Tissue plasminogen activator and stroke: Review of the literature for the clinician

Journal of Emergency Medicine

Volumn 43, Issue 6, 2012, Pages 1149-1154

  Demers, Gerard ^a   Meurer, William J ^b   Shih, Richard ^c   Rosenbaum, Steve ^d   Vilke, Gary M ^a  

^a UCSD MEDICAL CENTER   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c MORRISTOWN MEMORIAL HOSPITAL   (United States)

^d Mountainside Medical Center   (United States)

Author keywords

alteplase; cerebral vascular accident; CVA; stroke; TIA; tissue plasminogen activator; tPA

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

BLOOD CLOT LYSIS; CEREBROVASCULAR ACCIDENT; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; EMERGENCY PHYSICIAN; EMERGENCY WARD; HUMAN; MEDICAL LITERATURE; MEDLINE; PATIENT CARE; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; SYSTEMATIC REVIEW;

EID: 84870397199     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2012.05.005     Document Type: Article

References (20)

1. H.P. Adams Jr., G. del Zoppo, and M.J. Alberts Guidelines for the early management of adults with ischemic stroke: A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists Stroke 38 2007 1655 1711
2. W.J. Meurer, J.J. Majersik, and S.M. Frederiksen Kade1 AM, Sandretto AM, Scott PM. Provider perceptions of barriers to the emergency use of tPA for Acute Ischemic Stroke: a qualitative study BMC Emerg Med 11 2011 5
3. H.C. Schumacher, B.T. Bateman, and B. Boden-Albala Use of thrombolysis in acute ischemic stroke: analysis of the nationwide inpatient sample 1999 to 2004 Ann Emerg Med 50 2007 99 107
4. W. Hacke, G. Donnan, and C. Fieschi Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials Lancet 363 2004 768 774
5. G.D. Graham Tissue plasminogen activator for acute ischemic stroke in clinical practice: a meta-analysis of safety data Stroke 34 2003 2847 2850
6. M.G. Lansberg, E. Bluhmki, and V.N. Thijs Efficacy and safety of tissue plasminogen activator 3 to hours after acute ischemic stroke: a metaanalysis Stroke 40 2009 2438 2441
7. N. Wahlgren, N. Ahmed, and A. Dávalos Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study Lancet 369 2007 275 282
8. O. Mielke, J. Wardlaw, and M. Liu Thrombolysis (different doses, routes of administration and agents) for acute ischaemic stroke Cochrane Database Syst Rev 4 2004 CD000514
9. J.M. Wardlaw, G. Zoppo, T. Yamaguchi, and E. Berge Thrombolysis for acute ischaemic stroke Cochrane Database Syst Rev 3 2003 CD000213
10. J.M. Wardlaw, P.A. Sandercock, and E. Berge Thrombolytic therapy with recombinant tissue plasminogen activator for acute ischemic stroke: where do we go from here? A cumulative meta-analysis Stroke 34 2003 1437 1442
11. J.M. Wardlaw, C.P. Warlow, and C. Counsell Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke Lancet 350 1997 607 614
12. W. Hacke, M. Kaste, E. Bluhmki ECASS Investigators Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke N Engl J Med 359 2008 1317 1329
13. W.M. Clark, S. Wissman, G.W. Albers, J.H. Jhamandas, K.P. Madden, and S. Hamilton Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke JAMA 282 1999 2019 2026
14. W. Hacke, M. Kaste, and C. Fieschi Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators Lancet 352 1998 1245 1251
15. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group N Engl J Med 333 1995 1581 1587
16. W. Hacke, M. Kaste, and C. Fieschi Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) JAMA 274 1995 1017 1025
17. C.A. Cronin Intravenous tissue plasminogen activator for stroke: A review of the ECASS III results in relation to prior clinical trials J Emerg Med 38 2010 99 105
18. P. Bhatnagar, D. Sinha, and R.A. Parker Intravenous thrombolysis in acute ischaemic stroke: a systemic review and meta-analysis to aid decision making in patients over 80 years of age J Neurol Neurosurg Psychiatry 82 2011 712 717
19. A. Towfighi, and J.L. Saver Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead Stroke 42 2011 2351 2355
20. INSTINCT, Principal Investigator: Phillip A. Scott, ClinicalTrials.gov identifier: NCT00349479.