate
    • Engen, T., Lipsitt, L. P., and Kaye, H. (1963). Olfactory responses and adaptation in the human neonate. J. Comp. Physiol. Psychol. 56, 73-77.
    • (1963) J. Comp. Physiol. Psychol. , vol.56 , pp. 73-77
    • Engen, T.1    Lipsitt, L.P.2    Kaye, H.3
  • 49
    • 78649295230 scopus 로고    scopus 로고
    • The natural history of Caenorhabditis elegans
    • Felix, M. A., and Braendle, C. (2010). The natural history of Caenorhabditis elegans. Curr. Biol. 20, R965-R969.
    • (2010) Curr. Biol. , vol.20
    • Felix, M.A.1    Braendle, C.2
  • 50
    • 0035515923 scopus 로고    scopus 로고
    • Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
    • Feng, J., Bussiere, F., and Hekimi, S. (2001). Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell 1,633-644.
    • (2001) Dev. Cell , vol.1 , pp. 633-644
    • Feng, J.1    Bussiere, F.2    Hekimi, S.3
  • 51
    • 0018716096 scopus 로고
    • Habituation and prestimulus inhibition of the auditory startle reflex in decerebrate rats
    • Fox, J. E. (1979). Habituation and prestimulus inhibition of the auditory startle reflex in decerebrate rats. Physiol. Behav. 23,291-297.
    • (1979) Physiol. Behav. , vol.23 , pp. 291-297
    • Fox, J.E.1
  • 52
    • 0023831256 scopus 로고
    • A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
    • Friedman, D. B., and Johnson, T. E. (1988). A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118, 75-86.
    • (1988) Genetics , vol.118 , pp. 75-86
    • Friedman, D.B.1    Johnson, T.E.2
  • 53
    • 84855994224 scopus 로고    scopus 로고
    • A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction
    • Fusco, S., Ripoli, C., Podda, M. V., Ranieri, S. C., Leone, L., Toietta, G., et al. (2012). A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc. Natl. Acad. Sci. U.S.A. 109,621-626.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 621-626
    • Fusco, S.1    Ripoli, C.2    Podda, M.V.3    Ranieri, S.C.4    Leone, L.5    Toietta, G.6
  • 54
    • 0036021375 scopus 로고    scopus 로고
    • Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation
    • Garigan, D., Hsu, A. L., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-1112.
    • (2002) Genetics , vol.161 , pp. 1101-1112
    • Garigan, D.1    Hsu, A.L.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Kenyon, C.6
  • 55
    • 13444263237 scopus 로고    scopus 로고
    • Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty
    • Glenn, C. F., Chow, D. K., David, L., Cooke, C. A., Gami, M. S., Iser, W. B., et al. (2004). Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. J. Gerontol. A Biol. Sci. Med. Sci. 59,1251-1260.
    • (2004) J. Gerontol. A Biol. Sci. Med. Sci. , vol.59 , pp. 1251-1260
    • Glenn, C.F.1    Chow, D.K.2    David, L.3    Cooke, C.A.4    Gami, M.S.5    Iser, W.B.6
  • 56
    • 0034744301 scopus 로고    scopus 로고
    • Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans
    • Gomez, M., De Castro, E., Guarin, E., Sasakura, H., Kuhara, A., Mori, I., et al. (2001). Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans. Neuron 30, 241-248.
    • (2001) Neuron , vol.30 , pp. 241-248
    • Gomez, M.1    De Castro, E.2    Guarin, E.3    Sasakura, H.4    Kuhara, A.5    Mori, I.6
  • 57
    • 38449107943 scopus 로고    scopus 로고
    • WormBook, ed. The C. elegans Research Community (WormBook) doi/10.1895/wormbook.1.62.1
    • Goodman, M. B. (2006)."Mechanosen-sation," in WormBook, ed. The C. elegans Research Community (WormBook), doi/10.1895/ wormbook.1.62.1. Available at: http://www.wormbook.org
    • (2006) Mechanosen-sation
    • Goodman, M.B.1
  • 58
    • 0032055561 scopus 로고    scopus 로고
    • Active currents regulate sensitivity and dynamic range in C. elegans neurons
    • Goodman, M. B., Hall, D. H., Avery, L., and Lockery, S. R. (1998). Active currents regulate sensitivity and dynamic range in C. elegans neurons. Neuron 20, 763-772.
    • (1998) Neuron , vol.20 , pp. 763-772
    • Goodman, M.B.1    Hall, D.H.2    Avery, L.3    Lockery, S.R.4
  • 60
    • 3142674291 scopus 로고    scopus 로고
    • Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue
    • Gray, J. M., Karow, D. S., Lu, H., Chang, A. J., Chang, J. S., Ellis, R. E., et al. (2004). Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430, 317-322.
    • (2004) Nature , vol.430 , pp. 317-322
    • Gray, J.M.1    Karow, D.S.2    Lu, H.3    Chang, A.J.4    Chang, J.S.5    Ellis, R.E.6
  • 61
    • 34848850156 scopus 로고    scopus 로고
    • An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C-elegans
    • Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., et al. (2007). An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C-elegans. Curr. Biol. 17, 1646-1656.
    • (2007) Curr. Biol , vol.17 , pp. 1646-1656
    • Greer, E.L.1    Dowlatshahi, D.2    Banko, M.R.3    Villen, J.4    Hoang, K.5    Blanchard, D.6
  • 62
    • 0030982143 scopus 로고    scopus 로고
    • Degradation of oxidized proteins in mammalian cells
    • Grune, T., Reinheckel, T., and Davies, K. J.A. (1997). Degradation of oxidized proteins in mammalian cells. FASEB J. 11,526-534.
