O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 19, 2012, Pages 5884-5892

  Mao, Fei ^a   Huang, Ling ^a   Luo, Zonghua ^a   Liu, Anqiu ^a   Lu, Chuanjun ^a   Xie, Zhiyong ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Antioxidants; Biometals chelators; Inhibitors of cholinesterases; Multifunctional drug candidates

Indexed keywords

2 [[[8 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]OCTYL]AMINO]METHYL]PHENOL; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BENZALDEHYDE DERIVATIVE; BENZYLAMINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; COPPER; HYDROXYL GROUP; IRON; N1 (PYRIDIN 2 YLMETHYL) N8 (1,2,3,4 TETRAHYDROACRIDIN 9YL)OCTANE 1,8 DIAMINE; N1 [2 (DIMETHYLAMINO)BENZYL] N9 (1,2,3,4 TETRAHYDROACRIDIN 9YL)NONANE 1,9 DIAMINE; SALICYLALDEHYDE; TACRINE; TROLOX C; UNCLASSIFIED DRUG; ZINC;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHELATION; COMPUTER PROGRAM; DRUG STRUCTURE; ENZYME INHIBITION; IN VITRO STUDY; MOLECULAR MODEL; PROTEIN AGGREGATION; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROSCOPY;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BENZYLAMINES; CHELATING AGENTS; CHOLINESTERASE INHIBITORS; ELECTROPHORUS; HUMANS; MODELS, MOLECULAR; TACRINE;

EID: 84866413038     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.045     Document Type: Article

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