메뉴 건너뛰기




Volumn 24, Issue 5, 2013, Pages 504-518

Molecular analysis of the inhibitory effect of N-acetyl-L-cysteine on the proliferation and invasiveness of pancreatic cancer cells

Author keywords

atomic force microscopy; cancer invasion; cell stiffness; MYC; N acetyl L cysteine; nuclear factor B; pancreatic cancer; resazurin

Indexed keywords

ACETYLCYSTEINE; DOXORUBICIN; GEMCITABINE; MITOMYCIN; REACTIVE OXYGEN METABOLITE;

EID: 84875850949     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0b013e32836009d7     Document Type: Article
Times cited : (10)

References (82)
  • 2
    • 84875818123 scopus 로고    scopus 로고
    • Based on November 2011 SEER data submission, posted to the SEER website, [Accessed September 2012]
    • Bethesda, MD: Vintage 2011; Based on November 2011 SEER data submission, posted to the SEER website, 2012. Available at: http://seer.cancer.gov/csr/1975- 2009-pops09/[Accessed September 2012].
    • (2012)
  • 3
    • 77950635816 scopus 로고    scopus 로고
    • Pancreatic cancer: Pathobiology, treatment options, and drug delivery
    • Li J, Wientjes MG, Au JL. Pancreatic cancer: pathobiology, treatment options, and drug delivery. AAPS J 2010; 12:223-232.
    • (2010) AAPS J , vol.12 , pp. 223-232
    • Li, J.1    Wientjes, M.G.2    Au, J.L.3
  • 4
    • 70349298417 scopus 로고    scopus 로고
    • N-Acetylcysteine inhibits proliferation, adhesion, migration and invasion of human bladder cancer cells
    • Supabphol A, Muangman V, Chavasiri W, Supabphol R, Gritsanapan W. N-Acetylcysteine inhibits proliferation, adhesion, migration and invasion of human bladder cancer cells. J Med Assoc Thai 2009; 92:1171-1177.
    • (2009) J Med Assoc Thai , vol.92 , pp. 1171-1177
    • Supabphol, A.1    Muangman, V.2    Chavasiri, W.3    Supabphol, R.4    Gritsanapan, W.5
  • 5
    • 33745248407 scopus 로고    scopus 로고
    • The effect of N-acetylcysteine in combination with vitamin C on the activity of ornithine decarboxylase of lung carcinoma cells - In vitro
    • DOI 10.1016/j.lfs.2006.02.009, PII S0024320506001469
    • Vanisree AJ, Shyamaladevi CS. The effect of N-acetylcysteine in combination with vitamin C on the activity of ornithine decarboxylase of lung carcinoma cells - in vitro. Life Sci 2006; 79:654-659. (Pubitemid 43927977)
    • (2006) Life Sciences , vol.79 , Issue.7 , pp. 654-659
    • Vanisree, A.J.1    Shyamaladevi, C.S.2
  • 6
    • 0028864695 scopus 로고
    • N-acetylcysteine-promoted survival of PC12 cells is glutathione- independent but transcription-dependent
    • Yan CY, Ferrari G, Greene LA. N-acetylcysteine-promoted survival of PC12 cells is glutathione-independent but transcription-dependent. J Biol Chem 1995; 270:26827-26832.
    • (1995) J Biol Chem , vol.270 , pp. 26827-26832
    • Yan, C.Y.1    Ferrari, G.2    Greene, L.A.3
  • 7
    • 34547934035 scopus 로고    scopus 로고
    • N-acetyl cysteine inhibits human signet ring cell gastric cancer cell line (SJ-89) cell growth by inducing apoptosis and DNA synthesis arrest
    • DOI 10.1097/MEG.0b013e3282202bda, PII 0004273720070900000006
    • Li J, Tu HJ, Li J, Dai G, Dai YC,Wu Q, et al. N-acetyl cysteine inhibits human signet ring cell gastric cancer cell line (SJ-89) cell growth by inducing apoptosis and DNA synthesis arrest. Eur J Gastroenterol Hepatol 2007; 19:769-774. (Pubitemid 47266705)
    • (2007) European Journal of Gastroenterology and Hepatology , vol.19 , Issue.9 , pp. 769-774
    • Li, J.1    Tu, H.-J.2    Li, J.3    Dai, G.4    Dai, Y.-C.5    Wu, Q.6    Shi, Q.-Z.7    Cao, Q.8    Li, Z.-J.9
  • 8
    • 78650517946 scopus 로고    scopus 로고
    • Suppression of human prostate cancer PC-3 cell growth by N-acetylcysteine involves overexpression of Cyr61, toxicol
    • Lee YJ, Lee DM, Lee CH, Heo SH, Won SY, Im JH, et al. Suppression of human prostate cancer PC-3 cell growth by N-acetylcysteine involves overexpression of Cyr61, toxicol. In Vitro 2011; 25:199-205.
