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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 2111-2116

Design, synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 (aggrecanase-2) inhibitors

(6) Atobe, Masakazu a Maekawara, Naomi a Kawanishi, Masashi a Suzuki, Hiroko a Tanaka, Eiichi a Miyoshi, Shiro a

a ASAHI KASEI PHARMA CORPORATION (Japan)

Author keywords

ADAMTS 5; Aggrecanase 2; Osteoarthritis; S1 pocket; Thienosultam

Indexed keywords

AGGRECANASE 2; AGGRECANASE 2 INHIBITOR; GELATINASE A; METALLOPROTEINASE INHIBITOR; METHYL 2 [5 BROMO 1,1 DIOXOTHIENO[2,3 D]ISOTHIAZOLE 2(3H)YL]UTYRATE; METHYL 3 CHLOROSULFONYL 2 THIOPHENE CARBOXYLATE; THIENOSULTAM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADAM PROTEINS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MALE; MOLECULAR STRUCTURE; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIOPHENES;

EID: 84875224045 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.01.120 Document Type: Article

Times cited : (9)

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