-
1
-
-
77953463301
-
5-Fluorouracil in lethal mutagenesis of foot-and-mouth disease virus
-
Agudo, R., Arias, A. & Domingo, E. (2009). 5-Fluorouracil in lethal mutagenesis of foot-and-mouth disease virus. Future Medical Chemistry 1, 529-539.
-
(2009)
Future Medical Chemistry
, vol.1
, pp. 529-539
-
-
Agudo, R.1
Arias, A.2
Domingo, E.3
-
2
-
-
77958122066
-
A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape
-
Agudo, R., Ferrer-Orta, C., Arias, A., de la Higuera, I., Perales, C., Pérez-Luque, R., Verdaguer, N. & Domingo, E. (2010). A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. PLoS Pathog 6, e1001072.
-
(2010)
PLoS Pathog
, vol.6
-
-
Agudo, R.1
Ferrer-Orta, C.2
Arias, A.3
de la Higuera, I.4
Perales, C.5
Pérez-Luque, R.6
Verdaguer, N.7
Domingo, E.8
-
3
-
-
0038722333
-
Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis
-
Airaksinen, A., Pariente, N., Menéndez-Arias, L. & Domingo, E. (2003). Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis. Virology 311, 339-349.
-
(2003)
Virology
, vol.311
, pp. 339-349
-
-
Airaksinen, A.1
Pariente, N.2
Menéndez-Arias, L.3
Domingo, E.4
-
4
-
-
9244238208
-
Viral error catastrophe by mutagenic nucleosides
-
Anderson, J. P., Daifuku, R. & Loeb, L. A. (2004). Viral error catastrophe by mutagenic nucleosides. Annu Rev Microbiol 58, 183-205.
-
(2004)
Annu Rev Microbiol
, vol.58
, pp. 183-205
-
-
Anderson, J.P.1
Daifuku, R.2
Loeb, L.A.3
-
5
-
-
2342565012
-
Fitness increase of memory genomes in a viral quasispecies
-
Arias, A., Ruiz-Jarabo, C. M., Escarmís, C. & Domingo, E. (2004). Fitness increase of memory genomes in a viral quasispecies. J Mol Biol 339, 405-412.
-
(2004)
J Mol Biol
, vol.339
, pp. 405-412
-
-
Arias, A.1
Ruiz-Jarabo, C.M.2
Escarmís, C.3
Domingo, E.4
-
6
-
-
27144462037
-
Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding
-
Arias, A., Agudo, R., Ferrer-Orta, C., Pérez-Luque, R., Airaksinen, A., Brocchi, E., Domingo, E., Verdaguer, N. & Escarmís, C. (2005). Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding. J Mol Biol 353, 1021-1032.
-
(2005)
J Mol Biol
, vol.353
, pp. 1021-1032
-
-
Arias, A.1
Agudo, R.2
Ferrer-Orta, C.3
Pérez-Luque, R.4
Airaksinen, A.5
Brocchi, E.6
Domingo, E.7
Verdaguer, N.8
Escarmís, C.9
-
7
-
-
57349131683
-
Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin
-
Arias, A., Arnold, J. J., Sierra, M., Smidansky, E. D., Domingo, E. & Cameron, C. E. (2008). Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin. J Virol 82, 12346-12355.
-
(2008)
J Virol
, vol.82
, pp. 12346-12355
-
-
Arias, A.1
Arnold, J.J.2
Sierra, M.3
Smidansky, E.D.4
Domingo, E.5
Cameron, C.E.6
-
8
-
-
21844431621
-
Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase
-
Arnold, J. J., Vignuzzi, M., Stone, J. K., Andino, R. & Cameron, C. E. (2005). Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J Biol Chem 280, 25706-25716.
-
(2005)
J Biol Chem
, vol.280
, pp. 25706-25716
-
-
Arnold, J.J.1
Vignuzzi, M.2
Stone, J.K.3
Andino, R.4
Cameron, C.E.5
-
9
-
-
24344467918
-
Mutagenic effects of ribavirin and response to interferon/ ribavirin combination therapy in chronic hepatitis C
-
other authors
-
Asahina, Y., Izumi, N., Enomoto, N., Uchihara, M., Kurosaki, M., Onuki, Y., Nishimura, Y., Ueda, K., Tsuchiya, K. & other authors (2005). Mutagenic effects of ribavirin and response to interferon/ ribavirin combination therapy in chronic hepatitis C. J Hepatol 43, 623-629.
-
(2005)
J Hepatol
, vol.43
, pp. 623-629
-
-
Asahina, Y.1
Izumi, N.2
Enomoto, N.3
Uchihara, M.4
Kurosaki, M.5
Onuki, Y.6
Nishimura, Y.7
Ueda, K.8
Tsuchiya, K.9
-
10
-
-
0017038871
-
The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate
-
Batschelet, E., Domingo, E. & Weissmann, C. (1976). The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. Gene 1, 27-32.
