Design, synthesis, and preliminary biological evaluation of pyrrolo[3,4-c]quinolin-1-one and oxoisoindoline derivatives as aggrecanase inhibitors

ChemMedChem

Volumn 5, Issue 5, 2010, Pages 739-748

  Cappelli, Andrea ^a   Nannicini, Chiara ^a   Valenti, Salvatore ^a   Giuliani, Germano ^a   Anzini, Maurizio ^a   Mennuni, Laura ^b   Giordani, Antonio ^b   Caselli, Gianfranco ^b   Stasi, Luigi Piero ^b   Makovec, Francesco ^b   Giorgi, Gianluca ^a   Vomero, Salvatore ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b NONE   (Italy)

Author keywords

ADAMTS; Aggrecanase; Inhibitors; Osteoarthritis; Oxoisoindolines; Pyrroloquinolinones

Indexed keywords

2 [4 (BENZYLOXY)PHENYL] 2,3 DIHYDRO 1 OXO 1H PYRROLO[3,4 C]QUINOLINE 4 CARBALDEHYDE; 2 [4 (BENZYLOXY)PHENYL] 2,3 DIHYDRO 1 OXO 1H PYRROLO[3,4 C]QUINOLINE 4 CARBALDEHYDE OXIME; 2 [4 (BENZYLOXY)PHENYL] 2,3 DIHYDRO 1 OXO 1H PYRROLO[3,4 C]QUINOLINE 4 CARBOXYLIC ACID; 2 [4 (BENZYLOXY)PHENYL] 2,3 DIHYDRO 1H PYRROLO[3,4 C]QUINOLIN 1 ONE; 2 [4 (BENZYLOXY)PHENYL] 2,3 DIHYDRO 4 (PYRIDIN 2 YL) 1H PYRROLO[3,4 C]QUINOLIN 1 ONE; 2 [4 (BENZYLOXY)PHENYL] 2,3 DIHYDRO N HYDROXY 1 OXO 1H PYRROLO[3,4 C]QUINOLINE 4 CARBOXAMIDE; 2 [4 (BENZYLOXY)PHENYL] 3 OXOISOINDOLINE 4 CARBOXYLIC ACID; 2 [4 (BENZYLOXY)PHENYL] 4 (METHOXYMETHYL) 2,3 DIHYDRO 1H PYRROLO[3,4 C]QUINOLIN 1 ONE; 2 [4 (BENZYLOXY)PHENYL] 4 CHLORO 2,3 DIHYDRO 1H PYRROLO[3,4 C]QUINOLIN 1 ONE; 2 [4 (BENZYLOXY)PHENYL] 4 METHYL 2,3 DIHYDRO 1H PYRROLO[3,4 C] QUINOLIN 1 ONE; 2 [4 (BENZYLOXY)PHENYL] 4 METHYL 2,3 DIHYDRO 1H PYRROLO[3,4 C]QUINOLIN 1 ONE 5 OXIDE; 2 [4 (BENZYLOXY)PHENYL] N HYDROXY 3 OXOISOINDOLINE 4 CARBOXAMIDE; 3 (4 PROPOXYPHENYLIMINO) 1,3 DIHYDROISOBENZOFURAN 4 CARBOXYLIC ACID; [2 [4 (BENZYLOXY)PHENYL] 2,3 DIHYDRO 1 OXO 1H PYRROLO[3,4 C]QUINOLIN 4 YL]METHYL 4 METHYLBENZENESULFONATE; AGGRECANASE 1; AGGRECANASE 2; AGGRECANASE INHIBITOR; CARBOXYLIC ACID DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; INDOLE DERIVATIVE; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BIOASSAY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ADAM PROTEINS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENDOPEPTIDASES; INDOLES; MOLECULAR CONFORMATION; PROTEASE INHIBITORS; QUINOLONES;

EID: 77951687038     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900523     Document Type: Article

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