    • (2011) Vitro , vol.25 , pp. 199-205
    • Lee, Y.J.1    Lee, D.M.2    Lee, C.H.3    Heo, S.H.4    Won, S.Y.5    Im, J.H.6
  • 9
    • 0034576326 scopus 로고    scopus 로고
    • N-Acetyl cysteine inhibits cell cycle progression in pancreatic carcinoma cells
    • Kusano C, Takao S, Noma H, Yoh H, Aikou T, Okumura H, et al. N-Acetyl cysteine inhibits cell cycle progression in pancreatic carcinoma cells. Hum Cell 2000; 13:213-220.
    • (2000) Hum Cell , vol.13 , pp. 213-220
    • Kusano, C.1    Takao, S.2    Noma, H.3    Yoh, H.4    Aikou, T.5    Okumura, H.6
  • 10
    • 0035221859 scopus 로고    scopus 로고
    • Inhibitory effect of N-acetylcysteine on invasion and MMP-9 production of T24 human bladder cancer cell
    • Kawakami S, Kageyama Y, Fujii Y, Kihara K, Oshima H. Inhibitory effect of N-acetylcysteine on invasion and MMP-9 production of T24 human bladder cancer cell. Anticancer Res 2001; 21:213-219.
    • (2001) Anticancer Res , vol.21 , pp. 213-219
    • Kawakami, S.1    Kageyama, Y.2    Fujii, Y.3    Kihara, K.4    Oshima, H.5
  • 11
    • 0028905092 scopus 로고
    • Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine
    • Albini A, D'Agostini F, Giunciuglio D, Paglieri I, Balansky R, De Flora S. Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine. Int J Cancer 1995; 61:121-129.
    • (1995) Int J Cancer , vol.61 , pp. 121-129
    • Albini, A.1    D'Agostini, F.2    Giunciuglio, D.3    Paglieri, I.4    Balansky, R.5    De Flora, S.6
  • 12
    • 1942469320 scopus 로고    scopus 로고
    • N-Acetyl-Cysteine Promotes Angiostatin Production and Vascular Collapse in an Orthotopic Model of Breast Cancer
    • Agarwal A, Munoz-Ná jar U, Klueh U, Shih SC, Claffey KP. N-Acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer. Am J Pathol 2004; 164:1683-1696. (Pubitemid 38529771)
    • (2004) American Journal of Pathology , vol.164 , Issue.5 , pp. 1683-1696
    • Agarwal, A.1    Munoz-Najar, U.2    Klueh, U.3    Shih, S.-C.4    Claffey, K.P.5
  • 13
    • 0034929864 scopus 로고    scopus 로고
    • Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
    • De Flora S, Izzotti A, D'Agostini F, Balansky RM. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 2001; 22:999-1013. (Pubitemid 32633597)
    • (2001) Carcinogenesis , vol.22 , Issue.7 , pp. 999-1013
    • De Flora, S.1    Izzotti, A.2    D'Agostini, F.3    Balansky, R.M.4
  • 14
    • 0020055779 scopus 로고
    • Human pancreatic adenocarcinoma: In vitro and in vivo morphology of a new tumor line established from ascites
    • Chen WH, Horoszewicz JS, Leong SS, Shimano T, Penetrante R, Sanders WH, et al. Human pancreatic adenocarcinoma: in vitro and in vivo morphology of a new tumor line established from ascites. In Vitro 1982; 18:24-34. (Pubitemid 12116070)
    • (1982) In Vitro , vol.18 , Issue.1 , pp. 24-34
    • Chen, W.H.1    Horoszewicz, J.S.2    Leong, S.S.3
  • 15
    • 0033856957 scopus 로고    scopus 로고
    • Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
    • O'Brien J, Wilson I, Orton T, Pognan F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem 2000; 267:5421-5426.
