Association of increased phosphatidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas

Journal of Neurosurgery

Volumn 95, Issue 3, 2001, Pages 480-488

  Kubiatowski, Tomas ^a   Jang, Taichang ^a   Lachyankar, Mahesh B ^a   Salmonsen, Rebecca ^a   Nabi, Roya R ^a   Quesenberry, Peter J ^a   Litofsky, N Scott ^a   Ross, Alonzo H ^a   Recht, Lawrence D ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Gelatinase; Glioblastoma multiforme; Lipid signaling pathway; Matrix metalloproteinase; Phosphatidylinositol 3 kinase phosphatase and tensin homolog; Tumor invasion

Indexed keywords

GELATINASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ARTICLE; CANCER INVASION; CARCINOGENESIS; CONTROLLED STUDY; DISEASE ASSOCIATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ZYMOGRAPHY;

EID: 0034866190     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2001.95.3.0480     Document Type: Article

References (62)

1. A rapid in vitro assay for quantitating the invasive potential of tumor cells
2. Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells
3. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
4. A retroviral oncogene, akt, encoding a serine-threonine kinase containing a SH2-like region
5. C6 glioma cell invasion and migration of rat brain after neural homografting: Ultrastructure
6. Topographic anatomy and CT correlations in the untreated glioblastoma multiforme
7. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
8. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
9. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
10. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
11. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
12. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN
13. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis
14. Resection, biopsy, and survival in malignant glial neoplasms. A retrospective study of clinical parameters, therapy, and outcomes
15. Downstream signalling events regulated by phosphatidylinositol 3-kinase activity
16. Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas
17. Phosphoinositide kinases
18. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G, growth arrest in glioma cells
19. Glioma invasion in the central nervous system
20. Individual C6 glioma cells migrate in adult rat brain after neural homografting
21. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
22. Genetic analysis of benign, low-grade, and high-grade ovarian tumors
23. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
24. Cdc42 and Rac 1 induce integrin-mediated cell motility and invasiveness through PI(3)K
25. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
26. DNA copy number amplifications in human neoplasms: Review of comparative genomic hybridization studies
27. Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion
28. Surgical resection and radiation therapy versus biopsy and radiation therapy in the treatment of glioblastoma multiforme
29. A role for nuclear PTEN in neuronal differentiation
30. Zymographic techniques for detection and characterization of microbial proteases
31. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces Gl cell cycle arrest in human glioblastoma cells
32. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
33. Malignant astrocytoma cell attachment and migration to various matrix proteins is differentially sensitive to phosphoinositide 3-OH kinase inhibitors
34. The tumor suppressor, PTEN/MMAC 1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate
35. Phosphoinositide lipids as signaling molecules: Common themes for signal transduction, cytoskeletal regulation, and membrane trafficking
36. Matrix metalloproteinase gene expression
37. Matrix metalloproteinases: Multifunctional contributors to tumor progression
38. Biology and biochemistry of proteinases in tumor invasion
39. Isolation of DNA sequences amplified at chromosome 19q 13. 1-q13.2 including the AKT2 locus in human pancreatic cancer
40. Invasiveness of tumors of the central nervous system
41. Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-I by human brain tumors
42. Mecham RP (eds). San Diego: Academic Press
43. Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix matalloproteinase inhibitor, AG3340
44. Elevated levels of Mr 92,000 Type IV collagenase in human brain tumors
45. Expression and localization of 92 kDa type IV collagenase/gelatinase B (MMP-9) in human gliomas
46. Comparative analysis of matrix metalloproteinases by immunocytochemistry, immunohistochemistry and zymography in human primary brain tumors
47. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials
48. Activation of phosphoinositide 3-OH kinase by the a6b4 integrin promotes carcinoma invasion
49. PIK3CA is implicated as an oncogene in ovarian cancer
50. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
51. Identification of a candidate tumour suppressor gene, MMAC/PTEN, at chromosome 10q23.3 that is mutated in multiple advanced cancers
52. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-triphosphate and Akt/protein kinase B signaling pathway
53. Cas
54. Epidermal growth factor receptor-regulated human bladder cancer motility is in part a phosphatidylinolsitol 3-kinase-mediated process
55. Signalling through the lipid products of phosphoinositide-3-OH kinase
56. Glioma invasion in vitro: Regulation by matrix metalloprotease-2 and protein kinase C
57. Mechanisms of glioma invasion: Role of matrix-metalloproteinases
58. General protease and collagenase (IV) activity in C6 astrocytoma cells, C6 spheroids and implanted C6 spheroids
59. Quantitation of matrix metalloproteinases in cultured rat astrocytes using the polymerase chain reaction with a multi-competitor cDNA standard
60. Glioma cells release excitotoxic concentrations of glutamate
61. Matrix metalloproteinases and diseases of the CNS