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Volumn 86, Issue 2, 2013, Pages 143-160

Combination of vascular disrupting agents and ionizing radiation

Author keywords

Antiangiogenic agents; CA 4 P; Preclinical rationale; Radiotherapy; Tubulin binding agents; Vascular disrupting agents

Indexed keywords

2 METHOXYESTRA 1,3,5(10),16 TETRAENE 3 CARBOXAMIDE; ANG 501; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BNC 015; BNC 105; C 9; CA 4 P; CARBOPLATIN; CHLORDANE; CISPLATIN; COMBRETASTATIN A1 PHOSPHATE; COMBRETASTATIN A4 PHOSPHATE; DENIBULIN; DOCETAXEL; IRC 083927; LEXIBULIN; MICROTUBULE BINDING AGENT; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; N ACETYLCOLCHINOL PHOSPHATE; OMBRABULIN; PACLITAXEL; PLACEBO; PLINABULIN; SOBLIDOTIN; STX 140; TH 482; UNCLASSIFIED DRUG; UNINDEXED DRUG; VADIMEZAN; VASCULAR TARGETING AGENT; VINBLASTINE;

EID: 84876088405     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2012.10.002     Document Type: Review
Times cited : (38)

References (113)
  • 1
    • 24644441655 scopus 로고    scopus 로고
    • The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines
    • Delaney G., Jacob S., Featherstone C., Barton M. The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 2005, 104:1129-1137.
    • (2005) Cancer , vol.104 , pp. 1129-1137
    • Delaney, G.1    Jacob, S.2    Featherstone, C.3    Barton, M.4
  • 2
    • 79953054421 scopus 로고    scopus 로고
    • Strategies to improve radiotherapy with targeted drugs
    • Begg A.C., Stewart F.A., Vens C. Strategies to improve radiotherapy with targeted drugs. Nature Reviews Cancer 2011, 11:239-253.
    • (2011) Nature Reviews Cancer , vol.11 , pp. 239-253
    • Begg, A.C.1    Stewart, F.A.2    Vens, C.3
  • 3
    • 77951540327 scopus 로고    scopus 로고
    • Recent advances in radiotherapy
    • Bhide S.A., Nutting C.M. Recent advances in radiotherapy. BMC Medicine 2010, 8:25.
    • (2010) BMC Medicine , vol.8 , pp. 25
    • Bhide, S.A.1    Nutting, C.M.2
  • 4
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. New England Journal of Medicine 1971, 285:1182-1186.
    • (1971) New England Journal of Medicine , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 6
    • 44649197646 scopus 로고    scopus 로고
    • Targeting angiogenesis in head and neck cancer
    • Seiwert T.Y., Cohen E.E. Targeting angiogenesis in head and neck cancer. Seminars in Oncology 2008, 35:274-285.
    • (2008) Seminars in Oncology , vol.35 , pp. 274-285
    • Seiwert, T.Y.1    Cohen, E.E.2
  • 7
    • 78649833819 scopus 로고    scopus 로고
    • The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents
    • Siemann D.W. The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents. Cancer Treatment Reviews 2010, 37:63-74.
    • (2010) Cancer Treatment Reviews , vol.37 , pp. 63-74
    • Siemann, D.W.1
  • 8
    • 34247249906 scopus 로고    scopus 로고
    • Vascular disrupting agents in clinical development
    • Hinnen P., Eskens F.A. Vascular disrupting agents in clinical development. British Journal of Cancer 2007, 96:1159-1165.
    • (2007) British Journal of Cancer , vol.96 , pp. 1159-1165
    • Hinnen, P.1    Eskens, F.A.2
  • 9
    • 12244292196 scopus 로고    scopus 로고
    • Differentiation and definition of vascular-targeted therapies
    • Siemann D.W., Bibby M.C., Dark G.G., et al. Differentiation and definition of vascular-targeted therapies. Clinical Cancer Research 2005, 11:416-420.
    • (2005) Clinical Cancer Research , vol.11 , pp. 416-420
    • Siemann, D.W.1    Bibby, M.C.2    Dark, G.G.3
  • 10
    • 29244454573 scopus 로고    scopus 로고
    • Radiation combined with antiangiogenic and antivascular agents
    • O'Reilly M.S. Radiation combined with antiangiogenic and antivascular agents. Seminars in Radiation Oncology 2006, 16:45-50.
    • (2006) Seminars in Radiation Oncology , vol.16 , pp. 45-50
    • O'Reilly, M.S.1
  • 12
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 13
    • 68349128259 scopus 로고    scopus 로고
    • Hypoxia and radiation therapy: past history, ongoing research, and future promise
    • Rockwell S., Dobrucki I.T., Kim E.Y., et al. Hypoxia and radiation therapy: past history, ongoing research, and future promise. Current Molecular Medicine 2009, 9:442-458.
    • (2009) Current Molecular Medicine , vol.9 , pp. 442-458
    • Rockwell, S.1    Dobrucki, I.T.2    Kim, E.Y.3
  • 14
    • 40049110018 scopus 로고    scopus 로고
    • Advancement of antiangiogenic and vascular disrupting agents combined with radiation
    • Citrin D., Camphausen K. Advancement of antiangiogenic and vascular disrupting agents combined with radiation. Cancer Treatment and Research 2008, 139:153-171.