-
(1976)
Gene
, vol.1
, pp. 27-32
-
-
Batschelet, E.1
Domingo, E.2
Weissmann, C.3
-
11
-
-
77950397317
-
Rapid evolution of pandemic noroviruses of the GII.4 lineage
-
Bull, R. A., Eden, J. S., Rawlinson, W. D. & White, P. A. (2010). Rapid evolution of pandemic noroviruses of the GII.4 lineage. PLoS Pathog 6, e1000831.
-
(2010)
PLoS Pathog
, vol.6
-
-
Bull, R.A.1
Eden, J.S.2
Rawlinson, W.D.3
White, P.A.4
-
12
-
-
18144374835
-
Comparative genomics of foot-and-mouth disease virus
-
Carrillo, C., Tulman, E. R., Delhon, G., Lu, Z., Carreno, A., Vagnozzi, A., Kutish, G. F. & Rock, D. L. (2005). Comparative genomics of foot-and-mouth disease virus. J Virol 79, 6487-6504.
-
(2005)
J Virol
, vol.79
, pp. 6487-6504
-
-
Carrillo, C.1
Tulman, E.R.2
Delhon, G.3
Lu, Z.4
Carreno, A.5
Vagnozzi, A.6
Kutish, G.F.7
Rock, D.L.8
-
13
-
-
11844283982
-
Incorporation fidelity of the viral RNA-dependent RNA polymerase: A kinetic, thermodynamic and structural perspective
-
Castro, C., Arnold, J. J. & Cameron, C. E. (2005). Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res 107, 141-149.
-
(2005)
Virus Res
, vol.107
, pp. 141-149
-
-
Castro, C.1
Arnold, J.J.2
Cameron, C.E.3
-
14
-
-
34848832896
-
Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR
-
Cencic, R., Mayer, C., Juliano, M. A., Juliano, L., Konrat, R., Kontaxis, G. & Skern, T. (2007). Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR. J Mol Biol 373, 1071-1087.
-
(2007)
J Mol Biol
, vol.373
, pp. 1071-1087
-
-
Cencic, R.1
Mayer, C.2
Juliano, M.A.3
Juliano, L.4
Konrat, R.5
Kontaxis, G.6
Skern, T.7
-
15
-
-
34447248532
-
Analysis of ribavirin mutagenicity in human hepatitis C virus infection
-
Chevaliez, S., Brillet, R., Lázaro, E., Hézode, C. & Pawlotsky, J. M. (2007). Analysis of ribavirin mutagenicity in human hepatitis C virus infection. J Virol 81, 7732-7741.
-
(2007)
J Virol
, vol.81
, pp. 7732-7741
-
-
Chevaliez, S.1
Brillet, R.2
Lázaro, E.3
Hézode, C.4
Pawlotsky, J.M.5
-
16
-
-
80052836937
-
Safety, tolerability, and pharmacokinetics of KP-1461 in phase I clinical studies: A single oral dose study in non-HIV-infected adults, and a 14-day dose-escalating study in highly antiretroviral-experienced HIV-infected adults
-
Clay, P. G., McRae, M. & Laurent, J. P. (2011). Safety, tolerability, and pharmacokinetics of KP-1461 in phase I clinical studies: a single oral dose study in non-HIV-infected adults, and a 14-day dose-escalating study in highly antiretroviral-experienced HIV-infected adults. J Int Assoc Physicians AIDS Care (Chic) 10, 232-238.
-
(2011)
J Int Assoc Physicians AIDS Care (Chic)
, vol.10
, pp. 232-238
-
-
Clay, P.G.1
McRae, M.2
Laurent, J.P.3
-
17
-
-
0036333636
-
Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system
-
Contreras, A. M., Hiasa, Y., He, W., Terella, A., Schmidt, E. V. & Chung, R. T. (2002). Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system. J Virol 76, 8505-8517.
-
(2002)
J Virol
, vol.76
, pp. 8505-8517
-
-
Contreras, A.M.1
Hiasa, Y.2
He, W.3
Terella, A.4
Schmidt, E.V.5
Chung, R.T.6
-
18
-
-
0034532953
-
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
-
Crotty, S., Maag, D., Arnold, J. J., Zhong, W., Lau, J. Y., Hong, Z., Andino, R. & Cameron, C. E. (2000). The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med 6, 1375-1379.
-
(2000)
Nat Med
, vol.6
, pp. 1375-1379
-
-
Crotty, S.1
Maag, D.2
Arnold, J.J.3
Zhong, W.4
Lau, J.Y.5
Hong, Z.6
Andino, R.7
Cameron, C.E.8
-
19
-
-
66149098217
-
Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo
-
Cuevas, J. M., González-Candelas, F., Moya, A. & Sanjuán, R. (2009). Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo. J Virol 83, 5760-5764.
-
(2009)
J Virol
, vol.83
, pp. 5760-5764
-
-
Cuevas, J.M.1
González-Candelas, F.2
Moya, A.3
Sanjuán, R.4
-
20
-
-
0024023170
-
Coevolution of cells and viruses in a persistent infection of foot-and-mouth disease virus in cell culture
-
de la Torre, J. C., Martínez-Salas, E., Diez, J., Villaverde, A., Gebauer, F., Rocha, E., Dávila, M. & Domingo, E. (1988). Coevolution of cells and viruses in a persistent infection of foot-and-mouth disease virus in cell culture. J Virol 62, 2050-2058.