    • (1997) FASEB J , vol.11 , pp. 526-534
    • Grune, T.1    Reinheckel, T.2    Davies, K.J.A.3
  • 63
    • 84861194399 scopus 로고    scopus 로고
    • Behavioral decay in aging male C. elegans correlates with increased cell excitability
    • e1423
    • Guo, X., Navetta, A., Gualberto, D. G., and Garcia, L. R. (2012). Behavioral decay in aging male C. elegans correlates with increased cell excitability. Neurobiol. Aging 33, 1483 e1485-1483 e1423.
    • (2012) Neurobiol. Aging , vol.33 , Issue.1483
    • Guo, X.1    Navetta, A.2    Gualberto, D.G.3    Garcia, L.R.4
  • 64
    • 78650238966 scopus 로고    scopus 로고
    • Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans
    • Ha, H. I., Hendricks, M., Shen, Y., Gabel, C. V., Fang-Yen, C., Qin, Y., et al. (2010). Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans. Neuron 68, 1173-1186.
    • (2010) Neuron , vol.68 , pp. 1173-1186
    • Ha, H.I.1    Hendricks, M.2    Shen, Y.3    Gabel, C.V.4    Fang-Yen, C.5    Qin, Y.6
  • 65
    • 45849153072 scopus 로고    scopus 로고
    • Acute carbon dioxide avoidance in Caenorhabditis elegans
    • Hallem, E. A., and Sternberg, P. W. (2008). Acute carbon dioxide avoidance in Caenorhabditis elegans. Proc. Natl Acad. Sci. U.S.A. 105, 8038-8043.
    • (2008) Proc. Natl Acad. Sci. U.S.A. , vol.105 , pp. 8038-8043
    • Hallem, E.A.1    Sternberg, P.W.2
  • 66
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
    • doi:10.1371/journal.pgen.0040024
    • Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., and Kenyon, C. (2008). A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 4, e24. doi:10.1371/journal.pgen.0040024
    • (2008) PLoS Genet , vol.4
    • Hansen, M.1    Chandra, A.2    Mitic, L.L.3    Onken, B.4    Driscoll, M.5    Kenyon, C.6
  • 67
    • 79960642870 scopus 로고    scopus 로고
    • Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans
    • doi:10.1371/journal.pone.0021897
    • Harris, G., Korchnak, A., Summers, P., Hapiak, V., Law, W. J., Stein, A. M., et al. (2011). Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans. PLoS ONE 6, e21897. doi:10.1371/journal.pone.0021897
    • (2011) PLoS ONE , vol.6
    • Harris, G.1    Korchnak, A.2    Summers, P.3    Hapiak, V.4    Law, W.J.5    Stein, A.M.6
  • 68
    • 0016698202 scopus 로고
    • Normal and mutant thermotaxis in the nema-tode Caenorhabditis elegans
    • Hedgecock, E. M., and Russell, R. L. (1975). Normal and mutant thermotaxis in the nema-tode Caenorhabditis elegans. Proc. Natl Acad. Sci. U.S.A. 72, 4061-4065.
    • (1975) Proc. Natl Acad. Sci. U.S.A. , vol.72 , pp. 4061-4065
    • Hedgecock, E.M.1    Russell, R.L.2
  • 69
  • 70
    • 0037167855 scopus 로고    scopus 로고
    • Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
    • Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., et al. (2002). Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808-814.
    • (2002) Nature , vol.419 , pp. 808-814
    • Herndon, L.A.1    Schmeissner, P.J.2    Dudaronek, J.M.3    Brown, P.A.4    Listner, K.M.5    Sakano, Y.6
  • 71
    • 0037219784 scopus 로고    scopus 로고
    • Behavioral plasticity in C. elegans: paradigms, circuits, genes
    • Hobert, O. (2003). Behavioral plasticity in C. elegans: paradigms, circuits, genes. J. Neurobiol. 54,203-223.
    • (2003) J. Neurobiol. , vol.54 , pp. 203-223
    • Hobert, O.1
  • 72
    • 0024385843 scopus 로고
    • Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions
    • Hosono, R., Nishimoto, S., and Kuno, S. (1989). Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions. Exp. Gerontol. 24, 251-264.
    • (1989) Exp. Gerontol. , vol.24 , pp. 251-264
    • Hosono, R.1    Nishimoto, S.2    Kuno, S.3
  • 73
    • 0042886011 scopus 로고    scopus 로고
    • Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans
    • Houthoofd, K., Braeckman, B. P., Johnson, T. E., and Vanfleteren, J. R. (2003). Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. Exp. Gerontol. 38, 947-954.
    • (2003) Exp. Gerontol. , vol.38 , pp. 947-954
    • Houthoofd, K.1    Braeckman, B.P.2    Johnson, T.E.3    Vanfleteren, J.R.4
  • 74
    • 67650483333 scopus 로고    scopus 로고
    • Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans
    • Hsu, A. L., Feng, Z., Hsieh, M. Y., and Xu, X. Z. (2009). Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans. Neurobiol Aging 30,1498-1503.
    • (2009) Neurobiol Aging , vol.30 , pp. 1498-1503
    • Hsu, A.L.1    Feng, Z.2    Hsieh, M.Y.3    Xu, X.Z.4
  • 75
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu, A. L., Murphy, C. T., and Kenyon, C. (2003). Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300, 1142-1145.
    • (2003) Science , vol.300 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 76
    • 65649106496 scopus 로고    scopus 로고
    • Parallel use of two behavioral mechanisms for chemotaxis in Caenorhabditis elegans
    • Iino, Y., andYoshida, K. (2009). Parallel use of two behavioral mechanisms for chemotaxis in Caenorhabditis elegans. J. Neurosci. 29, 5370-5380.
    • (2009) J. Neurosci. , vol.29 , pp. 5370-5380
    • Iino, Y.1    Yoshida, K.2
  • 77
    • 0032514466 scopus 로고    scopus 로고
    • A mutation in suc-cinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes
    • Ishii, N., Fujii, M., Hartman, P. S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., et al. (1998). A mutation in suc-cinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature 394, 694-697.