    • (2008) Cancer Treatment and Research , vol.139 , pp. 153-171
    • Citrin, D.1    Camphausen, K.2
  • 15
    • 73249128368 scopus 로고    scopus 로고
    • Increasing sensitivity to radiotherapy and chemotherapy by using novel biological agents that alter the tumor microenvironment
    • Shinohara E.T., Maity A. Increasing sensitivity to radiotherapy and chemotherapy by using novel biological agents that alter the tumor microenvironment. Current Molecular Medicine 2009, 9:1034-1045.
    • (2009) Current Molecular Medicine , vol.9 , pp. 1034-1045
    • Shinohara, E.T.1    Maity, A.2
  • 16
    • 1842689545 scopus 로고    scopus 로고
    • Targeting the tumor vasculature: a strategy to improve radiation therapy
    • Siemann D.W., Horsman M.R. Targeting the tumor vasculature: a strategy to improve radiation therapy. Expert Review of Anticancer Therapy 2004, 4:321-327.
    • (2004) Expert Review of Anticancer Therapy , vol.4 , pp. 321-327
    • Siemann, D.W.1    Horsman, M.R.2
  • 17
    • 33748869678 scopus 로고    scopus 로고
    • Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies
    • Horsman M.R., Siemann D.W. Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies. Cancer Research 2006, 66:11520-11539.
    • (2006) Cancer Research , vol.66 , pp. 11520-11539
    • Horsman, M.R.1    Siemann, D.W.2
  • 18
    • 80052047659 scopus 로고    scopus 로고
    • Recent advances in anti-angiogenic therapy of cancer
    • Samant R.S., Shevde L.A. Recent advances in anti-angiogenic therapy of cancer. Oncotarget 2011, 2:122-134.
    • (2011) Oncotarget , vol.2 , pp. 122-134
    • Samant, R.S.1    Shevde, L.A.2
  • 20
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • Thorpe P.E. Vascular targeting agents as cancer therapeutics. Clinical Cancer Research 2004, 10:415-427.
    • (2004) Clinical Cancer Research , vol.10 , pp. 415-427
    • Thorpe, P.E.1
  • 21
    • 65549164757 scopus 로고    scopus 로고
    • Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies
    • Kanthou C., Tozer G.M. Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies. International Journal of Experimental Pathology 2009, 90:284-294.
    • (2009) International Journal of Experimental Pathology , vol.90 , pp. 284-294
    • Kanthou, C.1    Tozer, G.M.2
  • 22
    • 77950976702 scopus 로고    scopus 로고
    • Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer
    • McKeage M.J., Baguley B.C. Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer. Cancer 2010, 116:1859-1871.
    • (2010) Cancer , vol.116 , pp. 1859-1871
    • McKeage, M.J.1    Baguley, B.C.2
  • 25
    • 0242329757 scopus 로고    scopus 로고
    • Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis
    • Hori K., Saito S. Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis. British Journal of Cancer 2003, 89:1334-1344.
    • (2003) British Journal of Cancer , vol.89 , pp. 1334-1344
    • Hori, K.1    Saito, S.2
  • 26
    • 0037141466 scopus 로고    scopus 로고
    • A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs
    • Hori K., Saito S., Kubota K. A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs. British Journal of Cancer 2002, 86:1604-1614.
    • (2002) British Journal of Cancer , vol.86 , pp. 1604-1614
    • Hori, K.1    Saito, S.2    Kubota, K.3
  • 27
    • 0035985910 scopus 로고    scopus 로고
    • Antitumor and antivascular effects of AC-7700, a combretastatin A-4 derivative, against rat liver cancer
    • Ohno T., Kawano K., Sasaki A., et al. Antitumor and antivascular effects of AC-7700, a combretastatin A-4 derivative, against rat liver cancer. International Journal of Clinical Oncology 2002, 7:171-176.
    • (2002) International Journal of Clinical Oncology , vol.7 , pp. 171-176
    • Ohno, T.1    Kawano, K.2    Sasaki, A.3
  • 28
    • 0024513175 scopus 로고
    • Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
    • Pettit G.R., Singh S.B., Hamel E., et al. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia 1989, 45:209-211.
    • (1989) Experientia , vol.45 , pp. 209-211
    • Pettit, G.R.1    Singh, S.B.2    Hamel, E.3
  • 29
    • 37449001322 scopus 로고    scopus 로고
    • How do microtubule-targeted drugs work? An overview
    • Jordan M.A., Kamath K. How do microtubule-targeted drugs work? An overview. Current Cancer Drug Targets 2007, 7:730-742.
    • (2007) Current Cancer Drug Targets , vol.7 , pp. 730-742
    • Jordan, M.A.1    Kamath, K.2
  • 30
    • 0035860132 scopus 로고    scopus 로고
    • Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity
    • Galmarini C.M., Falette N., Tabone E., et al. Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity. British Journal of Cancer 2001, 85:902-908.
    • (2001) British Journal of Cancer , vol.85 , pp. 902-908
    • Galmarini, C.M.1    Falette, N.2    Tabone, E.3
  • 31
    • 0030026934 scopus 로고    scopus 로고
    • Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis
    • Wahl A.F., Donaldson K.L., Fairchild C., et al. Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis. Nature Medicine 1996, 2:72-79.
    • (1996) Nature Medicine , vol.2 , pp. 72-79
    • Wahl, A.F.1    Donaldson, K.L.2    Fairchild, C.3
  • 32
    • 66349136840 scopus 로고    scopus 로고
    • TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18
    • Huang Y.F., Chang M.D., Shieh S.Y. TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18. Molecular and Cellular Biology 2009, 29:2935-2944.
