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Volumn 24, Issue 3, 2010, Pages 451-460

Mouse models of endocrine tumours

Author keywords

endocrine neoplasia syndromes; knockout mice; oncogenes; transgenic mice; tumour suppressor genes

Indexed keywords

METHIONINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

EID: 77956597311     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beem.2010.01.004     Document Type: Review
Times cited : (10)

References (73)
  • 1
    • 0000319647 scopus 로고
    • Genetic aspects of adenomatosis of endocrine glands
    • P. Wermer Genetic aspects of adenomatosis of endocrine glands The American Journal of Medicine 16 1954 363 371
    • (1954) The American Journal of Medicine , vol.16 , pp. 363-371
    • Wermer, P.1
  • 3
    • 0033534510 scopus 로고    scopus 로고
    • Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription
    • S.K. Agarwal, S.C. Guru, and C. Heppner Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription Cell 96 1 1999 143 152
    • (1999) Cell , vol.96 , Issue.1 , pp. 143-152
    • Agarwal, S.K.1    Guru, S.C.2    Heppner, C.3
  • 4
    • 0024407432 scopus 로고
    • Characterization of junD: A new member of the jun proto-oncogene family
    • S.I. Hirai, R.P. Ryseck, and F. Mechta Characterization of junD: a new member of the jun proto-oncogene family The EMBO Journal 8 5 1989 1433 1439
    • (1989) The EMBO Journal , vol.8 , Issue.5 , pp. 1433-1439
    • Hirai, S.I.1    Ryseck, R.P.2    Mechta, F.3
  • 5
    • 0028325891 scopus 로고
    • Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras
    • C.M. Pfarr, F. Mechta, and G. Spyrou Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras Cell 76 4 1994 747 760
    • (1994) Cell , vol.76 , Issue.4 , pp. 747-760
    • Pfarr, C.M.1    Mechta, F.2    Spyrou, G.3
  • 7
    • 0001710006 scopus 로고    scopus 로고
    • Clinical studies of multiple endocrine neoplasia type 1 (MEN1)
    • D. Trump, B. Farren, and C. Wooding Clinical studies of multiple endocrine neoplasia type 1 (MEN1) QJM 89 9 1996 653 669
    • (1996) QJM , vol.89 , Issue.9 , pp. 653-669
    • Trump, D.1    Farren, B.2    Wooding, C.3
  • 8
    • 0030963446 scopus 로고    scopus 로고
    • Positional cloning of the gene for multiple endocrine neoplasia-type 1
    • S.C. Chandrasekharappa, S.C. Guru, and P. Manickam Positional cloning of the gene for multiple endocrine neoplasia-type 1 Science 276 5311 1997 404 407
    • (1997) Science , vol.276 , Issue.5311 , pp. 404-407
    • Chandrasekharappa, S.C.1    Guru, S.C.2    Manickam, P.3
  • 9
    • 0037684907 scopus 로고    scopus 로고
    • Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs
    • P. Bertolino, I. Radovanovic, and H. Casse Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs Mechanisms of Development 120 5 2003 549 560
    • (2003) Mechanisms of Development , vol.120 , Issue.5 , pp. 549-560
    • Bertolino, P.1    Radovanovic, I.2    Casse, H.3
  • 10
    • 33845677737 scopus 로고    scopus 로고
    • Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1
    • K.A. Loffler, C.A. Biondi, and M. Gartside Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1 International Journal of Cancer 120 2 2007 259 267
    • (2007) International Journal of Cancer , vol.120 , Issue.2 , pp. 259-267
    • Loffler, K.A.1    Biondi, C.A.2    Gartside, M.3
  • 11
    • 0041970059 scopus 로고    scopus 로고
    • Of mice and MEN1: Insulinomas in a conditional mouse knockout
    • J.S. Crabtree, P.C. Scacheri, and J.M. Ward Of mice and MEN1: Insulinomas in a conditional mouse knockout Molecular and Cellular Biology 23 17 2003 6075 6085
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.17 , pp. 6075-6085
    • Crabtree, J.S.1    Scacheri, P.C.2    Ward, J.M.3
  • 12
    • 10744233863 scopus 로고    scopus 로고
    • Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism
    • S.K. Libutti, J.S. Crabtree, and D. Lorang Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism Cancer Research 63 22 2003 8022 8028
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 8022-8028
    • Libutti, S.K.1    Crabtree, J.S.2    Lorang, D.3
