Gene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Li, Xiao Hong ^a,b   Chen, Jia Xu ^a   Yue, Guang Xin ^c   Liu, Yue Yun ^a   Zhao, Xin ^a   Guo, Xiao Ling ^a   Liu, Qun ^a   Jiang, You Ming ^a   Bai, Ming Hua ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

^c INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; CYCLIN DEPENDENT KINASE 6; CYTOKINE RECEPTOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CDK6 GENE; CHRONIC STRESS; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CRHR2 GENE; DOWN REGULATION; EXTRACELLULAR MATRIX; FADD GENE; GABRA1 GENE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IMMOBILIZATION STRESS; MALE; MICROARRAY ANALYSIS; NERVE CELL GROWTH; NONHUMAN; PRIMARY IMMUNE RESPONSE; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; DNA MICROARRAY; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; IMMOBILIZATION; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGICAL STRESS; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ANIMALS; DOWN-REGULATION; EXTRACELLULAR MATRIX; GENE REGULATORY NETWORKS; HIPPOCAMPUS; IMMOBILIZATION; MALE; MOLECULAR SEQUENCE ANNOTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TRANSCRIPTION, GENETIC; TRANSCRIPTOME; UP-REGULATION;

EID: 84875419986     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057621     Document Type: Article

References (91)

1. Bamberger CM, Wald M, Bamberger AM, Schulte HM, (1997) Inhibition of minera-corticoid and glucocorticoid receptor function by the heat shock protein 90 binding agent geldanamycin. Mol Cell Endocrinol 131: 233-240.
2. Herman JP, Spencer R (l998) Regulation of hippocampal glucoecorticoid receptor gene transcription and protein expression in vivo. J Neurosci 18: 7462-7473.
3. Chao HM, Ma LY, McEwen BS, Sakai RR, (1998) Regulation of glucocorticoid receptor and mineralocorticoid receptor messenger ribonueleic acids by selective agonists in the rat hippocampus. Endocrinology 139: 1810-1814.
4. Kempermann G, Kronenberg G, (2003) Depressed new neurons-adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol Psychiatry 54: 499-503.
5. Tang YT, Chen JX, (2002) Regulative effects of three TCM formulas on hypothalamus-pituitary-adrenal axis in the rats with chronic restrained stress. Journal of Beijing University of Traditional Chinese Medicine 25(3): 23-26.
6. Chen JX, Tang YT, Yang JX, (2008) Changes of glucocorticoid receptor and levels of CRF mRNA, POMC mRNA in brain of chronic immobilization stress rats. Cell Mol Neurobiol 28(2): 237-244.
7. Zhao X, Chen JX, Yang JX, Li W, Liu XL, et al. (2003) Study on the mechanism of the regulation of HPA on chronic restrained stress rat by compounded prescription of smoothing the liver of traditional Chinese medicine. Laboratory Animal Science and Management 20(2): 6-12.
8. Chen JX, Li W, Zhao X, Xu HY, Wang ZF, et al. (2007) Effects of three Chinese formulas on BDNF, TrkB in rat contex and hippocampus with chronic immobilization stress. Chinese Journal of Pathophysiology 23(7): 1296-1300.
9. Chen JX, Yang JX, Zhao X, Li W, Chen QH, et al. (2004) Change of ß-endorphin in hypothalamus of rats of chronic immobilization stress model and effect of composition of Chinese herbs. China Journal of Traditional Chinese Medicine and Pharmacy 19(2): 83-85.
10. Chen JX, Tang YT, (2004) Effect of Xiaoyao powder in changes of relative brain zone CRF gene expression in chronic restrained stress rats. Chinese Journal of Applied Physiology 20(1): 71-74.
11. Chen JX, Tang YT, (2006) Change of relative brain zone POMC gene expression and effect of Chinese medicine on chronic restrained stress model rats. Chinese Remedies & Clinics 3(3): 223-226.
12. Chen JX, Li W, Zhao X, Yang JX, (2008) Effects of the Chinese traditional prescription xiaoyaosan decoction on chronic immobilization stress-induced changes in behavior and brain BDNF, TrkB, and NT-3 in rats. Cell Mol Neurobiol 28(5): 745-755.
13. Toshinai K, Mondal MS, Nakazato M, Murakami N, Kojima M, et al. (2001) Pregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun 281(5): 1220-5.
14. Bustin SA, Benes V, Nolan T, (2005) Quantitative real-time RT-PCR-a perspective. J Mol Endocrinol 34: 597-601.
15. Osborne JD, Zhu LJ, Lin SM, Kibbe WA, (2007) Interpreting microarray results with gene ontology and MeSH. Methods Mol Biol 377: 223-242.
16. Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, et al. (2005) Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res 15: 1034-1050.
17. Mahony S, PV Benos (2007) STAMP: a web tool for exploring DNA-binding motif similarities. Nucleic Acids Res 35 (Web Server issue): W253-W258.
18. Mahony S, Auron PE, Benos PV, (2007) DNA familial binding profiles made easy: comparison of various motif alignment and clustering strategies. PLoS Comput Biol 3(3): e61.
19. Brin S, Page L (1998) The Anatomy of a Large-Scale Hypertextual Web Search Engine. Proceedings of the 7th international conference on World Wide Web (WWW) Brisbane Australia: 107-117.
20. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, et al. (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11): 2498-2504.
21. Bale TL, Contarino A, Smith GW, Chan R, Gold LH, et al. (2000) Mice deficient for corticotrophin-releasing hormone receptor-2 display Anxiety-like behaviour and are hypersensitive to stress. Nat Genet 24(4): 410-414.
22. Grammatopoulos DK, Chrousos GP, (2002) Functional characteristics of CRH receptors and potential clinical applications of CRH2 receptor antagonists. Trends Endocrin Met 13(10): 436-444.
23. Coste SC, Kesterson RA, Heldwein KA, Stevens SL, Heard AD, et al. (2000) Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet 24(4): 403-409.
24. Lawrenc DA, Kim D, (2000) Central/peripheral nervous system and immune responses. Toxicology 142 (3): 189-201.
25. Starkie RL, Hargreaves M, Rolland J, Febbraio MA, (2005) Heat stress, cytokines, and the immune response to exercise. Brain Behav Immun 19(5): 404-412.
26. Woiciechowsky C, Schöning B, Lanksch WR, Volk HD, Döcke WD, (1999) Mechanisms of brain-mediated systemic anti-inflammatory syndrome causing immunodepression. Mol Med 77(11): 769-780.
27. Schedlowski M, Jacobs R, Alker J, Pröhl F, Stratmann G, et al. (1993) Psychophysiological neuroendocrine and cellular immune reactions under psychological stress. Neuropsychobiology 28(12): 87-90.
28. Bartolomucci A, Sacerdote P, Panerai AE, Pederzani T, Palanza P, et al. (2003) Chronic psychosocial stress induced down-regulation of immunity dependsupon individual factors. Neuro Immunol 141(1-2): 58-64.
29. Sheela DR, Namasicayam A, Prabhakaran K, (1993) Modulation of nonspecific immunity by hippocampal stimulation. Neuroimmunol 42: 193-198.
30. Wang AJ, Yang YZ, Wu YM, Xie H, Hu MX, et al. (1996) Eeffet of intrahippocampal microinjection of cellular immune function and brain IL-1 a gene expression in rat. Acta Physiol Sin 48: 348-354.
31. Blalock JE, (1994) The syntax of immune-neuroendocrine communication. Immunol Today 15: 504-511.
32. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, et al. (1995) The RNA component of telomerase. Science 269: 1236-1241.
33. Kondo S, Tanaka Y, Kondo Y, Hitomi M, Barnett GH, et al. (1998) Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation. FASEBJ 12: 801-811.
34. Balasubramanian S, Kim KH, Ahmad N, Mukhtar H, (1999) Activation of telomerase and its association with G1-phase of the cell cycle during UVB-induced skin tumor genesis in SKH-1 hairless mouse. Oncogene 18(6): 1297-1302.
35. Savoysky E, Yoshida K, Ohtomo T, Yamaguchi Y, Akamatsu K, et al. (1996) Downregulation of telomerase activity is an early event in the differentiation of HL60 cells. Biochem Biophys Res Commun 226: 329-334.
36. Karlsson L, (2005) DM and DO shape the repertoire of peptide-MHC-class-II complexes. Curr Opin Immunol I7: 65-70.
37. Busch R, Rinderknecht CH, Roh S, Lee AW, Harding JJ, et al. (2005) Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression. Immunol Rev 207: 242-260.
38. Germain RN, (1994) MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76: 287.
39. Chiaretti S, Guarini A, De Propris MS, Tavolaro S, Intoppa S, et al. (2006) ZAP-70 expression in acute lymphoblastic leukemia: association with the E2A/PBX1 rearrangement and the pre-B stage of differentiation and prognostic implications. Blood 107(1): 197-204.
