Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4475-4484

  Huang, Ling ^a   Luo, Zonghua ^a   He, Feng ^a   Lu, Jing ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Acetylcholinesterase; Dual inhibitors; Molecular modeling; Synthesis and biological evaluation

Indexed keywords

9 O [3 (NAPHTHALENE 2 YLTHIO)BUTYL]BERBERINE BROMIDE; 9 O [[2 (3 METHYL)PYRIDINIUM BROMIDE]ETHYL]BERBERINE BROMIDE; BERBERINE DERIVATIVE; CHOLINESTERASE INHIBITOR; UNCLASSIFIED DRUG; 9-O-((2-(3-METHYL)PYRIDINIUM)ETHYL)BERBERINE; 9-O-(3-(NAPHTHALENE-2-YLTHIO)BUTYL)BERBERINE; ACETYLCHOLINESTERASE; BERBERINE; CHOLINESTERASE; NEUROPROTECTIVE AGENT; PYRIDINIUM DERIVATIVE;

ARTICLE; COMPETITIVE INHIBITION; DRUG BINDING; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME KINETICS; IC 50; IN VITRO STUDY; MOLECULAR MODEL; ANALOGS AND DERIVATIVES; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; KINETICS; METABOLISM; SYNTHESIS;

ACETYLCHOLINESTERASE; BERBERINE; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; KINETICS; MODELS, MOLECULAR; NEUROPROTECTIVE AGENTS; PYRIDINIUM COMPOUNDS;

EID: 77953138321     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.063     Document Type: Article

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