  • 13
    • 0030902536 scopus 로고    scopus 로고
    • Development of medullary thyroid carcinoma in transgenic mice expressing the RET proto-oncogene altered by a multiple endocrine neoplasia type 2A mutation
    • F.M. Michiels, S. Chappuis, and B. Caillou Development of medullary thyroid carcinoma in transgenic mice expressing the RET proto-oncogene altered by a multiple endocrine neoplasia type 2A mutation Proceedings of the National Academy of Sciences of the United States of America 94 7 1997 3330 3335
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.7 , pp. 3330-3335
    • Michiels, F.M.1    Chappuis, S.2    Caillou, B.3
  • 14
    • 0032762397 scopus 로고    scopus 로고
    • Sympathoadrenal hyperplasia causes renal malformations in Ret(MEN2B)-transgenic mice
    • C. Gestblom, D.A. Sweetser, and B. Doggett Sympathoadrenal hyperplasia causes renal malformations in Ret(MEN2B)-transgenic mice The American Journal of Pathology 155 6 1999 2167 2179
    • (1999) The American Journal of Pathology , vol.155 , Issue.6 , pp. 2167-2179
    • Gestblom, C.1    Sweetser, D.A.2    Doggett, B.3
  • 15
    • 0026530617 scopus 로고
    • Pheochromocytomas and C-cell thyroid neoplasms in transgenic c-mos mice: A model for the human multiple endocrine neoplasia type 2 syndrome
    • N. Schulz, F. Propst, and M.P. Rosenberg Pheochromocytomas and C-cell thyroid neoplasms in transgenic c-mos mice: a model for the human multiple endocrine neoplasia type 2 syndrome Cancer Research 52 2 1992 450 455
    • (1992) Cancer Research , vol.52 , Issue.2 , pp. 450-455
    • Schulz, N.1    Propst, F.2    Rosenberg, M.P.3
  • 16
    • 0022397926 scopus 로고
    • The complex of myxomas, spotty pigmentation, and endocrine overactivity
    • J.A. Carney, H. Gordon, and P.C. Carpenter The complex of myxomas, spotty pigmentation, and endocrine overactivity Medicine (Baltimore) 64 4 1985 270 283
    • (1985) Medicine (Baltimore) , vol.64 , Issue.4 , pp. 270-283
    • Carney, J.A.1    Gordon, H.2    Carpenter, P.C.3
  • 17
    • 0033812849 scopus 로고    scopus 로고
    • Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex
    • L.S. Kirschner, J.A. Carney, and S.D. Pack Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex Nature Genetics 26 1 2000 89 92
    • (2000) Nature Genetics , vol.26 , Issue.1 , pp. 89-92
    • Kirschner, L.S.1    Carney, J.A.2    Pack, S.D.3
  • 18
    • 0034642302 scopus 로고    scopus 로고
    • Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex
    • L.S. Kirschner, F. Sandrini, and J. Monbo Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex Human Molecular Genetics 9 20 2000 3037 3046
    • (2000) Human Molecular Genetics , vol.9 , Issue.20 , pp. 3037-3046
    • Kirschner, L.S.1    Sandrini, F.2    Monbo, J.3
  • 19
    • 19644364776 scopus 로고    scopus 로고
    • A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues
    • L.S. Kirschner, D.F. Kusewitt, and L. Matyakhina A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues Cancer Research 65 11 2005 4506 4514
    • (2005) Cancer Research , vol.65 , Issue.11 , pp. 4506-4514
    • Kirschner, L.S.1    Kusewitt, D.F.2    Matyakhina, L.3
  • 20
    • 0030835716 scopus 로고    scopus 로고
    • Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex)
    • C.A. Stratakis, N.A. Courcoutsakis, and A. Abati Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex) The Journal of Clinical Endocrinology and Metabolism 82 7 1997 2037 2043
    • (1997) The Journal of Clinical Endocrinology and Metabolism , vol.82 , Issue.7 , pp. 2037-2043
    • Stratakis, C.A.1    Courcoutsakis, N.A.2    Abati, A.3
  • 21
    • 41649121002 scopus 로고    scopus 로고
    • Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis
    • Z. Yin, G.N. Jones, and W.H. Towns 2nd heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis Circulation 117 2008 1414 1422
    • (2008) Circulation , vol.117 , pp. 1414-1422
    • Yin, Z.1    Jones, G.N.2    Towns II, W.H.3
  • 22
    • 40949119860 scopus 로고    scopus 로고
    • Development of a pituitary-specific cre line targeted to the Pit-1 lineage