    • (1998) Nature , vol.394 , pp. 694-697
    • Ishii, N.1    Fujii, M.2    Hartman, P.S.3    Tsuda, M.4    Yasuda, K.5    Senoo-Matsuda, N.6
  • 78
    • 45849113972 scopus 로고    scopus 로고
    • Memory in Caenorhabditis elegans is mediated by NMDA-type ionotropic glutamate receptors
    • Kano, T., Brockie, P. J., Sassa, T., Fujimoto, H., Kawahara, Y, lino, Y., et al. (2008). Memory in Caenorhabditis elegans is mediated by NMDA-type ionotropic glutamate receptors. Curr. Biol. 18,1010-1015.
    • (2008) Curr. Biol. , vol.18 , pp. 1010-1015
    • Kano, T.1    Brockie, P.J.2    Sassa, T.3    Fujimoto, H.4    Kawahara, Y.5    Lino, Y.6
  • 79
    • 77952923018 scopus 로고    scopus 로고
    • Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age
    • doi:10.1371/journal.pbio.1000372
    • Kauffman, A. L., Ashraf, J. M., Corces-Zimmerman, M. R., Landis, J. N., and Murphy, C. T. (2010). Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biol. 8, e1000372. doi:10.1371/journal.pbio.1000372
    • (2010) PLoS Biol , vol.8
    • Kauffman, A.L.1    Ashraf, J.M.2    Corces-Zimmerman, M.R.3    Landis, J.N.4    Murphy, C.T.5
  • 80
    • 0035827706 scopus 로고    scopus 로고
    • Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans
    • Kayser, E. B., Morgan, P. G., Hoppel, C. L., and Sedensky, M. M. (2001). Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans. J. Biol. Chem. 276,20551-20558.
    • (2001) J. Biol. Chem. , vol.276 , pp. 20551-20558
    • Kayser, E.B.1    Morgan, P.G.2    Hoppel, C.L.3    Sedensky, M.M.4
  • 81
    • 2942598255 scopus 로고    scopus 로고
    • The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans
    • Kayser, E. B., Sedensky, M. M., and Morgan, P. G. (2004). The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans. Mech. Ageing Dev. 125, 455-464.
    • (2004) Mech. Ageing Dev. , vol.125 , pp. 455-464
    • Kayser, E.B.1    Sedensky, M.M.2    Morgan, P.G.3
  • 82
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon, C., Chang, J., Gensch, E., Rudner, A., and Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 83
    • 0033680858 scopus 로고    scopus 로고
    • Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans
    • Kerr, R., Lev-Ram, V., Baird, G., Vincent, P., Tsien, R. Y., and Schafer, W. R. (2000). Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Neuron 26, 583-594.
    • (2000) Neuron , vol.26 , pp. 583-594
    • Kerr, R.1    Lev-Ram, V.2    Baird, G.3    Vincent, P.4    Tsien, R.Y.5    Schafer, W.R.6
  • 84
    • 0018725140 scopus 로고
    • The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans
    • Kimble, J., and Hirsh, D. (1979). The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev. Biol. 70, 396-417.
    • (1979) Dev. Biol. , vol.70 , pp. 396-417
    • Kimble, J.1    Hirsh, D.2
  • 85
    • 0030813398 scopus 로고    scopus 로고
    • daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura, K. D., Tissenbaum, H. A., Liu, Y., and Ruvkun, G. (1997). daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946.
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 86
    • 0017763799 scopus 로고
    • Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span
    • Klass, M. R. (1977). Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech. Ageing Dev. 6,413-429.
    • (1977) Mech. Ageing Dev. , vol.6 , pp. 413-429
    • Klass, M.R.1
  • 87
    • 33751116842 scopus 로고    scopus 로고
    • Insulin-like signaling and the neural circuit for integrative behavior in C. elegans
    • Kodama, E., Kuhara, A., Mohri-Shiomi, A., Kimura, K. D., Okumura, M., Tomioka, M., et al. (2006). Insulin-like signaling and the neural circuit for integrative behavior in C. elegans. Genes Dev. 20, 2955-2960.
    • (2006) Genes Dev , vol.20 , pp. 2955-2960
    • Kodama, E.1    Kuhara, A.2    Mohri-Shiomi, A.3    Kimura, K.D.4    Okumura, M.5    Tomioka, M.6
  • 89
    • 44049103544 scopus 로고    scopus 로고
    • Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans
    • Kuhara, A., Okumura, M., Kimata, T., Tanizawa, Y., Takano, R., Kimura, K. D., et al. (2008). Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans. Science 320, 803-807.
    • (2008) Science , vol.320 , pp. 803-807
    • Kuhara, A.1    Okumura, M.2    Kimata, T.3    Tanizawa, Y.4    Takano, R.5    Kimura, K.D.6
  • 90
    • 0034029917 scopus 로고    scopus 로고
    • Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics
    • Lai, C. H., Chou, C. Y., Ch'Ang, L. Y., Liu, C. S., and Lin, W. (2000). Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 10,703-713.
    • (2000) Genome Res , vol.10 , pp. 703-713
    • Lai, C.H.1    Chou, C.Y.2    Ch'Ang, L.Y.3    Liu, C.S.4    Lin, W.5
  • 91
    • 0032573178 scopus 로고    scopus 로고
    • The genetics of caloric restriction in Caenorhabditis elegans
    • Lakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 95, 13091-13096.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 13091-13096
    • Lakowski, B.1    Hekimi, S.2
  • 92
    • 80053312481 scopus 로고    scopus 로고
    • Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans
    • Lapierre, L. R., Gelino, S., Melendez, A., and Hansen, M. (2011). Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr. Biol. 21,1507-1514.
    • (2011) Curr. Biol. , vol.21 , pp. 1507-1514
    • Lapierre, L.R.1    Gelino, S.2    Melendez, A.3    Hansen, M.4
  • 93
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • Lee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 33, 40-48.