    • (2000) Eur J Biochem , vol.267 , pp. 5421-5426
    • O'Brien, J.1    Wilson, I.2    Orton, T.3    Pognan, F.4
  • 16
    • 0025738516 scopus 로고
    • Tetrazolium-based assays for cellular viability: A critical examination of selected parameters affecting formazan production
    • Erratum in: Cancer Res 51:4501
    • Vistica DT, Skehan P, Scudiero D, Monks A, Pittman A, Boyd MR. Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Res 1991; 51:2515-2520, Erratum in: Cancer Res. 51:4501.
    • (1991) Cancer Res , vol.51 , pp. 2515-2520
    • Vistica, D.T.1    Skehan, P.2    Scudiero, D.3    Monks, A.4    Pittman, A.5    Boyd, M.R.6
  • 17
    • 70449413861 scopus 로고    scopus 로고
    • Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - The involvement of rapidly activated kinases and caspases
    • Jeng YJ, Watson CS. Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases. BMC Cancer 2009; 9:334.
    • (2009) BMC Cancer , vol.9 , pp. 334
    • Jeng, Y.J.1    Watson, C.S.2
  • 18
    • 28544437074 scopus 로고    scopus 로고
    • 2-CMX-Ros) and MitoTracker Red 580 (MTR580)
    • DOI 10.1016/j.jim.2005.07.024, PII S002217590500270X
    • Jayaraman S. Flow cytometric determination of mitochondrial membrane potential changes during apoptosis of T lymphocytic and pancreatic bet cell lines: comparison of tetramethylrhodamineethylester (TMRE), chloromethyl- X-rosamine (H2-CMK-Ros) and MitoTracker Red 580 (MTR580). J Immunol Methods 2005; 306:68-79. (Pubitemid 41742215)
    • (2005) Journal of Immunological Methods , vol.306 , Issue.1-2 , pp. 68-79
    • Jayaraman, S.1
  • 19
    • 0030858046 scopus 로고    scopus 로고
    • Annexin V, the regulator of phosphatidylserine-catalyzed inflammation and coagulation during apoptosis
    • DOI 10.1007/s000180050067
    • Reutelingsperger CP, van Heerde WL. Annexin V, the regulator of phosphatidylserine-catalyzed inflammation and 625 coagulation during apoptosis. Cell Mol Life Sci 1997; 53:527-532. (Pubitemid 27374494)
    • (1997) Cellular and Molecular Life Sciences , vol.53 , Issue.6 , pp. 527-532
    • Reutelingsperger, C.P.M.1    Van Heerde, W.L.2
  • 20
    • 79960440317 scopus 로고    scopus 로고
    • Camalexin induces apoptosis in T-leukemia Jurkat cells by increased concentration of reactive oxygen species and activation of caspase-8 and caspase-9
    • Mezencev R, Updegrove T, Kutschy P, Repovská M, McDonald JF. Camalexin induces apoptosis in T-leukemia Jurkat cells by increased concentration of reactive oxygen species and activation of caspase-8 and caspase-9. J Nat Med 2011; 65:488-499.
    • (2011) J Nat Med , vol.65 , pp. 488-499
    • Mezencev, R.1    Updegrove, T.2    Kutschy, P.3    Repovská, M.4    McDonald, J.F.5
  • 21
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92:9363-9367.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3    Acosta, M.4    Scott, G.5    Roskelley, C.6
  • 22
    • 84867117776 scopus 로고    scopus 로고
    • Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells
    • XuW, Mezencev R, Kim B,Wang L, McDonald JF, Sulchek TA. Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells. PLoS One 2012; 7:e46609.
    • (2012) PLoS One , vol.7
    • Xuw Mezencev, R.1    Kim Bwang, L.2    McDonald, J.F.3    Sulchek, T.A.4
  • 23
    • 58249097252 scopus 로고    scopus 로고
    • Hydrocyanines: A class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue, and in vivo
    • Kundu K, Knight SF,Willett N, Lee S, Taylor WR, Murthy N. Hydrocyanines: a class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue, and in vivo. Angew Chem Int Ed Engl 2009; 48:299-303.