-
(1988)
J Virol
, vol.62
, pp. 2050-2058
-
-
de la Torre, J.C.1
Martínez-Salas, E.2
Diez, J.3
Villaverde, A.4
Gebauer, F.5
Rocha, E.6
Dávila, M.7
Domingo, E.8
-
21
-
-
11144330097
-
Modelling how ribavirin improves interferon response rates in hepatitis C virus infection
-
Dixit, N. M., Layden-Almer, J. E., Layden, T. J. & Perelson, A. S. (2004). Modelling how ribavirin improves interferon response rates in hepatitis C virus infection. Nature 432, 922-924.
-
(2004)
Nature
, vol.432
, pp. 922-924
-
-
Dixit, N.M.1
Layden-Almer, J.E.2
Layden, T.J.3
Perelson, A.S.4
-
22
-
-
0034630910
-
Viruses at the edge of adaptation
-
Domingo, E. (2000). Viruses at the edge of adaptation. Virology 270, 251-253.
-
(2000)
Virology
, vol.270
, pp. 251-253
-
-
Domingo, E.1
-
23
-
-
38349178145
-
Virus evolution
-
5th edn, Edited by D. M. Knipe & P. M. Howley. Philadelphia: LWW
-
Domingo, E. (2007). Virus evolution. In Fields Virology, 5th edn, pp. 389-421. Edited by D. M. Knipe & P. M. Howley. Philadelphia: LWW.
-
(2007)
Fields Virology
, pp. 389-421
-
-
Domingo, E.1
-
24
-
-
30644478836
-
Viruses as quasispecies: Biological implications
-
Domingo, E., Martin, V., Perales, C., Grande-Pérez, A., García-Arriaza, J. & Arias, A. (2006). Viruses as quasispecies: biological implications. Curr Top Microbiol Immunol 299, 51-82.
-
(2006)
Curr Top Microbiol Immunol
, vol.299
, pp. 51-82
-
-
Domingo, E.1
Martin, V.2
Perales, C.3
Grande-Pérez, A.4
García-Arriaza, J.5
Arias, A.6
-
25
-
-
84862579286
-
Viral quasispecies evolution
-
Domingo, E., Sheldon, J. & Perales, C. (2012). Viral quasispecies evolution. Microbiol Mol Biol Rev 76, 159-216.
-
(2012)
Microbiol Mol Biol Rev
, vol.76
, pp. 159-216
-
-
Domingo, E.1
Sheldon, J.2
Perales, C.3
-
27
-
-
0037108885
-
Error catastrophe and antiviral strategy
-
Eigen, M. (2002). Error catastrophe and antiviral strategy. Proc Natl Acad Sci U S A 99, 13374-13376.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 13374-13376
-
-
Eigen, M.1
-
28
-
-
15544373334
-
Sequence space and quasispecies distribution
-
Edited by E. Domingo, P. Ahlquist & J. J. Holland. Boca Raton, FL: CRC Press
-
Eigen, M. & Biebricher, C. K. (1988). Sequence space and quasispecies distribution. In RNA Genetics, vol. 3., pp. 211-245. Edited by E. Domingo, P. Ahlquist & J. J. Holland. Boca Raton, FL: CRC Press.
-
(1988)
RNA Genetics
, vol.3
, pp. 211-245
-
-
Eigen, M.1
Biebricher, C.K.2
-
30
-
-
0030606306
-
Genetic lesions associated with Muller's ratchet in an RNA virus
-
Escarmís, C., Dávila, M., Charpentier, N., Bracho, A., Moya, A. & Domingo, E. (1996). Genetic lesions associated with Muller's ratchet in an RNA virus. J Mol Biol 264, 255-267.
-
(1996)
J Mol Biol
, vol.264
, pp. 255-267
-
-
Escarmís, C.1
Dávila, M.2
Charpentier, N.3
Bracho, A.4
Moya, A.5
Domingo, E.6
-
31
-
-
17144461473
-
Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet
-
Escarmís, C., Dávila, M. & Domingo, E. (1999). Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet. J Mol Biol 285, 495-505.
-
(1999)
J Mol Biol
, vol.285
, pp. 495-505
-
-
Escarmís, C.1
Dávila, M.2
Domingo, E.3
-
32
-
-
30644469025
-
Population bottlenecks in quasispecies dynamics
-
Escarmís, C., Lázaro, E. & Manrubia, S. C. (2006). Population bottlenecks in quasispecies dynamics. Curr Top Microbiol Immunol 299, 141-170.
-
(2006)
Curr Top Microbiol Immunol
, vol.299
, pp. 141-170
-
-
Escarmís, C.1
Lázaro, E.2
Manrubia, S.C.3
-
33
-
-
38349170440
-
Repeated bottleneck transfers can lead to non-cytocidal forms of a cytopathic virus: Implications for viral extinction
-
Escarmís, C., Lázaro, E., Arias, A. & Domingo, E. (2008). Repeated bottleneck transfers can lead to non-cytocidal forms of a cytopathic virus: implications for viral extinction. J Mol Biol 376, 367-379.
