Stoppage of blood flow in 3-methylcholanthrene-induced autochthonous primary tumor due to a novel combretastatin A-4 derivative, AC7700, and its antitumor effect

Medical Science Monitor

Volumn 7, Issue 1, 2001, Pages 26-33

  Hori, Katsuyoshi ^a   Saito, Sachiko ^a   Sato, Yasufumi ^a   Kubota, Kazuo ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Antivascular; Autochthonous; Combretastatin A 4; Solid tumor; Tumor blood flow

Indexed keywords

3 METHYLCHOLANTHRENE; COMBRETASTATIN A4; SERINE 2 METHOXY 5 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]ANILIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER MODEL; CANCER TRANSPLANTATION; CONTROLLED STUDY; HISTOPATHOLOGY; MALE; NONHUMAN; RAT; SARCOMA; TUMOR BLOOD FLOW; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD PRESSURE; MALE; METHYLCHOLANTHRENE; NEOPLASMS, EXPERIMENTAL; RATS; RATS, INBRED F344; REGIONAL BLOOD FLOW; SERINE; STILBENES; TIME FACTORS;

EID: 0035146174     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
2. In vitro evaluation of the antineoplastic activity of combretastatin A-4, a natural product from Combretum caffrum (arid shrub)
3. The interaction with tubulin of a series of stilbenes based on combretastatin A-4
4. Antineoplastic agents 389. New syntheses of the combretastatin A-4 prodrug
5. Novel combretastatin analogues effective against marine solid tumors: Design and structure-activity relationships
6. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
7. In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
8. A novel combretastatin A-4 derivative, AC-7700, shows marked antitumor activity against advanced solid tumors and orthotopically transplanted tumors
9. Antitumor effects due to irreversible stoppage of tumor tissue blood flow: Evaluation ora novel combretastatin A-4 derivative, AC7700
10. Evaluation of antivascular and antimitotic effects of tubulin binding agents in solid tumor therapy
11. Autochthonous, acetoxymethyl-methylnitrosamine-induced colorectal cancer in rats: A useful tool in selecting new active antineoplastic compounds?
12. In vivo model systems for assessing an anticancer drug: Responses of autochthonous and transplanted prostate tumors to cyclophosphamide
13. Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension
14. Measurement of local blood flow with hydrogen gas
15. Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice
16. Vascular occlusion and tumor cell death
17. Vascular collapse after flavone acetic acid; a possible mechanism o fits anti-tumour action