메뉴 건너뛰기




Volumn 32, Issue 8, 2012, Pages 1508-1514

Imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized 13 C Magnetic Resonance Spectroscopic Imaging

Author keywords

13C; BCAT; hyperpolarization; magnetic resonance; metabolism

Indexed keywords

2 OXOISOCAPROIC ACID; AMINOTRANSFERASE; BICARBONATE; LACTATE DEHYDROGENASE; LACTIC ACID; LEUCINE; PYRUVIC ACID;

EID: 84864572382     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.34     Document Type: Article
Times cited : (31)

References (47)
  • 2
    • 0029990892 scopus 로고    scopus 로고
    • Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
    • Bittar PG, Charnay Y, Pellerin L, Bouras C, Magistretti PJ (1996) Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J Cereb Blood Flow Metab 16:1079-89
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 1079-1089
    • Bittar, P.G.1    Charnay, Y.2    Pellerin, L.3    Bouras, C.4    Magistretti, P.J.5
  • 3
    • 0039351371 scopus 로고    scopus 로고
    • Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes
    • Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW (1999) Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J 341(Part 3):529-35
    • (1999) Biochem J , vol.341 , Issue.PART 3 , pp. 529-535
    • Broer, S.1    Broer, A.2    Schneider, H.P.3    Stegen, C.4    Halestrap, A.P.5    Deitmer, J.W.6
  • 4
    • 33846595684 scopus 로고    scopus 로고
    • Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain
    • Castellano S, Casarosa S, Sweatt AJ, Hutson SM, Bozzi Y (2007) Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain. Gene Expr Patterns 7:485-90
    • (2007) Gene Expr Patterns , vol.7 , pp. 485-490
    • Castellano, S.1    Casarosa, S.2    Sweatt, A.J.3    Hutson, S.M.4    Bozzi, Y.5
  • 6
    • 0018287463 scopus 로고
    • Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats
    • Cremer JE, Cunningham VJ, Pardridge WM, Braun LD, Oldendorf WH (1979) Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats. J Neurochem 33:439-45
    • (1979) J Neurochem , vol.33 , pp. 439-445
    • Cremer, J.E.1    Cunningham, V.J.2    Pardridge, W.M.3    Braun, L.D.4    Oldendorf, W.H.5
  • 8
    • 0034663601 scopus 로고    scopus 로고
    • The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
    • Dimmer KS, Friedrich B, Lang F, Deitmer JW, Broer S (2000) The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J 350(Pt 1):219-27
    • (2000) Biochem J , vol.350 , Issue.PART 1 , pp. 219-227
    • Dimmer, K.S.1    Friedrich, B.2    Lang, F.3    Deitmer, J.W.4    Broer, S.5
  • 9
    • 0035089452 scopus 로고    scopus 로고
    • Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures
    • Erakovic V, Zupan G, Varljen J, Laginja J, Simonic A (2001) Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures. Epilepsia 42: 181-9
    • (2001) Epilepsia , vol.42 , pp. 181-189
    • Erakovic, V.1    Zupan, G.2    Varljen, J.3    Laginja, J.4    Simonic, A.5
  • 10
    • 33847709986 scopus 로고    scopus 로고
    • Widespread neuronal expression of branchedchain aminotransferase in the CNS: Implications for leucine/glutamate metabolism and for signaling by amino acids
    • Garcia-Espinosa MA, Wallin R, Hutson SM, Sweatt AJ (2007) Widespread neuronal expression of branchedchain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids. J Neurochem 100:1458-68
    • (2007) J Neurochem , vol.100 , pp. 1458-1468
    • Garcia-Espinosa, M.A.1    Wallin, R.2    Hutson, S.M.3    Sweatt, A.J.4