-
(2008)
J Mol Biol
, vol.376
, pp. 367-379
-
-
Escarmís, C.1
Lázaro, E.2
Arias, A.3
Domingo, E.4
-
34
-
-
34547178347
-
Sequential structures provide insights into the fidelity of RNA replication
-
Ferrer-Orta, C., Arias, A., Pérez-Luque, R., Escarmís, C., Domingo, E. & Verdaguer, N. (2007). Sequential structures provide insights into the fidelity of RNA replication. Proc Natl Acad Sci U S A 104, 9463-9468.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 9463-9468
-
-
Ferrer-Orta, C.1
Arias, A.2
Pérez-Luque, R.3
Escarmís, C.4
Domingo, E.5
Verdaguer, N.6
-
35
-
-
77952710653
-
Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
-
Ferrer-Orta, C., Sierra, M., Agudo, R., de la Higuera, I., Arias, A., Pérez-Luque, R., Escarmís, C., Domingo, E. & Verdaguer, N. (2010). Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin. J Virol 84, 6188-6199.
-
(2010)
J Virol
, vol.84
, pp. 6188-6199
-
-
Ferrer-Orta, C.1
Sierra, M.2
Agudo, R.3
de la Higuera, I.4
Arias, A.5
Pérez-Luque, R.6
Escarmís, C.7
Domingo, E.8
Verdaguer, N.9
-
36
-
-
84865279748
-
Coxsackievirus B3 mutator strains are attenuated in vivo
-
Gnadig, N. F., Beaucourt, S., Campagnola, G., Bordería, A. V., Sanz-Ramos, M., Gong, P., Blanc, H., Peersen, O. B. & Vignuzzi, M. (2012). Coxsackievirus B3 mutator strains are attenuated in vivo. Proc Natl Acad Sci U S A 109, E2294-E2303.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
Gnadig, N.F.1
Beaucourt, S.2
Campagnola, G.3
Bordería, A.V.4
Sanz-Ramos, M.5
Gong, P.6
Blanc, H.7
Peersen, O.B.8
Vignuzzi, M.9
-
37
-
-
1842510032
-
Preextinction viral RNA can interfere with infectivity
-
González-López, C., Arias, A., Pariente, N., Gómez-Mariano, G. & Domingo, E. (2004). Preextinction viral RNA can interfere with infectivity. J Virol 78, 3319-3324.
-
(2004)
J Virol
, vol.78
, pp. 3319-3324
-
-
González-López, C.1
Arias, A.2
Pariente, N.3
Gómez-Mariano, G.4
Domingo, E.5
-
38
-
-
25144524546
-
Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe
-
González-López, C., Gómez-Mariano, G., Escarmís, C. & Domingo, E. (2005). Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe. Infect Genet Evol 5, 366-374.
-
(2005)
Infect Genet Evol
, vol.5
, pp. 366-374
-
-
González-López, C.1
Gómez-Mariano, G.2
Escarmís, C.3
Domingo, E.4
-
39
-
-
70350132524
-
Therapeutically targeting RNA viruses via lethal mutagenesis
-
Graci, J. D. & Cameron, C. E. (2008). Therapeutically targeting RNA viruses via lethal mutagenesis. Future Virol 3, 553-566.
-
(2008)
Future Virol
, vol.3
, pp. 553-566
-
-
Graci, J.D.1
Cameron, C.E.2
-
40
-
-
0036789885
-
Molecular indetermination in the transition to error catastrophe: Systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity
-
Grande-Pérez, A., Sierra, S., Castro, M. G., Domingo, E. & Lowenstein, P. R. (2002). Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity. Proc Natl Acad Sci U S A 99, 12938-12943.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 12938-12943
-
-
Grande-Pérez, A.1
Sierra, S.2
Castro, M.G.3
Domingo, E.4
Lowenstein, P.R.5
-
41
-
-
23244443638
-
Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence
-
Grande-Pérez, A., Gómez-Mariano, G., Lowenstein, P. R. & Domingo, E. (2005a). Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence. J Virol 79, 10451-10459.
-
(2005)
J Virol
, vol.79
, pp. 10451-10459
-
-
Grande-Pérez, A.1
Gómez-Mariano, G.2
Lowenstein, P.R.3
Domingo, E.4
-
42
-
-
15444379112
-
Suppression of viral infectivity through lethal defection
-
Grande-Pérez, A., Lázaro, E., Lowenstein, P., Domingo, E. & Manrubia, S. C. (2005b). Suppression of viral infectivity through lethal defection. Proc Natl Acad Sci U S A 102, 4448-4452.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 4448-4452
-
-
Grande-Pérez, A.1
Lázaro, E.2
Lowenstein, P.3
Domingo, E.4
Manrubia, S.C.5
-
43
-
-
20444414897
-
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis
-
Harris, K. S., Brabant, W., Styrchak, S., Gall, A. & Daifuku, R. (2005). KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. Antiviral Res 67, 1-9.