    • (2009) Molecular and Cellular Biology , vol.29 , pp. 2935-2944
    • Huang, Y.F.1    Chang, M.D.2    Shieh, S.Y.3
  • 33
    • 0036215178 scopus 로고    scopus 로고
    • Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma
    • Li L., Rojiani A.M., Siemann D.W. Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma. Acta Oncologica 2002, 41:91-97.
    • (2002) Acta Oncologica , vol.41 , pp. 91-97
    • Li, L.1    Rojiani, A.M.2    Siemann, D.W.3
  • 36
    • 0035150786 scopus 로고    scopus 로고
    • Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model
    • Holwell S.E., Hill B.T., Bibby M.C. Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model. British Journal of Cancer 2001, 84:290-295.
    • (2001) British Journal of Cancer , vol.84 , pp. 290-295
    • Holwell, S.E.1    Hill, B.T.2    Bibby, M.C.3
  • 37
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
    • Dark G.G., Hill S.A., Prise V.E., et al. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Research 1997, 57:1829-1834.
    • (1997) Cancer Research , vol.57 , pp. 1829-1834
    • Dark, G.G.1    Hill, S.A.2    Prise, V.E.3
  • 38
    • 80455129668 scopus 로고    scopus 로고
    • Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation
    • Bertelsen L.B., Shen Y.Y., Nielsen T., et al. Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation. International Journal of Radiation Biology 2011, 87:1126-1134.
    • (2011) International Journal of Radiation Biology , vol.87 , pp. 1126-1134
    • Bertelsen, L.B.1    Shen, Y.Y.2    Nielsen, T.3
  • 39
    • 0142155561 scopus 로고    scopus 로고
    • Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response
    • Horsman M.R., Murata R. Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response. International Journal of Radiation Oncology, Biology, Physics 2003, 57:1047-1055.
    • (2003) International Journal of Radiation Oncology, Biology, Physics , vol.57 , pp. 1047-1055
    • Horsman, M.R.1    Murata, R.2
  • 40
    • 0034472914 scopus 로고    scopus 로고
    • Combretastatins novel vascular targeting drugs for improving anti-cancer therapy. Combretastatins and conventional therapy
    • Horsman M.R., Murata R., Breidahl T., et al. Combretastatins novel vascular targeting drugs for improving anti-cancer therapy. Combretastatins and conventional therapy. Advances in Experimental Medicine and Biology 2000, 476:311-323.
    • (2000) Advances in Experimental Medicine and Biology , vol.476 , pp. 311-323
    • Horsman, M.R.1    Murata, R.2    Breidahl, T.3
  • 41
    • 0036278972 scopus 로고    scopus 로고
    • Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models
    • Blakey D.C., Westwood F.R., Walker M., et al. Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models. Clinical Cancer Research 2002, 8:1974-1983.
    • (2002) Clinical Cancer Research , vol.8 , pp. 1974-1983
    • Blakey, D.C.1    Westwood, F.R.2    Walker, M.3
  • 42
    • 0032729686 scopus 로고    scopus 로고
    • Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700
    • Hori K., Saito S., Nihei Y., et al. Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700. Japanese Journal of Cancer Research 1999, 90:1026-1038.
    • (1999) Japanese Journal of Cancer Research , vol.90 , pp. 1026-1038
    • Hori, K.1    Saito, S.2    Nihei, Y.3
  • 43
    • 0035146174 scopus 로고    scopus 로고
    • Stoppage of blood flow in 3-methylcholanthrene-induced autochthonous primary tumor due to a novel combretastatin A-4 derivative, AC7700, and its antitumor effect
    • Hori K., Saito S., Sato Y., Kubota K. Stoppage of blood flow in 3-methylcholanthrene-induced autochthonous primary tumor due to a novel combretastatin A-4 derivative, AC7700, and its antitumor effect. Medical Science Monitor 2001, 7:26-33.
    • (2001) Medical Science Monitor , vol.7 , pp. 26-33
    • Hori, K.1    Saito, S.2    Sato, Y.3    Kubota, K.4
  • 44
    • 80052026194 scopus 로고    scopus 로고
    • Vascular effects dominate solid tumor response to treatment with combretastatin A-4-phosphate
    • Lunt S.J., Akerman S., Hill S.A., et al. Vascular effects dominate solid tumor response to treatment with combretastatin A-4-phosphate. International Journal of Cancer 2011, 129:1979-1989.
    • (2011) International Journal of Cancer , vol.129 , pp. 1979-1989
    • Lunt, S.J.1    Akerman, S.2    Hill, S.A.3
  • 45
    • 0033395393 scopus 로고    scopus 로고
    • Evaluation of antivascular and antimitotic effects of tubulin binding agents in solid tumor therapy
    • Nihei Y., Suzuki M., Okano A., et al. Evaluation of antivascular and antimitotic effects of tubulin binding agents in solid tumor therapy. Japanese Journal of Cancer Research 1999, 90:1387-1395.
    • (1999) Japanese Journal of Cancer Research , vol.90 , pp. 1387-1395
    • Nihei, Y.1    Suzuki, M.2    Okano, A.3
  • 46
    • 0035129337 scopus 로고    scopus 로고
    • Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy
    • Nabha S.M., Mohammad R.M., Wall N.R., et al. Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy. Anti-Cancer Drugs 2001, 12:57-63.
