메뉴 건너뛰기




Volumn 371, Issue 1-2, 2013, Pages 208-220

CAMP/PKA signaling defects in tumors: Genetics and tissue-specific pluripotential cell-derived lesions in human and mouse

Author keywords

Adrenal glands; Adrenocortical hyperplasia; CAMP signaling pathway; PRKAR1A gene; Tumor

Indexed keywords

CORTICOTROPIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 2; PHOSPHODIESTERASE; PROSTAGLANDIN E2; PROTEIN PRKACA; PROTEIN PRKAR1A; PROTEIN PRKAR2A; PROTEIN PRKAR2B; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84876083813     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.01.015     Document Type: Review
Times cited : (33)

References (189)
  • 1
    • 78649650474 scopus 로고    scopus 로고
    • Carney complex and other conditions associated with micronodular adrenal hyperplasias
    • Almeida M.Q., Stratakis C.A. Carney complex and other conditions associated with micronodular adrenal hyperplasias. Best Pract. Res. Clin. Endocrinol. Metab. 2010, 24:907-914.
    • (2010) Best Pract. Res. Clin. Endocrinol. Metab. , vol.24 , pp. 907-914
    • Almeida, M.Q.1    Stratakis, C.A.2
  • 3
    • 79956313489 scopus 로고    scopus 로고
    • Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors
    • Almeida M.Q., Tsang K.M., Cheadle C., Watkins T., Grivel J.C., Nesterova M., Goldbach-Mansky R., Stratakis C.A. Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors. Hum. Mol. Genet. 2011, 20:165-175.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 165-175
    • Almeida, M.Q.1    Tsang, K.M.2    Cheadle, C.3    Watkins, T.4    Grivel, J.C.5    Nesterova, M.6    Goldbach-Mansky, R.7    Stratakis, C.A.8
  • 4
    • 79953896631 scopus 로고    scopus 로고
    • Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions
    • Almeida M.Q., Harran M., Bimpaki E.I., Hsiao H.-P., Horvath A., Cheadle C., Watkins T., Nesterova M., Stratakis C.A. Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions. J. Clin. Endocrinol. Metab. 2011, 96:E728-E738.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96
    • Almeida, M.Q.1    Harran, M.2    Bimpaki, E.I.3    Hsiao, H.-P.4    Horvath, A.5    Cheadle, C.6    Watkins, T.7    Nesterova, M.8    Stratakis, C.A.9
  • 5
    • 79952070409 scopus 로고    scopus 로고
    • How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
    • Almeida M.Q., Stratakis C.A. How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?. Mol. Cell. Endocrinol. 2011, 336:162-168.
    • (2011) Mol. Cell. Endocrinol. , vol.336 , pp. 162-168
    • Almeida, M.Q.1    Stratakis, C.A.2
  • 7
    • 0036293582 scopus 로고    scopus 로고
    • The essential role of RI alpha in the maintenance of regulated PKA activity
    • Amieux P.S., McKnight G.S. The essential role of RI alpha in the maintenance of regulated PKA activity. Ann. N. Y. Acad. Sci. 2002, 968:75-95.
    • (2002) Ann. N. Y. Acad. Sci. , vol.968 , pp. 75-95
    • Amieux, P.S.1    McKnight, G.S.2
  • 11
    • 41549089945 scopus 로고    scopus 로고
    • SNP arrays in heterogeneous tissue: highly accurate collection of both germline and somatic genetic information from unpaired single tumor samples
    • Assié G., Laframboise T., Platzer P., Bertherat J., Stratakis C.A., Eng C. SNP arrays in heterogeneous tissue: highly accurate collection of both germline and somatic genetic information from unpaired single tumor samples. Am. J. Hum. Genet. 2008, 82:903-915.
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 903-915
    • Assié, G.1    Laframboise, T.2    Platzer, P.3    Bertherat, J.4    Stratakis, C.A.5    Eng, C.6
  • 17
    • 0032523095 scopus 로고    scopus 로고
    • Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells
    • Bianco P., Kuznetsov S.A., Riminucci M., Fisher L.W., Spiegel A.M., Robey P.G. Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells. J. Clin. Invest. 1998, 101:1737-1744.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1737-1744
    • Bianco, P.1    Kuznetsov, S.A.2    Riminucci, M.3    Fisher, L.W.4    Spiegel, A.M.5    Robey, P.G.6
  • 18
    • 0033371108 scopus 로고    scopus 로고
    • Inhibition of prostaglandin synthesis reduces cyclic AMP levels and inhibits chondrogenesis in cultured chick limb mesenchyme
    • Biddulph D.M., Dozier M.M., Capehart A.A. Inhibition of prostaglandin synthesis reduces cyclic AMP levels and inhibits chondrogenesis in cultured chick limb mesenchyme. Methods Cell Sci. 2000, 22:9-16.
    • (2000) Methods Cell Sci. , vol.22 , pp. 9-16
    • Biddulph, D.M.1    Dozier, M.M.2    Capehart, A.A.3
  • 19
    • 67650767017 scopus 로고    scopus 로고
    • Abnormalities of cAMP signaling are present in adrenocortical lesions associated with corticotropin-independent Cushing syndrome despite the absence of mutations in known genes
    • Bimpaki E., Nesterova M., Stratakis C.A. Abnormalities of cAMP signaling are present in adrenocortical lesions associated with corticotropin-independent Cushing syndrome despite the absence of mutations in known genes. Eur. J. Endocrinol. 2009, 161:153-161.
    • (2009) Eur. J. Endocrinol. , vol.161 , pp. 153-161
    • Bimpaki, E.1    Nesterova, M.2    Stratakis, C.A.3
  • 20
    • 77952627699 scopus 로고    scopus 로고
    • MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumorigenesis
    • Bimpaki E.I., Iliopoulos D., Moraitis A., Stratakis C.A. MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumorigenesis. Clin. Endocrinol. (Oxf) 2010, 72:744-751.
