-
1
-
-
24044479679
-
BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper
-
Angeletti, B., Waldron, K.J., Freeman, K.B., Bawagan, H., Hussain, I., Miller, C.C., Lau, K.F., Tennant, M.E., Dennison, C., Robinson, N.J., et al. 2005. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. J. Biol. Chem. 280: 17930-17937.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17930-17937
-
-
Angeletti, B.1
Waldron, K.J.2
Freeman, K.B.3
Bawagan, H.4
Hussain, I.5
Miller, C.C.6
Lau, K.F.7
Tennant, M.E.8
Dennison, C.9
Robinson, N.J.10
-
2
-
-
32444443485
-
Involvement of amyloid β precursor protein (AβPP) modulated copper homeostasis in Alzheimer's disease
-
Bayer, T.A. and Multhaup, G. 2005. Involvement of amyloid β precursor protein (AβPP) modulated copper homeostasis in Alzheimer's disease. J. Alzheimers Dis. 8: 201-215.
-
(2005)
J. Alzheimers Dis.
, vol.8
, pp. 201-215
-
-
Bayer, T.A.1
Multhaup, G.2
-
3
-
-
10744226316
-
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice
-
Bayer, T.A., Schafer, S., Simons, A., Kemmling, A., Kamer, T., Tepest, R., Eckert, A., Schussel, K., Eikenberg, O., Sturchler-Pierrat, C., et al. 2003. Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice. Proc. Natl. Acad. Sci. 100: 14187-14192.
-
(2003)
Proc. Natl. Acad. Sci.
, vol.100
, pp. 14187-14192
-
-
Bayer, T.A.1
Schafer, S.2
Simons, A.3
Kemmling, A.4
Kamer, T.5
Tepest, R.6
Eckert, A.7
Schussel, K.8
Eikenberg, O.9
Sturchler-Pierrat, C.10
-
4
-
-
0035815635
-
Post-translational processing of β-secretase (β-amyloid- converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production
-
Benjannet, S., Elagoz, A., Wickham, L., Mamarbachi, M., Munzer, J.S., Basak, A., Lazure, C., Cromlish, J.A., Sisodia, S., Checler, F., et al. 2001. Post-translational processing of β-secretase (β-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production. J. Biol. Chem. 276: 10879-10887.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10879-10887
-
-
Benjannet, S.1
Elagoz, A.2
Wickham, L.3
Mamarbachi, M.4
Munzer, J.S.5
Basak, A.6
Lazure, C.7
Cromlish, J.A.8
Sisodia, S.9
Checler, F.10
-
5
-
-
0033616819
-
Cytoplasmic RNA modulators of an inside-out signal-transduction cascade
-
Blind, M., Kolanus, W., and Famulok, M. 1999. Cytoplasmic RNA modulators of an inside-out signal-transduction cascade. Proc. Natl. Acad. Sci. 96: 3606-3610.
-
(1999)
Proc. Natl. Acad. Sci.
, vol.96
, pp. 3606-3610
-
-
Blind, M.1
Kolanus, W.2
Famulok, M.3
-
6
-
-
0028874701
-
Structural probing and damage selection of citrulline- and arginine-specific RNA aptamers identify base positions required for binding
-
Burgstaller, P., Kochoyan, M., and Famulok, M. 1995. Structural probing and damage selection of citrulline- and arginine-specific RNA aptamers identify base positions required for binding. Nucleic Acids Res. 23: 4769-4776.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 4769-4776
-
-
Burgstaller, P.1
Kochoyan, M.2
Famulok, M.3
-
7
-
-
0031278397
-
RNA aptamers to the peptidyl transferase inhibitor chloramphenicol
-
Burke, D.H., Hoffman, D.C., Brown, A., Hansen, M., Pardi, A., and Gold, L. 1997. RNA aptamers to the peptidyl transferase inhibitor chloramphenicol. Chem. Biol. 4: 833-843.
-
(1997)
Chem. Biol.
