Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 9, 2009, Pages 2487-2491

  Hopper, Darrin W ^a   Vera, Matthew D ^a   How, David ^a   Sabatini, Joshua ^a   Xiang, Jason S ^b   Ipek, Manus ^b   Thomason, Jennifer ^b   Hu, Yonghan ^b   Feyfant, Eric ^b   Wang, Qin ^b   Georgiadis, Katy E ^b   Reifenberg, Erica ^b   Sheldon, Richard T ^b   Keohan, Cristin C ^b   Majumdar, Manas K ^b   Morris, Elisabeth A ^b   Skotnicki, Jerauld ^a   Sum, Phaik Eng ^a  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

ADAMTS 4; Agg 1; Aggrecanase 1; Biphenylsulfonamides; MMP 13; MMP 2; OA; Osteoarthritis

Indexed keywords

AGGRECAN; AGGRECANASE; COLLAGENASE 3; GELATINASE A; SULFONAMIDE;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; CARTILAGE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; NONHUMAN; RAT;

ADAM PROTEINS; CARTILAGE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 2; MODELS, CHEMICAL; MOLECULAR CONFORMATION; OSTEOARTHRITIS; PROCOLLAGEN N-ENDOPEPTIDASE; PROTEOGLYCANS; SULFONAMIDES;

EID: 64249127623     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.056     Document Type: Article

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