N-acetylcysteine inhibits proliferation, adhesion, migration and invasion of human bladder cancer cells

Journal of the Medical Association of Thailand

Volumn 92, Issue 9, 2009, Pages 1171-1177

  Supabphol, Athikom ^a   Muangman, Verasing ^b   Chavasiri, Warinthorn ^c   Supabphol, Roongtawan ^d   Gritsanapan, Wandee ^e  

^a MAHIDOL UNIVERSITY   (Thailand)

^b Vichaiyut Hospital   (Thailand)

^c CHULALONGKORN UNIVERSITY   (Thailand)

^d SRINAKHARINWIROT UNIVERSITY   (Thailand)

^e MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Cell adhesion; Cell invasion; Cell migration; Cell proliferation; N acetylcysteine; Urinary bladder neoplasms

Indexed keywords

ACETYLCYSTEINE;

ARTICLE; BLADDER CANCER; CANCER CELL; CANCER GROWTH; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; IC 50; METASTASIS INHIBITION;

ACETYLCYSTEINE; CELL ADHESION; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; FREE RADICAL SCAVENGERS; HUMANS; NEOPLASM INVASIVENESS; URINARY BLADDER NEOPLASMS;

EID: 70349298417     PISSN: 01252208     EISSN: 01252208     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. U.S. National Center for Health Statistics, Health, United States, 2007.
2. Rukumnuaykit P. Mortality and causes of death in Thailand: Evidence from the survey of population change and death registration. Asia Pacific Pop J 2006; 21: 67-84.
3. Ratanawichitrasin A. Statistical report, 2007. Bangkok: Tumor Registry, Siriraj Cancer Center, Faculty of Medicine, Siriraj Hospital; 2007: 5.
4. Sriplung H. Urinary bladder. In: Khuhaprema T, Srivatanakul P, Sriplung H, Wiangnon S, Sumitsawan Y, Attasara P, edtors. Cancer in Thailand. Vol.IV, 1998-2000. Bangkok: National Cancer Institute, Ministry of Public Health, Thailand; 2007: 61-62
5. Ro JY, Staerkel GA, Ayala AG. Cytologic and histologic features of superficial bladder cancer. Urol Clin North Am 1992; 19: 435-453
6. Deneke SM. Thiol-based antioxidants. Curr Top Cell Regul 2000; 36: 151-180
7. Breitkreutz R, Pittack N, Nebe CT, Schuster D, Brust J, Beichert M, et al. Improvement of immune functions in HIV infection by sulfur supplementation: two randomized trials. J Mol Med 2000; 78: 55-62. (Pubitemid 30164439)
8. De Flora S, Izzotti A, D'Agostini F, Balansky RM. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 2001; 22: 999-1013. (Pubitemid 32633597)
9. Freshney R. Culture of animal cells. In: Freshney R, editor. A manual of basic technique. New York: Wiley-Liss; 2002: 296-298
10. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986; 89: 271-277 (Pubitemid 16080782)
11. Litynska A, Przybylo M, Pochec E, Laidler P. Adhesion properties of human bladder cell lines with extracellular matrix components: the role of integrins and glycosylation. Acta Biochim Pol 2002; 49: 643-650 (Pubitemid 135700590)
12. Price JT, Tiganis T, Agarwal A, Djakiew D, Thompson EW. Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism. Cancer Res 1999; 59: 5475-5478 (Pubitemid 29526460)
13. Albini A. Tumor and endothelial cell invasion of basement membranes. The matrigel chemoinvasion assay as a tool for dissecting molecular mechanisms. Pathol Oncol Res 1998; 4: 230-241
14. B□hle AS, Kalthoff H. Molecular mechanisms of tumor metastasis and angiogenesis. Langenbecks Arch Surg 1999; 384: 133-140 (Pubitemid 29227304)
15. Mareel M, Leroy A. Clinical, cellular, and molecular aspects of cancer invasion. Physiol Rev 2003; 83: 337-376 (Pubitemid 36382891)
16. Bogenrieder T, Herlyn M. Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 2003; 22: 6524-6536 (Pubitemid 37372332)
17. Sridharan S, Ramamurthy N, Devi CS. In vitro evaluation of the anticancer effect of N-acetylcysteine on oral carcinoma cell line. Indian J Pharmacol 2001; 33: 343-349
18. Ruoslahti E. The Walter Herbert Lecture. Control of cell motility and tumour invasion by extracellular matrix interactions. Br J Cancer 1992; 66: 239-242
19. Kornberg LJ. Focal adhesion kinase and its potential involvement in tumor invasion and metastasis. Head Neck 1998; 20: 745-752
20. Hamasaki T, Hattori T, Kimura G, Nakazawa N. Tumor progression and expression of matrix metalloproteinase-2 (MMP-2) mRNA by human urinary bladder cancer cells. Urol Res 1998; 26: 371-376 (Pubitemid 28566312)
21. Etienne-Manneville S. Polarity proteins in migration and invasion. Oncogene 2008; 27: 6970-6980
22. Sahai E. Mechanisms of cancer cell invasion. Curr Opin Genet Dev 2005; 15: 87-96.
23. Eccles SA, Welch DR. Metastasis: recent discoveries and novel treatment strategies. Lancet 2007; 369: 1742-1757 (Pubitemid 46755391)