    • (2010) Clin. Endocrinol. (Oxf) , vol.72 , pp. 744-751
    • Bimpaki, E.I.1    Iliopoulos, D.2    Moraitis, A.3    Stratakis, C.A.4
  • 22
    • 56649117453 scopus 로고    scopus 로고
    • A 2.3Mb deletion of 17q24.2-q24.3 associated with 'Carney Complex plus'
    • Blyth M., Huang S., Maloney V., Crolla J.A., Karen Temple.I. A 2.3Mb deletion of 17q24.2-q24.3 associated with 'Carney Complex plus'. Eur. J. Med. Genet. 2008, 51:672-678.
    • (2008) Eur. J. Med. Genet. , vol.51 , pp. 672-678
    • Blyth, M.1    Huang, S.2    Maloney, V.3    Crolla, J.A.4    Karen, T.5
  • 23
    • 45549099523 scopus 로고    scopus 로고
    • Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease and other corticotropin-independent lesions
    • Boikos A., Horvath A., Heyerdahl S., Stein E., Robinson-White A., Bossis I., Bertherat J., Stratakis C.A. Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease and other corticotropin-independent lesions. Horm. Metab. Res. 2008, 40:347-353.
    • (2008) Horm. Metab. Res. , vol.40 , pp. 347-353
    • Boikos, A.1    Horvath, A.2    Heyerdahl, S.3    Stein, E.4    Robinson-White, A.5    Bossis, I.6    Bertherat, J.7    Stratakis, C.A.8
  • 25
    • 9444247656 scopus 로고    scopus 로고
    • Minireview: PRKAR1A: normal and abnormal functions
    • 5452-5428
    • Bossis I., Stratakis C.A. Minireview: PRKAR1A: normal and abnormal functions. Endocrinology 2004, 145. 5452-5428.
    • (2004) Endocrinology , vol.145
    • Bossis, I.1    Stratakis, C.A.2
  • 26
    • 0027934280 scopus 로고
    • Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia
    • Boston B.A., Mandel S., LaFranchi S., Bliziotes M. Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia. J. Clin. Endocrinol. Metab. 1994, 79:890-893.
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , pp. 890-893
    • Boston, B.A.1    Mandel, S.2    LaFranchi, S.3    Bliziotes, M.4
  • 28
    • 0041381386 scopus 로고    scopus 로고
    • Primary pigmented nodular adrenocortical disease: paradoxical responses of cortisol secretion to dexamethasone occur in vitro and are associated with increased expression of the glucocorticoid receptor
    • Bourdeau I., Lacroix A., Schürch W., Caron P., Antakly T., Stratakis C.A. Primary pigmented nodular adrenocortical disease: paradoxical responses of cortisol secretion to dexamethasone occur in vitro and are associated with increased expression of the glucocorticoid receptor. J. Clin. Endocrinol. Metab. 2003, 88:3931-3937.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 3931-3937
    • Bourdeau, I.1    Lacroix, A.2    Schürch, W.3    Caron, P.4    Antakly, T.5    Stratakis, C.A.6
  • 29
    • 1542741588 scopus 로고    scopus 로고
    • Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators
    • Bourdeau I., Antonini S.R., Lacroix A., Kirschner L.S., Matyakhina L., Lorang D., Libutti S.K., Stratakis C.A. Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators. Oncogene 2004, 23:1575-1585.
    • (2004) Oncogene , vol.23 , pp. 1575-1585
    • Bourdeau, I.1    Antonini, S.R.2    Lacroix, A.3    Kirschner, L.S.4    Matyakhina, L.5    Lorang, D.6    Libutti, S.K.7    Stratakis, C.A.8
  • 30
    • 33748748991 scopus 로고    scopus 로고
    • 17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia
    • Bourdeau I., Matyakhina L., Stergiopoulos S.G., Sandrini F., Boikos S., Stratakis C.A. 17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. J. Clin. Endocrinol. Metab. 2006, 91:3626-3632.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 3626-3632
    • Bourdeau, I.1    Matyakhina, L.2    Stergiopoulos, S.G.3    Sandrini, F.4    Boikos, S.5    Stratakis, C.A.6
  • 32
    • 0029021176 scopus 로고
    • Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase
    • Brandon E.P., Zhuo M., Huang Y.Y., Qi M., Gerhold K.A., Burton K.A., Kandel E.R., McKnight G.S., Idzerda R.L. Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 1995, 92:8851-8855.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8851-8855
    • Brandon, E.P.1    Zhuo, M.2    Huang, Y.Y.3    Qi, M.4    Gerhold, K.A.5    Burton, K.A.6    Kandel, E.R.7    McKnight, G.S.8    Idzerda, R.L.9
  • 35
    • 0017736213 scopus 로고
    • The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma
    • Carney J.A., Sheps S.G., Go V.L., Gordon H. The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. N. Engl. J. Med. 1977, 296:1517-1518.
    • (1977) N. Engl. J. Med. , vol.296 , pp. 1517-1518
    • Carney, J.A.1    Sheps, S.G.2    Go, V.L.3    Gordon, H.4
  • 37
    • 0028798605 scopus 로고
    • The Carney complex (myxomas, spotty pigmentation, endocrine overactivity, and schwannomas)
    • Carney J.A. The Carney complex (myxomas, spotty pigmentation, endocrine overactivity, and schwannomas). Dermatol. Clin. 1995, 13:19-26.
    • (1995) Dermatol. Clin. , vol.13 , pp. 19-26
    • Carney, J.A.1
  • 38
    • 0036499042 scopus 로고    scopus 로고
    • Familial paraganglioma and gastric stromal sarcoma: a new syndrome distinct from the Carney Triad
    • Carney J.A., Stratakis C.A. Familial paraganglioma and gastric stromal sarcoma: a new syndrome distinct from the Carney Triad. Am. J. Med. Genet. 2002, 108:132-139.