, vol.4
, pp. 833-843
-
-
Burke, D.H.1
Hoffman, D.C.2
Brown, A.3
Hansen, M.4
Pardi, A.5
Gold, L.6
-
8
-
-
85045502002
-
Randomization of genes by PCR mutagenesis
-
Cadwell, R.C. and Joyce, G.F. 1992. Randomization of genes by PCR mutagenesis. PCR Methods Appl. 2: 28-33.
-
(1992)
PCR Methods Appl.
, vol.2
, pp. 28-33
-
-
Cadwell, R.C.1
Joyce, G.F.2
-
9
-
-
0034852021
-
Automated selection of anti-protein aptamers
-
Cox, J.C. and Ellington, A.D. 2001. Automated selection of anti-protein aptamers. Bioorg. Med. Chem. 9: 2525-2531.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 2525-2531
-
-
Cox, J.C.1
Ellington, A.D.2
-
10
-
-
4644229581
-
Design and development of BACE-1 inhibitors
-
Cumming, J.N., Iserloh, U., and Kennedy, M.E. 2004. Design and development of BACE-1 inhibitors. Curr. Opin. Drug Discov. Devel. 7: 536-556.
-
(2004)
Curr. Opin. Drug Discov. Devel.
, vol.7
, pp. 536-556
-
-
Cumming, J.N.1
Iserloh, U.2
Kennedy, M.E.3
-
11
-
-
0025074907
-
In vitro selection of RNA molecules that bind specific ligands
-
Ellington, A.D. and Szostak, J.W. 1990. In vitro selection of RNA molecules that bind specific ligands. Nature 346: 818-822.
-
(1990)
Nature
, vol.346
, pp. 818-822
-
-
Ellington, A.D.1
Szostak, J.W.2
-
12
-
-
0036263257
-
β-Secretase as a therapeutic target for inhibitor drugs
-
Ghosh, A.K., Hong, L., and Tang, J. 2002. β-Secretase as a therapeutic target for inhibitor drugs. Curr. Med. Chem. 9: 1135-1144.
-
(2002)
Curr. Med. Chem.
, vol.9
, pp. 1135-1144
-
-
Ghosh, A.K.1
Hong, L.2
Tang, J.3
-
13
-
-
1442264828
-
Take five-BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation
-
Haass, C. 2004. Take five-BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation. EMBO J. 23: 483-488.
-
(2004)
EMBO J.
, vol.23
, pp. 483-488
-
-
Haass, C.1
-
14
-
-
15744380393
-
GGA proteins mediate the recycling pathway of memapsin 2 (BACE)
-
He, X., Li, F., Chang, W.P., and Tang, J. 2005. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J. Biol. Chem. 280: 11696-11703.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11696-11703
-
-
He, X.1
Li, F.2
Chang, W.P.3
Tang, J.4
-
15
-
-
0028177269
-
The β A4 amyloid precursor protein binding to copper
-
Hesse, L., Beher, D., Masters, C.L., and Multhaup, G. 1994. The β A4 amyloid precursor protein binding to copper. FEBS Lett. 349: 109-116.
-
(1994)
FEBS Lett.
, vol.349
, pp. 109-116
-
-
Hesse, L.1
Beher, D.2
Masters, C.L.3
Multhaup, G.4
-
16
-
-
0141704284
-
Characterization of the ectodomain shedding of the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1)
-
Hussain, I., Hawkins, J., Shikotra, A., Riddell, D.R., Faller, A., and Dingwall, C. 2003. Characterization of the ectodomain shedding of the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1). J. Biol. Chem. 278: 36264-36268.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 36264-36268
-
-
Hussain, I.1
Hawkins, J.2
Shikotra, A.3
Riddell, D.R.4
Faller, A.5
Dingwall, C.6
-
17
-
-
0032445969
-
RNA aptamers that specifically bind to the Ras-binding domain of Raf-1
-
Kimoto, M., Sakamoto, K., Shirouzu, M., Hirao, I., and Yokoyama, S. 1998. RNA aptamers that specifically bind to the Ras-binding domain of Raf-1. FEBS Lett. 441: 322-326.