-
(2005)
Antiviral Res
, vol.67
, pp. 1-9
-
-
Harris, K.S.1
Brabant, W.2
Styrchak, S.3
Gall, A.4
Daifuku, R.5
-
44
-
-
85172052149
-
Safety, tolerability, and efficacy of KP-1461 as monotherapy for 124 days in antiretroviral-experienced, HIV type 1-infected subjects
-
120827084548003. (Epub ahead of print)
-
Hicks, C., Clay, P., Redfield, R. R., Lalezari, J. P., Liporace, R., Schneider, S., Sension, M., McRae, M. & Laurent, J. P. (2012). Safety, tolerability, and efficacy of KP-1461 as monotherapy for 124 days in antiretroviral-experienced, HIV type 1-infected subjects. AIDS Res Hum Retroviruses 120827084548003. (Epub ahead of print).
-
(2012)
AIDS Res Hum Retroviruses
-
-
Hicks, C.1
Clay, P.2
Redfield, R.R.3
Lalezari, J.P.4
Liporace, R.5
Schneider, S.6
Sension, M.7
McRae, M.8
Laurent, J.P.9
-
45
-
-
0020075533
-
Rapid evolution of RNA genomes
-
Holland, J., Spindler, K., Horodyski, F., Grabau, E., Nichol, S. & VandePol, S. (1982). Rapid evolution of RNA genomes. Science 215, 1577-1585.
-
(1982)
Science
, vol.215
, pp. 1577-1585
-
-
Holland, J.1
Spindler, K.2
Horodyski, F.3
Grabau, E.4
Nichol, S.5
Vandepol, S.6
-
46
-
-
0025284804
-
Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis
-
Holland, J. J., Domingo, E., de la Torre, J. C. & Steinhauer, D. A. (1990). Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis. J Virol 64, 3960-3962.
-
(1990)
J Virol
, vol.64
, pp. 3960-3962
-
-
Holland, J.J.1
Domingo, E.2
de la Torre, J.C.3
Steinhauer, D.A.4
-
47
-
-
8444233615
-
Inhibition of subgenomic hepatitis C virus RNA in Huh-7 cells: Ribavirin induces mutagenesis in HCV RNA
-
other authors
-
Kanda, T., Yokosuka, O., Imazeki, F., Tanaka, M., Shino, Y., Shimada, H., Tomonaga, T., Nomura, F., Nagao, K. & other authors (2004). Inhibition of subgenomic hepatitis C virus RNA in Huh-7 cells: ribavirin induces mutagenesis in HCV RNA. J Viral Hepat 11, 479-487.
-
(2004)
J Viral Hepat
, vol.11
, pp. 479-487
-
-
Kanda, T.1
Yokosuka, O.2
Imazeki, F.3
Tanaka, M.4
Shino, Y.5
Shimada, H.6
Tomonaga, T.7
Nomura, F.8
Nagao, K.9
-
48
-
-
77957658175
-
Quasispecies theory and the behavior of RNA viruses
-
Lauring, A. S. & Andino, R. (2010). Quasispecies theory and the behavior of RNA viruses. PLoS Pathog 6, e1001005.
-
(2010)
PLoS Pathog
, vol.6
-
-
Lauring, A.S.1
Andino, R.2
-
49
-
-
0141633021
-
Resistance of virus to extinction on bottleneck passages: Study of a decaying and fluctuating pattern of fitness loss
-
Lázaro, E., Escarmís, C., Pérez-Mercader, J., Manrubia, S. C. & Domingo, E. (2003). Resistance of virus to extinction on bottleneck passages: study of a decaying and fluctuating pattern of fitness loss. Proc Natl Acad Sci U S A 100, 10830-10835.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 10830-10835
-
-
Lázaro, E.1
Escarmís, C.2
Pérez-Mercader, J.3
Manrubia, S.C.4
Domingo, E.5
-
50
-
-
78449244303
-
Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds
-
Levi, L. I., Gnadig, N. F., Beaucourt, S., McPherson, M. J., Baron, B., Arnold, J. J. & Vignuzzi, M. (2010). Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds. PLoS Pathog 6, e1001163.
-
(2010)
PLoS Pathog
, vol.6
-
-
Levi, L.I.1
Gnadig, N.F.2
Beaucourt, S.3
McPherson, M.J.4
Baron, B.5
Arnold, J.J.6
Vignuzzi, M.7
-
51
-
-
0033573932
-
Lethal mutagenesis of HIV with mutagenic nucleoside analogs
-
Loeb, L. A., Essigmann, J. M., Kazazi, F., Zhang, J., Rose, K. D. & Mullins, J. I. (1999). Lethal mutagenesis of HIV with mutagenic nucleoside analogs. Proc Natl Acad Sci U S A 96, 1492-1497.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 1492-1497
-
-
Loeb, L.A.1
Essigmann, J.M.2
Kazazi, F.3
Zhang, J.4
Rose, K.D.5
Mullins, J.I.6
-
52
-
-
34247552260
-
Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy
-
Lutchman, G., Danehower, S., Song, B. C., Liang, T. J., Hoofnagle, J. H., Thomson, M. & Ghany, M. G. (2007). Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy. Gastroenterology 132, 1757-1766.