    • Z. Yin, L. Williams-Simons, and L. Rawahneh Development of a pituitary-specific cre line targeted to the Pit-1 lineage Genesis 46 1 2008 37 42
    • (2008) Genesis , vol.46 , Issue.1 , pp. 37-42
    • Yin, Z.1    Williams-Simons, L.2    Rawahneh, L.3
  • 23
    • 38749106141 scopus 로고    scopus 로고
    • Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis
    • Z. Yin, L. Williams-Simons, and A.F. Parlow Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis Molecular Endocrinology 22 2 2008 380 387
    • (2008) Molecular Endocrinology , vol.22 , Issue.2 , pp. 380-387
    • Yin, Z.1    Williams-Simons, L.2    Parlow, A.F.3
  • 24
    • 55849135795 scopus 로고    scopus 로고
    • Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production
    • G.N. Jones, C. Tep, and W.H. Towns 2nd Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production Neoplasia 10 11 2008 1213 1221
    • (2008) Neoplasia , vol.10 , Issue.11 , pp. 1213-1221
    • Jones, G.N.1    Tep, C.2    Towns II, W.H.3
  • 25
    • 2442681924 scopus 로고    scopus 로고
    • Comparative pathology of nerve sheath tumors in mouse models and humans
    • A.O. Stemmer-Rachamimov, D.N. Louis, and G.P. Nielsen Comparative pathology of nerve sheath tumors in mouse models and humans Cancer Research 64 10 2004 3718 3724
    • (2004) Cancer Research , vol.64 , Issue.10 , pp. 3718-3724
    • Stemmer-Rachamimov, A.O.1    Louis, D.N.2    Nielsen, G.P.3
  • 26
    • 0031004088 scopus 로고    scopus 로고
    • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    • D. Liaw, D.J. Marsh, and J. Li Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome Nature Genetics 16 1 1997 64 67
    • (1997) Nature Genetics , vol.16 , Issue.1 , pp. 64-67
    • Liaw, D.1    Marsh, D.J.2    Li, J.3
  • 28
    • 0034234268 scopus 로고    scopus 로고
    • High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice
    • V. Stambolic, M.S. Tsao, and D. Macpherson High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice Cancer Research 60 13 2000 3605 3611
    • (2000) Cancer Research , vol.60 , Issue.13 , pp. 3605-3611
    • Stambolic, V.1    Tsao, M.S.2    MacPherson, D.3
  • 29
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • A. Di Cristofano, B. Pesce, and C. Cordon-Cardo Pten is essential for embryonic development and tumour suppression Nature Genetics 19 4 1998 348 355
    • (1998) Nature Genetics , vol.19 , Issue.4 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3
  • 30
    • 33746154235 scopus 로고    scopus 로고
    • Genetic background controls tumor development in PTEN-deficient mice
    • D. Freeman, R. Lesche, and N. Kertesz Genetic background controls tumor development in PTEN-deficient mice Cancer Research 66 13 2006 6492 6496
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6492-6496
    • Freeman, D.1    Lesche, R.2    Kertesz, N.3
  • 31
    • 33745172528 scopus 로고    scopus 로고
    • The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice
    • M.L. Chen, P.Z. Xu, and X.D. Peng The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice Genes & Development 20 12 2006 1569 1574
    • (2006) Genes & Development , vol.20 , Issue.12 , pp. 1569-1574
    • Chen, M.L.1    Xu, P.Z.2    Peng, X.D.3
  • 32
    • 33847011426 scopus 로고    scopus 로고
    • Pten loss in the mouse thyroid causes goiter and follicular adenomas: Insights into thyroid function and Cowden disease pathogenesis
    • N. Yeager, A. Klein-Szanto, and S. Kimura Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis Cancer Research 67 3 2007 959 966
    • (2007) Cancer Research , vol.67 , Issue.3 , pp. 959-966
    • Yeager, N.1    Klein-Szanto, A.2    Kimura, S.3
  • 33
    • 59149086040 scopus 로고    scopus 로고
    • PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer
    • C.J. Guigon, L. Zhao, and M.C. Willingham PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer Oncogene 28 4 2009 509 517
    • (2009) Oncogene , vol.28 , Issue.4 , pp. 509-517
    • Guigon, C.J.1    Zhao, L.2    Willingham, M.C.3
  • 34
    • 0025022463 scopus 로고
    • PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