-
(1998)
FEBS Lett.
, vol.441
, pp. 322-326
-
-
Kimoto, M.1
Sakamoto, K.2
Shirouzu, M.3
Hirao, I.4
Yokoyama, S.5
-
18
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
-
Luo, Y., Bolon, B., Kahn, S., Bennett, B.D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., et al. 2001. Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation. Nat. Neurosci. 4: 231-232.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 231-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
Bennett, B.D.4
Babu-Khan, S.5
Denis, P.6
Fan, W.7
Kha, H.8
Zhang, J.9
Gong, Y.10
-
19
-
-
0035942221
-
Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers
-
Mayer, G., Blind, M., Nagel, W., Bohm, T., Knorr, T., Jackson, C.L., Kolanus, W., and Famulok, M. 2001. Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers. Proc. Natl. Acad. Sci. 98: 4961-4965.
-
(2001)
Proc. Natl. Acad. Sci.
, vol.98
, pp. 4961-4965
-
-
Mayer, G.1
Blind, M.2
Nagel, W.3
Bohm, T.4
Knorr, T.5
Jackson, C.L.6
Kolanus, W.7
Famulok, M.8
-
20
-
-
0036628728
-
Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease
-
Multhaup, G., Scheuermann, S., Schlicksupp, A., Simons, A., Strauss, M., Kemmling, A., Oehler, C., Cappai, R., Pipkorn, R., and Bayer, T.A. 2002. Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease. Free Radic. Biol. Med. 33: 45-51.
-
(2002)
Free Radic. Biol. Med.
, vol.33
, pp. 45-51
-
-
Multhaup, G.1
Scheuermann, S.2
Schlicksupp, A.3
Simons, A.4
Strauss, M.5
Kemmling, A.6
Oehler, C.7
Cappai, R.8
Pipkorn, R.9
Bayer, T.A.10
-
21
-
-
0029062420
-
In vitro selection of RNA ligands to substance P
-
Nieuwlandt, D., Wecker, M., and Gold, L. 1995. In vitro selection of RNA ligands to substance P. Biochemistry 34: 5651-5659.
-
(1995)
Biochemistry
, vol.34
, pp. 5651-5659
-
-
Nieuwlandt, D.1
Wecker, M.2
Gold, L.3
-
22
-
-
0036902277
-
Prion-protein-specific aptamer reduces PrPSc formation
-
Proske, D., Gilch, S., Wopfner, F., Schatzl, H.M., Winnacker, E.L., and Famulok, M. 2002a. Prion-protein-specific aptamer reduces PrPSc formation. Chembiochem 3: 717-725.
-
(2002)
Chembiochem
, vol.3
, pp. 717-725
-
-
Proske, D.1
Gilch, S.2
Wopfner, F.3
Schatzl, H.M.4
Winnacker, E.L.5
Famulok, M.6
-
23
-
-
0037192857
-
A Y2 receptor mimetic aptamer directed against neuropeptide Y
-
Proske, D., Hofliger, M., Soll, R.M., Beck-Sickinger, A.G., and Famulok, M. 2002b. A Y2 receptor mimetic aptamer directed against neuropeptide Y. J. Biol. Chem. 277: 11416-11422.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 11416-11422
-
-
Proske, D.1
Hofliger, M.2
Soll, R.M.3
Beck-Sickinger, A.G.4
Famulok, M.5
-
24
-
-
0141891211
-
Characterization of 2′-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion
-
Rhie, A., Kirby, L., Sayer, N., Wellesley, R., Disterer, P., Sylvester, I., Gill, A., Hope, J., James, W., and Tahiri-Alaoui, A. 2003. Characterization of 2′-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion. J. Biol. Chem. 278: 39697-39705.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 39697-39705
-
-
Rhie, A.1
Kirby, L.2
Sayer, N.3
Wellesley, R.4
Disterer, P.5
Sylvester, I.6
Gill, A.7
Hope, J.8
James, W.9
Tahiri-Alaoui, A.10
-
25
-
-
0036547481
-
Inhibition of BACE, a promising approach to Alzheimer's disease therapy
-
Roggo, S. 2002. Inhibition of BACE, a promising approach to Alzheimer's disease therapy. Curr. Top. Med. Chem. 2: 359-370.
