Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 2111-2120

  Qian, Xuesong ^a   Zhang, Jidong ^a   Liu, Jianguo ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED MACROPHAGES; BACTERIAL INFECTIONS; BREAST CANCER CELLS; CONDITIONED MEDIUM; ENDOTOXIC SHOCK; EPITHELIAL CELLS; FORSKOLIN; HOST IMMUNE RESPONSE; IMMUNE CELLS; IMMUNE DEFENSE; IMMUNOSURVEILLANCE; IN-VIVO; INHIBITORY EFFECT; MAMMARY GLAND; PARTIAL RECOVERY; POST-TRANSCRIPTIONAL; RECEPTOR ANTAGONISTS; SECRETED MOLECULES; SIGNALING PATHWAYS; T CELL PROLIFERATION; TUMOR CELLS;

BACTERIOLOGY; CELL PROLIFERATION; FETAL MONITORING; MACROPHAGES; PRODUCTION; SIGNALING; TRANSCRIPTION;

TUMORS;

CYCLIC AMP DEPENDENT PROTEIN KINASE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; RANTES; TUMOR NECROSIS FACTOR ALPHA; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; 6-ISOPROPOXY-9-OXOXANTHENE-2-CARBOXYLIC ACID; CCL5 PROTEIN, MOUSE; CYCLIC AMP; FORSKOLIN; GAMMA INTERFERON; INTERLEUKIN 2; ISOQUINOLINE DERIVATIVE; N (2 (4 BROMOCINNAMYLAMINO)ETHYL) 5 ISOQUINOLINESULFONAMIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N-(2-(4-BROMOCINNAMYLAMINO)ETHYL)-5-ISOQUINOLINESULFONAMIDE; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROTEIN KINASE INHIBITOR; SULFONAMIDE; XANTHONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BREAST TUMOR; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; IMMUNE RESPONSE; IN VIVO STUDY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; PROTEIN PROCESSING; SEPTIC SHOCK; SIGNAL TRANSDUCTION; TUMOR CELL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL LINE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; EXPERIMENTAL NEOPLASM; MACROPHAGE; MALE; METABOLISM; SECRETION; TUMOR ESCAPE;

BACTERIA (MICROORGANISMS); MUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BACTERIAL INFECTIONS; CELL LINE; CHEMOKINE CCL5; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; FORSKOLIN; INTERFERON-GAMMA; INTERLEUKIN-2; ISOQUINOLINES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; NEOPLASMS, EXPERIMENTAL; NITROBENZENES; PROSTAGLANDIN ANTAGONISTS; PROTEIN KINASE INHIBITORS; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; SULFONAMIDES; TUMOR ESCAPE; XANTHONES;

EID: 78751509028     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.154971     Document Type: Article

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