    • (2001) Anti-Cancer Drugs , vol.12 , pp. 57-63
    • Nabha, S.M.1    Mohammad, R.M.2    Wall, N.R.3
  • 47
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan M.A., Wilson L. Microtubules as a target for anticancer drugs. Nature Reviews Cancer 2004, 4:253-265.
    • (2004) Nature Reviews Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 49
    • 33846441659 scopus 로고    scopus 로고
    • Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer
    • Kamat A.A., Kim T.J., Landen C.N., et al. Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer. Cancer Research 2007, 67:281-288.
    • (2007) Cancer Research , vol.67 , pp. 281-288
    • Kamat, A.A.1    Kim, T.J.2    Landen, C.N.3
  • 50
    • 65249123159 scopus 로고    scopus 로고
    • Antivascular actions of microtubule-binding drugs
    • Schwartz E.L. Antivascular actions of microtubule-binding drugs. Clinical Cancer Research 2009, 15:2594-2601.
    • (2009) Clinical Cancer Research , vol.15 , pp. 2594-2601
    • Schwartz, E.L.1
  • 52
    • 0035131992 scopus 로고    scopus 로고
    • Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues
    • Murata R., Overgaard J., Horsman M.R. Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues. International Journal of Radiation Biology 2001, 77:195-204.
    • (2001) International Journal of Radiation Biology , vol.77 , pp. 195-204
    • Murata, R.1    Overgaard, J.2    Horsman, M.R.3
  • 53
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues
    • Tozer G.M., Prise V.E., Wilson J., et al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Research 1999, 59:1626-1634.
    • (1999) Cancer Research , vol.59 , pp. 1626-1634
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 54
    • 80052188022 scopus 로고    scopus 로고
    • Cardiovascular toxicity profiles of vascular-disrupting agents
    • Subbiah I.M., Lenihan D.J., Tsimberidou A.M. Cardiovascular toxicity profiles of vascular-disrupting agents. Oncologist 2011, 16:1120-1130.
    • (2011) Oncologist , vol.16 , pp. 1120-1130
    • Subbiah, I.M.1    Lenihan, D.J.2    Tsimberidou, A.M.3
  • 56
    • 0038576983 scopus 로고    scopus 로고
    • Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate
    • Hua J., Sheng Y., Pinney K.G., et al. Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate. Anticancer Research 2003, 23:1433-1440.
    • (2003) Anticancer Research , vol.23 , pp. 1433-1440
    • Hua, J.1    Sheng, Y.2    Pinney, K.G.3
  • 57
    • 78650826753 scopus 로고    scopus 로고
    • Support of a free radical mechanism for enhanced antitumor efficacy of the microtubule disruptor OXi4503
    • Rice L., Pampo C., Lepler S., et al. Support of a free radical mechanism for enhanced antitumor efficacy of the microtubule disruptor OXi4503. Microvascular Research 2011, 81:44-51.
    • (2011) Microvascular Research , vol.81 , pp. 44-51
    • Rice, L.1    Pampo, C.2    Lepler, S.3
  • 58
    • 33746091695 scopus 로고    scopus 로고
    • Effect of the second-generation vascular disrupting agent OXi4503 on tumor vascularity
    • Salmon H.W., Siemann D.W. Effect of the second-generation vascular disrupting agent OXi4503 on tumor vascularity. Clinical Cancer Research 2006, 12:4090-4094.
    • (2006) Clinical Cancer Research , vol.12 , pp. 4090-4094
    • Salmon, H.W.1    Siemann, D.W.2
  • 59
    • 78650376933 scopus 로고    scopus 로고
    • Phase 1 first-in-human trial of the vascular disrupting agent plinabulin (NPI-2358) in patients with solid tumors or lymphomas
    • Mita M.M., Spear M.A., Yee L.K., et al. Phase 1 first-in-human trial of the vascular disrupting agent plinabulin (NPI-2358) in patients with solid tumors or lymphomas. Clinical Cancer Research 2010, 16:5892-5899.
    • (2010) Clinical Cancer Research , vol.16 , pp. 5892-5899
    • Mita, M.M.1    Spear, M.A.2    Yee, L.K.3
  • 60
    • 33646118484 scopus 로고    scopus 로고
    • NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent
    • Nicholson B., Lloyd G.K., Miller B.R., et al. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anti-Cancer Drugs 2006, 17:25-31.
    • (2006) Anti-Cancer Drugs , vol.17 , pp. 25-31
    • Nicholson, B.1    Lloyd, G.K.2    Miller, B.R.3
  • 61
    • 34547685818 scopus 로고    scopus 로고
    • Comparison of the antivascular and cytotoxic activities of TZT-1027 (Soblidotin) with those of other anticancer agents
    • Watanabe J., Natsume T., Kobayashi M. Comparison of the antivascular and cytotoxic activities of TZT-1027 (Soblidotin) with those of other anticancer agents. Anti-Cancer Drugs 2007, 18:905-911.
    • (2007) Anti-Cancer Drugs , vol.18 , pp. 905-911
    • Watanabe, J.1    Natsume, T.2    Kobayashi, M.3
  • 62
    • 67649781901 scopus 로고    scopus 로고
    • Discovery of 4-aryl-4H-chromenes as potent apoptosis inducers using a cell- and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and the identification of novel vascular disrupting agents
    • Cai S.X., Drewe J., Kemnitzer W. Discovery of 4-aryl-4H-chromenes as potent apoptosis inducers using a cell- and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and the identification of novel vascular disrupting agents. Anti-Cancer Agents in Medicinal Chemistry 2009, 9:437-456.
