The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

Nature Medicine

Volumn 6, Issue 12, 2000, Pages 1375-1379

  Crotty, Shane ^a   Maag, David ^b   Arnold, Jamie J ^b   Zhong, Weidong ^c   Lau, Johnson Y N ^c   Hong, Zhi ^c   Andino, Raul ^a   Cameron, Craig E ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; MUTAGENIC AGENT; RIBAVIRIN; RIBONUCLEOSIDE DERIVATIVE; RNA POLYMERASE; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MUTAGENESIS; DRUG BINDING; DRUG EFFECT; HUMAN; NONHUMAN; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; RNA BINDING; RNA VIRUS; SEQUENCE ANALYSIS; VIRUS GENOME; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ANTIVIRAL AGENTS; DNA-DIRECTED RNA POLYMERASES; MUTAGENS; NUCLEOTIDES; POLIOVIRUS; PROTEIN BIOSYNTHESIS; RIBAVIRIN; RNA REPLICASE; RNA VIRUSES; VIRUS REPLICATION;

EID: 0034532953     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/82191     Document Type: Article

References (35)

1. Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
2. Antiviral agents: Characteristic activity spectrum depending on the molecular target with which they interact
3. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
4. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C
5. Lassa fever. Effective therapy with ribavirin
6. Respiratory syncytial virus (RSV) disease and prospects for its control
7. Mechanism of action of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent
8. Biochemistry and clinical applications of ribavirin
9. The broad spectrum antiviral agent ribavirin inhibits capping of mRNA
10. Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate
11. Mechanism of La Crosse virus inhibition by ribavirin
12. The relationship between the metabolism of ribavirin and its proposed mechanism of action
13. Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub)
14. Poliovirus RNA-dependent RNA Polymerase (3D(pol)): Structural, biochemical, and biological analysis of conserved structural motifs A and B
15. Poliovirus requires a precise 5' end for efficient positive-strand RNA synthesis
16. Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of viral RNA
17. Inhibition of poliovirus RNA synthesis by brefeldin A
18. Characterization of the nucleoside triphosphatase activity of poliovirus protein 2C reveals a mechanism by which guanidine inhibits poliovirus replication
19. Guanidine-selected mutants of poliovirus: Mapping of point mutations to polypeptide 2C
20. Guanidine-resistant mutants of poliovirus have distinct mutations in peptide 2C
21. Genetic characteristics of conditional lethal mutants of vesicular stomatitis virus induced by 5-fluorouracil, 5-azacytidine, and ethyl methane sulfonate
22. 5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate
23. Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis
24. Negative effects of chemical mutagenesis on the adaptive behavior of vesicular stomatitis virus
25. Involvement of membrane traffic in the replication of poliovirus genomes: Effects of brefeldin A
26. RNA virus mutations and fitness for survival
27. Viruses at the edge of adaptation
28. Lethal mutagenesis of HIV with mutagenic nucleoside analogs
29. Production of 'authentic' poliovirus RNA-dependent RNA polymerase (3D(pol)) by ubiquitin-protease-mediated cleavage in Escherichia coli
30. Cloned poliovirus complementary DNA is infectious in mammalian cells
31. Nuclear magnetic resonance studies of the solution properties of the antiviral nucleoside, 1-beta-D-ribofuranosyl-1,2,4-triazole-3- carboxamide, the corresponding 5'-phosphate, and related triazole nucleosides