    • (2002) Am. J. Med. Genet. , vol.108 , pp. 132-139
    • Carney, J.A.1    Stratakis, C.A.2
  • 39
    • 77950204638 scopus 로고    scopus 로고
    • Familial micronodular adrenocortical disease, Cushing syndrome, and mutations of the gene encoding phosphodiesterase 11A4 (PDE11A)
    • Carney J.A., Gaillard R.C., Bertherat J., Stratakis C.A. Familial micronodular adrenocortical disease, Cushing syndrome, and mutations of the gene encoding phosphodiesterase 11A4 (PDE11A). Am. J. Surg. Pathol. 2010, 34:547-555.
    • (2010) Am. J. Surg. Pathol. , vol.34 , pp. 547-555
    • Carney, J.A.1    Gaillard, R.C.2    Bertherat, J.3    Stratakis, C.A.4
  • 40
    • 81155161059 scopus 로고    scopus 로고
    • Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome
    • Carney J.A., Young W.F., Stratakis C.A. Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome. Am. J. Surg. Pathol. 2011, 35:1311-1326.
    • (2011) Am. J. Surg. Pathol. , vol.35 , pp. 1311-1326
    • Carney, J.A.1    Young, W.F.2    Stratakis, C.A.3
  • 41
    • 80052031185 scopus 로고    scopus 로고
    • Further study of chromosome 7p22 to identify the molecular basis of familial hyperaldosteronism type II
    • Carss K.J., Stowasser M., Gordon R.D., O'Shaughnessy K.M. Further study of chromosome 7p22 to identify the molecular basis of familial hyperaldosteronism type II. J. Hum. Hypertens. 2011, 25:560-564.
    • (2011) J. Hum. Hypertens. , vol.25 , pp. 560-564
    • Carss, K.J.1    Stowasser, M.2    Gordon, R.D.3    O'Shaughnessy, K.M.4
  • 43
    • 78650057361 scopus 로고    scopus 로고
    • The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways
    • Chun K.S., Lao H.C., Langenbach R. The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways. J. Biol. Chem. 2010, 285:39672-39681.
    • (2010) J. Biol. Chem. , vol.285 , pp. 39672-39681
    • Chun, K.S.1    Lao, H.C.2    Langenbach, R.3
  • 44
    • 34447265905 scopus 로고    scopus 로고
    • Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling
    • Conti M., Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu. Rev. Biochem. 2007, 76:481-511.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 481-511
    • Conti, M.1    Beavo, J.2
  • 45
    • 0029737861 scopus 로고    scopus 로고
    • Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A
    • Cummings D.E., Brandon E.P., Planas J.V., Motamed K., Idzerda R.L., McKnight G.S. Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A. Nature 1996, 382:622-626.
    • (1996) Nature , vol.382 , pp. 622-626
    • Cummings, D.E.1    Brandon, E.P.2    Planas, J.V.3    Motamed, K.4    Idzerda, R.L.5    McKnight, G.S.6
  • 46
    • 38349105880 scopus 로고    scopus 로고
    • Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice
    • Czyzyk T.A., Sikorski M.A., Yang L., McKnight G.S. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc. Natl. Acad. Sci. USA 2008, 105:276-281.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 276-281
    • Czyzyk, T.A.1    Sikorski, M.A.2    Yang, L.3    McKnight, G.S.4
  • 47
    • 33751022236 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor: update. Klin
    • Daum O., Vanecek T., Sima R., Michal M. Gastrointestinal stromal tumor: update. Klin. Onkologie 2006, 19:203-211.
    • (2006) Onkologie , vol.19 , pp. 203-211
    • Daum, O.1    Vanecek, T.2    Sima, R.3    Michal, M.4
  • 51
    • 38549127858 scopus 로고    scopus 로고
    • Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose
    • Dov A., Abramovitch E., Warwar N., Nesher R. Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose. Endocrinology 2008, 149:741-748.
    • (2008) Endocrinology , vol.149 , pp. 741-748
    • Dov, A.1    Abramovitch, E.2    Warwar, N.3    Nesher, R.4
  • 52
    • 10844268664 scopus 로고    scopus 로고
    • Genomic structure of the human gene for protein kinase A regulatory subunit R1-beta (PRKAR1B) on 7p22: no evidence for mutations in familial hyperaldosteronism type II in a large affected kindred
    • Elphinstone M.S., Gordon R.D., So A., Jeske Y.W., Stratakis C.A., Stowasser M. Genomic structure of the human gene for protein kinase A regulatory subunit R1-beta (PRKAR1B) on 7p22: no evidence for mutations in familial hyperaldosteronism type II in a large affected kindred. Clin. Endocrinol. (Oxf) 2004, 61:716-723.
    • (2004) Clin. Endocrinol. (Oxf) , vol.61 , pp. 716-723
    • Elphinstone, M.S.1    Gordon, R.D.2    So, A.3    Jeske, Y.W.4    Stratakis, C.A.5    Stowasser, M.6
  • 53
    • 0036302235 scopus 로고    scopus 로고
    • Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes
    • Feldmann J., Prieur A.M., Quartier P., Berquin P., Certain S., Cortis E., Teillac-Hamel D., Fischer A., de Saint Basile G. Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am. J. Hum. Genet. 2002, 71:198-203.
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 198-203
    • Feldmann, J.1    Prieur, A.M.2    Quartier, P.3    Berquin, P.4    Certain, S.5    Cortis, E.6    Teillac-Hamel, D.7    Fischer, A.8    de Saint Basile, G.9
  • 56
    • 0037409401 scopus 로고    scopus 로고
    • Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans
    • Gamanuma M., Yuasa K., Sasaki T., Sakurai N., Kotera J., Omori K. Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans. Cell. Signal. 2003, 15:565-574.