    • M. Grieco, M. Santoro, and M.T. Berlingieri PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas Cell 60 4 1990 557 563
    • (1990) Cell , vol.60 , Issue.4 , pp. 557-563
    • Grieco, M.1    Santoro, M.2    Berlingieri, M.T.3
  • 35
    • 0028233525 scopus 로고
    • Frequent activation of ret proto-oncogene by fusion with a new activating gene in papillary thyroid carcinomas
    • I. Bongarzone, M.G. Butti, and S. Coronelli Frequent activation of ret proto-oncogene by fusion with a new activating gene in papillary thyroid carcinomas Cancer Research 54 11 1994 2979 2985
    • (1994) Cancer Research , vol.54 , Issue.11 , pp. 2979-2985
    • Bongarzone, I.1    Butti, M.G.2    Coronelli, S.3
  • 36
    • 0027955122 scopus 로고
    • Molecular characterization of RET/PTC3; A novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma
    • M. Santoro, N.A. Dathan, and M.T. Berlingieri Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma Oncogene 9 2 1994 509 516
    • (1994) Oncogene , vol.9 , Issue.2 , pp. 509-516
    • Santoro, M.1    Dathan, N.A.2    Berlingieri, M.T.3
  • 37
    • 0026016207 scopus 로고
    • Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTC
    • G. Sozzi, M.A. Pierotti, and M. Miozzo Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTC Oncogene 6 2 1991 339 342
    • (1991) Oncogene , vol.6 , Issue.2 , pp. 339-342
    • Sozzi, G.1    Pierotti, M.A.2    Miozzo, M.3
  • 38
    • 0027980345 scopus 로고
    • The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2
    • F. Minoletti, M.G. Butti, and S. Coronelli The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2 Genes Chromosomes Cancer 11 1 1994 51 57
    • (1994) Genes Chromosomes Cancer , vol.11 , Issue.1 , pp. 51-57
    • Minoletti, F.1    Butti, M.G.2    Coronelli, S.3
  • 39
    • 9244255770 scopus 로고    scopus 로고
    • Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice
    • M. Santoro, G. Chiappetta, and A. Cerrato Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice Oncogene 12 8 1996 1821 1826
    • (1996) Oncogene , vol.12 , Issue.8 , pp. 1821-1826
    • Santoro, M.1    Chiappetta, G.2    Cerrato, A.3
  • 41
    • 3643067689 scopus 로고    scopus 로고
    • The RET/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids
    • D.J. Powell Jr., J. Russell, and K. Nibu The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids Cancer Research 58 23 1998 5523 5528
    • (1998) Cancer Research , vol.58 , Issue.23 , pp. 5523-5528
    • Powell Jr., D.J.1    Russell, J.2    Nibu, K.3
  • 42
    • 0037153375 scopus 로고    scopus 로고
    • The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation
    • T.L. Buckwalter, A. Venkateswaran, and M. Lavender The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation Oncogene 21 53 2002 8166 8172
    • (2002) Oncogene , vol.21 , Issue.53 , pp. 8166-8172
    • Buckwalter, T.L.1    Venkateswaran, A.2    Lavender, M.3
  • 43
    • 0033874066 scopus 로고    scopus 로고
    • Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas
    • K.M. La Perle, S.M. Jhiang, and C.C. Capen Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas The American Journal of Pathology 157 2 2000 671 677
    • (2000) The American Journal of Pathology , vol.157 , Issue.2 , pp. 671-677
    • La Perle, K.M.1    Jhiang, S.M.2    Capen, C.C.3
  • 44
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • M. Xing BRAF mutation in thyroid cancer Endocrine-Related Cancer 12 2 2005 245 262
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.2 , pp. 245-262
    • Xing, M.1
  • 45
    • 20144372793 scopus 로고    scopus 로고
    • Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    • J.A. Knauf, X. Ma, and E.P. Smith Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation Cancer Research 65 10 2005 4238 4245
    • (2005) Cancer Research , vol.65 , Issue.10 , pp. 4238-4245
    • Knauf, J.A.1    Ma, X.2    Smith, E.P.3
  • 46
    • 40849106396 scopus 로고    scopus 로고
    • Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage
