In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate

Journal of Magnetic Resonance

Volumn 206, Issue 2, 2010, Pages 210-218

  Marjańska, Małgorzata ^a   Iltis, Isabelle ^a   Shestov, Alexander A ^a   Deelchand, Dinesh K ^a   Nelson, Christopher ^a   Uurbil, Kâmil ^a   Henry, Pierre Gilles ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Bicarbonate; DNP; Lactate; Pyruvate; Time courses

Indexed keywords

BICARBONATE; DNP; LACTATE; PYRUVATES; TIME COURSE;

METABOLISM;

RATTUS;

BICARBONATE; CARBON; LACTIC ACID; PYRUVIC ACID; RADIOPHARMACEUTICAL AGENT;

ALGORITHM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; BRAIN; CHEMISTRY; COMPUTER SIMULATION; ISOTOPE LABELING; MALE; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SPRAGUE DAWLEY RAT; SYNTHESIS;

ALGORITHMS; ANIMALS; BICARBONATES; BRAIN; CARBON ISOTOPES; COMPUTER SIMULATION; ISOTOPE LABELING; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, BIOLOGICAL; PYRUVIC ACID; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77957942042     PISSN: 10907807     EISSN: 10960856     Source Type: Journal    
DOI: 10.1016/j.jmr.2010.07.006     Document Type: Article

References (69)