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 299-303
    • Kundu, K.1    Knight Sfwillett, N.2    Lee, S.3    Taylor, W.R.4    Murthy, N.5
  • 24
    • 80053457816 scopus 로고    scopus 로고
    • A switching mechanism in doxorubicin bioactivation can be exploited to control doxorubicin toxicity
    • Finn NA, Findley HW, Kemp ML. A switching mechanism in doxorubicin bioactivation can be exploited to control doxorubicin toxicity. PLoS Comput Biol 2011; 7:e1002151.
    • (2011) PLoS Comput Biol , vol.7
    • Finn, N.A.1    Findley, H.W.2    Kemp, M.L.3
  • 25
    • 0032783532 scopus 로고    scopus 로고
    • Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
    • DOI 10.1016/S0891-5849(99)00061-1, PII S0891584999000611
    • Hempel SL, Buettner GR, O'Malley YQ, Wessels DA, Flaherty DM. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 20,70-dichlorodihydrofluorescein diacetate, 5(and 6)- carboxy-20,70-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic Biol Med 1999; 27:146-159. (Pubitemid 29353095)
    • (1999) Free Radical Biology and Medicine , vol.27 , Issue.1-2 , pp. 146-159
    • Hempel, S.L.1    Buettner, G.R.2    O'Malley, Y.Q.3    Wessels, D.A.4    Flaherty, D.M.5
  • 26
    • 0033757902 scopus 로고    scopus 로고
    • 2,7-Dichlorofluorescin oxidation and reactive oxygen species: What does it measure?
    • Jakubowski W, Bartosz G. 2,7-Dichlorofluorescin oxidation and reactive oxygen species: what does it measure? Cell Biol Int 2000; 24:757-760.
    • (2000) Cell Biol Int , vol.24 , pp. 757-760
    • Jakubowski, W.1    Bartosz, G.2
  • 27
    • 0037474309 scopus 로고    scopus 로고
    • Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species
    • DOI 10.1074/jbc.M209264200
    • Setsukinai K, Urano Y, Kakinuma K, Majima HJ, Nagano T. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J Biol Chem 2003; 278:3170-3175. (Pubitemid 36801227)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.5 , pp. 3170-3175
    • Setsukinai, K.-I.1    Urano, Y.2    Kakinuma, K.3    Majima, H.J.4    Nagano, T.5
  • 30
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, et al. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 2009; 138:245-256.
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1    Li, W.2    Zhang, Y.3    Yuan, X.4    Xu, K.5    Yu, J.6
  • 31
    • 0037248812 scopus 로고    scopus 로고
    • RTPrimerDB: The real-time PCR primer and probe database
    • DOI 10.1093/nar/gkg011
    • Pattyn F, Speleman F, Depaepe A, Vandesompele J. RTPrimerDB: the real-time PCR primer and probe database. Nucleic Acids Res 2003; 31:122-123. (Pubitemid 36150349)
    • (2003) Nucleic Acids Research , vol.31 , Issue.1 , pp. 122-123
    • Pattyn, F.1    Speleman, F.2    De Paepe, A.3    Vandesompele, J.4
  • 32
    • 84857903344 scopus 로고    scopus 로고
    • Isolation and characterization of stem-like cells from a human ovarian cancer cell line
    • Wang L, Mezencev R, Bowen NJ, Matyunina LV, McDonald JF. Isolation and characterization of stem-like cells from a human ovarian cancer cell line. Mol Cell Biochem 2012; 363:257-268.
    • (2012) Mol Cell Biochem , vol.363 , pp. 257-268
    • Wang, L.1    Mezencev, R.2    Bowen, N.J.3    Matyunina, L.V.4    McDonald, J.F.5
  • 33
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    • Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002; 30:e36.
    • (2002) Nucleic Acids Res , vol.30
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 34
    • 70349576321 scopus 로고    scopus 로고
    • Functional analysis of OMICs data and small molecule compounds in an integrated 'knowledge based' platform
    • Nikolsky Y, Kirillov E, Zuev R, Rakhmatulin E, Nikolskaya T. Functional analysis of OMICs data and small molecule compounds in an integrated 'knowledge based' platform. Methods Mol Biol 2009; 563:177-196.