    • (2003) Nat. Genet. , vol.33 , pp. 40-48
    • Lee, S.S.1    Lee, R.Y.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Ruvkun, G.6
  • 94
    • 0018879884 scopus 로고
    • Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors
    • Lewis, J. A., Wu, C. H., Levine, J. H., and Berg, H. (1980). Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors. Neuroscience 5, 967-989.
    • (1980) Neuroscience , vol.5 , pp. 967-989
    • Lewis, J.A.1    Wu, C.H.2    Levine, J.H.3    Berg, H.4
  • 95
    • 0037380570 scopus 로고    scopus 로고
    • daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway
    • Li, W., Kennedy, S. G., and Ruvkun, G. (2003). daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 17, 844-858.
    • (2003) Genes Dev , vol.17 , pp. 844-858
    • Li, W.1    Kennedy, S.G.2    Ruvkun, G.3
  • 96
    • 77953524795 scopus 로고    scopus 로고
    • Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval
    • Lin, C. H., Tomioka, M., Pereira, S., Sellings, L., Iino, Y., and Van Der Kooy, D. (2010). Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval. J. Neurosci. 30, 8001-8011.
    • (2010) J. Neurosci. , vol.30 , pp. 8001-8011
    • Lin, C.H.1    Tomioka, M.2    Pereira, S.3    Sellings, L.4    Iino, Y.5    Van Der Kooy, D.6
  • 97
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • Lin, K., Hsin, H., Libina, N., and Kenyon, C. (2001). Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28, 139-145.
    • (2001) Nat. Genet. , vol.28 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 98
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • Lin, S. J., Defossez, P. A., and Guarente,L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-2128.
    • (2000) Science , vol.289 , pp. 2126-2128
    • Lin, S.J.1    Defossez, P.A.2    Guarente, L.3
  • 99
    • 0032313562 scopus 로고    scopus 로고
    • Tight-seal whole-cell patch clamping of Caenorhabditis elegans neurons
    • Lockery, S. R., and Goodman, M. B. (1998). Tight-seal whole-cell patch clamping of Caenorhabditis elegans neurons. Meth. Enzymol. 293, 201-217.
    • (1998) Meth. Enzymol. , vol.293 , pp. 201-217
    • Lockery, S.R.1    Goodman, M.B.2
  • 100
    • 74249099972 scopus 로고    scopus 로고
    • TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging
    • doi:10.1371/journal.pgen.1000789
    • Luo, S., Shaw, W. M., Ashraf, J., and Murphy, C. T. (2009). TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. PLoS Genet. 5, e1000789. doi:10.1371/journal.pgen.1000789
    • (2009) PLoS Genet , vol.5
    • Luo, S.1    Shaw, W.M.2    Ashraf, J.3    Murphy, C.T.4
  • 101
    • 0011164979 scopus 로고
    • Prolonging the Life Span
    • McCay,C.M.,andCrowell,M.F. (1934). Prolonging the Life Span. Sci. Mon. 39,405-414.
    • (1934) Sci. Mon. , vol.39 , pp. 405-414
    • McCay, C.M.1    Crowell, M.F.2
  • 102
    • 0002458132 scopus 로고
    • The effect of retarded growth upon the life span and upon the ultimate body size
    • McCay, C. M., Crowell, M. F., and Maynard, L. M. (1935). The effect of retarded growth upon the life span and upon the ultimate body size. J. Nutr. 10, 63-79.
    • (1935) J. Nutr. , vol.10 , pp. 63-79
    • McCay, C.M.1    Crowell, M.F.2    Maynard, L.M.3
  • 103
    • 0025942107 scopus 로고
    • Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences
    • Mello, C. C., Kramer, J. M., Stinchcomb, D., and Ambros, V (1991). Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970.
    • (1991) EMBO J , vol.10 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 104
    • 0035896557 scopus 로고    scopus 로고
    • Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans
    • Miyadera, H., Amino, H., Hiraishi, A., Taka, H., Murayama, K., Miyoshi, H., et al. (2001). Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. J. Biol. Chem. 276, 7713-7716.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7713-7716
    • Miyadera, H.1    Amino, H.2    Hiraishi, A.3    Taka, H.4    Murayama, K.5    Miyoshi, H.6
  • 105
    • 0030610646 scopus 로고    scopus 로고
    • Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin
    • Miyawaki, A., Llopis, J., Heim, R., McCaffery, J. M., Adams, J. A., Ikura, M., et al. (1997). Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature 388, 882-887.
    • (1997) Nature , vol.388 , pp. 882-887
    • Miyawaki, A.1    Llopis, J.2    Heim, R.3    McCaffery, J.M.4    Adams, J.A.5    Ikura, M.6
  • 106
    • 17444404136 scopus 로고    scopus 로고
    • Genetic control of temperature preference in the nema-tode Caenorhabditis elegans
    • Mohri, A., Kodama, E., Kimura, K. D., Koike, M., Mizuno, T., and Mori, I. (2005). Genetic control of temperature preference in the nema-tode Caenorhabditis elegans. Genetics 169, 1437-1450.
    • (2005) Genetics , vol.169 , pp. 1437-1450
    • Mohri, A.1    Kodama, E.2    Kimura, K.D.3    Koike, M.4    Mizuno, T.5    Mori, I.6
  • 107
    • 0033367293 scopus 로고    scopus 로고
    • Genetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans
    • Mori, I. (1999). Genetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans. Annu. Rev. Genet. 33, 399-422.
    • (1999) Annu. Rev. Genet. , vol.33 , pp. 399-422
    • Mori, I.1
  • 108
    • 0029050730 scopus 로고
    • Neural regulation of thermotaxis in Caenorhabditis elegans
    • Mori, I., and Ohshima, Y. (1995). Neural regulation of thermotaxis in Caenorhabditis elegans. Nature 376, 344-348.
