MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis

Clinical Endocrinology

Volumn 72, Issue 6, 2010, Pages 744-751

  Bimpaki, Eirini I ^a   Iliopoulos, Dimitrios ^b   Moraitis, Andreas ^a   Stratakis, Constantine A ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRILYSIN; MATRIN 3; MICRORNA; MICRORNA 130A; MICRORNA 200B; MICRORNA 203; MICRORNA 210; MICRORNA 382; MICRORNA 484; UNCLASSIFIED DRUG;

ADRENAL CORTEX TUMOR; ADRENAL HYPERPLASIA; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CUSHING DISEASE; DISEASE SEVERITY; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; HYPERCORTISOLISM; MALE; MASSIVE MACRONODULAR ADRENOCORTICAL DISEASE; MICROARRAY ANALYSIS; PATHOGENESIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TUMOR VOLUME; UPREGULATION; ADRENAL CORTEX DISEASE; CARCINOMA; CLUSTER ANALYSIS; CYST; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MIDDLE AGED; PATHOLOGY; PRECANCER; TUMOR CELL LINE; VALIDATION STUDY;

ADRENAL CORTEX DISEASES; ADRENAL CORTEX NEOPLASMS; ADULT; CARCINOMA; CELL LINE, TUMOR; CLUSTER ANALYSIS; CYSTS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRECANCEROUS CONDITIONS;

EID: 77952627699     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2009.03725.x     Document Type: Article

References (33)

1. Stratakis, C.A. Boikos, S.A. (2007) Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias. Nature Clinical Practice Endocrinology and Metabolism, 3, 748 757.
2. Bourdeau, I. Stratakis, C.A. (2002) Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease. Annals of the New York Academy of Sciences, 968, 240 255.
3. Lacroix, A., Ndiaye, N., Tremblay, J. et al. (2001) Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Endocrine Reviews, 22, 75 110. (Pubitemid 32187804)
4. Kirk, J.M., Brain, C.E., Carson, D.J. et al. (1999) Cushing's syndrome caused by nodular adrenal hyperplasia in children with McCune-Albright syndrome. The Journal of Pediatrics, 134, 789 792.
5. Fragoso, M.C., Domenice, S., Latronico, A.C. et al. (2003) Cushing's syndrome secondary to adrenocorticotropin - independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene. The Journal of Clinical Endocrinology and Metabolism, 88, 2147 2151.
6. Stratakis, C.A. (2007) Adrenocortical tumors, primary pigmented adrenocortical disease (PPNAD)/Carney complex, and other bilateral hyperplasias: the NIH studies. Hormone and Metabolic Research, 39, 467 473.
7. Bourdeau, I., Antonini, S.R., Lacroix, A. et al. (2004) Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators. Oncogene, 23, 1575 1585.
8. Esquela-Kerscher, A. Slack, F.J. (2006) Oncomirs - microRNAs with a role in cancer. Nature Reviews Cancer, 6, 259 269.
9. Filipowicz, W., Bhattacharyya, S.N. Sonenberg, N. (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nature Reviews Genetics, 9, 102 114.
10. Kent, O.A. Mendell, J.T. (2006) A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene, 25, 6188 6196.
11. Calin, G.A., Ferracin, M., Cimmino, A. et al. (2005) A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. New England Journal of Medicine, 353, 1793 1801.
12. Bloomston, M., Frankel, W.L., Petrocca, F. et al. (2007) MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. The Journal of the American Medical Association, 297, 1901 1908.
13. Lowery, A.J., Miller, N., McNeill, R.E. et al. (2008) MicroRNAs as prognostic indicators and therapeutic targets: potential effect on breast cancer management. Clinical Cancer Research, 14, 360 365.
14. Ambs, S., Prueitt, R.L., Yi, M. et al. (2008) Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Research, 68, 6162 6170.
15. Hu, Z., Chen, J., Tian, T. et al. (2008) Genetic variants of miRNA sequences and non-small cell lung cancer survival. Journal of Clinical Investigation, 118, 2600 2608.
16. Thum, T., Galuppo, P., Wolf, C. et al. (2007) MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation, 116, e135.
17. Poletto, R., Siegford, J.M., Steibel, J.P. et al. (2006) Investigation of changes in global gene expression in the frontal cortex of early-weaned and socially isolated piglets using microarray and quantitative real-time RT-PCR. Brain Research, 1068, 7 15.
18. Gregory, P.A., Bert, A.G., Paterson, E.L. et al. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10, 593 601.
19. Iorio, M.V., Visone, R., Di Leva, G. et al. (2007) MicroRNA signatures in human ovarian cancer. Cancer Research, 67, 8699 8707.
20. Kozaki, K., Imoto, I., Mogi, S. et al. (2008) Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Research, 68, 2094 2105.
21. Bueno, M.J., Pérez de Castro, I., Gómez de Cedrón, M. et al. (2008) Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell, 13, 496 506.
22. Lena, A.M., Shalom-Feuerstein, R., Rivetti di Val Cervo, P. et al. (2008) miR-203 represses 'stemness' by repressing DeltaNp63. Cell Death and Differentiation, 15, 1187 1195.
23. Matyakhina, L., Freedman, R.J., Bourdeau, I. et al. (2005) Hereditary leiomyomatosis associated with bilateral, massive, macronodular adrenocortical disease and atypical cushing syndrome: a clinical and molecular genetic investigation. The Journal of Clinical Endocrinology and Metabolism, 90, 3773 3779.
24. Lehtonen, H.J., Kiuru, M., Ylisaukko-Oja, S.K. et al. (2006) Increased risk of cancer in patients with fumarate hydratase germline mutation. Journal of Medical Genetics, 43, 523 526. (Pubitemid 43927328)
25. Ivan, M., Harris, A.L., Martelli, F. et al. (2008) Hypoxia response and microRNAs: no longer two separate worlds. Journal of Cellular and Molecular Medicine, 12, 1426 1431.
26. Camps, C., Buffa, F.M., Colella, S. et al. (2008) Hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer. Clinical Cancer Research, 14, 1340 1348.
27. Chen, Y. Gorski, D.H. (2008) Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Blood, 111, 1217 1226.
28. Li, Z., Lu, J., Sun, M. et al. (2008) Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proceedings of the National Academy of Sciences of the United States of America, 105, 15535 15540.
29. Giordano, G., Sánchez-Pérez, A.M., Montoliu, C. et al. (2005) Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death. Journal of Neurochemistry, 94, 808 818.
30. De Angelis, P.M., Svendsrud, D.H., Kravik, K.L. et al. (2006) Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Molecular Cancer, 5, 20.
31. Rossi, L., Bonmassar, E. Faraoni, I. (2007) Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro. Pharmacological Research 56, 248 253.
32. Jung, M., Mollenkopf, H.J., Grimm, C. et al. (2009) MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy. Journal of Cellular and Molecular Medicine [E-pub ahead of print].
33. Tryndyak, V.P., Ross, S.A., Beland, F.A. et al. (2008) Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Molecular Carcinogenesis, 48, 479 487.