    • M.R. Haymart, D.J. Repplinger, and G.E. Leverson Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage The Journal of Clinical Endocrinology and Metabolism 93 3 2008 809 814
    • (2008) The Journal of Clinical Endocrinology and Metabolism , vol.93 , Issue.3 , pp. 809-814
    • Haymart, M.R.1    Repplinger, D.J.2    Leverson, G.E.3
  • 48
    • 0030741024 scopus 로고    scopus 로고
    • Thyroid-specific expression of cholera toxin A1 subunit causes thyroid hyperplasia and hyperthyroidism in transgenic mice
    • M.A. Zeiger, M. Saji, and Y. Gusev Thyroid-specific expression of cholera toxin A1 subunit causes thyroid hyperplasia and hyperthyroidism in transgenic mice Endocrinology 138 8 1997 3133 3140
    • (1997) Endocrinology , vol.138 , Issue.8 , pp. 3133-3140
    • Zeiger, M.A.1    Saji, M.2    Gusev, Y.3
  • 49
    • 0030910680 scopus 로고    scopus 로고
    • Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
    • L. Pei, and S. Melmed Isolation and characterization of a pituitary tumor-transforming gene (PTTG) Molecular Endocrinology 11 4 1997 433 441
    • (1997) Molecular Endocrinology , vol.11 , Issue.4 , pp. 433-441
    • Pei, L.1    Melmed, S.2
  • 51
    • 17844400784 scopus 로고    scopus 로고
    • Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice
    • R.A. Abbud, I. Takumi, and E.M. Barker Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice Molecular Endocrinology 19 5 2005 1383 1391
    • (2005) Molecular Endocrinology , vol.19 , Issue.5 , pp. 1383-1391
    • Abbud, R.A.1    Takumi, I.2    Barker, E.M.3
  • 52
    • 77956562563 scopus 로고    scopus 로고
    • PTTG over-expression facilitates pituitary tumor development
    • I. Donangelo, S. Gutman, and E. Horvath PTTG over-expression facilitates pituitary tumor development Endocrinology 2006
    • (2006) Endocrinology
    • Donangelo, I.1    Gutman, S.2    Horvath, E.3
  • 53
    • 33744486595 scopus 로고    scopus 로고
    • Pituitary adenoma predisposition caused by germline mutations in the AIP gene
    • O. Vierimaa, M. Georgitsi, and R. Lehtonen Pituitary adenoma predisposition caused by germline mutations in the AIP gene Science 312 5777 2006 1228 1230
    • (2006) Science , vol.312 , Issue.5777 , pp. 1228-1230
    • Vierimaa, O.1    Georgitsi, M.2    Lehtonen, R.3
  • 54
    • 37249016342 scopus 로고    scopus 로고
    • Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality
    • B.C. Lin, R. Sullivan, and Y. Lee Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality The Journal of Biological Chemistry 282 49 2007 35924 35932
    • (2007) The Journal of Biological Chemistry , vol.282 , Issue.49 , pp. 35924-35932
    • Lin, B.C.1    Sullivan, R.2    Lee, Y.3
  • 55
    • 0036920488 scopus 로고    scopus 로고
    • The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors
    • C.A. Koch, K. Pacak, and G.P. Chrousos The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors The Journal of Clinical Endocrinology and Metabolism 87 12 2002 5367 5384
    • (2002) The Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.12 , pp. 5367-5384
    • Koch, C.A.1    Pacak, K.2    Chrousos, G.P.3
  • 56
    • 33751503705 scopus 로고    scopus 로고
    • Origin and identity of adrenocortical tumors in inhibin knockout mice: Implications for cellular plasticity in the adrenal cortex
    • B.D. Looyenga, and G.D. Hammer Origin and identity of adrenocortical tumors in inhibin knockout mice: implications for cellular plasticity in the adrenal cortex Molecular Endocrinology 20 11 2006 2848 2863
    • (2006) Molecular Endocrinology , vol.20 , Issue.11 , pp. 2848-2863
    • Looyenga, B.D.1    Hammer, G.D.2
  • 57
    • 33745548423 scopus 로고    scopus 로고
    • A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia
    • A. Horvath, S. Boikos, and C. Giatzakis A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia Nature Genetics 38 7 2006 794 800
    • (2006) Nature Genetics , vol.38 , Issue.7 , pp. 794-800
    • Horvath, A.1    Boikos, S.2    Giatzakis, C.3
  • 58
    • 39049101528 scopus 로고    scopus 로고
    • Mutation in PDE8B, a cyclic AMP-specific phosphodiesterase in adrenal hyperplasia