    • (2009) Methods Mol Biol , vol.563 , pp. 177-196
    • Nikolsky, Y.1    Kirillov, E.2    Zuev, R.3    Rakhmatulin, E.4    Nikolskaya, T.5
  • 35
    • 73549108541 scopus 로고    scopus 로고
    • A rapid and sensitive method for measuring cell adhesion
    • Lu W, McCallum L, Irvine AE. A rapid and sensitive method for measuring cell adhesion. J Cell Commun Signal 2009; 3:147-149.
    • (2009) J Cell Commun Signal , vol.3 , pp. 147-149
    • Lu, W.1    McCallum, L.2    Irvine, A.E.3
  • 36
    • 0028850087 scopus 로고
    • Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at ser residue
    • Kaneko I, Yamada N, Sakuraba Y, Kamenosono M, Tutumi S. Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue. J Neurochem 1995; 65:2585-2593.
    • (1995) J Neurochem , vol.65 , pp. 2585-2593
    • Kaneko, I.1    Yamada, N.2    Sakuraba, Y.3    Kamenosono, M.4    Tutumi, S.5
  • 38
    • 0022542305 scopus 로고
    • Prevention of adriamycin cardiotoxicity by niacin, isocitrate or N-acetyl-cysteine in mice. A morphological study
    • Schmitt-Graff A, Scheulen ME. Prevention of adriamycin cardiotoxicity by niacin, isocitrate or N-acetyl-cysteine in mice. A morphological study. Pathol Res Pract 1986; 181:168-174. (Pubitemid 16021503)
    • (1986) Pathology Research and Practice , vol.181 , Issue.2 , pp. 168-174
    • Schmitt-Graff, A.1    Scheulen, M.E.2
  • 39
    • 4644318540 scopus 로고    scopus 로고
    • Effect of change in cellular GSH levels on mitochondrial damage and cell viability loss due to mitomycin c in small cell lung cancer cells
    • DOI 10.1016/j.bcp.2004.06.010, PII S0006295204004265
    • Lee CS, Park SY, Ko HH, Han ES. Effect of change in cellular GSH levels on mitochondrial damage and cell viability loss due to mitomycin C in small cell lung cancer cells. Biochem Pharmacol 2004; 68:1857-1867. (Pubitemid 39278508)
    • (2004) Biochemical Pharmacology , vol.68 , Issue.9 , pp. 1857-1867
    • Lee, C.S.1    Park, S.Y.2    Ko, H.H.3    Han, E.S.4
  • 40
    • 2142846005 scopus 로고    scopus 로고
    • Identification of senescence in cancer cells
    • Langdon SP, editor cancer cell culture: methods and protocols. Totowa, NJ: Humana Press Inc.
    • Jardine LJ. Identification of senescence in cancer cells. In: Langdon SP, editor. Methods in molecular medicine, Vol 88: cancer cell culture: methods and protocols. Totowa, NJ: Humana Press Inc.; 2004. pp. 231-238.
    • (2004) Methods in Molecular Medicine , vol.88 , pp. 231-238
    • Jardine, L.J.1
  • 41
    • 79960942460 scopus 로고    scopus 로고
    • Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines
    • Swaminathan V, Mythreye K, O'Brien ET, Berchuck A, Blobe GC, Superfine R. Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. Cancer Res 2011; 71:5075-5080.
    • (2011) Cancer Res , vol.71 , pp. 5075-5080
    • Swaminathan, V.1    Mythreye, K.2    O'Brien, E.T.3    Berchuck, A.4    Blobe, G.C.5    Superfine, R.6
  • 42
    • 9644270341 scopus 로고    scopus 로고
    • N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts
    • Qanungo S,Wang M, Nieminen AL. N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts. J Biol Chem 2004; 279:50455-50464.
    • (2004) J Biol Chem , vol.279 , pp. 50455-50464
    • Qanungo Swang, M.1    Nieminen, A.L.2
  • 43
    • 0037087050 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine inhibits 26S proteasome function: Implications for effects on NF-κB activation
    • DOI 10.1016/S0891-5849(02)00743-8, PII S0891584902007438
    • Pajonk F, Riess K, Sommer A, McBride WH. N-Acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation. Free Radic Biol Med 2002; 32:536-543. (Pubitemid 34215038)
    • (2002) Free Radical Biology and Medicine , vol.32 , Issue.6 , pp. 536-543
    • Pajonk, F.1    Riess, K.2    Sommer, A.3    McBride, W.H.4
  • 44
    • 0036884292 scopus 로고    scopus 로고
    • A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants
    • Schubert SY, Neeman I, Resnick N. A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants. FASEB J 2002; 16:1931-1933.