40. Matsuda S, Miwa Y, Hirata Y, Minowa A, Tanaka J, et al. (2004) Negative feedback loop in T-cell activation through MAPK-catalyzed threonie phosphorylation of LAT. EMBO J 23(13): 2577-2585.
41. Malissen B, Aguado E, Malissen M, (2005) Role of the LAT adaptor in T- cell development and Th2 differentiation. Adv Immunol 87: 1-25.
42. Ohtani N, Yamakoshi K Takahashi A, Hara E, (2004) The p16 INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest 51(3-4): 146-153.
43. Palacios EH, Weiss A, (2004) Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 23: 7990-8000.
44. Kagami S, Nakajima H, Kumano K, Suzuki K, Suto A, et al. (2000) Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue. B1ood 95: 1370-1377.
45. Sexl V, Piekorz R, Moriggl R, Rohrer J, Brown MP, et al. (2000) Stat5a/b contribute to interleukin 7 induced B cell precursor expansion, but abl- and bcr/ abl-induced transfomation are independent of stat5. Blood 96: 2277-2283.
46. Schneider JJ, Unholzer A, Schaller M, Schäfer-Korting M, Korting HC, (2005) Human defensins. J Mol Med 83: 587-595.
47. Duits LA, Ravensbergen B, Rademaker M, Hiemstra PS, Nibbering PH, (2002) Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 106: 517-525.
48. Bogdan C, Mattner J, Schleicher U, (2004) The role of type I interferons in non-viral infections. Immunol Rev 202: 33-48.
49. Du Clos TW, Mold C, (2004) C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity. Immunol Res 30(3): 261-277.
50. Ryu J, Lee CW, Shin JA, Park CS, Kim JJ, et al. (2007) FcgammaRIIa mediates C-reactive protein-induced inflammatory responses of human vascular smooth muscle cells by activating NADPH oxidase 4. Cardiovasc Res 75(3): 555-565.
51. Lu J, Marnell LL, Marjon KD, Mold C, Du Clos TW, et al. (2008) Structural recognition and functional activation of FcgammaR by innate pentraxins. Nature 456(7224): 989-992.
52. Marnell L, Mold C, Du Clos TW, (2005) C-reactive protein: ligands, receptors and role in inflammation. Clin Immunol 117(2): 104-111.
53. West MA, Heagy W, (2002) Endotoxin tolerance: A review. Crit Care Med 30: S64-S73.
54. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL, (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348-2357.
55. Huaux F, Liu T, Mcgarry B, Ullenbruch M, Xing Z, et al. (2003) Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis. J Immunol 171(10): 5470-5481.
56. Harrington LE, Mangan PR, Weaver CT, (2006) Expanding the effector CD4T-cell repertoire: the Thl7 lineage. Curr Opin Immunol 18: 349-356.
57. Bettelli E, Kom T, Kuchroo VK, (2007) Th17: the third member of the effector T cell trilogy. Curr Opin lmmunol 119: 652-657.
58. Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3 (-) effector T cells. Nat Immunol 9: 1347-55.
59. Nograles KE, Zaba LC, Shemer A, Fuentes-Duculan J, Cardinale I, et al. (2009) IL-22 producing "T22" T cells account for up regulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells. J Allergy Clin Immunol 123: 1244-1252.
60. Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, et al. (2009) Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 119: 3573-3585.
61. Wilson NJ, Boniface K, Chan JR, Mckenzie BS, Blumenschein WM, et al. (2007) Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8: 950-957.
62. Chiu BC, Shang X, Fraint KA, Hu JS, Komuniecki E, et al. (2002) Differential effects of aging on cytokine and chemokine responses during type-1 (mycobacterial) and type-2 (schistosomal) pulmonary granulomatous inflammation in mice. Mech Aging Dev 123(4): 313-326.
63. Skjoaas KA, Grieger DM, Hill CM, Minton JE, (2000) Glucocorticoid regulation of type1 and type2 cytokines in cultured porcinesplenocytes. Vet-Immunol-Immunopathol 87(1-2): 79-87.
64. Franchimont D, Galon J, Gadina M, Visconti R, Zhou Y, et al. (2000) Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes. J Immunol 164(4): 1768-1774.
65. BlottaMH, DeKruyff RH, Umetsu DT, (1997) Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes. J Immunol 158(12): 5589-5595.
66. Dozmorov IM, Miller RA, (1998) Generation of antigen-specific Th2 cells from unprimed mice in vitro: effects of dexamethasone and anti-IL-10 antibody. J Immunol 160(6): 2700-2705.
