K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension

Science

Volumn 331, Issue 6018, 2011, Pages 768-772

  Choi, Murim ^a   Scholl, Ute I ^a   Yue, Peng ^b   Björklund, Peyman ^a,c   Zhao, Bixiao ^a   Nelson Williams, Carol ^a   Ji, Weizhen ^a   Cho, Yoonsang ^a   Patel, Aniruddh ^a   Men, Clara J ^a   Lolis, Elias ^a   Wisgerhof, Max V ^d   Geller, David S ^a,e   Mane, Shrikant ^a   Hellman, Per ^c   Westin, Gunnar ^c   Åkerström, Göran ^c   Wang, Wenhui ^b   Carling, Tobias ^a   Lifton, Richard P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

^d HENRY FORD HOSPITAL   (United States)

^e VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ5 PROTEIN; UNCLASSIFIED DRUG;

CALCIUM; CATION; ENDOCRINE SYSTEM; HORMONE; HYPERTENSION; MUTATION; POTASSIUM; SODIUM;

ADENOMA; ADRENAL HYPERPLASIA; ALDOSTERONE PRODUCING ADENOMA; ALDOSTERONE RELEASE; ARTICLE; CLINICAL ARTICLE; GENE SEQUENCE; GENETIC ASSOCIATION; HEREDITARY HYPERTENSION; HUMAN; HYPERALDOSTERONISM; PRIORITY JOURNAL; SODIUM CONDUCTANCE; SOMATIC MUTATION;

ADRENAL CORTEX NEOPLASMS; ADRENAL GLANDS; ADRENOCORTICAL ADENOMA; ALDOSTERONE; CELL LINE; CELL PROLIFERATION; FEMALE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HUMANS; HYPERALDOSTERONISM; HYPERPLASIA; HYPERTENSION; MALE; MUTANT PROTEINS; MUTATION; POTASSIUM; PROTEIN MULTIMERIZATION; SODIUM; ZONA GLOMERULOSA;

EID: 79951506090     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1198785     Document Type: Article

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30. We thank the patients whose participation made this study possible and the staff of the Yale West Campus Genomics Center and the Endocrine Surgical Laboratory, Clinical Research Centre, University Hospital, Uppsala. Supported in part by the Fondation Leducq Transatlantic Network in Hypertension, National Institutes of Health (NIH) grant DK54983, the Yale Center for Human Genetics and Genomics, Yale NIH O'Brien Center for Kidney Research, and the Yale NIH Clinical Translational Science Award, and by the Swedish Cancer Society, the Swedish Research Council, and the Lions Cancer Fund, Uppsala. U.I.S. is a fellow of the Deutsche Forschungsgemeinschaft; B.Z. is an investigator of the Yale Medical Scientist Training Program; T.C. is a Doris Duke-Damon Runyon Clinical Investigator; R.P.L. is a paid scientific advisor to Merck and is an investigator of the Howard Hughes Medical Institute.