  • 12
    • 33845292936 scopus 로고    scopus 로고
    • Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis
    • Golman K, Zandt RI, Lerche M, Pehrson R, Ardenkjaer-Larsen JH (2006) Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res 66:10855-60
    • (2006) Cancer Res , vol.66 , pp. 10855-10860
    • Golman, K.1    Zandt, R.I.2    Lerche, M.3    Pehrson, R.4    Ardenkjaer-Larsen, J.H.5
  • 14
    • 78649630375 scopus 로고    scopus 로고
    • Lactate levels in the brain are elevated upon exposure to volatile anesthetics: A microdialysis study
    • Horn T, Klein J (2010) Lactate levels in the brain are elevated upon exposure to volatile anesthetics: a microdialysis study. Neurochem Int 57:940-7
    • (2010) Neurochem Int , vol.57 , pp. 940-947
    • Horn, T.1    Klein, J.2
  • 16
    • 77957702064 scopus 로고    scopus 로고
    • Cerebral dynamics and metabolism of hyperpolarized 1-(13)Cpyruvate using time-resolved MR spectroscopic imaging
    • Hurd RE, Yen YF, Tropp J, Pfefferbaum A, Spielman DM, Mayer D (2010b) Cerebral dynamics and metabolism of hyperpolarized 1-(13)Cpyruvate using time-resolved MR spectroscopic imaging. J Cereb Blood Flow Metab 30:1734-41
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1734-1741
    • Hurd, R.E.1    Yen, Y.F.2    Tropp, J.3    Pfefferbaum, A.4    Spielman, D.M.5    Mayer, D.6
  • 17
    • 0035233080 scopus 로고    scopus 로고
    • Structure and function of branched chain aminotransferases
    • Hutson S (2001) Structure and function of branched chain aminotransferases. Prog Nucleic Acid Res Mol Biol 70: 175-206
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.70 , pp. 175-206
    • Hutson, S.1
  • 18
    • 0029584470 scopus 로고
    • Cloning and expression of the mammalian cytosolic branched chain aminotransferase isoenzyme
    • Hutson SM, Bledsoe RK, Hall TR, Dawson PA (1995) Cloning and expression of the mammalian cytosolic branched chain aminotransferase isoenzyme. J Biol Chem 270:30344-52
    • (1995) J Biol Chem , vol.270 , pp. 30344-30352
    • Hutson, S.M.1    Bledsoe, R.K.2    Hall, T.R.3    Dawson, P.A.4
  • 19
    • 0023270663 scopus 로고
    • Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone
    • Hyman BT, Van Hoesen GW, Damasio AR (1987) Alzheimer's disease: glutamate depletion in the hippocampal perforant pathway zone. Ann Neurol 22:37-40
    • (1987) Ann Neurol , vol.22 , pp. 37-40
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3
  • 22
    • 0027305798 scopus 로고
    • Analysis of femtomole concentrations of alpha-ketoisocaproic acid in brain tissue by precolumn fluorescence derivatization with 4,5-dimethoxy-1,2- diaminobenzene
    • Keen RE, Nissenson CH, Barrio JR (1993) Analysis of femtomole concentrations of alpha-ketoisocaproic acid in brain tissue by precolumn fluorescence derivatization with 4,5-dimethoxy-1,2-diaminobenzene. Anal Biochem 213:23-8
    • (1993) Anal Biochem , vol.213 , pp. 23-28
    • Keen, R.E.1    Nissenson, C.H.2    Barrio, J.R.3
  • 24
    • 0034097103 scopus 로고    scopus 로고
    • Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain
    • Laughton JD, Charnay Y, Belloir B, Pellerin L, Magistretti PJ, Bouras C (2000) Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain. Neuroscience 96:619-25
    • (2000) Neuroscience , vol.96 , pp. 619-625
    • Laughton, J.D.1    Charnay, Y.2    Belloir, B.3    Pellerin, L.4    Magistretti, P.J.5    Bouras, C.6
