메뉴 건너뛰기




Volumn 164, Issue 5, 2004, Pages 1683-1696

N-Acetyl-Cysteine Promotes Angiostatin Production and Vascular Collapse in an Orthotopic Model of Breast Cancer

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANGIOSTATIN; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; PLASMINOGEN; VASCULOTROPIN;

EID: 1942469320     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63727-3     Document Type: Article
Times cited : (63)

References (60)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 0015311426 scopus 로고
    • Anti-angiogenesis: New concept for therapy of solid tumors
    • Folkman J: Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 1972, 175:409-416
    • (1972) Ann Surg , vol.175 , pp. 409-416
    • Folkman, J.1
  • 3
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N: Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 1993, 362:841-844
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 4
    • 0036984738 scopus 로고    scopus 로고
    • Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor
    • Jain RK: Tumor angiogenesis and accessibility: role of vascular endothelial growth factor. Semin Oncol 2002, 29 (6 Suppl 16):3-9
    • (2002) Semin Oncol , vol.29 , Issue.6 SUPPL. 16 , pp. 3-9
    • Jain, R.K.1
  • 5
    • 0032889698 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis
    • Dvorak HF, Nagy JA, Feng D, Brown LF, Dvorak AM: Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr Top Microbiol Immunol 1999, 237:97-132
    • (1999) Curr Top Microbiol Immunol , vol.237 , pp. 97-132
    • Dvorak, H.F.1    Nagy, J.A.2    Feng, D.3    Brown, L.F.4    Dvorak, A.M.5
  • 6
    • 0034000338 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor in breast cancer
    • Gasparini G: Prognostic value of vascular endothelial growth factor in breast cancer. Oncologist 2000, 5(Suppl 1):37-44
    • (2000) Oncologist , vol.5 , Issue.SUPPL. 1 , pp. 37-44
    • Gasparini, G.1
  • 7
    • 0029143990 scopus 로고
    • Tumor angiogenesis in breast cancer: Its importance as a prognostic indicator and the association with vascular endothelial growth factor expression
    • Toi M, Inada K, Suzuki H, Tominaga T: Tumor angiogenesis in breast cancer: its importance as a prognostic indicator and the association with vascular endothelial growth factor expression. Breast Cancer Res Treat 1995, 36:193-204
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 193-204
    • Toi, M.1    Inada, K.2    Suzuki, H.3    Tominaga, T.4
  • 8
    • 0035800441 scopus 로고    scopus 로고
    • Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers
    • Fujimoto J, Sakaguchi H, Aoki I, Khatun S, Tamaya T: Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers. Br J Cancer 2001, 85:313-316
    • (2001) Br J Cancer , vol.85 , pp. 313-316
    • Fujimoto, J.1    Sakaguchi, H.2    Aoki, I.3    Khatun, S.4    Tamaya, T.5
  • 10
    • 0026660977 scopus 로고
    • Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways
    • Claffey KP, Wilkison WO, Spiegelman BM: Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways. J Biol Chem 1992, 267:16317-16322
    • (1992) J Biol Chem , vol.267 , pp. 16317-16322
    • Claffey, K.P.1    Wilkison, W.O.2    Spiegelman, B.M.3
  • 11
    • 0030054914 scopus 로고    scopus 로고
    • Regulation of VEGF/VPF expression in tumor cells: Consequences for tumor growth and metastasis
    • Claffey KP, Robinson GS: Regulation of VEGF/VPF expression in tumor cells: consequences for tumor growth and metastasis. Cancer Metastasis Rev 1996, 15:165-176
    • (1996) Cancer Metastasis Rev , vol.15 , pp. 165-176
    • Claffey, K.P.1    Robinson, G.S.2
  • 12
    • 0032079312 scopus 로고    scopus 로고
    • Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway
    • Graham CH, Fitzpatrick TE, McCrae KR: Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway. Blood 1998, 91:3300-3307
