Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: Relationship with cell proliferation

Experimental Cell Research

Volumn 314, Issue 1, 2008, Pages 123-130

  Mantovani, G ^a   Lania, A G ^a   Bondioni, S ^a   Peverelli, E ^a   Pedroni, C ^a   Ferrero, S ^b   Pellegrini, C ^b   Vicentini, L ^c   Arnaldi, G ^d   Bosari, S ^b   Beck Peccoz, P ^a   Spada, A ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Department of Medicine Surgery and Dentistry   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d OSPEDALI RIUNITI   (Italy)

Author keywords

Adrenocortical tumors; Apoptosis; cAMP; PKA; Proliferation

Indexed keywords

CORTICOTROPIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; HYDROCORTISONE; PROTEIN KINASE A REGULATORY SUBUNIT R1A; PROTEIN KINASE A REGULATORY SUBUNIT R1B; PROTEIN KINASE A REGULATORY SUBUNIT R2A; PROTEIN KINASE A REGULATORY SUBUNIT R2B; UNCLASSIFIED DRUG;

ADRENAL CORTEX TUMOR; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CUSHING SYNDROME; DOSE RESPONSE; GENE SEQUENCE; HUMAN; HUMAN TISSUE; HYDROCORTISONE RELEASE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

EID: 36549062074     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.08.024     Document Type: Article

References (33)

1. Stratakis C.A. Genetics of adrenocortical tumors: gatekeepers, landscapers and conductors in symphony. Trends Endocrinol. Metab. 14 (2003) 404-410
2. Tissier F., Cavard C., Groussin L., Perlemoine K., Fumey G., Hagnere A.M., Rene-Corail F., Jullian E., Gicquel C., Bertagna X., Vacher-Lavenu M.C., Perret C., and Bertherat J. Mutations of b-catenin in adrenocortical tumors: activation of the Wnt signalling pathway is a frequent event in both benign and malignant adrenocortical tumors. Cancer Res. 65 (2005) 7622-7627
3. Levine M.A. The McCune-Albright syndrome. The whys and wherefores of abnormal signal transduction. N. Engl. J. Med. 325 (1991) 1738-1740
4. Fragoso M.C., Domenice S., Latronico A.C., Martin R.M., Pereira M.A., Zerbini M.C., Lucon A.M., and Mendonca B.B. Cushing's syndrome secondary to adrenocorticotropin-independent macronodular hyperplasia due to activating mutations of GNAS1 gene. J. Clin. Endocrinol. Metab. 88 (2003) 2147-2151
5. Lacroix A., Badacchino V., Bordeau I., Hamet P., and Tremblay J. Cushing's syndrome variants secondary to aberrant hormone receptors. Trends Endocrinol. Metab. 8 (2004) 375-382
6. Kirschner L.S., Carney J.A., Pack S.D., Taymans S.E., Giatzakis C., Cho Y.S., Cho-Chung Y.S., and Stratakis C.A. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat. Genet. 26 (2000) 89-92
7. Kirschner L.S., Sandrini F., Monbo J., Lin J.P., Carney J.A., and Stratakis C.A. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex. Hum. Mol. Genet. 9 (2000) 3037-3046
8. Sandrini F., and Stratakis C.A. Clinical and molecular genetics of Carney complex. Mol. Genet. Metab. 78 (2003) 83-92
9. Groussin L., Jullian E., Perlemoine K., Louvel A., Leheup B., Luton J.P., Bertagna X., and Bertherat J. Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. J. Clin. Endocrinol. Metab. 87 (2002) 4324-4329
10. Bertherat J., Groussin L., Sandrini F., Matyakhina L., Bei T., Stergiopoulos S., Papageorgiou T., Bourdeau I., Kirschner L.S., Vincent-Dejean C., Perlemoine K., Gicquel C., Bertagna X., and Stratakis C.A. Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity. Cancer Res. 638 (2003) 5308-5319
11. Horvath A., Boikos S., Giatzakis C., Robinson-White A., Groussin L., Griffin K.J., Stein E., Levine E., Delimpasi G., Hsiao H.P., Keil M., Heyerdahl S., Matyakhina L., Libe R., Fratticci A., Kirschner L.S., Cramer K., Gaillard R.C., Bertagna X., Carney J.A., Bertherat J., Bossis I., and Stratakis C.A. A genome-wide scan identifies mutations in the gene encoding phosphodiesterase11A4 (PDE11A) in individuals with adrenocortical hyperplasia. Nat. Genet. 38 (2006) 794-800
12. Lania A.G., Mantovani G., Ferrero S., Pellegrini C., Bondioni S., Peverelli E., Braidotti P., Locatelli M., Zavanone M.L., Ferrante E., Bosari S., Beck-Peccoz P., and Spada A. Proliferation of transformed somatotroph cells related to low or absent expression of PKA regulatory subunit 1A protein. Cancer Res. 64 (2004) 9193-9198
13. Cho-Chung Y.S. Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy. Cancer Res. 50 (1990) 7093-7100
14. Cho-Chung Y.S., Pepe S., Clair T., Budillon A., and Nesterova M. cAMP-dependent protein kinase: role in normal and malignant growth. Crit. Rev. Oncol./Hematol. 21 (1995) 33-61
15. Rohlff C., Clair T., and Cho-Chung Y.S. 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J. Biol. Chem. 268 (1993) 5774-5782
16. sα is associated with an increased phosphodiesterase activity in human growth hormone secreting adenomas. J. Clin. Endocrinol. Metab. 83 (1998) 1624-1628
17. Luciani P., Gelmini S., Ferrante E., Lania A., Benvenuti S., Baglioni S., Mantovani G., Cellai I., Ammannati F., Spada A., Serio M., and Peri A. Expression of the anti-apoptotic gene seladin-1 and octeotide-induced apoptosis in GH-secreting and in non-functioning pituitary adenomas. J. Clin. Endocrinol. Metab. 90 (2005) 6156-6161
18. Yamasaki H., Mizusawa N., Nagahiro S., Yamada S., Sano T., Itakura M., and Yoshimoto K. GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24. Clin. Endocrinol. 58 (2003) 464-470
19. Haga H., Yamada R., Ohnishi Y., Nakamura Y., and Tanaka T. Gene-based SNP discovery as part of Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Single-nucleotide polymorphism. J. Hum. Genet. 47 (2002) 605-610
20. Schwede F., Christensen A., Liauw S., Hippe T., Kopperud R., Jastorff B., and Doskeland S.O. 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochemistry 39 (2000) 8803-8812
21. Griffoen G., and Thevelein J.M. Molecular mechanisms controlling the localization of protein kinase A. Curr. Genet. 41 (2002) 199-207
22. Stork P.J., and Schmitt J.M. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell. Biol. 12 (2002) 258-266
23. Rainey W.E., Saner K., and Schimmer B.P. Adrenocortical cell lines. Mol. Cell. Endocrinol. 228 (2004) 23-38
24. Kim S.N., Ahn Y.H., Kim S.G., Cho-Chung Y.S., and Hong S.H. 8-Cl-cAMP induces cell cycle-specific apoptosis in human cancer cell lines. Int. J. Cancer 93 (2001) 33-41
25. Boatright K.M., and Salvesen G.S. Mechanisms of caspase activation. Curr. Opin. Cell. Biol. 15 (2003) 725-731
26. Le T., and Schimmer B.P. The regulation of MAPKs in Y1 mouse adrenocortical tumor cells. Endocrinology 142 (2001) 4282-4287
27. Nesterova M., Yokozaki H., McDuffie E., and Cho-Chung Y.S. Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta. Eur. J. Biochem. 235 (1996) 486-494
28. McDaid H.M., Cairns M.T., Atkinson R.J., McAleer S., Harkin D.P., Gilmore P., and Johnston P.G. Increased expression of the RI alpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer. Br. J. Cancer 79 (1999) 933-939
29. Olson M.F., Krolczyk A.L., Gorman K.B., Steinberg R.A., and Schimmer B.P. Molecular basis for the 3′,5′-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells. Mol. Endocrinol. 7 (1993) 477-487
30. Lepique A.P., Forti F.L., Moraes M.S., and Armelin H.A. Signal transduction in G0/G1-arrested mouse Y1 adrenocortical cells stimulated by ACTH and FGF2. Endocr. Res. 26 (2000) 825-832
31. Costa E.T., Forti F.L., Rocha K.M., Moraes M.S., and Armelin H.A. Molecular mechanisms of cell cycle control in the mouse Y1 adrenal cell line. Endocr. Res. 30 (2004) 503-509
32. Rosenberg D., Groussin L., Jullian E., Perlemoine K., Medjane S., Louvel A., Bertagna X., and Bertherat J. Transcription factor 3′,5′-cyclic adenosine 5′-monophosphate responsive element-binding protein (CREB) is decreased during human adrenal cortex tumorigenesis and fetal development. J. Clin. Endocrinol. Metab. 88 (2003) 3958-3965
33. Bossis I., Voutetakis A., Bei T., Sandrini F., and Griffith K.J. Protein Kinase A and its role in human neoplasia: the Carney complex paradigm. Endocr. Relat. Cancer 11 (2004) 265-280