    • (2003) Cell. Signal. , vol.15 , pp. 565-574
    • Gamanuma, M.1    Yuasa, K.2    Sasaki, T.3    Sakurai, N.4    Kotera, J.5    Omori, K.6
  • 58
    • 53749096474 scopus 로고    scopus 로고
    • Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors
    • Gaujoux S., Tissier F., Groussin L., Libé R., Ragazzon B., Launay P., Audebourg A., Dousset B., Bertagna X., Bertherat J. Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors. J. Clin. Endocrinol. Metab. 2008, 93:4135-4140.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 4135-4140
    • Gaujoux, S.1    Tissier, F.2    Groussin, L.3    Libé, R.4    Ragazzon, B.5    Launay, P.6    Audebourg, A.7    Dousset, B.8    Bertagna, X.9    Bertherat, J.10
  • 62
    • 54049112731 scopus 로고    scopus 로고
    • A novel PRKAR1A mutation associated with hepatocellular carcinoma in a young patient and a variable Carney complex phenotype in affected subjects in older generations
    • Gennari M., Stratakis C.A., Hovarth A., Pirazzoli P., Cicognani A. A novel PRKAR1A mutation associated with hepatocellular carcinoma in a young patient and a variable Carney complex phenotype in affected subjects in older generations. Clin. Endocrinol. (Oxf) 2008, 69:751-755.
    • (2008) Clin. Endocrinol. (Oxf) , vol.69 , pp. 751-755
    • Gennari, M.1    Stratakis, C.A.2    Hovarth, A.3    Pirazzoli, P.4    Cicognani, A.5
  • 66
    • 39149133729 scopus 로고    scopus 로고
    • In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay
    • Greene E.L., Horvath A.D., Nesterova M., Giatzakis C., Bossis I., Stratakis C.A. In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay. Hum. Mut. 2008, 29:633-639.
    • (2008) Hum. Mut. , vol.29 , pp. 633-639
    • Greene, E.L.1    Horvath, A.D.2    Nesterova, M.3    Giatzakis, C.4    Bossis, I.5    Stratakis, C.A.6
  • 69
    • 0035650943 scopus 로고    scopus 로고
    • COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib
    • Grösch S., Tegeder I., Niederberger E., Bräutigam L., Geisslinger G. COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. FASEB J. 2001, 15:2742-2744.
    • (2001) FASEB J. , vol.15 , pp. 2742-2744
    • Grösch, S.1    Tegeder, I.2    Niederberger, E.3    Bräutigam, L.4    Geisslinger, G.5
  • 71
    • 0036907704 scopus 로고    scopus 로고
    • Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD
    • Groussin L., Kirschner L.S., Vincent-Dejean C., Perlemoine K., Jullian E., Delemer B., Zacharieva S., Pignatelli D., Carney J.A., Luton J.P., Bertagna X., Stratakis C.A., Bertherat J. Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD. Am. J. Hum. Genet. 2002, 71:1433-1442.
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 1433-1442
    • Groussin, L.1    Kirschner, L.S.2    Vincent-Dejean, C.3    Perlemoine, K.4    Jullian, E.5    Delemer, B.6    Zacharieva, S.7    Pignatelli, D.8    Carney, J.A.9    Luton, J.P.10    Bertagna, X.11    Stratakis, C.A.12    Bertherat, J.13
  • 79
    • 39049101528 scopus 로고    scopus 로고
    • Mutation in PDE8B, a cAMP-specific phosphodiesterase in adrenal hyperplasia
    • Horvath A., Mericq V., Stratakis C.A. Mutation in PDE8B, a cAMP-specific phosphodiesterase in adrenal hyperplasia. N. Engl. J. Med. 2008, 358:750-752.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 750-752
    • Horvath, A.1    Mericq, V.2    Stratakis, C.A.3
  • 84
    • 77952389559 scopus 로고    scopus 로고
    • Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels
    • Horvath A., Faucz F., Finkielstain G.P., Nikita M.E., Rothenbuhler A., Almeida M., Mericq V., Stratakis C.A. Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels. Thyroid 2010, 20:363-367.
    • (2010) Thyroid , vol.20 , pp. 363-367
    • Horvath, A.1    Faucz, F.2    Finkielstain, G.P.3    Nikita, M.E.4    Rothenbuhler, A.5    Almeida, M.6    Mericq, V.7    Stratakis, C.A.8
  • 85
    • 0036351299 scopus 로고    scopus 로고
    • Molecular and behavioral effects of a null mutation in all PKA C beta isoforms
    • Howe D.G., Wiley J.C., McKnight G.S. Molecular and behavioral effects of a null mutation in all PKA C beta isoforms. Mol. Cell. Neurosci. 2002, 20:515-524.
    • (2002) Mol. Cell. Neurosci. , vol.20 , pp. 515-524
    • Howe, D.G.1    Wiley, J.C.2    McKnight, G.S.3
  • 86
    • 68549109424 scopus 로고    scopus 로고
    • Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors
    • Hsiao H.P., Kirschner L.S., Bourdeau I., Keil M.F., Boikos S.A., Verma S., Robinson-White A.J., Nesterova M., Lacroix A., Stratakis C.A. Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors. J. Clin. Endocrinol. Metab. 2009, 94:2930-2937.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 2930-2937
    • Hsiao, H.P.1    Kirschner, L.S.2    Bourdeau, I.3    Keil, M.F.4    Boikos, S.A.5    Verma, S.6    Robinson-White, A.J.7    Nesterova, M.8    Lacroix, A.9    Stratakis, C.A.10
  • 87
    • 65949092330 scopus 로고    scopus 로고
    • MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling
    • Iliopoulos D., Bimpaki E.I., Nesterova M., Stratakis C.A. MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling. Cancer Res. 2009, 69:3278-3282.