    • (1995) Nature , vol.376 , pp. 344-348
    • Mori, I.1    Ohshima, Y.2
  • 109
    • 0742323000 scopus 로고    scopus 로고
    • Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
    • Morley, J. F., and Morimoto, R. I. (2004). Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol. Biol. Cell 15, 657-664.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 657-664
    • Morley, J.F.1    Morimoto, R.I.2
  • 110
    • 0029768753 scopus 로고    scopus 로고
    • A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    • Morris, J. Z., Tissenbaum, H. A., and Ruvkun, G. (1996). A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382, 536-539.
    • (1996) Nature , vol.382 , pp. 536-539
    • Morris, J.Z.1    Tissenbaum, H.A.2    Ruvkun, G.3
  • 111
    • 84858702953 scopus 로고    scopus 로고
    • The ageing cortical synapse: hallmarks and implications for cognitive decline
    • Morrison, J. H., and Baxter, M. G. (2012). The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat. Rev. Neurosci. 13, 240-250.
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 240-250
    • Morrison, J.H.1    Baxter, M.G.2
  • 112
    • 33645226449 scopus 로고    scopus 로고
    • Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats
    • Mouravlev, A., Dunning, J., Young, D., and During, M. J. (2006). Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats. Proc. Natl. Acad. Sci. U.S.A. 103, 4705-4710.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 4705-4710
    • Mouravlev, A.1    Dunning, J.2    Young, D.3    During, M.J.4
  • 113
    • 84876139055 scopus 로고    scopus 로고
    • Pharmacological assays reveal age-related changes in synaptic transmission at the Caenorhabditis elegans neuromus-cular junction that are modified by reduced insulin signalling
    • (in press)
    • Mulcahy, B., Holden-Dye, L., and O'Connor, V. (2012). Pharmacological assays reveal age-related changes in synaptic transmission at the Caenorhabditis elegans neuromus-cular junction that are modified by reduced insulin signalling. J. Exp. Biol. (in press)
    • (2012) J. Exp. Biol.
    • Mulcahy, B.1    Holden-Dye, L.2    O'Connor, V.3
  • 114
    • 28044472729 scopus 로고    scopus 로고
    • Aging-dependent and -independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans
    • Murakami, H., Bessinger, K., Hellmann, J., and Murakami, S. (2005). Aging-dependent and -independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans. J. Neurosci. 25,10894-10904.
    • (2005) J. Neurosci. , vol.25 , pp. 10894-10904
    • Murakami, H.1    Bessinger, K.2    Hellmann, J.3    Murakami, S.4
  • 115
    • 13844277030 scopus 로고    scopus 로고
    • The effects of aging and oxidative stress on learning behavior in C. elegans
    • Murakami, S., and Murakami, H. (2005). The effects of aging and oxidative stress on learning behavior in C. elegans. Neurobiol Aging 26, 899-905.
    • (2005) Neurobiol Aging , vol.26 , pp. 899-905
    • Murakami, S.1    Murakami, H.2
  • 116
    • 37649022616 scopus 로고    scopus 로고
    • Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
    • Murphy, C. T., Lee, S. J., and Kenyon, C. (2007). Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 104, 19046-19050.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19046-19050
    • Murphy, C.T.1    Lee, S.J.2    Kenyon, C.3
  • 117
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R.S.,Ahringer,J.,etal. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283.
    • (2003) Nature , vol.424 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3    Fraser, A.4    Kamath, R.S.5    Ahringer, J.6
  • 118
    • 0035129282 scopus 로고    scopus 로고
    • A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein
    • Nakai, J., Ohkura, M., and Imoto, K. (2001). A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein. Nat. Biotechnol. 19, 137-141.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 137-141
    • Nakai, J.1    Ohkura, M.2    Imoto, K.3
  • 119
    • 0025836930 scopus 로고
    • Theory of the locomotion of nema-todes: dynamics of undulatory progression on a surface
    • Niebur, E., and Erdos, P. (1991). Theory of the locomotion of nema-todes: dynamics of undulatory progression on a surface. Biophys. J. 60, 1132-1146.
    • (1991) Biophys. J. , vol.60 , pp. 1132-1146
    • Niebur, E.1    Erdos, P.2
  • 120
    • 0032769032 scopus 로고    scopus 로고
    • Visualization of synaptic specializations in live C. elegans with synaptic vesicle protein-GFP fusions
    • Nonet, M. L. (1999). Visualization of synaptic specializations in live C. elegans with synaptic vesicle protein-GFP fusions. J. Neurosci. Methods 89, 33-40.
    • (1999) J. Neurosci. Methods , vol.89 , pp. 33-40
    • Nonet, M.L.1
  • 121
    • 0037126006 scopus 로고    scopus 로고
    • Serotonin mediates food-odor associative learning in the nematode Caenorhabditis elegans
    • Nuttley, W. M., Atkinson-Leadbeater, K. P., and Van Der Kooy, D. (2002). Serotonin mediates food-odor associative learning in the nematode Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 99, 12449-12454.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 12449-12454
    • Nuttley, W.M.1    Atkinson-Leadbeater, K.P.2    Van Der Kooy, D.3
  • 122
    • 79959988096 scopus 로고    scopus 로고
    • Neuronal plasticity regulated by the insulin-like signaling pathway underlies salt chemotaxis learning in Caenorhabditis elegans
    • Oda, S., Tomioka, M., and Iino, Y. (2011). Neuronal plasticity regulated by the insulin-like signaling pathway underlies salt chemotaxis learning in Caenorhabditis elegans. J. Neurophysiol. 106, 301-308.
    • (2011) J. Neurophysiol. , vol.106 , pp. 301-308
    • Oda, S.1    Tomioka, M.2    Iino, Y.3
  • 123
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., et al. (1997). The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999.
