메뉴 건너뛰기




Volumn 108, Issue 2, 2004, Pages 181-188

NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells

Author keywords

Angiogenesis; Apoptosis; Metastasis; NF B; Pancreatic cancer

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LUCIFERASE; MESSENGER RNA; VASCULOTROPIN;

EID: 0348012946     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11562     Document Type: Article
Times cited : (111)

References (54)
  • 2
    • 0031934765 scopus 로고    scopus 로고
    • Role of growth factors in pancreatic cancer
    • Korc M. Role of growth factors in pancreatic cancer. Surg Oncol Clin N Am 1998;7:25-41.
    • (1998) Surg Oncol Clin N Am , vol.7 , pp. 25-41
    • Korc, M.1
  • 4
    • 0034094977 scopus 로고    scopus 로고
    • Molecular genetic alterations in ductal pancreatic adenocarcinomas
    • Kern SE. Molecular genetic alterations in ductal pancreatic adenocarcinomas. Med Clin N Am 2000;84:691-5.
    • (2000) Med Clin N Am , vol.84 , pp. 691-695
    • Kern, S.E.1
  • 5
    • 0030636257 scopus 로고    scopus 로고
    • Angiogenesis and angiogenesis inhibition: An overview
    • Folkman J. Angiogenesis and angiogenesis inhibition: an overview. EXS 1997;79:1-8.
    • (1997) EXS , vol.79 , pp. 1-8
    • Folkman, J.1
  • 6
    • 0027482251 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract
    • Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger DR, Dvorak HF. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res 1993;53:4727-35.
    • (1993) Cancer Res , vol.53 , pp. 4727-4735
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3    Tognazzi, K.4    Manseau, E.J.5    Senger, D.R.6    Dvorak, H.F.7
  • 7
    • 0030754056 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression
    • Itakura J, Ishiwata T, Friess H, Fujii H, Matsumoto Y, Buchler MW, Korc M. Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clin Cancer Res 1997;3:1309-16.
    • (1997) Clin Cancer Res , vol.3 , pp. 1309-1316
    • Itakura, J.1    Ishiwata, T.2    Friess, H.3    Fujii, H.4    Matsumoto, Y.5    Buchler, M.W.6    Korc, M.7
  • 8
    • 0035872399 scopus 로고    scopus 로고
    • Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma
    • Shi Q, Le X, Peng Z, Tang H, Xiong Q, Wang B, Li X-C, Abbruzzese JL, Xie K. Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res 2001;61:4143-54.
    • (2001) Cancer Res , vol.61 , pp. 4143-4154
    • Shi, Q.1    Le, X.2    Peng, Z.3    Tang, H.4    Xiong, Q.5    Wang, B.6    Li, X.-C.7    Abbruzzese, J.L.8    Xie, K.9
  • 9
    • 0032712997 scopus 로고    scopus 로고
    • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic
    • Shi Q, Abbruzzese JL, Huang S, Fidler IJ, Xiong Q, Xie K. Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res 1999;5:7234-43.
    • (1999) Clin Cancer Res , vol.5 , pp. 7234-7243
    • Shi, Q.1    Abbruzzese, J.L.2    Huang, S.3    Fidler, I.J.4    Xiong, Q.5    Xie, K.6
  • 10
    • 0034849755 scopus 로고    scopus 로고
    • Interleukin-8 and human cancer biology
    • Xie K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev 2001;12:375-391.
    • (2001) Cytokine Growth Factor Rev , vol.12 , pp. 375-391
    • Xie, K.1
  • 11
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WH, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-9.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.H.3    Goeddel, D.V.4    Ferrara, N.5
  • 12
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983;219:983-5.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 15
    • 0033623902 scopus 로고    scopus 로고
    • Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice
    • Huang S, DeGuzman A, Bucana CD, Fidler IJ. Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice. Clin Cancer Res 2000;6:2573-81.
    • (2000) Clin Cancer Res , vol.6 , pp. 2573-2581
    • Huang, S.1    DeGuzman, A.2    Bucana, C.D.3    Fidler, I.J.4
  • 16
    • 0034306969 scopus 로고    scopus 로고
    • Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8
    • Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ. Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 2000;60:5334-9.
    • (2000) Cancer Res , vol.60 , pp. 5334-5339
    • Huang, S.1    Robinson, J.B.2    Deguzman, A.3    Bucana, C.D.4    Fidler, I.J.5
  • 17
    • 0035927544 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
