Regulation of hippocampal glucocorticoid receptor gene transcription and protein expression in vivo

Journal of Neuroscience

Volumn 18, Issue 18, 1998, Pages 7462-7473

  Herman, James P ^a   Spencer, Robert ^b  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Adrenalectomy; Glucocorticoid receptor; Hippocampus; Mineralocorticoid receptor; mRNA regulation; Spironolactone; Stress

Indexed keywords

GLUCOCORTICOID RECEPTOR; MESSENGER RNA;

ADRENALECTOMY; ANIMAL TISSUE; ARTICLE; GENE SEQUENCE; HIPPOCAMPUS; HORMONAL REGULATION; IMMUNOBLOTTING; MALE; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; RECEPTOR DOWN REGULATION; TRANSCRIPTION REGULATION;

EID: 0032530380     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-18-07462.1998     Document Type: Article

References (27)

1. Ahima RS, Harlan RE (1990) Charting of type II glucocorticoid receptor-like immunoreactivity in the rat central nervous system. Neuroscience 39:579-604.
2. Aronsson M, Fuxe K, Dong Y, Agnati LF, Okret S, Gustafsson J-A (1988) Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization. Proc Natl Acad Sci USA 85:9331-9335.
3. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM (1987) Cloning of the human mineralocorticoid receptor complementary DNA: structural and functional kinship with glucocorticoid receptor. Science 237:268-275.
4. Arriza JL, Simerly RB, Swanson LW, Evans RM (1988) Neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. Neuron 1:887-900.
5. Baron A, Riesselmann A, Fregly MJ (1991) Effect of chronic treatment with clonidine and spironolactone on cold-induced elevation of blood pressure. Pharmacology 43:173-186.
6. Blanchard V, Raisman VR, Savasta M, Hirsch E, Javoy AF, Feuerstein C, Agid Y (1993) Cellular quantification of tyrosine hydroxylase in the rat brain by immunoautoradiography. J Neurochem 61:617-626.
7. Bodnoff SR, Humphreys AG, Lehman JC, Diamond DM, Rose GM, Meaney MJ (1995) Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats. J Neurosci 15:61-69.
8. Brady LS, Whitfield HJ, Fox RJ, Gold PW, Herkenham M (1991) Long-term antidepressant administration alters corticotropin- releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. J Clin Invest 87:831-837.
9. Diamond DM, Rose GM (1994) Stress impairs LTP and hippocampal-dependent memory. Ann NY Acad Sci 746:411-414.
10. Drouin J, Sun YL, Tremblay S, Lavender P, Schmidt TJ, deLean A, Nemer M (1992) Homodimer formation is rate limiting for high affinity binding by the glucocorticoid receptor. Mol Endocrinol 6:1299-1309.
11. Eldridge JC, Brodish A, Kute TE, Landfield PW (1989) Apparent age-related resistance of type 2 hippocampal corticosteroid receptors to down-regulation during chronic escape training. J Neurosci 9:3237-3242.
12. Elliott EM, Mattson MP, Vanderklish P, Lynch G, Chang I, Sapolsky RM (1993) Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo. J Neurochem 61:57-67.
13. Fuxe K, Wikstrom AC, Okret S, Agnati LF, Harfstrand A, Yu ZY, Granholm L, Zoli M, Vale W, Gustafsson JA (1985) Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor. Endocrinology 117:1803-1812.
14. Grupp LA, Elias J, Perlanski E, Stewart RB (1985) Modification of ethanol-induced motor impairment by diet, diuretic, mineralocorticoid, or prostaglandin synthetase inhibitor. Psychopharmacology (Berl) 87:20-24.
15. Herman JP (1993) Regulation of adrenocorticosteroid receptor mRNA expression in the central nervous system. Cell Mol Neurobiol 13:349-372.
16. Herman JP, Morrison DG (1996) Immunoautoradiographic and in situ hybridization analysis of corticotropin-releasing hormone biosynthesis in the hypothalamus paraventricular nucleus. J Chem Neuroanat 11:49-56.
17. Herman JP, Watson SJ (1995) Stress regulation of mineralocorticoid receptor heteronuclear RNA in rat hippocampus. Brain Res 677:243-249.
18. Herman JP, Patel PD, Akil H, Watson SJ (1989) Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat. Mol Endocrinol 3:1886-1894.
19. Herman JP, Schäfer MK-H, Watson SJ, Sherman TG (1991) In situ hybridization analysis of arginine vasopressin gene transcription using intron-specific probes. Mol Endocrinol 5:1447-1456.
20. Herman JP, Schafer MK-H, Thompson RC, Watson SJ (1992) Rapid regulation of CRH gene expression in vivo. Mol Endocrinol 6:1061-1069.
21. Herman JP, Watson SJ, Chao HM, Coirini HM, McEwen BS (1993) Diurnal regulation of glucocorticoid receptor and mineralocorticoid receptor mRNAs in the rat hippocampus. Mol Cell Neurosci 4:181-190.
22. Herman JP, Adams D, Prewitt CM (1995) Regulatory changes in neuroendocrine stress-integrative circuitry produced by a variable stress paradigm. Neuroendocrinology 61:180-190.
23. Holmes MC, Yau JL, French KL, Seckl JR (1995) The effect of adrenalectomy on 5-hydroxytryptamine and corticosteroid receptor subtype messenger RNA expression in rat hippocampus. Neuroscience 64:327-337.
24. Jacobson L, Sapolsky RM (1991) The role of the hippocampus in feedback regulation of the hypothalamo-pituitary-adrenocortical axis. Endocrine Rev 12:118-134.
25. Landfield PW, Eldridge JC (1991) The glucocorticoid hypothesis of brain aging and neurodegeneration: recent modifications. Acta Endocrinol 125:54-64.
26. Makino S, Smith MA, Gold PW (1995) Increased expression of corticotropin-releasing hormone and vasopressin messenger ribonucleic acid (mRNA) in the hypothalamic paraventricular nucleus during repeated stress: association with reduction in glucocorticoid receptor mRNA levels. Endocrinology 136:3299-3309.
27. Miesfeld R, Rusconi S, Godowski P, Maler BA, Okret S, Wikstrom A-C, Gustafsson J-A, Yamamoto KR (1986) Genetic complementation of a glucocorticoid deficiency by expression of cloned receptor cDNA. Cell 46:389-399.