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6
  • 124
    • 79959339376 scopus 로고    scopus 로고
    • Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons
    • Pan, C. L., Peng, C. Y., Chen, C. H., and McIntire, S. (2011). Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons. Proc. Natl. Acad. Sci. U.S.A. 108, 9274-9279.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 9274-9279
    • Pan, C.L.1    Peng, C.Y.2    Chen, C.H.3    McIntire, S.4
  • 125
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J., and Dillin, A. (2007). PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447, 550-555.
    • (2007) Nature , vol.447 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 126
    • 0033151613 scopus 로고    scopus 로고
    • A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
    • Paradis, S., Ailion, M., Toker, A., Thomas, J. H., and Ruvkun, G. (1999). A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 13,1438-1452.
    • (1999) Genes Dev , vol.13 , pp. 1438-1452
    • Paradis, S.1    Ailion, M.2    Toker, A.3    Thomas, J.H.4    Ruvkun, G.5
  • 127
    • 0032529189 scopus 로고    scopus 로고
    • Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
    • Paradis, S., and Ruvkun, G. (1998). Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12, 2488-2498.
    • (1998) Genes Dev , vol.12 , pp. 2488-2498
    • Paradis, S.1    Ruvkun, G.2
  • 129
    • 84862870882 scopus 로고    scopus 로고
    • Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons
    • Pereira, S., and van der Kooy, D. (2012). Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons. J. Neurosci. 32, 9035-9044.
    • (2012) J. Neurosci. , vol.32 , pp. 9035-9044
    • Pereira, S.1    van der Kooy, D.2
  • 130
    • 0035868890 scopus 로고    scopus 로고
    • Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
    • Pierce, S. B., Costa, M., Wisotzkey, R., Devadhar, S., Homburger, S. A., Buchman, A. R., et al. (2001). Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 15, 672-686.
    • (2001) Genes Dev , vol.15 , pp. 672-686
    • Pierce, S.B.1    Costa, M.2    Wisotzkey, R.3    Devadhar, S.4    Homburger, S.A.5    Buchman, A.R.6
  • 131
    • 0033232522 scopus 로고    scopus 로고
    • The fundamental role of pirouettes in Caenorhabditis elegans chemotaxis
    • Pierce-Shimomura, J. T., Morse, T. M., and Lockery, S. R. (1999). The fundamental role of pirouettes in Caenorhabditis elegans chemotaxis. J.Neurosci. 19,9557-9569.
    • (1999) J.Neurosci. , vol.19 , pp. 9557-9569
    • Pierce-Shimomura, J.T.1    Morse, T.M.2    Lockery, S.R.3
  • 132
    • 49149105430 scopus 로고    scopus 로고
    • Alteration of CREB phos-phorylation and spatial memory deficits in aged 129T2/Sv mice
    • Porte, Y., Buhot, M. C., and Mons, N. (2008). Alteration of CREB phos-phorylation and spatial memory deficits in aged 129T2/Sv mice. Neurobiol. Aging 29, 1533-1546.
    • (2008) Neurobiol. Aging , vol.29 , pp. 1533-1546
    • Porte, Y.1    Buhot, M.C.2    Mons, N.3
  • 133
    • 0028871952 scopus 로고
    • Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans
    • Raizen, D. M., Lee, R. Y., and Avery, L. (1995). Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans. Genetics 141, 1365-1382.
    • (1995) Genetics , vol.141 , pp. 1365-1382
    • Raizen, D.M.1    Lee, R.Y.2    Avery, L.3
  • 134
    • 0021383455 scopus 로고
    • Choline acetyltransferase-deficient mutants of the nematode Caenorhabditis elegans
    • Rand, J. B., and Russell, R. L. (1984). Choline acetyltransferase-deficient mutants of the nematode Caenorhabditis elegans. Genetics 106, 227-248.
    • (1984) Genetics , vol.106 , pp. 227-248
    • Rand, J.B.1    Russell, R.L.2
  • 135
    • 0025191247 scopus 로고
    • Caenorhabditis elegans: a new model system for the study of learning and memory. Behav
    • Rankin, C. H., Beck, C. D., and Chiba, C. M. (1990). Caenorhabditis elegans: a new model system for the study of learning and memory. Behav. Brain Res. 37, 89-92.
    • (1990) Brain Res , vol.37 , pp. 89-92
    • Rankin, C.H.1    Beck, C.D.2    Chiba, C.M.3
  • 136
    • 44849117364 scopus 로고    scopus 로고
    • Synaptic function
    • The C. Research Community (WormBook) doi/10.1895/wormbook.1.69.1
    • Richmond, J. (2007). "Synaptic function," in WormBook, ed. The C. elegans Research Community (WormBook), doi/10.1895/ wormbook.1.69.1. Available at: http://www.wormbook.org
    • (2007) WormBook, elegans ed
    • Richmond, J.1
  • 137
    • 0033349884 scopus 로고    scopus 로고
    • UNC-13 is required for synaptic vesicle fusion in C. elegans
    • Richmond, J. E., Davis, W. S., and Jorgensen, E. M. (1999). UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat. Neurosci. 2, 959-964.
    • (1999) Nat. Neurosci. , vol.2 , pp. 959-964
    • Richmond, J.E.1    Davis, W.S.2    Jorgensen, E.M.3
  • 138
    • 0033361969 scopus 로고    scopus 로고
    • One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction
    • Richmond, J. E., and Jorgensen, E. M. (1999). One GABA and two acetyl-choline receptors function at the C. elegans neuromuscular junction. Nat. Neurosci. 2, 791-797.
    • (1999) Nat. Neurosci , vol.2 , pp. 791-797
    • Richmond, J.E.1    Jorgensen, E.M.2
  • 139
    • 0023811053 scopus 로고
    • Normal oxidative damage to mitochondrial and nuclear-DNA is extensive
    • Richter, C., Park, J. W., and Ames, B. N. (1988). Normal oxidative damage to mitochondrial and nuclear-DNA is extensive. Proc. Natl. Acad. Sci. U.S.A. 85, 6465-6467.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 6465-6467
    • Richter, C.1    Park, J.W.2    Ames, B.N.3
  • 140
    • 0019496482 scopus 로고
    • Interacting genes in nematode dauer larva formation
    • Riddle, D. L., Swanson, M. M., and Albert, P. S.(1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-671.