    • Shi Q, Le X, Wang B, Abbruzzese JL, Xiong Q, He Y, Xie K. Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Oncogene 2001;20:3751-6.
    • (2001) Oncogene , vol.20 , pp. 3751-3756
    • Shi, Q.1    Le, X.2    Wang, B.3    Abbruzzese, J.L.4    Xiong, Q.5    He, Y.6    Xie, K.7
  • 19
    • 0033549875 scopus 로고    scopus 로고
    • Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA
    • Wang W, Abbruzzese JL, Evans DB, Chiao PJ. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. Oncogene 1999;18:4554-63.
    • (1999) Oncogene , vol.18 , pp. 4554-4563
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Chiao, P.J.4
  • 20
    • 0037217892 scopus 로고    scopus 로고
    • Regulation of cancer metastasis by stress pathways
    • Xie K, Huang S. Regulation of cancer metastasis by stress pathways. Clin Exp Metastasis 2003;20:31-43.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 31-43
    • Xie, K.1    Huang, S.2
  • 21
    • 0037043125 scopus 로고    scopus 로고
    • Rel/NF-κB/IκB signal transduction in the generation and treatment of human cancer
    • Gilmore T, Gapuzan ME, Kalaitzidis D, Starczynowski D. Rel/NF-κB/IκB signal transduction in the generation and treatment of human cancer. Cancer Lett 2002;181:1-9.
    • (2002) Cancer Lett , vol.181 , pp. 1-9
    • Gilmore, T.1    Gapuzan, M.E.2    Kalaitzidis, D.3    Starczynowski, D.4
  • 22
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB Regulation in the Immune System
    • Li Q, Verma IM. NF-κB Regulation in the Immune System. Nat Rev Immunol 2002;2:725-34.
    • (2002) Nat Rev Immunol , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 23
  • 24
    • 0027332498 scopus 로고
    • The I kappa B proteins: Multifunctional regulators of Rel/NF-kappa B transcription factors
    • Beg AA, Baldwin AS Jr. The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors. Genes Dev 1993; (11):2064-70.
    • (1993) Genes Dev , Issue.11 , pp. 2064-2070
    • Beg, A.A.1    Baldwin Jr., A.S.2
  • 27
    • 0028986075 scopus 로고
    • Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
    • Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation. Science 1995;267:1485-8.
    • (1995) Science , vol.267 , pp. 1485-1488
    • Brown, K.1    Gerstberger, S.2    Carlson, L.3    Franzoso, G.4    Siebenlist, U.5
  • 28
    • 0028978032 scopus 로고
    • Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli
    • Traenckner EB, Pahl HL, Henkel T, Schmidt KN, Wilk S, Baeuerle PA. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. EMBO J 1995;14:2876-83.
    • (1995) EMBO J , vol.14 , pp. 2876-2883
    • Traenckner, E.B.1    Pahl, H.L.2    Henkel, T.3    Schmidt, K.N.4    Wilk, S.5    Baeuerle, P.A.6
  • 32
    • 0032479996 scopus 로고    scopus 로고
    • Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis
    • Huang S, Jean D, Luca M, Tainsky MA, Bar-Eli M. Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. EMBO J 1998;17:4358-69.
    • (1998) EMBO J , vol.17 , pp. 4358-4369
    • Huang, S.1    Jean, D.2    Luca, M.3    Tainsky, M.A.4    Bar-Eli, M.5
  • 33
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang S, Pettaway CA, Uehara H, Bucana CD, Fidler IJ. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 2001;20:4188-97.
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 34
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nat (Lond) 1992;359:843-5.
    • (1992) Nat (Lond) , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 35
    • 0033617532 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
    • Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 1999;284:808-12.
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1    Javaherian, K.2    Lo, K.M.3    Folkman, J.4    Hanahan, D.5
  • 36
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-inducible factor 1
    • Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002;64:993-8.
    • (2002) Biochem Pharmacol , vol.64 , pp. 993-998
    • Semenza, G.1
  • 38
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
    • Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991;266:11947-54.
    • (1991) J Biol Chem , vol.266 , pp. 11947-11954
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3    Silva, M.4    Gospodarowicz, D.5    Fiddes, J.C.6    Abraham, J.A.7
  • 39
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujiikuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997;94:4273-8.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujiikuriyama, Y.6