    • (1998) Blood , vol.91 , pp. 3300-3307
    • Graham, C.H.1    Fitzpatrick, T.E.2    McCrae, K.R.3
  • 13
    • 0033056944 scopus 로고    scopus 로고
    • Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells
    • Shih SC, Mullen A, Abrams K, Mukhopadhyay D, Claffey KP: Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells. J Biol Chem 1999, 274:15407-15414
    • (1999) J Biol Chem , vol.274 , pp. 15407-15414
    • Shih, S.C.1    Mullen, A.2    Abrams, K.3    Mukhopadhyay, D.4    Claffey, K.P.5
  • 14
    • 0034531952 scopus 로고    scopus 로고
    • MAP kinases and hypoxia in the control of VEGF expression
    • Berra E, Pages G, Pouyssegur J: MAP kinases and hypoxia in the control of VEGF expression. Cancer Metastasis Rev 2000, 19:139-145
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 139-145
    • Berra, E.1    Pages, G.2    Pouyssegur, J.3
  • 15
    • 0034531766 scopus 로고    scopus 로고
    • HIF-1: Using two hands to flip the angiogenic switch
    • Semenza GL: HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Rev 2000, 19:59-65
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 59-65
    • Semenza, G.L.1
  • 16
    • 0035831465 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells
    • Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY: Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J Biol Chem 2001, 276:7614-7620
    • (2001) J Biol Chem , vol.276 , pp. 7614-7620
    • Kim, I.1    Moon, S.O.2    Kim, S.H.3    Kim, H.J.4    Koh, Y.S.5    Koh, G.Y.6
  • 18
    • 0032720628 scopus 로고    scopus 로고
    • Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is FIk-1-dependent
    • Bernatchez PN, Soker S, Sirois MG: Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is FIk-1-dependent. J Biol Chem 1999, 274:31047-31054
    • (1999) J Biol Chem , vol.274 , pp. 31047-31054
    • Bernatchez, P.N.1    Soker, S.2    Sirois, M.G.3
  • 19
    • 0036985699 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications
    • Ferrara N: Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin Oncol 2002, 29:10-14
    • (2002) Semin Oncol , vol.29 , pp. 10-14
    • Ferrara, N.1
  • 20
    • 0026321129 scopus 로고
    • Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
    • Pepper MS, Ferrara N, Orci L, Montesano R: Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 1991, 181:902-906
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 902-906
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 22
    • 0035721955 scopus 로고    scopus 로고
    • Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis
    • Pepper MS: Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis. Arterioscler Thromb Vasc Biol 2001, 21:1104-1117
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1104-1117
    • Pepper, M.S.1
  • 23
    • 0037387683 scopus 로고    scopus 로고
    • VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor
    • Behzadian MA, Windsor LJ, Ghaly N, Liou G, Tsai NT, Caldwell RB: VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor. EMBO J 2003, 17:752-754
    • (2003) EMBO J , vol.17 , pp. 752-754
    • Behzadian, M.A.1    Windsor, L.J.2    Ghaly, N.3    Liou, G.4    Tsai, N.T.5    Caldwell, R.B.6
  • 25
    • 0038663072 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator expression correlates with tumor angiogenesis and poor outcome in gastric cancer
    • Kaneko T, Konno H, Baba M, Tanaka T, Nakamura S: Urokinase-type plasminogen activator expression correlates with tumor angiogenesis and poor outcome in gastric cancer. Cancer Sci 2003, 94:43-49
    • (2003) Cancer Sci , vol.94 , pp. 43-49
    • Kaneko, T.1    Konno, H.2    Baba, M.3    Tanaka, T.4    Nakamura, S.5
  • 26
    • 0033499275 scopus 로고    scopus 로고
    • Vitreous concentrations of TPA and plasminogen activator inhibitor are associated with VEGF in proliferative diabetic vitreoretinopathy