    • (2002) FASEB J , vol.16 , pp. 1931-1933
    • Schubert, S.Y.1    Neeman, I.2    Resnick, N.3
  • 45
    • 33644819208 scopus 로고    scopus 로고
    • N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-κB activation in alveolar macrophages by different mechanisms
    • DOI 10.1111/j.1745-7254.2006.00264.x
    • Li YQ, Zhang ZX, Xu YJ, Ni W, Chen SX, Yang Z, et al. N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kappaB activation in alveolar macrophages by different mechanisms. Acta Pharmacol Sin 2006; 27:339-346. (Pubitemid 43357031)
    • (2006) Acta Pharmacologica Sinica , vol.27 , Issue.3 , pp. 339-346
    • Li, Y.-Q.1    Zhang, Z.-X.2    Xu, Y.-J.3    Ni, W.4    Chen, S.-X.5    Yang, Z.6
  • 48
    • 84875071763 scopus 로고    scopus 로고
    • Attenuation of reactive oxygen species by antioxidants suppresses hypoxiainduced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells
    • Shimojo Y, Akimoto M, Hisanaga T, Tanaka T, Tajima Y, Honma Y, et al. Attenuation of reactive oxygen species by antioxidants suppresses hypoxiainduced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells. Clin Exp Metastasis 2013; 30:143-154.
    • Clin Exp Metastasis , vol.2013 , Issue.30 , pp. 143-154
    • Shimojo, Y.1    Akimoto, M.2    Hisanaga, T.3    Tanaka, T.4    Tajima, Y.5    Honma, Y.6
  • 49
    • 84858687882 scopus 로고    scopus 로고
    • Novel agents in early phase clinical studies on refractory pancreatic cancer
    • Strimpakos AS, Syrigos KN, Saif MW. Novel agents in early phase clinical studies on refractory pancreatic cancer. JOP 2012; 13:166-168.
    • (2012) JOP , vol.13 , pp. 166-168
    • Strimpakos, A.S.1    Syrigos, K.N.2    Saif, M.W.3
  • 50
    • 3142606712 scopus 로고    scopus 로고
    • Comparison of alamar blue and MTT assays for high through-put screening
    • DOI 10.1016/j.tiv.2004.03.012, PII S0887233304000633
    • Hamid R, Rotshteyn Y, Rabadi L, Parikh R, Bullock P. Comparison of alamar blue and MTT assays for high through-put screening. Toxicol In Vitro 2004; 18:703-710. (Pubitemid 38900879)
    • (2004) Toxicology in Vitro , vol.18 , Issue.5 , pp. 703-710
    • Hamid, R.1    Rotshteyn, Y.2    Rabadi, L.3    Parikh, R.4    Bullock, P.5
  • 51
    • 34548799705 scopus 로고    scopus 로고
    • Methods to detect biomarkers of cellular senescence: The senescence-associated β-galactosidase assay
    • DOI 10.1385/1-59745-361-7:21, Biological Aging: Methods and Protocols
    • Ithana K, Campisi J, Dimri GP. Methods to detect biomarkers of cellular senescence: the senescence-associated b-galactosidase assay. In: Tollefsbol TO, editor. Methods in molecular biology: biological aging: methods and protocols. Totowa, NJ: Humana Press 2007. pp. 21-31. (Pubitemid 350183415)
    • (2007) Methods in Molecular Biology , vol.371 , pp. 21-31
    • Itahana, K.1    Campisi, J.2    Dimri, G.P.3
  • 52
    • 84855888094 scopus 로고    scopus 로고
    • Regulation of senescence in cancer and aging
    • Kong Y, Cui H, Ramkumar C, Zhang H. Regulation of senescence in cancer and aging. J Aging Res 2011; 2011:963172.
    • (2011) J Aging Res , vol.2011 , pp. 963172
    • Kong, Y.1    Cui, H.2    Ramkumar, C.3    Zhang, H.4
  • 56
    • 0029023626 scopus 로고
    • Senescent human fibroblasts resist programmed cell death, and failure to suppress Bcl2 is involved
    • Wang E. Senescent human fibroblasts resist programmed cell death, and failure to suppress Bcl2 is involved. Cancer Res 1995; 55:2284-2292.