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, pp. 359-370
-
-
Roggo, S.1
-
26
-
-
1842424691
-
Structural determinants of conformationally selective, prion-binding aptamers
-
Sayer, N.M., Cubin, M., Rhie, A., Bullock, M., Tahiri-Alaoui, A., and James, W. 2004. Structural determinants of conformationally selective, prion-binding aptamers. J. Biol. Chem. 279: 13102-13109.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 13102-13109
-
-
Sayer, N.M.1
Cubin, M.2
Rhie, A.3
Bullock, M.4
Tahiri-Alaoui, A.5
James, W.6
-
27
-
-
0034131429
-
Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA 5′-ends
-
Sengle, G., Jenne, A., Arora, P.S., Seelig, B., Nowick, J.S., Jaschke, A., and Famulok, M. 2000. Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA 5′-ends. Bioorg. Med. Chem. 8: 1317-1329.
-
(2000)
Bioorg. Med. Chem.
, vol.8
, pp. 1317-1329
-
-
Sengle, G.1
Jenne, A.2
Arora, P.S.3
Seelig, B.4
Nowick, J.S.5
Jaschke, A.6
Famulok, M.7
-
28
-
-
3843086053
-
Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2
-
Theis, M.G., Knorre, A., Kellersch, B., Moelleken, J., Wieland, F., Kolanus, W., and Famulok, M. 2004. Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2. Proc. Natl. Acad. Sci. 101: 11221-11226.
-
(2004)
Proc. Natl. Acad. Sci.
, vol.101
, pp. 11221-11226
-
-
Theis, M.G.1
Knorre, A.2
Kellersch, B.3
Moelleken, J.4
Wieland, F.5
Kolanus, W.6
Famulok, M.7
-
29
-
-
0025194307
-
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
-
Tuerk, C. and Gold, L. 1990. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249: 505-510.
-
(1990)
Science
, vol.249
, pp. 505-510
-
-
Tuerk, C.1
Gold, L.2
-
30
-
-
0037388067
-
Misfolded CuZnSOD and amyotrophic lateral sclerosis
-
Valentine, J.S. and Hart, P.J. 2003. Misfolded CuZnSOD and amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. 100: 3617-3622.
-
(2003)
Proc. Natl. Acad. Sci.
, vol.100
, pp. 3617-3622
-
-
Valentine, J.S.1
Hart, P.J.2
-
31
-
-
15944378214
-
β-Secretase, APP and Aβ in Alzheimer's disease
-
Vassar, R. 2005. β-Secretase, APP and Aβ in Alzheimer's disease. Subcell. Biochem. 38: 79-103.
-
(2005)
Subcell. Biochem.
, vol.38
, pp. 79-103
-
-
Vassar, R.1
-
32
-
-
9444282652
-
Demonstration of BACE (β-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy
-
von Arnim, C.A., Tangredi, M.M., Peltan, I.D., Lee, B.M., Irizarry, M.C., Kinoshita, A., and Hyman, B.T. 2004. Demonstration of BACE (β-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy. J. Cell Sci. 117: 5437-5445.
-
(2004)
J. Cell Sci.
, vol.117
, pp. 5437-5445
-
-
Von Arnim, C.A.1
Tangredi, M.M.2
Peltan, I.D.3
Lee, B.M.4
Irizarry, M.C.5
Kinoshita, A.6
Hyman, B.T.7
-
33
-
-
20444377260
-
GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network
-
Wahle, T., Prager, K., Raffler, N., Haass, C., Famulok, M., and Walter, J. 2005. GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Mol. Cell. Neurosci. 29: 453-461.