    • (2009) Anti-Cancer Agents in Medicinal Chemistry , vol.9 , pp. 437-456
    • Cai, S.X.1    Drewe, J.2    Kemnitzer, W.3
  • 63
    • 27944450310 scopus 로고    scopus 로고
    • Preclinical studies of the novel vascular disrupting agent MN-029
    • Shi W., Siemann D.W. Preclinical studies of the novel vascular disrupting agent MN-029. Anticancer Research 2005, 25:3899-3904.
    • (2005) Anticancer Research , vol.25 , pp. 3899-3904
    • Shi, W.1    Siemann, D.W.2
  • 64
    • 0037115398 scopus 로고    scopus 로고
    • ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature
    • Davis P.D., Dougherty G.J., Blakey D.C., et al. ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature. Cancer Research 2002, 62:7247-7253.
    • (2002) Cancer Research , vol.62 , pp. 7247-7253
    • Davis, P.D.1    Dougherty, G.J.2    Blakey, D.C.3
  • 66
    • 0035254653 scopus 로고    scopus 로고
    • In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment
    • Landuyt W., Ahmed B., Nuyts S., et al. In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment. International Journal of Radiation Oncology, Biology, Physics 2001, 49:443-450.
    • (2001) International Journal of Radiation Oncology, Biology, Physics , vol.49 , pp. 443-450
    • Landuyt, W.1    Ahmed, B.2    Nuyts, S.3
  • 67
    • 0034759198 scopus 로고    scopus 로고
    • Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid
    • Murata R., Siemann D.W., Overgaard J., Horsman M.R. Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid. Radiation Research 2001, 156:503-509.
    • (2001) Radiation Research , vol.156 , pp. 503-509
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 69
    • 34248581988 scopus 로고    scopus 로고
    • The novel microtubule-interfering agent TZT-1027 enhances the anticancer effect of radiation in vitro and in vivo
    • Akashi Y., Okamoto I., Suzuki M., et al. The novel microtubule-interfering agent TZT-1027 enhances the anticancer effect of radiation in vitro and in vivo. British Journal of Cancer 2007, 96:1532-1539.
    • (2007) British Journal of Cancer , vol.96 , pp. 1532-1539
    • Akashi, Y.1    Okamoto, I.2    Suzuki, M.3
  • 70
  • 71
    • 20344394640 scopus 로고    scopus 로고
    • The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors
    • Siemann D.W., Rojiani A.M. The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors. International Journal of Radiation Oncology, Biology, Physics 2005, 62:846-853.
    • (2005) International Journal of Radiation Oncology, Biology, Physics , vol.62 , pp. 846-853
    • Siemann, D.W.1    Rojiani, A.M.2
  • 72
    • 17544397865 scopus 로고    scopus 로고
    • Vascular targeting of solid tumours: a major 'inverse' volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas
    • Landuyt W., Verdoes O., Darius D.O., et al. Vascular targeting of solid tumours: a major 'inverse' volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas. European Journal of Cancer 2000, 36:1833-1843.
    • (2000) European Journal of Cancer , vol.36 , pp. 1833-1843
    • Landuyt, W.1    Verdoes, O.2    Darius, D.O.3
  • 73
    • 36148979672 scopus 로고    scopus 로고
    • Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability
    • Gabrys D., Greco O., Patel G., et al. Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability. International Journal of Radiation Oncology, Biology, Physics 2007, 69:1553-1562.
    • (2007) International Journal of Radiation Oncology, Biology, Physics , vol.69 , pp. 1553-1562
    • Gabrys, D.1    Greco, O.2    Patel, G.3
  • 74
    • 44449155486 scopus 로고    scopus 로고
    • Tumor blood flow interruption after radiotherapy strongly inhibits tumor regrowth
    • Hori K., Furumoto S., Kubota K. Tumor blood flow interruption after radiotherapy strongly inhibits tumor regrowth. Cancer Science 2008, 99:1485-1491.
    • (2008) Cancer Science , vol.99 , pp. 1485-1491
    • Hori, K.1    Furumoto, S.2    Kubota, K.3
  • 75
    • 0033564974 scopus 로고    scopus 로고
    • Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
    • Gorski D.H., Beckett M.A., Jaskowiak N.T., et al. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Research 1999, 59:3374-3378.
    • (1999) Cancer Research , vol.59 , pp. 3374-3378
    • Gorski, D.H.1    Beckett, M.A.2    Jaskowiak, N.T.3
  • 76
    • 33947504434 scopus 로고    scopus 로고
    • Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer
    • Ng Q.S., Goh V., Carnell D., et al. Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer. International Journal of Radiation Oncology, Biology, Physics 2007, 67:1375-1380.
    • (2007) International Journal of Radiation Oncology, Biology, Physics , vol.67 , pp. 1375-1380
    • Ng, Q.S.1    Goh, V.2    Carnell, D.3
  • 77
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • Pugh C.W., Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nature Medicine 2003, 9:677-684.
    • (2003) Nature Medicine , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 78
    • 33845914327 scopus 로고    scopus 로고
    • Anti-vascular agent combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression
    • Dachs G.U., Steele A.J., Coralli C., et al. Anti-vascular agent combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression. BMC Cancer 2006, 6:280.