67. Rinehart JJ, Balcerzak SP, Sagone AL, LoBuglio AF, (1974) Effects of corticosteroids on human monocyte function. J Clin Invest 54(6): 1337-1343.
68. Rozkova D, Horvath R, Bartunkova J, Spisek R, (2006) Glucocorticoids severely impair differentiation and antigen presenting function of dendritic cells despite upregulation of Toll-like receptors. Clin Immunol 120(3): 260-271.
69. Ashwell JD, Lu FW, (2000) VacchioMS (2000) Glucocorticoids in T cell development and function. Annu Rev Immunol 18: 309-345.
70. Pan J, JuD, Wang Q, Zhang M, Xia D, et al. (2001) Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class?pathway. Immunol Lett 76(3): 153-161.
71. Herman JP, Watson SJ, Spencer RL, (1999) Defense of adrenlcorticosteroid receptor expression in rat hippocampus: effects of stress and strain. Endocrinology 140: 3981-3991.
72. Bremnet JD, (1999) Does stress damage the brain? Biol Psychiatry 45(7): 797-805.
73. Suzuki T, Aizawa K, Matsumura T, Nagai R, (2005) Vascular implications of the Krüppel-like family of transcription factors. Arterioscler Thromb Vasc Biol 25(6): 1135-1141.
74. Lemons ML, Condic ML, (2006) Combined integrin activation and intracellular cAMP cause Rho GTPase dependent growth cone collapse on laminin-1. Exp Neurol 202(2): 324-335.
75. Lemons ML, Condic ML, (2008) Integrin signaling is integral to regeneration. Exp Neurol 209(2): 343-352.
76. Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E, et al. (2004) Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 430(7003): 1034-1039.
77. Gu ZZ, Cui JK, Brown S, Fridman R, Mobashery S, et al. (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis is and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci 25(27): 6401- 6408.
78. Nakanishi T, Kadomatsu K, OkamotoT, Ichihara-Tanaka K, Kojima T, et al. (1997) Expression of syndecan-1 and-3 during embryogenesis of the central nervous system in relation to binding with midkine. J Biochem (Tokyo) 121(2): 197-205.
79. Hornberger LK, Singhroy S, Cavalle-Garrido T, Tsang W, Keeley F, et al. (2000) Synthesis of extracellular matrix and adhesion through beta(1) integrins are critical for fetal ventricular myocyte proliferation. Circ Res 87(6): 508-515.
80. Henriet P, Zhong ZD, Brooks PC, Weinberg KI, DeClerck YA, (2000) Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1. Proc Natl Acad Sci USA 29 97(18): 10026.
81. Falconer MA, Serafetinides EA, Corsellis JA, (1964) Etiology and pathogenesis of temporal lobe epilepsy. Arch Neurol 10: 233-248.
82. Young W, (1992) Role of calcium incentral nervous system Injuries. J Neurotrauma 9(1): 9-25.
83. Wilson CJ, Finch CE, Cohen HJ, (2002) Cytokines and cognition-the case for a head to-toe inflammatory paradigm. J Am Geriatr Soc 50: 2041-2056.
84. Parnet P, Kelley KW, Bluthe RM, Dantzer R, (2002) Expression and regulation of interleukin-1 receptors in the brain: role in cytokines-induced sickness behavior, J Neuroimmunol. 125: 5-14.
85. Dodd JS, Lum E, Goulding J, Muir R, Van Snick J, et al. (2009) L-9 Regulates pathology during primary and memory responses to respiratory syncytial virus infection. Immunol 183(11): 7006-7013.
86. Nowak EC, Weaver CT, Turner H, Begum-Haque S, Becher B, et al. (2009) IL-9 as a mediator of Th17-driven inflammatory disease. Exp Med 206: 1653-1660.
87. Stephan Brand, Florian Beige, Torsten Olszak, Zitzmann K, Eichhorst ST, et al. (2006) IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am J Physiol Gastrointest Liver Physiol 290: G827-G838.
88. Lubberts E, Koenders MI, Van WB, (2005) The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal model. Arthritis Res Ther 7(1): 29-37.
89. Dong C, (2008) IL-23/IL-17 biology and therapeutic considerations. Journal of Immunotoxicology 5: 43-46.
90. Gianaros PJ, Jennings JR, Sheu LK, Greer PJ, Kuller LH, et al. (2007) Prospective reports of chronic life stress predict decreased grey matter volume in the hippocampus. Neuroimage 35(2): 795-803.
91. Sapolsky RM, (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen psychiatry 5(9)7: 925-935.