    • (2009) Cancer Res. , vol.69 , pp. 3278-3282
    • Iliopoulos, D.1    Bimpaki, E.I.2    Nesterova, M.3    Stratakis, C.A.4
  • 91
    • 80052545178 scopus 로고    scopus 로고
    • Functional imaging of SDHx-related head and neck paragangliomas: comparison of 18F-fluorodihydroxyphenylalanine, 18F-fluorodopamine, 18F-fluoro-2-deoxy-D-glucose PET, 123I-metaiodobenzylguanidine scintigraphy, and 111In-pentetreotide scintigraphy
    • King K.S., Chen C.C., Alexopoulos D.K., Whatley M.A., Reynolds J.C., Patronas N., Ling A., Adams K.T., Xekouki P., Lando H., Stratakis C.A., Pacak K. Functional imaging of SDHx-related head and neck paragangliomas: comparison of 18F-fluorodihydroxyphenylalanine, 18F-fluorodopamine, 18F-fluoro-2-deoxy-D-glucose PET, 123I-metaiodobenzylguanidine scintigraphy, and 111In-pentetreotide scintigraphy. J. Clin. Endocrinol. Metab. 2011, 96:2779-2785.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 2779-2785
    • King, K.S.1    Chen, C.C.2    Alexopoulos, D.K.3    Whatley, M.A.4    Reynolds, J.C.5    Patronas, N.6    Ling, A.7    Adams, K.T.8    Xekouki, P.9    Lando, H.10    Stratakis, C.A.11    Pacak, K.12
  • 94
    • 0034642302 scopus 로고    scopus 로고
    • Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex
    • Kirschner L.S., Sandrini F., Monbo J., Lin J.P., Carney J.A., Stratakis C.A. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex. Hum. Mol. Genet. 2000, 9:3037-3046.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 3037-3046
    • Kirschner, L.S.1    Sandrini, F.2    Monbo, J.3    Lin, J.P.4    Carney, J.A.5    Stratakis, C.A.6
  • 96
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • Klaus A., Birchmeier W. Wnt signalling and its impact on development and cancer. Nat. Rev. Cancer 2008, 8:387-398.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 97
    • 42649118106 scopus 로고    scopus 로고
    • Human mesenchymal stem cell proliferation is regulated by PGE2 through differential activation of cAMP-dependent protein kinase isoforms
    • Kleiveland C.R., Kassem M., Lea T. Human mesenchymal stem cell proliferation is regulated by PGE2 through differential activation of cAMP-dependent protein kinase isoforms. Exp. Cell Res. 2008, 314:1831-1838.
    • (2008) Exp. Cell Res. , vol.314 , pp. 1831-1838
    • Kleiveland, C.R.1    Kassem, M.2    Lea, T.3
  • 101
    • 82255192267 scopus 로고    scopus 로고
    • Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment
    • Levy I., Horvath A., Azevedo M., de Alexandre R.B., Stratakis C.A. Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment. Curr. Opin. Pharmacol. 2011, 11:689-697.
    • (2011) Curr. Opin. Pharmacol. , vol.11 , pp. 689-697
    • Levy, I.1    Horvath, A.2    Azevedo, M.3    de Alexandre, R.B.4    Stratakis, C.A.5
  • 102
    • 22944472450 scopus 로고    scopus 로고
    • Profiles of PrKX expression in developmental mouse embryo and human tissues
    • Li W., Yu Z.X., Kotin R.M. Profiles of PrKX expression in developmental mouse embryo and human tissues. J. Histochem. Cytochem. 2005, 53:1003-1009.
    • (2005) J. Histochem. Cytochem. , vol.53 , pp. 1003-1009
    • Li, W.1    Yu, Z.X.2    Kotin, R.M.3
  • 106
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • Liu S., Dontu G., Mantle I.D., Patel S., Ahn N.S., Jackson K.W., Suri P., Wicha M.S. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 2006, 66:6063-6071.
    • (2006) Cancer Res. , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3    Patel, S.4    Ahn, N.S.5    Jackson, K.W.6    Suri, P.7    Wicha, M.S.8
  • 109
    • 67650242193 scopus 로고    scopus 로고
    • The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits
    • Louiset E., Stratakis C.A., Perraudin V., Griffin K.J., Libé R., Cabrol S., Fève B., Young J., Groussin L., Bertherat J., Lefebvre H. The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits. J. Clin. Endocrinol. Metab. 2009, 94:2406-2413.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 2406-2413
    • Louiset, E.1    Stratakis, C.A.2    Perraudin, V.3    Griffin, K.J.4    Libé, R.5    Cabrol, S.6    Fève, B.7    Young, J.8    Groussin, L.9    Bertherat, J.10    Lefebvre, H.11
  • 111
    • 23444442691 scopus 로고    scopus 로고
    • Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
    • Maier T.J., Janssen A., Schmidt R., Geisslinger G., Grösch S. Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. FASEB J. 2005, 19:1353-2355.
    • (2005) FASEB J. , vol.19 , pp. 1353-2355
    • Maier, T.J.1    Janssen, A.2    Schmidt, R.3    Geisslinger, G.4    Grösch, S.5
  • 112
    • 34548610383 scopus 로고    scopus 로고
    • Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells
    • Martin B.R., Deerinck T.J., Ellisman M.H., Taylor S.S., Tsien R.Y. Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chem. Biol. 2007, 14:1031-1042.
    • (2007) Chem. Biol. , vol.14 , pp. 1031-1042
    • Martin, B.R.1    Deerinck, T.J.2    Ellisman, M.H.3    Taylor, S.S.4    Tsien, R.Y.5
  • 117
    • 33749000851 scopus 로고    scopus 로고
    • Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency
    • Mavrakis M., Lippincott-Schwartz J., Stratakis C.A., Bossis I. Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency. Hum. Mol. Genet. 2006, 15:2962-2971.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 2962-2971
    • Mavrakis, M.1    Lippincott-Schwartz, J.2    Stratakis, C.A.3    Bossis, I.4
  • 119
    • 34548386693 scopus 로고    scopus 로고
    • International Carney Triad and Carney-Stratakis Syndrome Consortium. Familial gastrointestinal stromal tumors and germ-line mutations
    • McWhinney S.R., Pasini B., Stratakis C.A. International Carney Triad and Carney-Stratakis Syndrome Consortium. Familial gastrointestinal stromal tumors and germ-line mutations. N. Engl. J. Med. 2007, 357:1054-1056.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1054-1056
    • McWhinney, S.R.1    Pasini, B.2    Stratakis, C.A.3
  • 123
    • 0029330671 scopus 로고
    • Immunolocalization of glutathione-peroxidase (GSH-PO) in human adrenal gland-studies on adrenocortical adenomas associated with primary aldosteronism and Cushing's syndrome
    • Murakoshi M., Osamura R.Y., Yoshimura S., Watanabe K. Immunolocalization of glutathione-peroxidase (GSH-PO) in human adrenal gland-studies on adrenocortical adenomas associated with primary aldosteronism and Cushing's syndrome. Tokai J. Exp. Clin. Med. 1995, 20:89-97.
    • (1995) Tokai J. Exp. Clin. Med. , vol.20 , pp. 89-97
    • Murakoshi, M.1    Osamura, R.Y.2    Yoshimura, S.3    Watanabe, K.4
  • 124
    • 34648833460 scopus 로고    scopus 로고
    • CAMP and protein kinase A in endocrine (and other) tumors
    • Nesterova M., Stratakis C.A. CAMP and protein kinase A in endocrine (and other) tumors. Exp. Rev. Endocrinol. Metab. 2007, 2:667-676.
    • (2007) Exp. Rev. Endocrinol. Metab. , vol.2 , pp. 667-676
    • Nesterova, M.1    Stratakis, C.A.2
  • 125
    • 39049144821 scopus 로고    scopus 로고
    • An immortalized human cell line bearing a PRKAR1A-inactivating mutation: effects of over-expression of the wild-type allele and other protein kinase A (PKA) subunits
    • Nesterova M., Wen F., Horvath A., Matyakhina L., Stratakis C.A. An immortalized human cell line bearing a PRKAR1A-inactivating mutation: effects of over-expression of the wild-type allele and other protein kinase A (PKA) subunits. J. Clin. Endocrinol. Metab. 2008, 93:565-571.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 565-571
    • Nesterova, M.1    Wen, F.2    Horvath, A.3    Matyakhina, L.4    Stratakis, C.A.5
  • 126
    • 0036711353 scopus 로고    scopus 로고
    • Familial ACTH-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia clinically affecting only female family members
    • Nies C., Bartsch D.K., Ehlenz K., Wild A., Langer P., Fleischhacker S., Rothmund M. Familial ACTH-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia clinically affecting only female family members. Exp. Clin. Endocrinol. Diabetes 2002, 110:277-283.
    • (2002) Exp. Clin. Endocrinol. Diabetes , vol.110 , pp. 277-283
    • Nies, C.1    Bartsch, D.K.2    Ehlenz, K.3    Wild, A.4    Langer, P.5    Fleischhacker, S.6    Rothmund, M.7
  • 127
    • 13244287677 scopus 로고    scopus 로고
    • Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
    • Nishimura E.K., Granter S.R., Fisher D.E. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 2005, 307(5710):720-724.
    • (2005) Science , vol.307 , Issue.5710 , pp. 720-724
    • Nishimura, E.K.1    Granter, S.R.2    Fisher, D.E.3
  • 128
    • 67650481889 scopus 로고    scopus 로고
    • Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case
    • Onoda N., Ishikawa T., Nishio K., Tahara H., Inaba M., Wakasa K., Sumi T., Yamazaki T., Shigematsu K., Hirakawa K. Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case. Endocr. J. 2009, 56:495-502.
    • (2009) Endocr. J. , vol.56 , pp. 495-502
    • Onoda, N.1    Ishikawa, T.2    Nishio, K.3    Tahara, H.4    Inaba, M.5    Wakasa, K.6    Sumi, T.7    Yamazaki, T.8    Shigematsu, K.9    Hirakawa, K.10
  • 129
    • 33745266737 scopus 로고    scopus 로고
    • Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases
    • Park J.Y., Pillinger M.H., Abramson S.B. Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin. Immunol. 2006, 119:229-240.
    • (2006) Clin. Immunol. , vol.119 , pp. 229-240
    • Park, J.Y.1    Pillinger, M.H.2    Abramson, S.B.3
  • 130
    • 34548707237 scopus 로고    scopus 로고
    • Multiple gastrointestinal stromal and other tumors caused by platelet-derived growth factor receptor alpha gene mutations: a case associated with a germline V561D defect
    • Pasini B., Matyakhina L., Bei T., Muchow M., Boikos S., Ferrando B., Carney J.A., Stratakis C.A. Multiple gastrointestinal stromal and other tumors caused by platelet-derived growth factor receptor alpha gene mutations: a case associated with a germline V561D defect. J. Clin. Endocrinol. Metab. 2007, 92:3728-3732.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 3728-3732
    • Pasini, B.1    Matyakhina, L.2    Bei, T.3    Muchow, M.4    Boikos, S.5    Ferrando, B.6    Carney, J.A.7    Stratakis, C.A.8
  • 132
    • 84858054011 scopus 로고    scopus 로고
    • In vitro studies of novel PRKAR1A mutants that extend the predicted R1α protein sequence into the 3'-untranslated open reading frame: proteosomal degradation leads to RIα haploinsufficiency and Carney complex
    • Patronas Y., Horvath A., Greene E., Tsang K., Bimpaki E., Haran M., Nesterova M., Stratakis C.A. In vitro studies of novel PRKAR1A mutants that extend the predicted R1α protein sequence into the 3'-untranslated open reading frame: proteosomal degradation leads to RIα haploinsufficiency and Carney complex. J. Clin. Endocrinol. Metab. 2012, 97:E496-E502.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97
    • Patronas, Y.1    Horvath, A.2    Greene, E.3    Tsang, K.4    Bimpaki, E.5    Haran, M.6    Nesterova, M.7    Stratakis, C.A.8
  • 133
    • 38749151856 scopus 로고    scopus 로고
    • Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A
    • Pavel E., Nadella K., Towns W.H., Kirschner L.S. Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A. Mol. Endocrinol. 2008, 22:430-440.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 430-440
    • Pavel, E.1    Nadella, K.2    Towns, W.H.3    Kirschner, L.S.4
  • 136
    • 78751509028 scopus 로고    scopus 로고
    • Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway
    • Qian X., Zhang J., Liu J. Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway. J. Biol. Chem. 2011, 286:2111-2120.