    • (2006) BMC Cancer , vol.6 , pp. 280
    • Dachs, G.U.1    Steele, A.J.2    Coralli, C.3
  • 79
    • 33749005405 scopus 로고    scopus 로고
    • Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
    • Shaked Y., Ciarrocchi A., Franco M., et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 2006, 313:1785-1787.
    • (2006) Science , vol.313 , pp. 1785-1787
    • Shaked, Y.1    Ciarrocchi, A.2    Franco, M.3
  • 81
    • 0034962379 scopus 로고    scopus 로고
    • Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors
    • Murata R., Siemann D.W., Overgaard J., Horsman M.R. Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors. Radiotherapy and Oncology 2001, 60:155-161.
    • (2001) Radiotherapy and Oncology , vol.60 , pp. 155-161
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 83
    • 0034923996 scopus 로고    scopus 로고
    • Improving local tumor control by combining vascular targeting drugs, mild hyperthermia and radiation
    • Horsman M.R., Murata R., Overgaard J. Improving local tumor control by combining vascular targeting drugs, mild hyperthermia and radiation. Acta Oncologica 2001, 40:497-503.
    • (2001) Acta Oncologica , vol.40 , pp. 497-503
    • Horsman, M.R.1    Murata, R.2    Overgaard, J.3
  • 84
    • 32144452792 scopus 로고    scopus 로고
    • In vivo antitumour effect of combretastatin A-4 phosphate added to fractionated irradiation
    • Ahmed B., Landuyt W., Griffioen A.W., et al. In vivo antitumour effect of combretastatin A-4 phosphate added to fractionated irradiation. Anticancer Research 2006, 26:307-310.
    • (2006) Anticancer Research , vol.26 , pp. 307-310
    • Ahmed, B.1    Landuyt, W.2    Griffioen, A.W.3
  • 85
    • 4444280232 scopus 로고    scopus 로고
    • Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xenograft model
    • Raben D., Bianco C., Damiano V., et al. Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xenograft model. Molecular Cancer Therapeutics 2004, 3:977-983.
    • (2004) Molecular Cancer Therapeutics , vol.3 , pp. 977-983
    • Raben, D.1    Bianco, C.2    Damiano, V.3
  • 86
    • 12244296444 scopus 로고    scopus 로고
    • Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma
    • Wachsberger P.R., Burd R., Marero N., et al. Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma. Clinical Cancer Research 2005, 11:835-842.
    • (2005) Clinical Cancer Research , vol.11 , pp. 835-842
    • Wachsberger, P.R.1    Burd, R.2    Marero, N.3
  • 87
    • 84855176809 scopus 로고    scopus 로고
    • Phase Ib trial of radiotherapy in combination with combretastatin-A4-phosphate in patients with non-small-cell lung cancer, prostate adenocarcinoma, and squamous cell carcinoma of the head and neck
    • Ng Q.S., Mandeville H., Goh V., et al. Phase Ib trial of radiotherapy in combination with combretastatin-A4-phosphate in patients with non-small-cell lung cancer, prostate adenocarcinoma, and squamous cell carcinoma of the head and neck. Annals of Oncology 2012, 23:231-237.
    • (2012) Annals of Oncology , vol.23 , pp. 231-237
    • Ng, Q.S.1    Mandeville, H.2    Goh, V.3
  • 88
    • 0142170363 scopus 로고    scopus 로고
    • Combination studies with combretastatin and radiation: effects in early and late responding tissues
    • Horsman M.R., Murata R., Overgaard J. Combination studies with combretastatin and radiation: effects in early and late responding tissues. Radiotherapy and Oncology 2002, 64:S50.
    • (2002) Radiotherapy and Oncology , vol.64
    • Horsman, M.R.1    Murata, R.2    Overgaard, J.3
  • 89
    • 41049093659 scopus 로고    scopus 로고
    • A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity
    • Meng F., Cai X., Duan J., et al. A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity. Cancer Chemotherapy and Pharmacology 2008, 61:953-963.
    • (2008) Cancer Chemotherapy and Pharmacology , vol.61 , pp. 953-963
    • Meng, F.1    Cai, X.2    Duan, J.3
  • 90
    • 53349127748 scopus 로고    scopus 로고
    • IRC-083927 is a new tubulin binder that inhibits growth of human tumor cells resistant to standard tubulin-binding agents
    • Liberatore A.M., Coulomb H., Pons D., et al. IRC-083927 is a new tubulin binder that inhibits growth of human tumor cells resistant to standard tubulin-binding agents. Molecular Cancer Therapeutics 2008, 7:2426-2434.
    • (2008) Molecular Cancer Therapeutics , vol.7 , pp. 2426-2434
    • Liberatore, A.M.1    Coulomb, H.2    Pons, D.3
  • 91
    • 84875527506 scopus 로고    scopus 로고
    • The novel vascular disrupting agent ANG501 induces cell cycle arrest and enhances endothelial cell sensitivity to radiation
    • Dougherty S.T., Walker S.E., Davis P.D., Dougherty G.J. The novel vascular disrupting agent ANG501 induces cell cycle arrest and enhances endothelial cell sensitivity to radiation. Cancer Growth and Metastasis 2009, 2:1-10.
