Human mesenchymal stem cell proliferation is regulated by PGE2 through differential activation of cAMP-dependent protein kinase isoforms

Experimental Cell Research

Volumn 314, Issue 8, 2008, Pages 1831-1838

  Kleiveland, Charlotte Ramstad ^a   Kassem, Moustapha ^b   Lea, Tor ^a,c  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

cAMP; Mesenchymal stem cell; PGE2; PKA; Proliferation; Prostanoid

Indexed keywords

BETA CATENIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GLYCOGEN SYNTHASE KINASE 3BETA; ISOENZYME; PROSTAGLANDIN E2; PROSTANOID; SERINE; WNT PROTEIN;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 42649118106     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.02.004     Document Type: Article

References (36)

1. F.P. Barry J.M. Murphy Mesenchymal stem cells: clinical applications and biological characterization Int. J. Biochem. Cell Biol. 36 2004 568 584
2. S. Aggarwal M.F. Pittenger Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 105 2005 1815 1822
3. P. Davies P.J. Bailey M.M. Goldenberg A.W. Ford-Hutchinson The role of arachidonic acid oxygenation products in pain and inflammation Annu. Rev. Immunol. 2 1984 335 357
4. K. Takayama G. Garcia-Cardena G.K. Sukhova J. Comander M.A. Gimbrone Jr. P. Libby Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor J. Biol. Chem. 277 2002 44147 44154
5. C.D. Funk L.B. Funk M.E. Kennedy A.S. Pong G.A. Fitzgerald Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment FASEB J. 5 1991 2304 2312
6. A. Ichikawa Y. Sugimoto M. Negishi Molecular aspects of the structures and functions of the prostaglandin E receptors J. Lipid Mediators Cell Signal. 14 1996 83 87
7. J.L. Meinkoth Y. Ji S.S. Taylor J.R. Feramisco Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells PNAS 87 1990 9595 9599
8. D.L. Beene J.D. Scott A-kinase anchoring proteins take shape Curr. Opin. Cell Biol. 19 2007 192 198
9. A. Wodarz R. Nusse Mechanisms of wnt signaling in development Ann. Rev. Cell Dev. Biol. 14 1998 59 88
10. G.M. Boland G. Perkins D.J. Hall R.S. Tuan Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells J. Cell. Biochem. 93 2004 1210 1230
11. S. Ikeda M. Kishida Y. Matsuura H. Usui A. Kikuchi GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin Oncogene 19 2000 537 545
12. M. Kitagawa S. Hatakeyama M. Shirane M. Matsumoto N. Ishida K. Hattori I. Nakamichi A. Kikuchi K. Nakayama K. Nakayama An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin EMBO J. 18 1999 2401 2410
13. X. He M. Semenov K. Tamai X. Zeng LDL receptor-related proteins 5 and 6 in Wnt/{beta}-catenin signaling: arrows point the way Development 131 2004 1663 1677
14. P. Polakis Wnt signaling and cancer Genes Dev. 14 2000 1837 1851
15. A. Hurlstone H. Clevers T-cell factors: turn-ons and turn-offs EMBO J. 21 2002 2303 2311
16. D.A. Cross D.R. Alessi P. Cohen M. Andjelkovich B.A. Hemmings Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 1995 785 789
17. R.S. Jope G.V. Johnson The glamour and gloom of glycogen synthase kinase-3 Trends Biochem. Sci. 29 2004 95 102
18. C. Tanji H. Yamamoto N. Yorioka N. Kohno K. Kikuchi A. Kikuchi A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta) and mediates protein kinase A-dependent inhibition of GSK-3beta J. Biol. Chem. 277 2002 36955 36961
19. V. Stambolic J.R. Woodgett Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation Biochem. J. 303 Pt 3 1994 701 704
20. X. Fang S.X. Yu Y. Lu R.C. Bast Jr. J.R. Woodgett G.B. Mills Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A PNAS 97 2000 11960 11965
21. B.M. Abdallah M. Haack-Sorensen J.S. Burns B. Elsnab F. Jakob P. Hokland M. Kassem Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite [corrected] extensive proliferation Biochem. Biophys. Res. Commun. 326 2005 527 538
22. L.L. Vindelov I.J. Christensen N.I. Nissen A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis Cytometry 3 1983 323 327
23. C.A. Winter E.A. Risley G.W. Nuss Anti-inflammatory and antipyretic activities of indomethacin, 1-(P-Chlorobenzoyl)-5-Methoxy-2-Methylindole-3-Acetic acid J. Pharmacol. Exp. Ther. 141 1963 369 376
24. C. Tordjman F. Coge N. Andre H. Rique M. Spedding J. Bonnet Characterisation of cyclooxygenase 1 and 2 expression in mouse resident peritoneal macrophages in vitro; interactions of non steroidal anti-inflammatory drugs with COX2 Biochim. Biophys. Acta 1256 1995 249 256
25. S. Frame P. Cohen R.M. Biondi A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation Mol. Cell 7 2001 1321 1327
26. Y.S. Cho-Chung M.V. Nesterova Tumor reversion: protein kinase A isozyme switching Ann. N. Y. Acad. Sci. 1058 2005 76 86
27. D.W. Stacey Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells Curr. Opin. Cell Biol. 15 2003 158 163
28. Y. Wang X. Chen W. Zhu H. Zhang S. Hu X. Cong Growth inhibition of mesenchymal stem cells by aspirin: involvement of the wnt/beta-Catenin signal pathway Clin. Exp. Pharmacol. Physiol. 33 2006 696 701
29. D.A. Cross D.R. Alessi J.R. Vandenheede H.E. McDowell H.S. Hundal P. Cohen The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf Biochem. J. 303 Pt 1 1994 21 26
30. N. Filippa C.L. Sable C. Filloux B. Hemmings O.E. Van Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase Mol. Cell. Biol. 19 1999 4989 5000
31. G.K. Carnegie J.D. Scott A-kinase anchoring proteins and neuronal signaling mechanisms Genes Dev. 17 2003 1557 1568
32. R. Angelo C.S. Rubin Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans J. Biol. Chem. 273 1998 14633 14643
33. D.W. Carr R.E. Stofko-Hahn I.D. Fraser S.M. Bishop T.S. Acott R.G. Brennan J.D. Scott Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif J. Biol. Chem. 266 1991 14188 14192
34. K.A. Burton B.D. Johnson Z.E. Hausken R.E. Westenbroek R.L. Idzerda T. Scheuer J.D. Scott W.A. Catterall G.S. McKnight Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent protein kinase Proc. Natl. Acad. Sci. U. S. A. 94 1997 11067 11072
35. S.J. Beebe R. Holloway S.R. Rannels J.D. Corbin Two classes of cAMP analogs which are selective for the two different cAMP-binding sites of type II protein kinase demonstrate synergism when added together to intact adipocytes J. Biol. Chem. 259 1984 3539 3547
36. M. Lanotte J.B. Riviere S. Hermouet G. Houge O.K. Vintermyr B.T. Gjertsen S.O. Doskeland Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line J. Cell. Physiol. 146 1991 73 80