Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model

British Journal of Cancer

Volumn 84, Issue 2, 2001, Pages 290-295

  Holwell, S E ^a   Hill, B T ^b   Bibby, M C ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Anti vascular effects; MAC 15A murine tumour; Vinflunine; Vinorelbine

Indexed keywords

HOE 33342; NAVELBINE; VINCA ALKALOID; VINCRISTINE; VINFLUNINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER MODEL; CELL LINE; CLINICAL TRIAL; COLON ADENOCARCINOMA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG TOLERABILITY; HUMAN; MALE; MOUSE; NECROSIS; NONHUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; VASCULARIZATION;

ADENOCARCINOMA; ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; MALE; MICE; MICE, INBRED STRAINS; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; TIME FACTORS; TUMOR CELLS, CULTURED; UMBILICAL VEINS; VINBLASTINE; VINCRISTINE;

EID: 0035150786     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2000.1587     Document Type: Article

References (26)

1. Vascular reactions of normal and malignant tissues in vivo. VI. The role of hypotension in the action of components of podophyllin on transplanted sarcomas
2. Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine. Evidence for a vascular mechanism
3. Phase I-II study of vinorelbine (Navelbine) plus cisplatin in advanced non-small cell lung cancer
4. New vinca alkaloids and related compounds
5. Vinorelbine (Navelbine): A third-generation Vinca alkaloid
6. Tumour vasculature as a target to cancer therapy
7. Characterisation of the vasculature within a murine adenocarcinoma growing in different sites to evaluate the potential of vascular therapies
8. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumour vasculature
9. Vinca alkaloids in superacid media: A method for creating a new family of antitumor derivatives
10. Phase II trial of weekly intravenous vinorelbine in first-line advanced breast cancer chemotherapy
11. Vinorelbine (Navelbine) in the treatment of breast cancer: The European experience
12. In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
13. Antivascular therapy: A new approach to cancer treatment
14. Vinca alkaloids: Antivascular effects in a murine tumour
15. Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts
16. Vinorelbine: An overview
17. Preclinical in vivo antitumour activity of vinflunine, a novel fluorinated Vinca alkaloid
18. Antimitotic and tubulin-interacfive properties of vinflunine, a novel fluorinated vinca alkaloid
19. Preclinical in vitro and in vivo activity of 5,6-dimethylxanthenone-4-acetic acid
20. Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: Results of a European multicenter trial including 612 patients
21. Factors determining the action of colchicine on tumour growth
22. Experimental correlations of in vitro drug sensitivity with in vivo responses to Thio TEPA in a panel of murine: Tumours
23. The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours
24. Vinorelbine as first-line chemotherapy for metastatic breast cancer
25. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues