Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5106-5116

  Marcelo, Filipa ^a,c   Silva, Filipa V M ^a,b   Goulart, Margarida ^a,b   Justino, Jorge ^b   Sinaÿ, Pierre ^c   Blériot, Yves ^c   Rauter, Amélia P ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b POLYTECHNIC INSTITUTE OF SANTARÉM   (Portugal)

^c Université Pierre et Marie Curie   (France)

Author keywords

Alzheimer disease; BChE inhibition; Purine nucleosides; Regioselective N7 glycosylation

Indexed keywords

1 ACETOXY BICYCLIC GLYCOSYL; 2 ACETAMIDE 6 CHLOROPURINE NUCLEOSIDE; ACETONITRILE; ACETYLCHOLINESTERASE; BENZYL DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; METHYLGLUCOSIDE; NEUROPROTECTIVE AGENT; NUCLEIC ACID BASE; PURINE NUCLEOSIDE; RIVASTIGMINE; SOLVENT; TRIMETHYLSILYL TRIFLATE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INACTIVATION; ENZYME INHIBITION; GLYCOSYLATION; HUMAN; HUMAN CELL; NEUROPROTECTION; NONHUMAN; STEREOCHEMISTRY;

ALZHEIMER DISEASE; BUTYRYLCHOLINESTERASE; CELL LINE; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; FIBROBLASTS; GLYCOSYLATION; HUMANS; PURINE NUCLEOSIDES; STEREOISOMERISM;

EID: 67650264160     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.057     Document Type: Article

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