A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia

Journal of Neuroscience

Volumn 25, Issue 27, 2005, Pages 6401-6408

  Gu, Zezong ^a   Cui, Jiankun ^a   Brown, Stephen ^b   Fridman, Rafael ^c   Mobashery, Shahriar ^b   Strongin, Alex Y ^a   Lipton, Stuart A ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Laminin; Matrix metalloproteinases; Neurons; Proteolysis; Thiirane inhibitor

Indexed keywords

GELATINASE A; GELATINASE B; GELATINASE INHIBITOR; LAMININ; MATRIX METALLOPROTEINASE INHIBITOR; SB 3CT; THIIRANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STROKE; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; APOPTOSIS; CEREBRAL INFARCTION; COLLAGENASES; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; ENZYME PRECURSORS; HETEROCYCLIC COMPOUNDS, 1-RING; INFUSION PUMPS, IMPLANTABLE; ISCHEMIC ATTACK, TRANSIENT; KINETICS; LAMININ; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; MICE; MICE, INBRED C57BL; NEURONS; PROTEASE INHIBITORS; REPERFUSION; SULFONES;

EID: 21844450866     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1563-05.2005     Document Type: Article

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