    • (2011) J. Biol. Chem. , vol.286 , pp. 2111-2120
    • Qian, X.1    Zhang, J.2    Liu, J.3
  • 137
    • 3843115756 scopus 로고    scopus 로고
    • Reduced ocular dominance plasticity and long-term potentiation in the developing visual cortex of protein kinase A RII alpha mutant mice
    • Rao Y., Fischer Q.S., Yang Y., McKnight G.S., LaRue A., Daw N.W. Reduced ocular dominance plasticity and long-term potentiation in the developing visual cortex of protein kinase A RII alpha mutant mice. Eur. J. Neurosci. 2004, 20:837-842.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 837-842
    • Rao, Y.1    Fischer, Q.S.2    Yang, Y.3    McKnight, G.S.4    LaRue, A.5    Daw, N.W.6
  • 143
    • 33751301602 scopus 로고    scopus 로고
    • PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes
    • Robinson-White A.J., Leitner W.W., Aleem E., Kaldis P., Bossis I., Stratakis C.A. PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes. Cancer Res. 2006, 66:10603-10612.
    • (2006) Cancer Res. , vol.66 , pp. 10603-10612
    • Robinson-White, A.J.1    Leitner, W.W.2    Aleem, E.3    Kaldis, P.4    Bossis, I.5    Stratakis, C.A.6
  • 147
    • 0030986161 scopus 로고    scopus 로고
    • Primary pigmented nodular adrenocortical disease: reevaluation of a patient with carney complex 27 years after unilateral adrenalectomy
    • Sarlis N.J., Chrousos G.P., Doppman J.L., Carney J.A., Stratakis C.A. Primary pigmented nodular adrenocortical disease: reevaluation of a patient with carney complex 27 years after unilateral adrenalectomy. J. Clin. Endocrinol. Metab. 1997, 82:1274-1278.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1274-1278
    • Sarlis, N.J.1    Chrousos, G.P.2    Doppman, J.L.3    Carney, J.A.4    Stratakis, C.A.5
  • 149
    • 84876082481 scopus 로고    scopus 로고
    • Cyclic AMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis
    • in press
    • Shimizu-Albergine, M., Tsai, L.C., Patrucco, E., Beavo, J.A., in press. Cyclic AMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis. Mol. Pharmacol.
    • Mol. Pharmacol.
    • Shimizu-Albergine, M.1    Tsai, L.C.2    Patrucco, E.3    Beavo, J.A.4
  • 151
    • 0034241380 scopus 로고    scopus 로고
    • Specificity in the cAMP/PKA signaling pathway: differential expression, regulation, and subcellular localization of subunits of PKA
    • Skalhegg B.S., Tasken K. Specificity in the cAMP/PKA signaling pathway: differential expression, regulation, and subcellular localization of subunits of PKA. Front Biosci. 2000, 5:D678-D693.
    • (2000) Front Biosci. , vol.5
    • Skalhegg, B.S.1    Tasken, K.2
  • 154
    • 0030049026 scopus 로고    scopus 로고
    • Carney complex, a familial multiple neoplasia and lentiginosis syndrome: analysis of 11 kindreds and linkage to the short arm of chromosome 2
    • Stratakis C.A., Carney J.A., Lin J.P., Papanicolaou D.A., Karl M., Kastner D.L., Pras E., Chrousos G.P. Carney complex, a familial multiple neoplasia and lentiginosis syndrome: analysis of 11 kindreds and linkage to the short arm of chromosome 2. J. Clin. Invest. 1996, 97:699-705.
    • (1996) J. Clin. Invest. , vol.97 , pp. 699-705
    • Stratakis, C.A.1    Carney, J.A.2    Lin, J.P.3    Papanicolaou, D.A.4    Karl, M.5    Kastner, D.L.6    Pras, E.7    Chrousos, G.P.8
  • 157
    • 0034853288 scopus 로고    scopus 로고
    • Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation
    • Stratakis C.A., Kirschner L.S., Carney J.A. Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. J. Clin. Endocrinol. Metab. 2001, 86:4041-4046.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 4041-4046
    • Stratakis, C.A.1    Kirschner, L.S.2    Carney, J.A.3
  • 158
    • 34347213389 scopus 로고    scopus 로고
    • Adrenocortical tumors, primary pigmented adrenocortical disease (PPNAD)/Carney complex, and other bilateral hyperplasias: the NIH studies
    • Stratakis C.A. Adrenocortical tumors, primary pigmented adrenocortical disease (PPNAD)/Carney complex, and other bilateral hyperplasias: the NIH studies. Horm. Metab. Res. 2007, 39:467-473.
    • (2007) Horm. Metab. Res. , vol.39 , pp. 467-473
    • Stratakis, C.A.1
  • 159
    • 35448973741 scopus 로고    scopus 로고
    • Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias
    • Stratakis C.A., Boikos S.A. Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias. Nat. Clin. Pract. Endocrinol. Metab. 2007, 3:748-757.
    • (2007) Nat. Clin. Pract. Endocrinol. Metab. , vol.3 , pp. 748-757
    • Stratakis, C.A.1    Boikos, S.A.2
  • 160
    • 48949107188 scopus 로고    scopus 로고
    • Cushing syndrome caused by adrenocortical tumors and hyperplasias (corticotropin-independent Cushing syndrome)
    • Stratakis C.A. Cushing syndrome caused by adrenocortical tumors and hyperplasias (corticotropin-independent Cushing syndrome). Endocr. Dev. 2008, 13:117-132.
    • (2008) Endocr. Dev. , vol.13 , pp. 117-132
    • Stratakis, C.A.1
  • 161
    • 59849101194 scopus 로고    scopus 로고
    • New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors
    • Stratakis C.A. New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors. Mol. Cell. Endocrinol. 2009, 300:152-157.
    • (2009) Mol. Cell. Endocrinol. , vol.300 , pp. 152-157
    • Stratakis, C.A.1
  • 162
    • 66849135214 scopus 로고    scopus 로고
    • The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications
    • Stratakis C.A., Carney J.A. The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications. J. Intern. Med. 2009, 266:43-52.
