Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance

International Journal of Oncology

Volumn 41, Issue 5, 2012, Pages 1707-1714

  Huang, Feng Ting ^a   Zhuan Sun, Yong Xun ^a   Zhuang, Yan Yan ^a   Wei, Shu Li ^b   Tang, Jian ^a   Chen, Wen Bo ^a   Zhang, Shi Neng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

ABCG2; Bmi 1; Cancer stem cell; Hedgehog signaling pathway; Pancreatic cancer; Tumorsphere

Indexed keywords

BMI1 PROTEIN; CYCLOPAMINE; FLUOROURACIL; GEMCITABINE; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CANCER STEM CELL; CARCINOGENESIS; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CELL STRUCTURE; CONTROLLED STUDY; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MALE; MEDIATOR; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DRUG RESISTANCE, NEOPLASM; GLYCOPROTEINS; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; PEPTIDES; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED; VERATRUM ALKALOIDS;

EID: 84867820011     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1597     Document Type: Article

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