  • 27
    • 79954576631 scopus 로고    scopus 로고
    • Dynamic and high-resolution metabolic imaging of hyperpolarized 1-(13)C-pyruvate in the rat brain using a high-performance gradient insert
    • Mayer D, Yen YF, Takahashi A, Josan S, Tropp J, Rutt BK, Hurd RE, Spielman DM, Pfefferbaum A (2011) Dynamic and high-resolution metabolic imaging of hyperpolarized 1-(13)C-pyruvate in the rat brain using a high-performance gradient insert. Magn Reson Med 65:1228-33
    • (2011) Magn Reson Med , vol.65 , pp. 1228-1233
    • Mayer, D.1    Yen, Y.F.2    Takahashi, A.3    Josan, S.4    Tropp, J.5    Rutt, B.K.6    Hurd, R.E.7    Spielman, D.M.8    Pfefferbaum, A.9
  • 30
    • 33947608441 scopus 로고    scopus 로고
    • Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons
    • O'Brien J, Kla KM, Hopkins IB, Malecki EA, McKenna MC (2007) Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons. Neurochem Res 32:597-607
    • (2007) Neurochem Res , vol.32 , pp. 597-607
    • O'Brien, J.1    Kla, K.M.2    Hopkins, I.B.3    Malecki, E.A.4    McKenna, M.C.5
  • 31
    • 23444445363 scopus 로고    scopus 로고
    • How astrocytes feed hungry neurons
    • Pellerin L (2005) How astrocytes feed hungry neurons. Mol Neurobiol 32:59-72
    • (2005) Mol Neurobiol , vol.32 , pp. 59-72
    • Pellerin, L.1
  • 32
    • 12244262261 scopus 로고    scopus 로고
    • Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
    • Pellerin L, Bergersen LH, Halestrap AP, Pierre K (2005) Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. J Neurosci Res 79:55-64
    • (2005) J Neurosci Res , vol.79 , pp. 55-64
    • Pellerin, L.1    Bergersen, L.H.2    Halestrap, A.P.3    Pierre, K.4
  • 35
    • 33746620085 scopus 로고    scopus 로고
    • A stereotaxic MRI template set for the rat brain with tissue class distribution maps and co-registered anatomical atlas: Application to pharmacological MRI
    • Schwarz AJ, Danckaert A, Reese T, Gozzi A, Paxinos G, Watson C, Merlo-Pich EV, Bifone A (2006) A stereotaxic MRI template set for the rat brain with tissue class distribution maps and co-registered anatomical atlas: application to pharmacological MRI. NeuroImage 32: 538-50
    • (2006) NeuroImage , vol.32 , pp. 538-550
    • Schwarz, A.J.1    Danckaert, A.2    Reese, T.3    Gozzi, A.4    Paxinos, G.5    Watson, C.6    Merlo-Pich, E.V.7    Bifone, A.8
  • 36
    • 0020561445 scopus 로고
    • Fetal fuels VI. Metabolism of alpha-ketoisocaproic acid in fetal rat brain
    • Shambaugh III GE, Koehler RA (1983) Fetal fuels VI. Metabolism of alpha-ketoisocaproic acid in fetal rat brain. Metabolism 32:421-7
    • (1983) Metabolism , vol.32 , pp. 421-427
    • Shambaugh Iii, G.E.1    Koehler, R.A.2
  • 37
    • 0022504397 scopus 로고
    • Blood-brain barrier transport of the alpha-keto acid analogs of amino acids
    • Steele RD (1986) Blood-brain barrier transport of the alpha-keto acid analogs of amino acids. Fed Proc 45: 2060-4
    • (1986) Fed Proc , vol.45 , pp. 2060-2064
    • Steele, R.D.1
  • 39
    • 4444293612 scopus 로고    scopus 로고
    • Branched-chain amino acids and neurotransmitter metabolism: Expression of cytosolic branched-chain aminotransferase (BCATc) in the cerebellum and hippocampus
    • Sweatt AJ, Garcia-Espinosa MA, Wallin R, Hutson SM (2004) Branched-chain amino acids and neurotransmitter metabolism: expression of cytosolic branched-chain aminotransferase (BCATc) in the cerebellum and hippocampus. J Comp Neurol 477:360-70