-
(2005)
Mol. Cell. Neurosci.
, vol.29
, pp. 453-461
-
-
Wahle, T.1
Prager, K.2
Raffler, N.3
Haass, C.4
Famulok, M.5
Walter, J.6
-
34
-
-
0035805592
-
Phosphorylation regulates intracellular trafficking of β-secretase
-
Walter, J., Fluhrer, R., Hartung, B., Willem, M., Kaether, C., Capell, A., Lammich, S., Multhaup, G., and Haass, C. 2001a. Phosphorylation regulates intracellular trafficking of β-secretase. J. Biol. Chem. 276: 14634-14641.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14634-14641
-
-
Walter, J.1
Fluhrer, R.2
Hartung, B.3
Willem, M.4
Kaether, C.5
Capell, A.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
35
-
-
0035477333
-
The cell biology of Alzheimer's disease: Uncovering the secrets of secretases
-
Walter, J., Kaether, C., Steiner, H., and Haass, C. 2001b. The cell biology of Alzheimer's disease: Uncovering the secrets of secretases. Curr. Opin. Neurobiol. 11: 585-590.
-
(2001)
Curr. Opin. Neurobiol.
, vol.11
, pp. 585-590
-
-
Walter, J.1
Kaether, C.2
Steiner, H.3
Haass, C.4
-
36
-
-
0030843497
-
RNA aptamers specifically interact with the prion protein PrP
-
Weiss, S., Proske, D., Neumann, M., Groschup, M.H., Kretzschmar, H.A., Famulok, M., and Winnacker, E.L. 1997. RNA aptamers specifically interact with the prion protein PrP. J. Virol. 71: 8790-8797.
-
(1997)
J. Virol.
, vol.71
, pp. 8790-8797
-
-
Weiss, S.1
Proske, D.2
Neumann, M.3
Groschup, M.H.4
Kretzschmar, H.A.5
Famulok, M.6
Winnacker, E.L.7
-
37
-
-
0034646410
-
Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase
-
Wong, P.C., Waggoner, D., Subramaniam, J.R., Tessarollo, L., Bartnikas, T.B., Culotta, V.C., Price, D.L., Rothstein, J., and Gitlin, J.D. 2000. Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc. Natl. Acad. Sci. 97: 2886-2891.
-
(2000)
Proc. Natl. Acad. Sci.
, vol.97
, pp. 2886-2891
-
-
Wong, P.C.1
Waggoner, D.2
Subramaniam, J.R.3
Tessarollo, L.4
Bartnikas, T.B.5
Culotta, V.C.6
Price, D.L.7
Rothstein, J.8
Gitlin, J.D.9
-
38
-
-
2442442119
-
Directed in vitro evolution and crystallographic analysis of a peptide-binding single chain antibody fragment (scFv) with low picomolar affinity
-
Zahnd, C., Spinelli, S., Luginbuhl, B., Amstutz, P., Cambillau, C., and Pluckthun, A. 2004. Directed in vitro evolution and crystallographic analysis of a peptide-binding single chain antibody fragment (scFv) with low picomolar affinity. J. Biol. Chem. 279: 18870-18877.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18870-18877
-
-
Zahnd, C.1
Spinelli, S.2
Luginbuhl, B.3
Amstutz, P.4
Cambillau, C.5
Pluckthun, A.6
-
39
-
-
30744457479
-
Probing RNA structure with chemical reagents and enzymes
-
Wiley-VCH, Weinheim, Germany
-
Ziehler, W.A. and Engelke, D.R. 2000. Probing RNA structure with chemical reagents and enzymes. In Current protocols in nucleic acid chemistry, pp. 6.1.1-6.1.21. Wiley-VCH, Weinheim, Germany.
-
(2000)
Current Protocols in Nucleic Acid Chemistry
-
-
Ziehler, W.A.1
Engelke, D.R.2
|