Synthesis, biological activity and HPLC validation of 1,2,3,4- tetrahydroacridine derivatives as acetylcholinesterase inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3250-3257

  Szymanski, Paweł ^a   Karpiński, Adam ^b   Mikiciuk Olasik, Elzbieta ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b Formulation Development Services   (India)

Author keywords

4 Fluoroacetic acid; Acetylcholinesterase; Alzheimer's disease (AD); Butyrylcholinesterase; HPLC validation; Tacrine

Indexed keywords

1,2,3,4 TETRAHYDROACRIDINE DERIVATIVE; 4 FLUOROBENZOIC ACID DERIVATIVE; ACETONITRILE; ACETYLCHOLINESTERASE; ACRIDINE DERIVATIVE; BENZOIC ACID DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; SODIUM DIHYDROGEN PHOSPHATE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; BIOLOGICAL ACTIVITY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IC 50; OXIDATION; PH; ULTRAVIOLET SPECTROSCOPY;

ACETYLCHOLINESTERASE; ACRIDINES; ALZHEIMER DISEASE; BENZOIC ACIDS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ENZYME ACTIVATION; HUMANS; HYDROLYSIS; KINETICS; LIMIT OF DETECTION; OXIDATION-REDUCTION; SENSITIVITY AND SPECIFICITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 79958253377     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.038     Document Type: Article

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