-
(2007)
Gastroenterology
, vol.132
, pp. 1757-1766
-
-
Lutchman, G.1
Danehower, S.2
Song, B.C.3
Liang, T.J.4
Hoofnagle, J.H.5
Thomson, M.6
Ghany, M.G.7
-
53
-
-
0035824671
-
Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin
-
Maag, D., Castro, C., Hong, Z. & Cameron, C. E. (2001). Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J Biol Chem 276, 46094-46098.
-
(2001)
J Biol Chem
, vol.276
, pp. 46094-46098
-
-
Maag, D.1
Castro, C.2
Hong, Z.3
Cameron, C.E.4
-
54
-
-
10644233879
-
Introduction and history of foot-and-mouth disease virus
-
Mahy, B. W. (2005). Introduction and history of foot-and-mouth disease virus. Curr Top Microbiol Immunol 288, 1-8.
-
(2005)
Curr Top Microbiol Immunol
, vol.288
, pp. 1-8
-
-
Mahy, B.W.1
-
55
-
-
47749097091
-
No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus
-
Martín, V., Grande-Pérez, A. & Domingo, E. (2008). No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus. Virology 378, 185-192.
-
(2008)
Virology
, vol.378
, pp. 185-192
-
-
Martín, V.1
Grande-Pérez, A.2
Domingo, E.3
-
56
-
-
77949527717
-
An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis
-
Martín, V., Abia, D., Domingo, E. & Grande-Pérez, A. (2010). An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis. J Gen Virol 91, 990-1003.
-
(2010)
J Gen Virol
, vol.91
, pp. 990-1003
-
-
Martín, V.1
Abia, D.2
Domingo, E.3
Grande-Pérez, A.4
-
57
-
-
77950020240
-
Unfinished stories on viral quasispecies and Darwinian views of evolution
-
Más, A., López-Galíndez, C., Cacho, I., Gómez, J. & Martínez, M. A. (2010). Unfinished stories on viral quasispecies and Darwinian views of evolution. J Mol Biol 397, 865-877.
-
(2010)
J Mol Biol
, vol.397
, pp. 865-877
-
-
Más, A.1
López-Galíndez, C.2
Cacho, I.3
Gómez, J.4
Martínez, M.A.5
-
58
-
-
0142039882
-
Complete alanine scanning of intersubunit interfaces in a foot-and-mouth disease virus capsid reveals critical contributions of many side chains to particle stability and viral function
-
Mateo, R., Díaz, A., Baranowski, E. & Mateu, M. G. (2003). Complete alanine scanning of intersubunit interfaces in a foot-and-mouth disease virus capsid reveals critical contributions of many side chains to particle stability and viral function. J Biol Chem 278, 41019-41027.
-
(2003)
J Biol Chem
, vol.278
, pp. 41019-41027
-
-
Mateo, R.1
Díaz, A.2
Baranowski, E.3
Mateu, M.G.4
-
59
-
-
84855269254
-
Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4
-
other authors
-
McFadden, N., Bailey, D., Carrara, G., Benson, A., Chaudhry, Y., Shortland, A., Heeney, J., Yarovinsky, F., Simmonds, P. & other authors (2011). Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4. PLoS Pathog 7, e1002413.
-
(2011)
PLoS Pathog
, vol.7
-
-
McFadden, N.1
Bailey, D.2
Carrara, G.3
Benson, A.4
Chaudhry, Y.5
Shortland, A.6
Heeney, J.7
Yarovinsky, F.8
Simmonds, P.9
-
60
-
-
79960387914
-
Ribavirin can be mutagenic for arenaviruses
-
Moreno, H., Gallego, I., Sevilla, N., de la Torre, J. C., Domingo, E. & Martín, V. (2011). Ribavirin can be mutagenic for arenaviruses. J Virol 85, 7246-7255.
-
(2011)
J Virol
, vol.85
, pp. 7246-7255
-
-
Moreno, H.1
Gallego, I.2
Sevilla, N.3
de la Torre, J.C.4
Domingo, E.5
Martín, V.6
-
61
-
-
37849012228
-
Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity
-
Moriyama, K., Suzuki, T., Negishi, K., Graci, J. D., Thompson, C. N., Cameron, C. E. & Watanabe, M. (2008). Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity. J Med Chem 51, 159-166.
-
(2008)
J Med Chem
, vol.51
, pp. 159-166
-
-
Moriyama, K.1
Suzuki, T.2
Negishi, K.3
Graci, J.D.4
Thompson, C.N.5
Cameron, C.E.6
Watanabe, M.7
-
62
-
-
79251565236
-
Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461
-
other authors
-
Mullins, J. I., Heath, L., Hughes, J. P., Kicha, J., Styrchak, S., Wong, K. G., Rao, U., Hansen, A., Harris, K. S. & other authors (2011). Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461. PLoS ONE 6, e15135.
-
(2011)
PLoS ONE
, vol.6
-
-
Mullins, J.I.1
Heath, L.2
Hughes, J.P.3
Kicha, J.4
Styrchak, S.5
Wong, K.G.6
Rao, U.7
Hansen, A.8
Harris, K.S.9
-
63
-
-
77955488013
-
Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations?