    • (1995) Cancer Res , vol.55 , pp. 2284-2292
    • Wang, E.1
  • 57
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 1999; 5:119-127. (Pubitemid 29045184)
    • (1999) Clinical Cancer Research , vol.5 , Issue.1 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 58
    • 0348012946 scopus 로고    scopus 로고
    • NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells
    • DOI 10.1002/ijc.11562
    • Xiong HQ, Abbruzzese JL, Lin E, Wang L, Zheng L, Xie K. NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. Int J Cancer 2004; 108:181-188. (Pubitemid 37541768)
    • (2004) International Journal of Cancer , vol.108 , Issue.2 , pp. 181-188
    • Xiong, H.Q.1    Abbruzzese, J.L.2    Lin, E.3    Wang, L.4    Zheng, L.5    Xie, K.6
  • 59
    • 84862291483 scopus 로고    scopus 로고
    • Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-kB and nuclear factor-kB regulated gene products in pancreatic cancer both in vitro and in vivo
    • Wang YW, Wang SJ, Zhou YN, Pan SH, Sun B. Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-kB and nuclear factor-kB regulated gene products in pancreatic cancer both in vitro and in vivo. J Cancer Res Clin Oncol 2012; 138:785-797.
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 785-797
    • Wang, Y.W.1    Wang, S.J.2    Zhou, Y.N.3    Pan, S.H.4    Sun, B.5
  • 60
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signaling
    • Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signaling. Nature 1999; 401:86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 61
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV. MYC on the path to cancer. Cell 2012; 149:22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 62
  • 63
    • 33144481710 scopus 로고    scopus 로고
    • The Mad side of the Max network: Antagonizing the function of Myc and more
    • DOI 10.1007/3-540-32952-8-4
    • Rottmann S, Luscher B. The Mad side of the Max network: antagonizing the function of Myc and more. In: Eisenman RN, editor. The Myc/Max/Mad transcription factor network. Berlin Heidelberg: Springer-Verlag; 2006. pp. 63-122. (Pubitemid 43268504)
    • (2006) Current Topics in Microbiology and Immunology , vol.302 , pp. 63-122
    • Rottmann, S.1    Luscher, B.2
  • 64
    • 77952490843 scopus 로고    scopus 로고
    • Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells
    • Cho KB, Cho MK, Lee WY, Kang KW. Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells. Cancer Lett 2010; 293:230-239.
    • (2010) Cancer Lett , vol.293 , pp. 230-239
    • Cho, K.B.1    Cho, M.K.2    Lee, W.Y.3    Kang, K.W.4
  • 66
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • DOI 10.1016/j.cell.2004.07.011, PII S0092867404007020
    • Kang Y, Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004; 118:277-279. (Pubitemid 39061108)
    • (2004) Cell , vol.118 , Issue.3 , pp. 277-279
    • Kang, Y.1    Massague, J.2
  • 68
    • 22244492306 scopus 로고    scopus 로고
    • Carcinoma invasion and metastasis: A role for epithelial-mesenchymal transition?
    • Thompson EW, Newgreen DF. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res 2005; 65:5991-5995. (Pubitemid 40994377)
    • (2005) Cancer Research , vol.65 , Issue.14 , pp. 5991-5995
    • Thompson, E.W.1    Newgreen, D.F.2
  • 69
    • 24644487443 scopus 로고    scopus 로고
    • Cadherins and catenins in breast cancer
    • DOI 10.1016/j.ceb.2005.08.014, PII S0955067405001171
    • Cowin P, Rowlands TM, Hatsell SJ. Cadherins and catenins in breast cancer. Curr Opin Cell Biol 2005; 17:499-508. (Pubitemid 41267164)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.5 SPEC. ISS. , pp. 499-508
    • Cowin, P.1    Rowlands, T.M.2    Hatsell, S.J.3
  • 70
    • 68149166466 scopus 로고    scopus 로고
    • Hyperoxic treatment induces mesenchymal-to-epithelial transition in a rat adenocarcinoma model
    • Moen I, Øyan AM, Kalland KH, Tronstad KJ, Akslen LA, Chekenya M, et al. Hyperoxic treatment induces mesenchymal-to-epithelial transition in a rat adenocarcinoma model. PLoS One 2009; 4:e6381.