    • (1981) Nature , vol.290 , pp. 668-671
    • Riddle, D.L.1    Swanson, M.M.2    Albert, P.S.3
  • 141
    • 0035745772 scopus 로고    scopus 로고
    • Plasticity of chemotaxis revealed by paired presentation of a chemoattractant and starvation in the nematode Caenorhabditis elegans
    • Saeki, S., Yamamoto, M., and Iino, Y. (2001). Plasticity of chemotaxis revealed by paired presentation of a chemoattractant and starvation in the nematode Caenorhabditis elegans. J. Exp. Biol. 204, 1757-1764.
    • (2001) J. Exp. Biol. , vol.204 , pp. 1757-1764
    • Saeki, S.1    Yamamoto, M.2    Iino, Y.3
  • 142
    • 77955348076 scopus 로고    scopus 로고
    • Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function
    • doi:10.1371/journal.pone.00 11602
    • Shirai, Y., Kouzuki, T., Kakefuda, K., Moriguchi,S.,Oyagi,A.,Horie, K.,et al. (2010). Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function. PLoS ONE 5, e1 1602. doi:10.1371/journal.pone.00 11602
    • (2010) PLoS ONE , vol.5
    • Shirai, Y.1    Kouzuki, T.2    Kakefuda, K.3    Moriguchi, S.4    Oyagi, A.5    Horie, K.6
  • 144
    • 42149141146 scopus 로고    scopus 로고
    • Functionally significant insulin-like growth factor I receptor mutations in centenarians
    • Suh, Y., Atzmon, G., Cho, M. O., Hwang, D., Liu, B., Leahy, D. J., et al. (2008). Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc. Natl. Acad. Sci. U.S.A. 105, 3438-3442.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 3438-3442
    • Suh, Y.1    Atzmon, G.2    Cho, M.O.3    Hwang, D.4    Liu, B.5    Leahy, D.J.6
  • 146
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans
    • Sulston, J. E., Schierenberg, E., White, J. G., and Thomson, J. N. (1983). The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100,64-119.
    • (1983) Dev. Biol. , vol.100 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 147
    • 0141741337 scopus 로고    scopus 로고
    • In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation
    • Suzuki, H., Kerr, R., Bianchi, L., Frokjaer-Jensen, C., Slone, D., Xue, J., et al. (2003). In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. Neuron 39, 1005-1017.
    • (2003) Neuron , vol.39 , pp. 1005-1017
    • Suzuki, H.1    Kerr, R.2    Bianchi, L.3    Frokjaer-Jensen, C.4    Slone, D.5    Xue, J.6
  • 148
    • 0345735938 scopus 로고    scopus 로고
    • Aging specifically impairs amnesiac-dependent memory in Drosophila
    • Tamura, T., Chiang, A. S.,Ito, N.,Liu, H. P., Horiuchi, J., Tully, T., et al. (2003). Aging specifically impairs amnesiac-dependent memory in Drosophila. Neuron 40, 1003-1011.
    • (2003) Neuron , vol.40 , pp. 1003-1011
    • Tamura, T.1    Chiang, A.S.2    Ito, N.3    Liu, H.P.4    Horiuchi, J.5    Tully, T.6
  • 149
    • 79959654038 scopus 로고    scopus 로고
    • Spontaneous age-related neurite branching in Caenorhabditis elegans
    • Tank, E. M., Rodgers, K. E., and Kenyon, C. (2011). Spontaneous age-related neurite branching in Caenorhabditis elegans. J. Neurosci. 31, 9279-9288.
    • (2011) J. Neurosci. , vol.31 , pp. 9279-9288
    • Tank, E.M.1    Rodgers, K.E.2    Kenyon, C.3
  • 150
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • Tatar, M.,Kopelman, A., Epstein, D., Tu, M. P., Yin, C. M., and Garofalo, R. S. (2001). A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292,107-110.
    • (2001) Science , vol.292 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.P.4    Yin, C.M.5    Garofalo, R.S.6
  • 151
    • 0013865890 scopus 로고
    • Habituation: a model phenomenon for the study of neuronal substrates of behavior
    • Thompson, R. F., and Spencer, W A. (1966). Habituation: a model phenomenon for the study of neuronal substrates of behavior. Psychol. Rev. 73, 16-43.
    • (1966) Psychol. Rev. , vol.73 , pp. 16-43
    • Thompson, R.F.1    Spencer, W.A.2
  • 152
    • 73349108496 scopus 로고    scopus 로고
    • Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
    • Tian, L., Hires, S. A., Mao, T., Huber, D., Chiappe, M. E., Chalasani, S. H., et al. (2009). Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat. Methods 6, 875-881.
    • (2009) Nat. Methods , vol.6 , pp. 875-881
    • Tian, L.1    Hires, S.A.2    Mao, T.3    Huber, D.4    Chiappe, M.E.5    Chalasani, S.H.6
  • 153
    • 79960969175 scopus 로고    scopus 로고
    • Tap withdrawal circuit interneurons require CREB for long-term habituation in Caenorhabditis elegans
    • Timbers, T. A., and Rankin, C. H. (2011). Tap withdrawal circuit interneurons require CREB for long-term habituation in Caenorhabditis elegans. Behav. Neurosci. 125, 560-566.
    • (2011) Behav. Neurosci. , vol.125 , pp. 560-566
    • Timbers, T.A.1    Rankin, C.H.2
  • 154
    • 33748068817 scopus 로고    scopus 로고
    • The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans
    • Tomioka, M., Adachi, T., Suzuki, H., Kunitomo, H., Schafer, W. R., and Iino, Y. (2006). The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans. Neuron 51, 613-625.