-
O'Dea, E. B., Keller, T. E. & Wilke, C. O. (2010). Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations? PLOS Comput Biol 6, e1000811.
-
(2010)
PLOS Comput Biol
, vol.6
-
-
O'Dea, E.B.1
Keller, T.E.2
Wilke, C.O.3
-
64
-
-
33846829804
-
HIV-1 protease catalytic efficiency effects caused by random single amino acid substitutions
-
Parera, M., Fernàndez, G., Clotet, B. & Martínez, M. A. (2007). HIV-1 protease catalytic efficiency effects caused by random single amino acid substitutions. Mol Biol Evol 24, 382-387.
-
(2007)
Mol Biol Evol
, vol.24
, pp. 382-387
-
-
Parera, M.1
Fernàndez, G.2
Clotet, B.3
Martínez, M.A.4
-
65
-
-
0034813056
-
Efficient virus extinction by combinations of a mutagen and antiviral inhibitors
-
Pariente, N., Sierra, S., Lowenstein, P. R. & Domingo, E. (2001). Efficient virus extinction by combinations of a mutagen and antiviral inhibitors. J Virol 75, 9723-9730.
-
(2001)
J Virol
, vol.75
, pp. 9723-9730
-
-
Pariente, N.1
Sierra, S.2
Lowenstein, P.R.3
Domingo, E.4
-
66
-
-
34248577724
-
Insights into RNA virus mutant spectrum and lethal mutagenesis events: Replicative interference and complementation by multiple point mutants
-
Perales, C., Mateo, R., Mateu, M. G. & Domingo, E. (2007). Insights into RNA virus mutant spectrum and lethal mutagenesis events: replicative interference and complementation by multiple point mutants. J Mol Biol 369, 985-1000.
-
(2007)
J Mol Biol
, vol.369
, pp. 985-1000
-
-
Perales, C.1
Mateo, R.2
Mateu, M.G.3
Domingo, E.4
-
67
-
-
65849141020
-
Counteracting quasispecies adaptability: Extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment
-
Perales, C., Agudo, R. & Domingo, E. (2009a). Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment. PLoS ONE 4, e5554.
-
(2009)
PLoS ONE
, vol.4
-
-
Perales, C.1
Agudo, R.2
Domingo, E.3
-
68
-
-
73549116556
-
Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections
-
Perales, C., Agudo, R., Tejero, H., Manrubia, S. C. & Domingo, E. (2009b). Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections. PLoS Pathog 5, e1000658.
-
(2009)
PLoS Pathog
, vol.5
-
-
Perales, C.1
Agudo, R.2
Tejero, H.3
Manrubia, S.C.4
Domingo, E.5
-
69
-
-
78650038621
-
Mutant spectra in virus behavior
-
Perales, C., Lorenzo-Redondo, R., López-Galíndez, C., Martínez, M. A. & Domingo, E. (2010). Mutant spectra in virus behavior. Future Virology 5, 679-698.
-
(2010)
Future Virology
, vol.5
, pp. 679-698
-
-
Perales, C.1
Lorenzo-Redondo, R.2
López-Galíndez, C.3
Martínez, M.A.4
Domingo, E.5
-
70
-
-
81255200497
-
Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space
-
Perales, C., Henry, M., Domingo, E., Wain-Hobson, S. & Vartanian, J. P. (2011). Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space. J Virol 85, 12227-12240.
-
(2011)
J Virol
, vol.85
, pp. 12227-12240
-
-
Perales, C.1
Henry, M.2
Domingo, E.3
Wain-Hobson, S.4
Vartanian, J.P.5
-
71
-
-
34247607729
-
Ribavirin: Is it a mutagen for hepatitis C virus?
-
Perelson, A. S. & Layden, T. J. (2007). Ribavirin: is it a mutagen for hepatitis C virus? Gastroenterology 132, 2050-2052.
-
(2007)
Gastroenterology
, vol.132
, pp. 2050-2052
-
-
Perelson, A.S.1
Layden, T.J.2
-
72
-
-
0038809107
-
A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity
-
Pfeiffer, J. K. & Kirkegaard, K. (2003). A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity. Proc Natl Acad Sci U S A 100, 7289-7294.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 7289-7294
-
-
Pfeiffer, J.K.1
Kirkegaard, K.2
-
73
-
-
33745490138
-
Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice
-
Pfeiffer, J. K. & Kirkegaard, K. (2005). Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice. PLoS Pathog 1, e11.
-
(2005)
PLoS Pathog
, vol.1
-
-
Pfeiffer, J.K.1
Kirkegaard, K.2
-
74
-
-
0141737150
-
Foot-and-mouth disease
-
Rowlands, D. J. E. (2003). Foot-and-mouth disease. Virus Res 91, 1-161.
-
(2003)
Virus Res
, vol.91
, pp. 1-161
-
-
Rowlands, D.J.E.1
-
75
-
-
0345578679
-
Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV)
-
Ruiz-Jarabo, C. M., Ly, C., Domingo, E. & de la Torre, J. C. (2003). Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). Virology 308, 37-47.