    • (2004) J Comp Neurol , vol.477 , pp. 360-370
    • Sweatt, A.J.1    Garcia-Espinosa, M.A.2    Wallin, R.3    Hutson, S.M.4
  • 40
    • 84861234142 scopus 로고    scopus 로고
    • Cardiovascular applications of hyperpolarized MRI
    • Tyler DJ (2011) Cardiovascular applications of hyperpolarized MRI. Curr Cardiovasc Imaging Rep 4:108-15
    • (2011) Curr Cardiovasc Imaging Rep , vol.4 , pp. 108-115
    • Tyler, D.J.1
  • 41
    • 0142084655 scopus 로고    scopus 로고
    • Developmental switch in brain nutrient transporter expression in the rat
    • Vannucci SJ, Simpson IA (2003) Developmental switch in brain nutrient transporter expression in the rat. Am J Physiol Endocrinol Metab 285:E1127-34
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Vannucci, S.J.1    Simpson, I.A.2
  • 43
    • 85047680719 scopus 로고
    • Alterations in circulating and cardiac tissue concentrations of brain natriuretic peptide in spontaneously hypertensive rats
    • Yokota N, Yamamoto Y, Kitamura K, Kangawa K, Minamino N, Matsuo H, Eto T (1993) Alterations in circulating and cardiac tissue concentrations of brain natriuretic peptide in spontaneously hypertensive rats. Cardiovasc Res 27:1312-5
    • (1993) Cardiovasc Res , vol.27 , pp. 1312-1315
    • Yokota, N.1    Yamamoto, Y.2    Kitamura, K.3    Kangawa, K.4    Minamino, N.5    Matsuo, H.6    Eto, T.7
  • 44
    • 0030033642 scopus 로고    scopus 로고
    • Astrocyte leucine metabolism: Significance of branched-chain amino acid transamination
    • Yudkoff M, Daikhin Y, Grunstein L, Nissim I, Stern J, Pleasure D (1996a) Astrocyte leucine metabolism: significance of branched-chain amino acid transamination. J Neurochem 66:378-85
    • (1996) J Neurochem , vol.66 , pp. 378-385
    • Yudkoff, M.1    Daikhin, Y.2    Grunstein, L.3    Nissim, I.4    Stern, J.5    Pleasure, D.6
  • 45
    • 38449086860 scopus 로고    scopus 로고
    • The ketogenic diet and brain metabolism of amino acids: Relationship to the anticonvulsant effect
    • Yudkoff M, Daikhin Y, Melø TM, Nissim I, Sonnewald U, Nissim I (2007) The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect. Annu Rev Nutr 27:415-30
    • (2007) Annu Rev Nutr , vol.27 , pp. 415-430
    • Yudkoff, M.1    Daikhin, Y.2    Melø, T.M.3    Nissim, I.4    Sonnewald, U.5    Nissim, I.6
  • 46
    • 0029935376 scopus 로고    scopus 로고
    • Neuronal metabolism of branched-chain amino acids: Flux through the aminotransferase pathway in synaptosomes
    • Yudkoff M, Daikhin Y, Nelson D, Nissim I, Erecinska M (1996b) Neuronal metabolism of branched-chain amino acids: flux through the aminotransferase pathway in synaptosomes. J Neurochem 66:2136-45
    • (1996) J Neurochem , vol.66 , pp. 2136-2145
    • Yudkoff, M.1    Daikhin, Y.2    Nelson, D.3    Nissim, I.4    Erecinska, M.5
  • 47
    • 0030793603 scopus 로고    scopus 로고
    • Effect of alpha-ketoisocaproate and leucine on the in vivo oxidation of glutamate and glutamine in the rat brain
    • Zielke HR, Huang Y, Baab PJ, Collins Jr RM, Zielke CL, Tildon JT (1997) Effect of alpha-ketoisocaproate and leucine on the in vivo oxidation of glutamate and glutamine in the rat brain. Neurochem Res 22:1159-1164
    • (1997) Neurochem Res , vol.22 , pp. 1159-1164
    • Zielke, H.R.1    Huang, Y.2    Baab, P.J.3    Collins Jr., R.M.4    Zielke, C.L.5    Tildon, J.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.