    • Hattenbach LO, Allers A, Gumbel HO, Scharrer I, Koch FH: Vitreous concentrations of TPA and plasminogen activator inhibitor are associated with VEGF in proliferative diabetic vitreoretinopathy. Retina 1999, 19:383-389
    • (1999) Retina , vol.19 , pp. 383-389
    • Hattenbach, L.O.1    Allers, A.2    Gumbel, H.O.3    Scharrer, I.4    Koch, F.H.5
  • 34
    • 0033010312 scopus 로고    scopus 로고
    • Angiostatin diminishes activation of the mitogen-activated protein kinases ERK-1 and ERK-2 in human dermal microvascular endothelial cells
    • Redlitz A, Daum G, Sage EH: Angiostatin diminishes activation of the mitogen-activated protein kinases ERK-1 and ERK-2 in human dermal microvascular endothelial cells. J Vasc Res 1999, 36:28-34
    • (1999) J Vasc Res , vol.36 , pp. 28-34
    • Redlitz, A.1    Daum, G.2    Sage, E.H.3
  • 35
    • 0036041980 scopus 로고    scopus 로고
    • Angiostatin induces intracellular acidosis and anoikis in endothelial cells at a tumor-like low pH
    • Wahl ML, Owen CS, Grant DS: Angiostatin induces intracellular acidosis and anoikis in endothelial cells at a tumor-like low pH. Endothelium 2002, 9:205-216
    • (2002) Endothelium , vol.9 , pp. 205-216
    • Wahl, M.L.1    Owen, C.S.2    Grant, D.S.3
  • 36
    • 0028409135 scopus 로고
    • Partial protection of photodynamic-induced skin reactions in mice by N-acetylcysteine: A preclinical study
    • Baas P, Oppelaar H, van der Valk MA, van Zandwijk N, Stewart FA: Partial protection of photodynamic-induced skin reactions in mice by N-acetylcysteine: a preclinical study. Photochem Photobiol 1994, 59:448-454
    • (1994) Photochem Photobiol , vol.59 , pp. 448-454
    • Baas, P.1    Oppelaar, H.2    Van Der Valk, M.A.3    Van Zandwijk, N.4    Stewart, F.A.5
  • 38
    • 0034929864 scopus 로고    scopus 로고
    • Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
    • De Flora S, Izzotti A, D'Agostini F, Balansky RM: Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 2001, 22:999-1013
    • (2001) Carcinogenesis , vol.22 , pp. 999-1013
    • De Flora, S.1    Izzotti, A.2    D'Agostini, F.3    Balansky, R.M.4
  • 39
    • 0028905092 scopus 로고
    • Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine
    • Albini A, D'Agostini F, Giunciuglio D, Paglieri I, Balansky R, De Flora S: Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine. Int J Cancer 1995, 61:121-129
    • (1995) Int J Cancer , vol.61 , pp. 121-129
    • Albini, A.1    D'Agostini, F.2    Giunciuglio, D.3    Paglieri, I.4    Balansky, R.5    De Flora, S.6
  • 40
    • 0033789022 scopus 로고    scopus 로고
    • Antiapoptotic and antigenotoxic effects of N-acetylcysteine in human cells of endothelial origin
    • Aluigi MG, De Flora S, D'Agostini F, Albini A, Fassina G: Antiapoptotic and antigenotoxic effects of N-acetylcysteine in human cells of endothelial origin. Anticancer Res 2000, 20:3183-3187
    • (2000) Anticancer Res , vol.20 , pp. 3183-3187
    • Aluigi, M.G.1    De Flora, S.2    D'Agostini, F.3    Albini, A.4    Fassina, G.5
  • 41
    • 0030002735 scopus 로고    scopus 로고
    • Synergism between N-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models
    • De Flora S, D'Agostini F, Masiello L, Giunciuglio D, Albini A: Synergism between N-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models. Int J Cancer 1996, 67:842-848
    • (1996) Int J Cancer , vol.67 , pp. 842-848
    • De Flora, S.1    D'Agostini, F.2    Masiello, L.3    Giunciuglio, D.4    Albini, A.5
  • 42
    • 0031849623 scopus 로고    scopus 로고
    • Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice
    • D'Agostini F, Bagnasco M, Giunciuglio D, Albini A, De Flora S: Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice. Int J Oncol 1998, 13:217-224
    • (1998) Int J Oncol , vol.13 , pp. 217-224
    • D'Agostini, F.1    Bagnasco, M.2    Giunciuglio, D.3    Albini, A.4    De Flora, S.5
  • 46
    • 0025192243 scopus 로고
    • Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice
    • Price JE, Polyzos A, Zhang RD, Daniels LM: Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice. Cancer Res 1990, 50:717-721
    • (1990) Cancer Res , vol.50 , pp. 717-721
    • Price, J.E.1    Polyzos, A.2    Zhang, R.D.3    Daniels, L.M.4
  • 48
    • 0023499529 scopus 로고
    • A simple quantitative assay for studying the invasive potential of high and low human metastatic variants
    • Hendrix MJ, Seftor EA, Seftor RE, Fidler IJ: A simple quantitative assay for studying the invasive potential of high and low human metastatic variants. Cancer Lett 1987, 38:137-147
    • (1987) Cancer Lett , vol.38 , pp. 137-147
    • Hendrix, M.J.1    Seftor, E.A.2    Seftor, R.E.3    Fidler, I.J.4
  • 51
    • 0034791260 scopus 로고    scopus 로고
    • Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression
    • Shih SC, Claffey KP: Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression. Growth Factors 2001, 19:19-34
    • (2001) Growth Factors , vol.19 , pp. 19-34
    • Shih, S.C.1    Claffey, K.P.2
  • 53
    • 0023265819 scopus 로고
    • Adapter plasmids simply the insertion of foreign DNA into helper-independent retroviral vectors
    • Hughes SH, Greenhouse JJ, Petropoulos CJ, Sutrave P: Adapter plasmids simply the insertion of foreign DNA into helper-independent retroviral vectors. J Virology 1987, 61:3004-3012
    • (1987) J Virology , vol.61 , pp. 3004-3012
    • Hughes, S.H.1    Greenhouse, J.J.2    Petropoulos, C.J.3    Sutrave, P.4
  • 54
    • 0034528886 scopus 로고    scopus 로고
    • Angiostatin and angiostatin-related proteins
    • Soff GA: Angiostatin and angiostatin-related proteins. Cancer Metastasis Rev 2000, 19:97-107
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 97-107
    • Soff, G.A.1
  • 55
    • 0032832479 scopus 로고    scopus 로고
    • Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance
    • O'Reilly MS, Wiederschain D, Stetler-Stevenson WG, Folkman J, Moses MA: Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. J Biol Chem 1999 274:29568-29571
    • (1999) J Biol Chem , vol.274 , pp. 29568-29571
    • O'Reilly, M.S.1    Wiederschain, D.2    Stetler-Stevenson, W.G.3    Folkman, J.4    Moses, M.A.5
  • 56
    • 0034007381 scopus 로고    scopus 로고
    • Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization
    • Pozzi A, Moberg PE, Miles LA, Wagner S, Soloway P, Gardner HA: Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Proc Natl Acad Sci USA 2000, 97:2202-2207
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2202-2207
    • Pozzi, A.1    Moberg, P.E.2    Miles, L.A.3    Wagner, S.4    Soloway, P.5    Gardner, H.A.6
  • 57
    • 0033902642 scopus 로고    scopus 로고
    • Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose
    • Woo OF, Mueller PD, Olson KR, Anderson IB, Kim SY: Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose. Ann Emerg Med 2000, 35:363-368
    • (2000) Ann Emerg Med , vol.35 , pp. 363-368
    • Woo, O.F.1    Mueller, P.D.2    Olson, K.R.3    Anderson, I.B.4    Kim, S.Y.5
  • 58
    • 1942542909 scopus 로고    scopus 로고
    • A prospective evaluation of abbreviated oral N-acetylcysteine (NAC) therapy for acetaminophen poisoning
    • Bird SB, Mazzola JL, Brush DE, Boyer EW, Aaron CK: A prospective evaluation of abbreviated oral N-acetylcysteine (NAC) therapy for acetaminophen poisoning. Acad Emerg Med 2003, 10:521
    • (2003) Acad Emerg Med , vol.10 , pp. 521
    • Bird, S.B.1    Mazzola, J.L.2    Brush, D.E.3    Boyer, E.W.4    Aaron, C.K.5
  • 59
    • 0030848490 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor
    • Mandriota SJ, Pepper MS: Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor. J Cell Sci 1997, 110:2293-2302
    • (1997) J Cell Sci , vol.110 , pp. 2293-2302
    • Mandriota, S.J.1    Pepper, M.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.