-
(2003)
Virology
, vol.308
, pp. 37-47
-
-
Ruiz-Jarabo, C.M.1
Ly, C.2
Domingo, E.3
de la Torre, J.C.4
-
76
-
-
7444221704
-
The contribution of epistasis to the architecture of fitness in an RNA virus
-
Sanjuán, R., Moya, A. & Elena, S. F. (2004). The contribution of epistasis to the architecture of fitness in an RNA virus. Proc Natl Acad Sci U S A 101, 15376-15379.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 15376-15379
-
-
Sanjuán, R.1
Moya, A.2
Elena, S.F.3
-
77
-
-
34347327212
-
Selection for robustness in mutagenized RNA viruses
-
Sanjuán, R., Cuevas, J. M., Furió, V., Holmes, E. C. & Moya, A. (2007). Selection for robustness in mutagenized RNA viruses. PLoS Genet 3, e93.
-
(2007)
PLoS Genet
, vol.3
-
-
Sanjuán, R.1
Cuevas, J.M.2
Furió, V.3
Holmes, E.C.4
Moya, A.5
-
78
-
-
84862999117
-
Mutagenesis-mediated decrease of pathogenicity as a feature of the mutant spectrum of a viral population
-
Sanz-Ramos, M., Rodríguez-Calvo, T. & Sevilla, N. (2012). Mutagenesis-mediated decrease of pathogenicity as a feature of the mutant spectrum of a viral population. PLoS ONE 7, e39941.
-
(2012)
PLoS ONE
, vol.7
-
-
Sanz-Ramos, M.1
Rodríguez-Calvo, T.2
Sevilla, N.3
-
79
-
-
0033850837
-
Response of foot-and-mouth disease virus to increased mutagenesis: Influence of viral load and fitness in loss of infectivity
-
Sierra, S., Dávila, M., Lowenstein, P. R. & Domingo, E. (2000). Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity. J Virol 74, 8316-8323.
-
(2000)
J Virol
, vol.74
, pp. 8316-8323
-
-
Sierra, S.1
Dávila, M.2
Lowenstein, P.R.3
Domingo, E.4
-
80
-
-
33846813925
-
Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: Implications for error catastrophe
-
Sierra, M., Airaksinen, A., González-López, C., Agudo, R., Arias, A. & Domingo, E. (2007). Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe. J Virol 81, 2012-2024.
-
(2007)
J Virol
, vol.81
, pp. 2012-2024
-
-
Sierra, M.1
Airaksinen, A.2
González-López, C.3
Agudo, R.4
Arias, A.5
Domingo, E.6
-
82
-
-
0020544508
-
Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture
-
Sobrino, F., Dávila, M., Ortín, J. & Domingo, E. (1983). Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture. Virology 128, 310-318.
-
(1983)
Virology
, vol.128
, pp. 310-318
-
-
Sobrino, F.1
Dávila, M.2
Ortín, J.3
Domingo, E.4
-
83
-
-
79952584759
-
Theiler's virus L protein is targeted to the mitochondrial outer membrane
-
Sorgeloos, F., Vertommen, D., Rider, M. H. & Michiels, T. (2011). Theiler's virus L protein is targeted to the mitochondrial outer membrane. J Virol 85, 3690-3694.
-
(2011)
J Virol
, vol.85
, pp. 3690-3694
-
-
Sorgeloos, F.1
Vertommen, D.2
Rider, M.H.3
Michiels, T.4
-
84
-
-
84961572401
-
Self-replication with errors. A model for polynucleotide replication
-
Swetina, J. & Schuster, P. (1982). Self-replication with errors. A model for polynucleotide replication. Biophys Chem 16, 329-345.
-
(1982)
Biophys Chem
, vol.16
, pp. 329-345
-
-
Swetina, J.1
Schuster, P.2
-
85
-
-
31144465690
-
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
-
Vignuzzi, M., Stone, J. K., Arnold, J. J., Cameron, C. E. & Andino, R. (2006). Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature 439, 344-348.
-
(2006)
Nature
, vol.439
, pp. 344-348
-
-
Vignuzzi, M.1
Stone, J.K.2
Arnold, J.J.3
Cameron, C.E.4
Andino, R.5
-
86
-
-
38949184924
-
Engineering attenuated virus vaccines by controlling replication fidelity
-
Vignuzzi, M., Wendt, E. & Andino, R. (2008). Engineering attenuated virus vaccines by controlling replication fidelity. Nat Med 14, 154-161.
-
(2008)
Nat Med
, vol.14
, pp. 154-161
-
-
Vignuzzi, M.1
Wendt, E.2
Andino, R.3
-
87
-
-
85047692907
-
The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA
-
Zhou, S., Liu, R., Baroudy, B. M., Malcolm, B. A. & Reyes, G. R. (2003). The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA. Virology 310, 333-342.
-
(2003)
Virology
, vol.310
, pp. 333-342
-
-
Zhou, S.1
Liu, R.2
Baroudy, B.M.3
Malcolm, B.A.4
Reyes, G.R.5
-
88
-
-
0042121256
-
Mfold web server for nucleic acid folding and hybridization prediction
-
Zuker, M. (2003). Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 31, 3406-3415.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 3406-3415
-
-
Zuker, M.1
|