    • (2009) Cancer Growth and Metastasis , vol.2 , pp. 1-10
    • Dougherty, S.T.1    Walker, S.E.2    Davis, P.D.3    Dougherty, G.J.4
  • 92
    • 70949094381 scopus 로고    scopus 로고
    • CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo
    • Burns C.J., Fantino E., Phillips I.D., et al. CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Molecular Cancer Therapeutics 2009, 8:3036-3045.
    • (2009) Molecular Cancer Therapeutics , vol.8 , pp. 3036-3045
    • Burns, C.J.1    Fantino, E.2    Phillips, I.D.3
  • 93
    • 81555204261 scopus 로고    scopus 로고
    • The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo
    • Burns C.J., Fantino E., Powell A.K., et al. The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo. Journal of Pharmacology and Experimental Therapeutics 2011, 339:799-806.
    • (2011) Journal of Pharmacology and Experimental Therapeutics , vol.339 , pp. 799-806
    • Burns, C.J.1    Fantino, E.2    Powell, A.K.3
  • 94
    • 68749089715 scopus 로고    scopus 로고
    • Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agent
    • Ren X., Dai M., Lin L.P., et al. Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agent. British Journal of Pharmacology 2009, 156:1228-1238.
    • (2009) British Journal of Pharmacology , vol.156 , pp. 1228-1238
    • Ren, X.1    Dai, M.2    Lin, L.P.3
  • 95
    • 77952123093 scopus 로고    scopus 로고
    • ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties
    • Pasquier E., Sinnappan S., Munoz M.A., Kavallaris M. ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. Molecular Cancer Therapeutics 2010, 9:1408-1418.
    • (2010) Molecular Cancer Therapeutics , vol.9 , pp. 1408-1418
    • Pasquier, E.1    Sinnappan, S.2    Munoz, M.A.3    Kavallaris, M.4
  • 96
    • 38949192004 scopus 로고    scopus 로고
    • STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells
    • Newman S.P., Foster P.A., Stengel C., et al. STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells. Clinical Cancer Research 2008, 14:597-606.
    • (2008) Clinical Cancer Research , vol.14 , pp. 597-606
    • Newman, S.P.1    Foster, P.A.2    Stengel, C.3
  • 97
    • 77953423945 scopus 로고    scopus 로고
    • BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy
    • Kremmidiotis G., Leske A.F., Lavranos T.C., et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Molecular Cancer Therapeutics 2010, 9:1562-1573.
    • (2010) Molecular Cancer Therapeutics , vol.9 , pp. 1562-1573
    • Kremmidiotis, G.1    Leske, A.F.2    Lavranos, T.C.3
  • 98
    • 77955799467 scopus 로고    scopus 로고
    • Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075
    • Chen C.P., Hu C.B., Yeh K.C., et al. Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075. Anticancer Research 2010, 30:2813-2822.
    • (2010) Anticancer Research , vol.30 , pp. 2813-2822
    • Chen, C.P.1    Hu, C.B.2    Yeh, K.C.3
  • 99
    • 3042740981 scopus 로고    scopus 로고
    • BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo
    • Kuo C.C., Hsieh H.P., Pan W.Y., et al. BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Research 2004, 64:4621-4628.
    • (2004) Cancer Research , vol.64 , pp. 4621-4628
    • Kuo, C.C.1    Hsieh, H.P.2    Pan, W.Y.3
  • 100
    • 79957444495 scopus 로고    scopus 로고
    • Anti-tumor activity and mechanisms of a novel vascular disrupting agent, (Z)-3,4',5-trimethoxylstilbene-3'-O-phosphate disodium (M410)
    • Cai Y.C., Zou Y., Ye Y.L., et al. Anti-tumor activity and mechanisms of a novel vascular disrupting agent, (Z)-3,4',5-trimethoxylstilbene-3'-O-phosphate disodium (M410). Investigational New Drugs 2011, 29:300-311.
    • (2011) Investigational New Drugs , vol.29 , pp. 300-311
    • Cai, Y.C.1    Zou, Y.2    Ye, Y.L.3
  • 101
    • 42949169386 scopus 로고    scopus 로고
    • Stilbene derivatives that are colchicine-site microtubule inhibitors have antileukemic activity and minimal systemic toxicity
    • Cao T.M., Durrant D., Tripathi A., et al. Stilbene derivatives that are colchicine-site microtubule inhibitors have antileukemic activity and minimal systemic toxicity. American Journal of Hematology 2008, 83:390-397.
    • (2008) American Journal of Hematology , vol.83 , pp. 390-397
    • Cao, T.M.1    Durrant, D.2    Tripathi, A.3
  • 102
    • 57149142361 scopus 로고    scopus 로고
    • Cis-3, 4', 5-Trimethoxy-3'-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion
    • Durrant D., Corwin F., Simoni D., et al. cis-3, 4', 5-Trimethoxy-3'-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion. Cancer Chemotherapy and Pharmacology 2009, 63:191-200.
    • (2009) Cancer Chemotherapy and Pharmacology , vol.63 , pp. 191-200
    • Durrant, D.1    Corwin, F.2    Simoni, D.3
  • 103
    • 80555131123 scopus 로고    scopus 로고
    • Effects of the novel vascular targeting agent MDS-11P on tumor vascularity and its antitumor activity
    • Deng Z.T., Feng T., Wang P., et al. Effects of the novel vascular targeting agent MDS-11P on tumor vascularity and its antitumor activity. Biochemical Pharmacology 2011, 82:1832-1842.
