Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease

American Journal of Pathology

Volumn 179, Issue 1, 2011, Pages 116-124

  Darisipudi, Murthy N ^a   Kulkarni, Onkar P ^a   Sayyed, Sufyan G ^a   Ryu, Mi ^a   Migliorini, Adriana ^a   Sagrinati, Costanza ^b   Parente, Eliana ^b   Vater, Axel ^c   Eulberg, Dirk ^c   Klussmann, Sven ^c   Romagnani, Paola ^b   Anders, Hans Joachim ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF FLORENCE   (Italy)

^c NOXXON PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; CREATININE; DRUG ADDITIVE; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MESSENGER RNA; MNOXE 36; MONOCYTE CHEMOTACTIC PROTEIN 1; NEPHRIN; NOXA 12; PODOCIN; SPIEGELMER; UNCLASSIFIED DRUG;

ALBUMIN BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DISEASE COURSE; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; ENANTIOMER; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE REPRESSION; GLOMERULOSCLEROSIS; GLOMERULUS; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; LEUKOCYTE COUNT; MALE; MONOTHERAPY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; RENAL PROTECTION; STEM CELL; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINE CXCL12; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; GLOMERULAR FILTRATION RATE; GLOMERULONEPHRITIS; IMMUNOENZYME TECHNIQUES; INTERLEUKIN-6; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY GLOMERULUS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, OBESE; NITRIC OXIDE SYNTHASE TYPE II; PODOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELLS;

EID: 80052435113     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.03.004     Document Type: Article

References (31)

