In vivo MRSI of hyperpolarized [1-13C]pyruvate metabolism in rat hepatocellular carcinoma

NMR in Biomedicine

Volumn 24, Issue 5, 2011, Pages 506-513

  Darpolor, Moses M ^a   Yen, Yi Fen ^b   Chua, Mei Sze ^a   Xing, Lei ^a   Clarke Katzenberg, Regina H ^a   Shi, Wenfang ^a   Mayer, Dirk ^a,c   Josan, Sonal ^a,c   Hurd, Ralph E ^b   Pfefferbaum, Adolf ^c   Senadheera, Lasitha ^a   So, Samuel ^a   Hofmann, Lawrence V ^a   Glazer, Gary M ^a   Spielman, Daniel M ^a  

^a STANFORD UNIVERSITY   (United States)

^b GE HEALTHCARE   (United States)

^c SRI INTERNATIONAL   (United States)

Author keywords

1 13C pyruvate; Alanine transaminase; Hepatocellular carcinoma; Hyperpolarized three dimensional 13C MRSI

Indexed keywords

ALANINE TRANSAMINASE; CELLULAR METABOLISM; DINUCLEOTIDES; HEPATOCELLULAR CARCINOMA; HISTOPATHOLOGICAL ANALYSIS; HYPERPOLARIZED; IN-VIVO; INTRAVENOUS INJECTIONS; LACTATE DEHYDROGENASE; LIVER TISSUE; METABOLIC FATE; MRNA LEVEL; NICOTINAMIDE ADENINE; ORTHOTOPIC; PYRUVATE METABOLISM; PYRUVATES; QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION; RAT LIVERS; SURVIVAL RATE;

AMIDES; AMINO ACIDS; DIAGNOSIS; METABOLISM; PATIENT TREATMENT; PHYSIOLOGY; POLYMERASE CHAIN REACTION; THREE DIMENSIONAL; TUMORS;

RATS;

ALANINE AMINOTRANSFERASE; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE ISOENZYME 5; PYRUVIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BOLUS INJECTION; CANCER GROWTH; CARBON NUCLEAR MAGNETIC RESONANCE; CELL METABOLISM; HISTOPATHOLOGY; HYPERPOLARIZATION; IN VIVO STUDY; LIVER CELL CARCINOMA; LIVER METABOLISM; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; THREE DIMENSIONAL IMAGING;

ALANINE; ANIMALS; CARBON ISOTOPES; CARCINOMA, HEPATOCELLULAR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LACTIC ACID; LIVER NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; PYRUVIC ACID; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS; RATTUS NORVEGICUS;

EID: 79958856364     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1616     Document Type: Article

References (33)

1. Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J. Clin. Oncol. 2009; 27: 1485-1491.
2. Warburg O, Posener K, Negelein E. Uber den Stoffwechsel der Carcinomzelle. Biochem. Z. 1924; 152: 309-344.
3. Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell, 2006; 9: 425-434.
4. DeBerardinis RJ. Is cancer a disease of abnormal cellular metabolism? New angles on a old idea. Genet. Med. 2008; 10: 767-777.
5. Plathow C, Weber WA. Tumor cell metabolism imaging. J. Nucl. Med. 2008; 49: 43S-63S.
6. Hirayama A, Kami K, Sugimoto M, Sugawara M, Toki N, Onozuka H, Kinoshita T, Saito N, Ochiai A, Tomita M, Esumi H, Soga T. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 2009; 69: 4918-4925.
7. Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K. Increase in signal-to-noise ratio of >10, 000 times in liquid-state NMR. Proc. Natl. Acad. Sci. USA, 2003; 100: 10, 158-10, 163.
8. 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res. 2006; 66: 10, 855-10, 860.
9. Chen AP, Albers MJ, Cunningham CH, Kohler SJ, Yen Y-F, Hurd RE, Tropp J, Bok R, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T - initial experience. Magn. Reson. Med. 2007; 58: 1099-1106.
10. 13C magnetic resonance imaging and spectroscopy. Nat. Med. 2007; 13: 1382-1387.
11. 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res. 2008; 68: 8607-8615.
12. 13C magnetic resonance spectroscopy. Cancer Res. 2010; 70: 1296-1305.
13. 13C]lactate in a murine lymphoma. Magn. Reson. Med. 2010; 63: 872-880.
14. 13C]pyruvate. NMR Biomed. 2010; 23: 414-423.
15. 13C-labelled bicarbonate. Nature, 2008; 453: 940-943.
16. 13C]fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J. Am. Chem. Soc. 2009; 131: 17, 591-17, 596.
17. 2]fumarate is a marker of cell necrosis and treatment response in tumors. Proc. Natl. Acad. Sci. USA, 2009; 106: 19, 801-19, 806.
18. 13C ketoisocaproate. Int. J. Cancer, 2010; 127: 729-736.
19. 13C-pyruvate. Mol. Imag. Biol. 2009; 11: 399-407.
20. 13C]pyruvate. Magn. Reson. Med. 2009; 62: 307-313.
21. Shonk CE, Morris HP, Boxer GE. Patterns of glycolytic enzymes in rat liver and hepatoma. Cancer Res. 1965; 25: 671-676.
22. 6 on the in vitro inactivation of rat tyrosine aminotransferase in host and Morris hepatomas. Cancer Res. 1979; 39: 2988-2994.
23. Euhus DM, Hudd C, LaRegina MC, Johnson FE. Tumor measurement in the nude mouse. J. Surg. Oncol. 1986; 31: 229-234.
24. 13C-pyruvate. Magn. Reson. Med. 2009; 62: 1-10.
25. Lee C, Simard-Duquesne N, Ernster L, Hoberman H. Stereochemistry of hydrogen-transfer in the energy-linked pyridine nucleotide transhydrogenase and related reactions. Biochim. Biophys. Acta, 1965; 105: 397-409.
26. Li R, Bianchet MA, Talalay P, Amzel LM. The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction. Proc. Natl. Acad. Sci. USA, 1995; 92: 8846-8850.
27. Aleksunes LM, Goedken M, Manautou JE. Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury. World J. Gastroenterol. 2006; 12: 1937-1940.
28. Arizono K, Sugiura S, Miyazato S, Takiguchi M, Ariyoshi T. DT-diaphorase induction by lead acetate in the liver of rats. Bull. Environ. Contam. Toxicol. 1996; 57: 41-46.
29. Winski SL, Koutalos Y, Bentley DL, Ross D. Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells. Cancer Res. 2002; 62: 1420-1424.
30. Asher G, Lotem J, Cohen B, Sachs L, Shaul Y. Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc. Natl. Acad. Sci. USA, 2001; 98: 1188-1193.
31. Tsvetkov P, Asher G, Reiss V, Shaul Y, Sachs L, Lotem J. Inbition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin. Proc. Natl. Acad. Sci. USA, 2005; 102: 5535-5540.
32. Sparkes RS, Weiss MC. Expression of differentiated functions in hepatoma cell hybrids: alanine aminotransferase. Proc. Natl. Acad. Sci. USA, 1973; 70: 377-381.
33. Fields ALA, Wolman SL, Cheema-Dhadli S, Morris HP, Halperin ML. Regulation of energy metabolism in Morris hepatoma 7777 and 7800. Cancer Res. 1981; 41: 2762-2766.