    • A. Horvath, V. Mericq, and C.A. Stratakis Mutation in PDE8B, a cyclic AMP-specific phosphodiesterase in adrenal hyperplasia The New England Journal of Medicine 358 7 2008 750 752
    • (2008) The New England Journal of Medicine , vol.358 , Issue.7 , pp. 750-752
    • Horvath, A.1    Mericq, V.2    Stratakis, C.A.3
  • 59
    • 38049130282 scopus 로고    scopus 로고
    • Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas
    • M. Tadjine, A. Lampron, and L. Ouadi Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas Clinical Endocrinology 68 2 2008 264 270
    • (2008) Clinical Endocrinology , vol.68 , Issue.2 , pp. 264-270
    • Tadjine, M.1    Lampron, A.2    Ouadi, L.3
  • 60
    • 0026702996 scopus 로고
    • Effects of an Rb mutation in the mouse
    • T. Jacks, A. Fazeli, and E.M. Schmitt Effects of an Rb mutation in the mouse Nature 359 6393 1992 295 300
    • (1992) Nature , vol.359 , Issue.6393 , pp. 295-300
    • Jacks, T.1    Fazeli, A.2    Schmitt, E.M.3
  • 61
    • 0031897273 scopus 로고    scopus 로고
    • Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice
    • L. Yamasaki, R. Bronson, and B.O. Williams Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice Nature Genetics 18 4 1998 360 364
    • (1998) Nature Genetics , vol.18 , Issue.4 , pp. 360-364
    • Yamasaki, L.1    Bronson, R.2    Williams, B.O.3
  • 62
    • 0001445037 scopus 로고    scopus 로고
    • E2F4 loss suppresses tumorigenesis in Rb mutant mice
    • E.Y. Lee, H. Cam, and U. Ziebold E2F4 loss suppresses tumorigenesis in Rb mutant mice Cancer Cell 2 6 2002 463 472
    • (2002) Cancer Cell , vol.2 , Issue.6 , pp. 463-472
    • Lee, E.Y.1    Cam, H.2    Ziebold, U.3
  • 63
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • K. Nakayama, N. Ishida, and M. Shirane Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors Cell 85 5 1996 707 720
    • (1996) Cell , vol.85 , Issue.5 , pp. 707-720
    • Nakayama, K.1    Ishida, N.2    Shirane, M.3
  • 64
    • 15844415946 scopus 로고    scopus 로고
    • Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
    • H. Kiyokawa, R.D. Kineman, and K.O. Manova-Todorova Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1) Cell 85 5 1996 721 732
    • (1996) Cell , vol.85 , Issue.5 , pp. 721-732
    • Kiyokawa, H.1    Kineman, R.D.2    Manova-Todorova, K.O.3
  • 65
    • 15844384256 scopus 로고    scopus 로고
    • A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
    • M.L. Fero, M. Rivkin, and M. Tasch A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice Cell 85 5 1996 733 744
    • (1996) Cell , vol.85 , Issue.5 , pp. 733-744
    • Fero, M.L.1    Rivkin, M.2    Tasch, M.3
  • 66
    • 34047241387 scopus 로고    scopus 로고
    • Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis
    • W.M. Chien, K. Garrison, and E. Caufield Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis Cell Cycle 6 6 2007 750 757
    • (2007) Cell Cycle , vol.6 , Issue.6 , pp. 750-757
    • Chien, W.M.1    Garrison, K.2    Caufield, E.3
  • 69
    • 0032530112 scopus 로고    scopus 로고
    • CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
    • D.S. Franklin, V.L. Godfrey, and H. Lee CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis Genes & Development 12 18 1998 2899 2911
    • (1998) Genes & Development , vol.12 , Issue.18 , pp. 2899-2911
    • Franklin, D.S.1    Godfrey, V.L.2    Lee, H.3
  • 71
    • 0028582034 scopus 로고
    • Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
    • K.L. Guan, C.W. Jenkins, and Y. Li Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function Genes & Development 8 24 1994 2939 2952
    • (1994) Genes & Development , vol.8 , Issue.24 , pp. 2939-2952
    • Guan, K.L.1    Jenkins, C.W.2    Li, Y.3
  • 72
    • 2442680251 scopus 로고    scopus 로고
    • A dynamic switch in Rb+/- mediated neuroendocrine tumorigenesis
    • S.W. Leung, E.H. Wloga, and A.F. Castro A dynamic switch in Rb+/- mediated neuroendocrine tumorigenesis Oncogene 23 19 2004 3296 3307
    • (2004) Oncogene , vol.23 , Issue.19 , pp. 3296-3307
    • Leung, S.W.1    Wloga, E.H.2    Castro, A.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.