1. P. Zimmet, K.G. Alberti, and J. Shaw Global and societal implications of the diabetes epidemic Nature 414 2001 782 787
2. E. Ritz, I. Rychlik, F. Locatelli, and S. Halimi End-stage renal failure in type 2 diabetes: a medical catastrophe of worldwide dimensions Am J Kidney Dis 34 1999 795 808
3. II: incidence and prevalence of ESRD Am J Kidney Dis 34 Suppl 1 1999 S40 S50
4. M. Svensson, G. Sundkvist, H.J. Arnqvist, E. Bjork, G. Blohme, J. Bolinder, M. Henricsson, L. Nystrom, O. Torffvit, I. Waernbaum, J. Ostman, and J.W. Eriksson Signs of nephropathy may occur early in young adults with diabetes despite modern diabetes management: results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS) Diabetes Care 26 2003 2903 2909
5. Y. Qian, E. Feldman, S. Pennathur, M. Kretzler, and F.C. Brosius 3rd From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy Diabetes 57 2008 1439 1445
6. S. Yamagishi, K. Fukami, S. Ueda, and S. Okuda Molecular mechanisms of diabetic nephropathy and its therapeutic intervention Curr Drug Targets 8 2007 952 959
7. C. Ruster, and G. Wolf The role of chemokines and chemokine receptors in diabetic nephropathy Front Biosci 13 2008 944 955
8. E. Galkina, and K. Ley Leukocyte recruitment and vascular injury in diabetic nephropathy J Am Soc Nephrol 17 2006 368 377
9. G.H. Tesch MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy Am J Physiol Renal Physiol 294 2008 F697 F701
10. V. Vielhauer, O. Kulkarni, C.A. Reichel, and H.J. Anders Targeting the recruitment of monocytes and macrophages in renal disease Semin Nephrol 30 2010 318 333
11. F.Y. Chow, D.J. Nikolic-Paterson, F.Y. Ma, E. Ozols, B.J. Rollins, and G.H. Tesch Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice Diabetologia 50 2007 471 480
12. F.Y. Chow, D.J. Nikolic-Paterson, E. Ozols, R.C. Atkins, B.J. Rollin, and G.H. Tesch Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice Kidney Int 69 2006 73 80
13. V. Ninichuk, S. Clauss, O. Kulkarni, H. Schmid, S. Segerer, E. Radomska, D. Eulberg, K. Buchner, N. Selve, S. Klussmann, and H.J. Anders Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3′PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice Am J Pathol 172 2008 628 637
14. B. Moser, M. Wolf, A. Walz, and P. Loetscher Chemokines: multiple levels of leukocyte migration control Trends Immunol 25 2004 75 84
15. S.G. Sayyed, H. Hagele, O.P. Kulkarni, K. Endlich, S. Segerer, D. Eulberg, S. Klussmann, and H.J. Anders Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes Diabetologia 52 2009 2445 2454
16. D. Eulberg, W. Purschke, H.J. Anders, N. Selve, and S. Klussmann Spiegelmer NOX-E36 for renal diseases Therapeutic Oligonucleotides J. Kurreck, 2008 Biomolecular Sciences Series of the Royal Society of Chemistry (RSC) Cambridge, UK 200 221
17. O. Kulkarni, R.D. Pawar, W. Purschke, D. Eulberg, N. Selve, K. Buchner, V. Ninichuk, S. Segerer, V. Vielhauer, S. Klussmann, and H.J. Anders Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice J Am Soc Nephrol 18 2007 2350 2358
18. V. Ninichuk, A.G. Khandoga, S. Segerer, P. Loetscher, A. Schlapbach, L. Revesz, R. Feifel, A. Khandoga, F. Krombach, P.J. Nelson, D. Schlondorff, and H.J. Anders The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice Am J Pathol 170 2007 1267 1276
19. S.G. Sayyed, A.B. Gaikwad, J. Lichtnekert, O. Kulkarni, D. Eulberg, S. Klussmann, K. Tikoo, and H.J. Anders Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation: H3K4 dimethylation and phosphorylation at serine 10 Nephrol Dial Transplant 25 2010 1811 1817
20. P.S. Patole, S. Schubert, K. Hildinger, S. Khandoga, A. Khandoga, S. Segerer, A. Henger, M. Kretzler, M. Werner, F. Krombach, D. Schlondorff, and H.J. Anders Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis Kidney Int 68 2005 2582 2587
21. F. Chow, E. Ozols, D.J. Nikolic-Paterson, R.C. Atkins, and G.H. Tesch Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury Kidney Int 65 2004 116 128
22. S.G. Sayyed, M. Ryu, O.P. Kulkarni, H. Schmid, J. Lichtnekert, S. Grner, L. Green, P. Mattei, G. Hartmann, and H.J. Anders Oral treatment with a chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes Kidney Int 2011 in press
23. A. Mantovani, A. Sica, S. Sozzani, P. Allavena, A. Vecchi, and M. Locati The chemokine system in diverse forms of macrophage activation and polarization Trends Immunol 25 2004 677 686
24. S.D. Ricardo, H. van Goor, and A.A. Eddy Macrophage diversity in renal injury and repair J Clin Invest 118 2008 3522 3530
25. J. Patrakka, and K. Tryggvason New insights into the role of podocytes in proteinuria Nat Rev Nephrol 5 2009 463 468
26. K. Susztak, A.C. Raff, M. Schiffer, and E.P. Bottinger Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy Diabetes 55 2006 225 233
27. D. Appel, D.B. Kershaw, B. Smeets, G. Yuan, A. Fuss, B. Frye, M. Elger, W. Kriz, J. Floege, and M.J. Moeller Recruitment of podocytes from glomerular parietal epithelial cells J Am Soc Nephrol 20 2009 333 343
28. E. Ronconi, C. Sagrinati, M.L. Angelotti, E. Lazzeri, B. Mazzinghi, L. Ballerini, E. Parente, F. Becherucci, M. Gacci, M. Carini, E. Maggi, M. Serio, G.B. Vannelli, L. Lasagni, S. Romagnani, and P. Romagnani Regeneration of glomerular podocytes by human renal progenitors J Am Soc Nephrol 20 2009 322 332
29. A. Peled, I. Petit, O. Kollet, M. Magid, T. Ponomaryov, T. Byk, A. Nagler, H. Ben-Hur, A. Many, L. Shultz, O. Lider, R. Alon, D. Zipori, and T. Lapidot Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4 Science 283 1999 845 848
30. S.T. Avecilla, K. Hattori, B. Heissig, R. Tejada, F. Liao, K. Shido, D.K. Jin, S. Dias, F. Zhang, T.E. Hartman, N.R. Hackett, R.G. Crystal, L. Witte, D.J. Hicklin, P. Bohlen, D. Eaton, D. Lyden, F. de Sauvage, and S. Rafii Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis Nat Med 10 2004 64 71
31. T. Sugiyama, H. Kohara, M. Noda, and T. Nagasawa Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches Immunity 25 2006 977 988