1. 13C NMR studies of compartmentalized cerebral carbohydrate metabolism Neurochem. Int. 41 2002 143 154
2. 129Xe using low temperatures and high magnetic fields J. Low Temp. Phys. 111 1998 521 532
3. 3He gas induced by optical pumping and dipolar exchange Phys. Rev. Lett. 5 1960 373 375
4. B.C. Grover Noble-gas NMR detection through noble-gas-rubidium hyperfine contact interaction Phys. Rev. Lett. 40 1978 391 392
5. C.R. Bowers, and D.P. Weitekamp Transformation of symmetrization order to nuclear-spin magnetization by chemical reaction and nuclear magnetic resonance Phys. Rev. Lett. 57 1986 2645 2648
6. M. Haake, J. Natterer, and J. Bargon Efficient NMR pulse sequences to transfer the parahydrogen-induced polarization to hetero nuclei J. Am. Chem. Soc. 118 1996 8688 8691
7. 13C angiography Magn. Reson. Med. 46 2001 1 5
8. C.R. Bowers, and D.P. Weitekamp Para-hydrogen and synthesis allow dramatically enhanced nuclear alignment J. Am. Chem. Soc. 109 1987 5541 5542
9. A. Abragam, and M. Goldman Principles of dynamic nuclear-polarization Rep. Prog. Phys. 41 1978 395 467
10. M. Goldman Spin Temperature and Nuclear Magnetic Resonance in Solids 1970 Oxford University Press Oxford
11. J.H. Ardenkjaer-Larsen, B. Fridlund, A. Gram, G. Hansson, L. Hansson, M.H. Lerche, R. Servin, M. Thaning, and K. Golman Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR Proc. Natl. Acad. Sci. U. S. A. 100 2003 10158 10163
12. J. Wolber, F. Ellner, B. Fridlund, A. Gram, H. Johannesson, G. Hansson, L.H. Hansson, M.H. Lerche, S. Mansson, R. Servin, M. Thaning, K. Golman, and J.H. Ardenkjaer-Larsen Generating highly polarized nuclear spins in solution using dynamic nuclear polarization Nucl. Instrum. Methods. A 526 2004 173 181
13. 13C in vivo Magn. Reson. Mater. Phys., Biol. Med. 18 2005 245 256
14. 13C Br. J. Radiol. 76 SP2 2003 S118 S127
15. E. Johansson, L.E. Olsson, S. Mansson, J.S. Petersson, K. Golman, F. Stahlberg, and R. Wirestam Perfusion assessment with bolus differentiation: a technique applicable to hyperpolarized tracers Magn. Reson. Med. 52 2004 1043 1051 (Pubitemid 39453277)
16. 13C through order transfer from parahydrogen: a new contrast agent for MRI Magn. Reson. Imaging 23 2005 153 157
17. 13C imaging-a new diagnostic platform Eur. Radiol. 16 2006 57 67
18. 13C substance Magn. Reson. Med. 55 2006 731 737
19. 13C MRI of the pulmonary vasculature and parenchyma Magn. Reson. Med. 57 2007 459 463
20. 13C-angiography Acad. Radiol. 9 2002 S507 S510
21. K. Golman, J.H. Ardenaer-Larsen, J.S. Petersson, S. Mansson, and I. Leunbach Molecular imaging with endogenous substances Proc. Natl. Acad. Sci. U. S. A. 100 2003 10435 10439
22. 13C MR angiography using TrueFISP Magn. Reson. Med. 50 2003 256 262
23. 13C Magn. Reson. Med. 51 2004 464 472 (Pubitemid 38298658)
24. 13C Acad. Radiol. 13 2006 932 942
25. K. Golman, R. in't Zandt, and M. Thaning Real-time metabolic imaging Proc. Natl. Acad. Sci. U. S. A. 103 2006 11270 11275
26. 13C magnetic resonance imaging for in vivo tumor diagnosis Cancer Res. 66 2006 10855 10860
27. 13C J. Magn. Reson. 187 2007 357 362
28. 13C-1-pyruvate Magn. Reson. Med. 58 2007 65 69
29. M.A. Schroeder, L.E. Cochlin, L.C. Heather, K. Clarke, G.K. Radda, D.J. Tyler, and R.G. Shulman In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance Proc. Natl. Acad. Sci. U. S. A. 105 2008 12051 12056
30. D.J. Tyler, M.A. Schroeder, L.E. Cochlin, K. Clarke, and G.K. Radda Application of hyperpolarized magnetic resonance in the study of cardiac metabolism Appl. Magn. Reson. 34 2008 523 531
31. A.P. Chen, M.J. Albers, C.H. Cunningham, S.J. Kohler, Y.F. Yen, R.E. Hurd, J. Tropp, R. Bok, J.M. Pauly, S.J. Nelson, J. Kurhanewicz, and D.B. Vigneron Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience Magn. Reson. Med. 58 2007 1099 1106
32. 13C magnetic resonance imaging and spectroscopy Nat. Med. 13 2007 1521
33. 13C flyback 3D-MRSI J. Magn. Reson. 192 2008 258 264
34. 13C MRI Magn. Reson. Med. 59 2008 1005 1013
35. 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR Proc. Natl. Acad. Sci. U. S. A. 104 2007 19773 19777
36. 13 Magn. Reson. Med. 60 2008 1029 1036
37. M.A. Schroeder, H.J. Atherton, D.R. Ball, M.A. Cole, L.C. Heather, J.L. Griffin, K. Clarke, G.K. Radda, and D.J. Tyler Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy FASEB J. 2009
38. 13C MRSI studies Magn. Reson. Imaging 26 2008 721 726
39. 13C-labelled bicarbonate Nature 453 2008 940 973
40. 1-acetate Int. Soc. Magn. Reson. Med., Toronto 90 2008 892