    • (2009) J. Intern. Med. , vol.266 , pp. 43-52
    • Stratakis, C.A.1    Carney, J.A.2
  • 165
    • 77953715690 scopus 로고    scopus 로고
    • Targeting Wnt signaling: can we safely eradicate cancer stem cells?
    • Takahashi-Yanaga F., Kahn M. Targeting Wnt signaling: can we safely eradicate cancer stem cells?. Clin. Cancer Res. 2010, 16:3153-3162.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 172
    • 79953012232 scopus 로고    scopus 로고
    • The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland
    • Tsai L.C., Shimizu-Albergine M., Beavo J.A. The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Mol. Pharmacol. 2011, 79:639-648.
    • (2011) Mol. Pharmacol. , vol.79 , pp. 639-648
    • Tsai, L.C.1    Shimizu-Albergine, M.2    Beavo, J.A.3
  • 174
    • 80155188674 scopus 로고    scopus 로고
    • Cardiac paraganglioma and gastrointestinal stromal tumor: a pediatric case of Carney-Stratakis syndrome
    • Vaughan P., Pabla L., Hobin D., Barron D.J., Parikh D. Cardiac paraganglioma and gastrointestinal stromal tumor: a pediatric case of Carney-Stratakis syndrome. Ann. Thorac. Surg. 2011, 92:1877-1878.
    • (2011) Ann. Thorac. Surg. , vol.92 , pp. 1877-1878
    • Vaughan, P.1    Pabla, L.2    Hobin, D.3    Barron, D.J.4    Parikh, D.5
  • 175
    • 79960983785 scopus 로고    scopus 로고
    • The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA
    • Vetter M.M., Zenn H.M., Méndez E., van den Boom H., Herberg F.W., Skålhegg B.S. The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA. BMC Biochem. 2011, 12:40.
    • (2011) BMC Biochem. , vol.12 , pp. 40
    • Vetter, M.M.1    Zenn, H.M.2    Méndez, E.3    van den Boom, H.4    Herberg, F.W.5    Skålhegg, B.S.6
  • 177
  • 178
    • 79959921466 scopus 로고    scopus 로고
    • Succinate dehydrogenase subunit B (SDHB) Is expressed in neurofibromatosis 1-associated gastrointestinal stromal tumors (GISTs): implications for the SDHB expression-based classification of GISTs
    • Wang J.H., Lasota J., Miettinen M. Succinate dehydrogenase subunit B (SDHB) Is expressed in neurofibromatosis 1-associated gastrointestinal stromal tumors (GISTs): implications for the SDHB expression-based classification of GISTs. J. Cancer 2011, 2:90-93.
    • (2011) J. Cancer , vol.2 , pp. 90-93
    • Wang, J.H.1    Lasota, J.2    Miettinen, M.3
  • 179
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: an old idea-a paradigm shift
    • Wicha M.S., Liu S., Dontu G. Cancer stem cells: an old idea-a paradigm shift. Cancer Res. 2006, 66:1883-1890.
    • (2006) Cancer Res. , vol.66 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 180
  • 184
    • 40949119860 scopus 로고    scopus 로고
    • Development of a pituitary-specific cre line targeted to the Pit-1 lineage
    • Yin Z., Williams-Simons L., Rawahneh L., Asa S., Kirschner L.S. Development of a pituitary-specific cre line targeted to the Pit-1 lineage. Genesis 2008, 46:37-42.
    • (2008) Genesis , vol.46 , pp. 37-42
    • Yin, Z.1    Williams-Simons, L.2    Rawahneh, L.3    Asa, S.4    Kirschner, L.S.5
  • 185
    • 38749106141 scopus 로고    scopus 로고
    • Pituitary-specific knockout of the carney complex gene prkar1a leads to pituitary tumorigenesis
    • Yin Z., Williams-Simons L., Parlow A.F., Asa S., Kirschner L.S. Pituitary-specific knockout of the carney complex gene prkar1a leads to pituitary tumorigenesis. Mol. Endocrinol. 2008, 22:380-387.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 380-387
    • Yin, Z.1    Williams-Simons, L.2    Parlow, A.F.3    Asa, S.4    Kirschner, L.S.5
  • 186
    • 80053450655 scopus 로고    scopus 로고
    • Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a
    • Yin Z., Pringle D.R., Jones G.N., Kelly K.M., Kirschner L.S. Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a. Mol. Endocrinol. 2011, 25:1786-1793.
    • (2011) Mol. Endocrinol. , vol.25 , pp. 1786-1793
    • Yin, Z.1    Pringle, D.R.2    Jones, G.N.3    Kelly, K.M.4    Kirschner, L.S.5
  • 187
    • 73949152219 scopus 로고    scopus 로고
    • Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases
    • Zhang L., Smyrk T.C., Young W.F., Stratakis C.A., Carney J.A. Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. Am. J. Surg. Pathol. 2010, 34:53-64.
    • (2010) Am. J. Surg. Pathol. , vol.34 , pp. 53-64
    • Zhang, L.1    Smyrk, T.C.2    Young, W.F.3    Stratakis, C.A.4    Carney, J.A.5
  • 188
    • 81155149481 scopus 로고    scopus 로고
    • PGE2 promotes angiogenesis through EP4 and PKA Cγ pathway
    • Zhang Y., Daaka Y. PGE2 promotes angiogenesis through EP4 and PKA Cγ pathway. Blood 2011, 118:5355-5364.
    • (2011) Blood , vol.118 , pp. 5355-5364
    • Zhang, Y.1    Daaka, Y.2
  • 189
    • 84876080599 scopus 로고    scopus 로고
    • Online Mendelian Inheritance in Man ; entry#606864 paraganglioma and gastric stromal sarcoma.
    • Online Mendelian Inheritance in Man ; entry#606864 paraganglioma and gastric stromal sarcoma. http://www.ncbi.nlm.nih.gov/omim.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.