    • (2011) Biochemical Pharmacology , vol.82 , pp. 1832-1842
    • Deng, Z.T.1    Feng, T.2    Wang, P.3
  • 104
    • 84875516469 scopus 로고    scopus 로고
    • Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy
    • Clemenson C., Chargari C., Desire L., et al. Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy. Investigational New Drugs 2012, 30:2173-2186.
    • (2012) Investigational New Drugs , vol.30 , pp. 2173-2186
    • Clemenson, C.1    Chargari, C.2    Desire, L.3
  • 105
    • 84875548877 scopus 로고    scopus 로고
    • Erratum to: " Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy"
    • Clemenson C., Chargari C., Desire L., et al. Erratum to: " Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy". Investigational New Drugs 2012, 30:2451-2453.
    • (2012) Investigational New Drugs , vol.30 , pp. 2451-2453
    • Clemenson, C.1    Chargari, C.2    Desire, L.3
  • 106
    • 67249084753 scopus 로고    scopus 로고
    • ABT-751, a novel tubulin-binding agent, decreases tumor perfusion and disrupts tumor vasculature
    • Luo Y., Hradil V.P., Frost D.J., et al. ABT-751, a novel tubulin-binding agent, decreases tumor perfusion and disrupts tumor vasculature. Anti-Cancer Drugs 2009, 20:483-492.
    • (2009) Anti-Cancer Drugs , vol.20 , pp. 483-492
    • Luo, Y.1    Hradil, V.P.2    Frost, D.J.3
  • 107
    • 84866737041 scopus 로고    scopus 로고
    • Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor
    • Hsu L.C., Durrant D.E., Huang C.C., et al. Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor. Investigational New Drugs 2012, 30:1379-1388.
    • (2012) Investigational New Drugs , vol.30 , pp. 1379-1388
    • Hsu, L.C.1    Durrant, D.E.2    Huang, C.C.3
  • 108
    • 35148825036 scopus 로고    scopus 로고
    • Antitumor and antivascular effects of AVE8062 in ovarian carcinoma
    • Kim T.J., Ravoori M., Landen C.N., et al. Antitumor and antivascular effects of AVE8062 in ovarian carcinoma. Cancer Research 2007, 67:9337-9345.
    • (2007) Cancer Research , vol.67 , pp. 9337-9345
    • Kim, T.J.1    Ravoori, M.2    Landen, C.N.3
  • 109
    • 80051638135 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer
    • Lara P.N., Douillard J.Y., Nakagawa K., et al. Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. Journal of Clinical Oncology 2011, 29:2965-2971.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 2965-2971
    • Lara, P.N.1    Douillard, J.Y.2    Nakagawa, K.3
  • 110
    • 77952399799 scopus 로고    scopus 로고
    • Phase II study on the addition of ASA404 (vadimezan; 5,6-dimethylxanthenone-4-acetic acid) to docetaxel in CRMPC
    • Pili R., Rosenthal M.A., Mainwaring P.N., et al. Phase II study on the addition of ASA404 (vadimezan; 5,6-dimethylxanthenone-4-acetic acid) to docetaxel in CRMPC. Clinical Cancer Research 2010, 16:2906-2914.
    • (2010) Clinical Cancer Research , vol.16 , pp. 2906-2914
    • Pili, R.1    Rosenthal, M.A.2    Mainwaring, P.N.3
  • 111
    • 57449103348 scopus 로고    scopus 로고
    • Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage M.J., Von Pawel J., Reck M., et al. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. British Journal of Cancer 2008, 99:2006-2012.
    • (2008) British Journal of Cancer , vol.99 , pp. 2006-2012
    • McKeage, M.J.1    Von Pawel, J.2    Reck, M.3
  • 112
    • 77956311177 scopus 로고    scopus 로고
    • Randomized phase II trial of a tumor vascular disrupting agent fosbretabulin tromethamine (CA4P) with carboplatin (C), paclitaxel (P), and bevacizumab (B) in stage IIIb/IV nonsquamous non-small cell lung cancer (NSCLC): the FALCON trial
    • [abstr 7587]
    • Garon E.B., Kabbinavar F.F., Neidhart J.A., et al. Randomized phase II trial of a tumor vascular disrupting agent fosbretabulin tromethamine (CA4P) with carboplatin (C), paclitaxel (P), and bevacizumab (B) in stage IIIb/IV nonsquamous non-small cell lung cancer (NSCLC): the FALCON trial. Journal of Clinical Oncology 2010, 28. [suppl; abstr 7587].
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.SUPPL.
    • Garon, E.B.1    Kabbinavar, F.F.2    Neidhart, J.A.3
  • 113
    • 84860183520 scopus 로고    scopus 로고
    • A randomized phase II/III trial of a tumor vascular disrupting agent fosbretabulin tromethamine (CA4P) with carboplatin (C) and paclitaxel (P) in anaplastic thyroid cancer (ATC): final survival analysis for the FACT trial
    • [abstr 5502]
    • Sosa J.A., Elisei R., Jarzab B., et al. A randomized phase II/III trial of a tumor vascular disrupting agent fosbretabulin tromethamine (CA4P) with carboplatin (C) and paclitaxel (P) in anaplastic thyroid cancer (ATC): final survival analysis for the FACT trial. Journal of Clinical Oncology 2011, 29. [suppl; abstr 5502].
    • (2011) Journal of Clinical Oncology , vol.29 , Issue.SUPPL.
    • Sosa, J.A.1    Elisei, R.2    Jarzab, B.3


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