41. 13C-labeled glutamine Magn. Reson. Med. 60 2008 253 257
42. G. Adriany, and R. Gruetter A half-volume coil for efficient proton decoupling in humans at 4 tesla J. Magn. Reson. 125 1997 178 184
43. R. Gruetter Automatic, localized in vivo adjustment of all first- and second-order shim coils Magn. Reson. Med. 29 1993 804 811
44. R. Gruetter, and I. Tkac Field mapping without reference scan using asymmetric echo-planar techniques Magn. Reson. Med. 43 2000 319 323
45. M. Garwood, and Y. Ke Symmetric pulses to induce arbitrary flip angles with compensation for RF inhomogeneity and resonance offsets J. Magn. Reson. 94 1991 511 525
46. M. Garwood, and L. DelaBarre The return of the frequency sweep: designing adiabatic pulses for contemporary NMR J. Magn. Reson. 153 2001 155 177
47. A.J. Shaka, J. Keeler, T. Frenkiel, and R. Freeman An improved sequence for broad-band decoupling-Waltz-16 J. Magn. Reson. 52 1983 335 338
48. F. Hyder, A.B. Patel, A. Gjedde, D.L. Rothman, K.L. Behar, and R.G. Shulman Neuronal-glial glucose oxidation and glutamatergic-GABAergic function J. Cereb. Blood Flow Metab. 26 2006 865 877
49. 13C saturation transfer effect of the lactate dehydrogenase reaction Magn. Reson. Med. 57 2007 258 264
50. S.V. Gonzalez, N.H. Nguyen, F. Rise, and B. Hassel Brain metabolism of exogenous pyruvate J. Neurochem. 95 2005 284 293
51. D.K. Deelchand, A.A. Shestov, D.M. Koski, K. Ugurbil, and P.G. Henry Acetate transport and utilization in the rat brain J. Neurochem. 109 Suppl. 1 2009 46 54
52. 1H NMR spectra of the rat brain J. Magn. Reson. 141 1999 104 120
53. 2, lactate, and pyruvate in brain biopsies taken after freezing the tissue in situ Acta Neurol. Scand. 46 1970 141 148
54. G. Ahlborg, P. Felig, L. Hagenfeldt, R. Hendler, and J. Wahren Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids J. Clin. Invest. 53 1974 1080 1090
55. A.R. Panchal, B. Comte, H. Huang, T. Kerwin, A. Darvish, C. des Rosiers, H. Brunengraber, and W.C. Stanley Partitioning of pyruvate between oxidation and anaplerosis in swine hearts Am. J. Physiol. Heart Circ. Physiol. 279 2000 H2390 H2398
56. R.L. Veech, R.L. Harris, D. Veloso, and E.H. Veech Freeze-blowing: a new technique for the study of brain in vivo J. Neurochem. 20 1973 183 188
57. C.T. Putman, N.L. Jones, E. Hultman, M.G. Hollidge-Horvat, A. Bonen, D.R. McConachie, and G.J. Heigenhauser Effects of short-term submaximal training in humans on muscle metabolism in exercise Am. J. Physiol. 275 1998 E132 E139
58. 2, and pH during and after hypoxic, ischemic brain insult in dogs Crit. Care Med. 24 1996 1858 1868
59. J.L. Hall, G.D. Lopaschuk, A. Barr, J. Bringas, R.D. Pizzurro, and W.C. Stanley Increased cardiac fatty acid uptake with dobutamine infusion in swine is accompanied by a decrease in malonyl CoA levels Cardiovasc. Res. 32 1996 879 885
60. B.D. Guth, J.A. Wisneski, R.A. Neese, F.C. White, G. Heusch, C.D. Mazer, and E.W. Gertz Myocardial lactate release during ischemia in swine. Relation to regional blood flow Circulation 81 1990 1948 1958
61. 13C NMR studies in perfused rat hearts J. Biol. Chem. 258 1983 13785 13794
62. J.A. Romijn, D.L. Chinkes, J.M. Schwarz, and R.R. Wolfe Lactate-pyruvate interconversion in blood: implications for in vivo tracer studies Am. J. Physiol. 266 1994 E334 E340
63. R. Gruetter, E.R. Seaquist, and K. Ugurbil A mathematical model of compartmentalized neurotransmitter metabolism in the human brain Am. J. Physiol. Endocrinol. Metab. 281 2001 E100 E112
64. D.L. Chinkes, X.J. Zhang, J.A. Romijn, Y. Sakurai, and R.R. Wolfe Measurement of pyruvate and lactate kinetics across the hindlimb and gut of anesthetized dogs Am. J. Physiol. 267 1994 E174 E182
65. S. Broer, H.P. Schneider, A. Broer, B. Rahman, B. Hamprecht, and J.W. Deitmer Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH Biochem. J. 333 Pt. 1 1998 167 174
66. 13C]bicarbonate washout kinetics Am. J. Physiol. 259 1990 R163 R171
67. A.P. Halestrap, and A.E. Armston A re-evaluation of the role of mitochondrial pyruvate transport in the hormonal control of rat liver mitochondrial pyruvate metabolism Biochem. J. 223 1984 677 685
68. J.E. Salem, M.E. Cabrera, M.P. Chandler, T.A. McElfresh, H. Huang, J.P. Sterk, and W.C. Stanley Step and ramp induction of myocardial ischemia: comparison of in vivo and in silico results J. Physiol. Pharmacol. 55 2004 519 536
69. H.B. Lee, and M.D. Blaufox Blood volume in the rat J. Nucl. Med. 26 1985 72 76