    • (2006) Neuron , vol.51 , pp. 613-625
    • Tomioka, M.1    Adachi, T.2    Suzuki, H.3    Kunitomo, H.4    Schafer, W.R.5    Iino, Y.6
  • 155
    • 33846591937 scopus 로고    scopus 로고
    • Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone
    • Torayama, I., Ishihara, T., and Katsura, I. (2007). Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone. J. Neurosci. 27, 741-750.
    • (2007) J. Neurosci. , vol.27 , pp. 741-750
    • Torayama, I.1    Ishihara, T.2    Katsura, I.3
  • 156
    • 84862900160 scopus 로고    scopus 로고
    • Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system
    • Toth, M. L., Melentijevic, I., Shah, L., Bhatia, A., Lu, K., Talwar, A., et al. (2012). Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system. J. Neurosci. 32, 8778-8790.
    • (2012) J. Neurosci. , vol.32 , pp. 8778-8790
    • Toth, M.L.1    Melentijevic, I.2    Shah, L.3    Bhatia, A.4    Lu, K.5    Talwar, A.6
  • 157
    • 0030669834 scopus 로고    scopus 로고
    • Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans
    • Troemel, E. R., Kimmel, B. E., and Bargmann, C. I. (1997). Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans. Cell 91, 161-169.
    • (1997) Cell , vol.91 , pp. 161-169
    • Troemel, E.R.1    Kimmel, B.E.2    Bargmann, C.I.3
  • 158
    • 0037490793 scopus 로고    scopus 로고
    • Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans
    • Tsalik, E. L., and Hobert, O. (2003). Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. J. Neurobiol. 56, 178-197.
    • (2003) J. Neurobiol. , vol.56 , pp. 178-197
    • Tsalik, E.L.1    Hobert, O.2
  • 159
    • 0022119763 scopus 로고
    • Classical conditioning and retention in normal and mutant Drosophila melanogaster
    • Tully, T., and Quinn, W. G. (1985). Classical conditioning and retention in normal and mutant Drosophila melanogaster. J. Comp. Physiol. A 157,263-277.
    • (1985) J. Comp. Physiol. A , vol.157 , pp. 263-277
    • Tully, T.1    Quinn, W.G.2
  • 160
    • 79952483532 scopus 로고    scopus 로고
    • Structural properties of the Caenorhabditis elegans neuronal network
    • doi:10.1371/journal.pcbi.1001066
    • Varshney, L. R., Chen, B. L., Paniagua, E., Hall, D. H., and Chklovskii, D. B. (2011). Structural properties of the Caenorhabditis elegans neuronal network. PLoS Comput. Biol. 7, e1001066. doi:10.1371/journal.pcbi.1001066
    • (2011) PLoS Comput. Biol. , vol.7
    • Varshney, L.R.1    Chen, B.L.2    Paniagua, E.3    Hall, D.H.4    Chklovskii, D.B.5
  • 161
    • 0015594065 scopus 로고
    • Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants
    • Ward, S. (1973). Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants. Proc. Natl.Acad. Sci. U.S.A. 70,817-821.
    • (1973) Proc. Natl.Acad. Sci. U.S.A. , vol.70 , pp. 817-821
    • Ward, S.1
  • 162
    • 0007502637 scopus 로고
    • Conditioned emotional responses
    • Watson, J. B., and Raynor, R. (1920). Conditioned emotional responses. J. Exp. Psychol. 3,1-14.
    • (1920) J. Exp. Psychol. , vol.3 , pp. 1-14
    • Watson, J.B.1    Raynor, R.2
  • 163
    • 0030466371 scopus 로고    scopus 로고
    • The retardation of aging by caloric restriction: studies in rodents and primates
    • Weindruch, R. (1996). The retardation of aging by caloric restriction: studies in rodents and primates. Toxicol. Pathol. 24, 742-745.
    • (1996) Toxicol. Pathol. , vol.24 , pp. 742-745
    • Weindruch, R.1
  • 164
    • 2942596447 scopus 로고    scopus 로고
    • Genomic cis-regulatory architecture and transacting regulators of a single interneuron-specific gene battery in C. elegans
    • Wenick, A. S., and Hobert, O. (2004). Genomic cis-regulatory architecture and transacting regulators of a single interneuron-specific gene battery in C. elegans. Dev. Cell 6, 757-770.
    • (2004) Dev. Cell , vol.6 , pp. 757-770
    • Wenick, A.S.1    Hobert, O.2
  • 167
    • 0028950419 scopus 로고
    • Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
    • Wong, A., Boutis, P., and Hekimi, S. (1995). Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 139, 1247-1259.
    • (1995) Genetics , vol.139 , pp. 1247-1259
    • Wong, A.1    Boutis, P.2    Hekimi, S.3
  • 168
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., et al. (2004). Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-689.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5    Tatar, M.6
  • 169
    • 27744466522 scopus 로고    scopus 로고
    • Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans
    • Zhang, Y., Lu, H., and Bargmann, C. I. (2005). Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans. Nature 438, 179-184.
    • (2005) Nature , vol.438 , pp. 179-184
    • Zhang, Y.1    Lu, H.2    Bargmann, C.I.3
  • 170
    • 0033212996 scopus 로고    scopus 로고
    • Neuronal control of locomotion in C. elegans is modified by a dominant mutation in the GLR-1 ionotropic glutamate receptor
    • Zheng, Y., Brockie, P. J., Mellem, J. E., Madsen, D. M., and Maricq, A. V. (1999). Neuronal control of locomotion in C. elegans is modified by a dominant mutation in the GLR-1 ionotropic glutamate receptor. Neuron 24, 347-361.
    • (1999) Neuron , vol.24 , pp. 347-361
    • Zheng, Y.1    Brockie, P.J.2    Mellem, J.E.3    Madsen, D.M.4    Maricq, A.V.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.