  • 40
    • 0343683375 scopus 로고    scopus 로고
    • HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels
    • Flamme I, Frohlich T, Vonreutern M, Kappel A, Damert A, Risau W. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. Mech Dev 1997;63:51-60.
    • (1997) Mech Dev , vol.63 , pp. 51-60
    • Flamme, I.1    Frohlich, T.2    Vonreutern, M.3    Kappel, A.4    Damert, A.5    Risau, W.6
  • 41
    • 0031869662 scopus 로고    scopus 로고
    • Translation of vascular endothelial growth factor mRNA by internal ribosome entry: Implications for translation under hypoxia
    • Stein I, Itin A, Einat P, Grossman Z, Keshet E. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol Biol Cell 1998;18:3112-9.
    • (1998) Mol Biol Cell , vol.18 , pp. 3112-3119
    • Stein, I.1    Itin, A.2    Einat, P.3    Grossman, Z.4    Keshet, E.5
  • 42
    • 0032537757 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription
    • Akiri G, Nahari D, Finkelstein Y, Le S, Elroy-Stein O, Levi B. Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription. Oncogene 1998;12:227-36.
    • (1998) Oncogene , vol.12 , pp. 227-236
    • Akiri, G.1    Nahari, D.2    Finkelstein, Y.3    Le, S.4    Elroy-Stein, O.5    Levi, B.6
  • 43
    • 0034595565 scopus 로고    scopus 로고
    • Mechanism of transforming growth factor-beta1-induced expression of vascular endothelial growth factor in murine osteoblastic
    • Chua CC, Hamdy RC, Chua BH. Mechanism of transforming growth factor-beta1-induced expression of vascular endothelial growth factor in murine osteoblastic. Biochim Biophys Acta 2000;1497:69-76.
    • (2000) Biochim Biophys Acta , vol.1497 , pp. 69-76
    • Chua, C.C.1    Hamdy, R.C.2    Chua, B.H.3
  • 44
    • 0034526135 scopus 로고    scopus 로고
    • Inhibition of NF kappa B activation by pyrrolidine dithiocarbamate prevents in vivo hypoxia/reoxygenation-mediated myocardial angiogenesis
    • Sasaki H, Zhu L, Fukuda S, Maulik N. Inhibition of NF kappa B activation by pyrrolidine dithiocarbamate prevents in vivo hypoxia/reoxygenation-mediated myocardial angiogenesis. Int J Tissue React 2000;22:93-100.
    • (2000) Int J Tissue React , vol.22 , pp. 93-100
    • Sasaki, H.1    Zhu, L.2    Fukuda, S.3    Maulik, N.4
  • 45
    • 0031009807 scopus 로고    scopus 로고
    • Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis
    • Yoshida S, Ono M, Shono T, Izumi H, Ishibashi T, Suzuki H, Kuwano M. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol 1997;17:4015-23.
    • (1997) Mol Cell Biol , vol.17 , pp. 4015-4023
    • Yoshida, S.1    Ono, M.2    Shono, T.3    Izumi, H.4    Ishibashi, T.5    Suzuki, H.6    Kuwano, M.7
  • 46
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999;13:9-22.
    • (1999) FASEB J , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 47
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 1999;5:119-27.
    • (1999) Clin Cancer Res , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 49
    • 0028129836 scopus 로고
    • Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
    • Vanmeir EG, Polverini PJ, Chazin VR, Detribolet N, Cavenee WK. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nat Genet 1994;8:171-6.
    • (1994) Nat Genet , vol.8 , pp. 171-176
    • Vanmeir, E.G.1    Polverini, P.J.2    Chazin, V.R.3    Detribolet, N.4    Cavenee, W.K.5
  • 50
    • 0027958348 scopus 로고
    • Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression
    • Kieser A, Welch HA, Brandner G, Marme D, Kolch W. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 1994;9:963-9.
    • (1994) Oncogene , vol.9 , pp. 963-969
    • Kieser, A.1    Welch, H.A.2    Brandner, G.3    Marme, D.4    Kolch, W.5
  • 52
    • 0033565217 scopus 로고    scopus 로고
    • Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo
    • Duffey DC, Chen Z, Dong G, Ondrey FG, Wolf JS, Brown K, Siebenlist U, Waes CV. Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. Cancer Res 1999;59:3468-74.
    • (1999) Cancer Res , vol.59 , pp. 3468-3474
    • Duffey, D.C.1    Chen, Z.2    Dong, G.3    Ondrey, F.G.4    Wolf, J.S.5    Brown, K.6    Siebenlist, U.7    Waes, C.V.8
  • 53
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    • Beg AA, Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 1996;274:782-4.
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.