    • (2009) PLoS One , vol.4
    • Moen, I.1    Øyan, A.M.2    Kalland, K.H.3    Tronstad, K.J.4    Akslen, L.A.5    Chekenya, M.6
  • 73
    • 84867820011 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance
    • Huang FT, Zhuan-Sun YX, Zhuang YY, Wei SL, Tang J, Chen WB, et al. Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance. Int J Oncol 2012; 41:1707-1714.
    • (2012) Int J Oncol , vol.41 , pp. 1707-1714
    • Huang, F.T.1    Zhuan-Sun, Y.X.2    Zhuang, Y.Y.3    Wei, S.L.4    Tang, J.5    Chen, W.B.6
  • 75
    • 0001068771 scopus 로고
    • Mechanisms of anticarcinogenesis: The example of N-acetylcysteine
    • Ioannides C, Lewis DFV, editors. Mechanistic approaches to cancer. Hemel Hempstead, UK: Ellis Horwood
    • De Flora S, Balansky R, Bennicelli C, Camoirano A, D'Agostini F, Izzotti A, et al. Mechanisms of anticarcinogenesis: the example of N-acetylcysteine. In: Ioannides C, Lewis DFV, editors. Drugs, diet and disease, Vol. 1. Mechanistic approaches to cancer. Hemel Hempstead, UK: Ellis Horwood1995. pp. 151-203.
    • (1995) Drugs, Diet and Disease , vol.1 , pp. 151-203
    • De Flora, S.1    Balansky, R.2    Bennicelli, C.3    Camoirano, A.4    D'Agostini, F.5    Izzotti, A.6
  • 77
    • 0032841575 scopus 로고    scopus 로고
    • N-acetylcysteine, a cancer chemopreventive agent, causes oxidative damage to cellular and isolated DNA
    • DOI 10.1093/carcin/20.8.1485
    • Oikawa S, Yamada K, Yamashita N, Tada-Oikawa S, Kawanishi S. N-Acetylcysteine, a cancer chemopreventive agent, causes oxidative damage to cellular and isolated DNA. Carcinogenesis 1999; 20:1485-1490. (Pubitemid 29385434)
    • (1999) Carcinogenesis , vol.20 , Issue.8 , pp. 1485-1490
    • Oikawa, S.1    Yamada, K.2    Yamashita, N.3    Tada-Oikawa, S.4    Kawanishi, S.5
  • 79
    • 0033898870 scopus 로고    scopus 로고
    • The effect of oral N-acetylcysteine in chronic bronchitis: A quantitative systematic review
    • DOI 10.1034/j.1399-3003.2000.16b12.x
    • Stey C, Steurer J, Bachmann S, Medici TC, Tramer MR. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J 2000; 16:253-262. (Pubitemid 30624944)
    • (2000) European Respiratory Journal , vol.16 , Issue.2 , pp. 253-262
    • Stey, C.1    Steurer, J.2    Bachmann, S.3    Medici, T.C.4    Tramer, M.R.5
  • 81
    • 0024380927 scopus 로고
    • The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage
    • DOI 10.1007/BF00558131
    • Prescott LF, Donovan JW, Jarvie DR, Proudfoot AT. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol 1989; 37:501-506. (Pubitemid 20013446)
    • (1989) European Journal of Clinical Pharmacology , vol.37 , Issue.5 , pp. 501-506
    • Prescott, L.F.1    Donovan, J.W.2    Jarvie, D.R.3    Proudfoot, A.T.4
  • 82
    • 28444448432 scopus 로고    scopus 로고
    • Effect of highdose intravenous N-acetylcysteine on the concentration of plasma sulfurcontaining amino acids
    • Hong SY, Gil HW, Yang JO, Lee EY, Kim HK, Kim SH, et al. Effect of highdose intravenous N-acetylcysteine on the concentration of plasma sulfurcontaining amino acids. Korean J Intern Med 2005; 20:217-223.
    • (2005) Korean J Intern Med , vol.20 , pp. 217-223
    • Hong, S.Y.1    Gil, H.W.2    Yang, J.O.3    Lee, E.Y.4    Kim, H.K.5    Kim, S.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.