Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging

Neuro-Oncology

Volumn 15, Issue 4, 2013, Pages 433-441

  Park, Jae Mo ^a,b   Recht, Lawrence D ^c   Josan, Sonal ^a,d   Merchant, Milton ^c   Jang, Taichang ^c   Yen, Yi Fen ^e   Hurd, Ralph E ^e   Spielman, Daniel M ^a,b   Mayer, Dirk ^a,d  

^a STANFORD UNIVERSITY   (United States)

^b Stanford University   (United States)

^c STANFORD UNIVERSITY   (United States)

^d SRI INTERNATIONAL   (United States)

^e GE HEALTHCARE   (United States)

Author keywords

Bicarbonate; Dichloroacetate; Glioma; Hyperpolarized 13C; Pyruvate

Indexed keywords

BICARBONATE; DICHLOROACETIC ACID; LACTIC ACID; PYRUVATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; ENZYME ACTIVITY; GLIOMA; IN VIVO STUDY; MALE; METABOLISM; MOLECULAR SIZE; NONHUMAN; RAT; SIGNAL NOISE RATIO;

ACETYL COENZYME A; ANIMALS; BRAIN; BRAIN NEOPLASMS; CARBON RADIOISOTOPES; DICHLOROACETIC ACID; GLIOMA; MAGNETIC RESONANCE IMAGING; MALE; MITOCHONDRIA; PROTEIN-SERINE-THREONINE KINASES; PYRUVATES; RATS; RATS, WISTAR; TUMOR CELLS, CULTURED;

EID: 84875753357     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nos319     Document Type: Article

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