RNA aptamers as reversible antagonists of coagulation factor IXa

Nature

Volumn 419, Issue 6902, 2002, Pages 90-94

  Rusconi, Christopher P ^a   Scardino, Elizabeth ^a   Layzer, Juliana ^a   Pitoc, George A ^a   Ortel, Thomas L ^a   Monroe, Dougald ^a   Sullenger, Bruce A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; PHYSIOLOGY; PROTEINS; RNA;

COAGULATION FACTOR; DRUG ACTION;

DRUG THERAPY;

ANTICOAGULANT AGENT; ANTIDOTE; APTAMER; BLOOD CLOTTING FACTOR 9A; BLOOD CLOTTING FACTOR 9A INHIBITOR; HEPARIN; PROTAMINE; PROTEIN INHIBITOR; RNA DERIVATIVE; UNCLASSIFIED DRUG;

RNA;

ANTICOAGULATION; ARTICLE; BLEEDING; CLINICAL ARTICLE; DRUG INDUCED DISEASE; DRUG SAFETY; HUMAN; MORBIDITY; MORTALITY; PRIORITY JOURNAL;

ANTICOAGULANTS; ANTIDOTES; BASE SEQUENCE; BINDING, COMPETITIVE; DRUG DESIGN; FACTOR IXA; FACTOR VIIIA; FACTOR X; HEPARIN; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGORIBONUCLEOTIDES; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; RNA; THROMBOCYTOPENIA;

EID: 0037026484     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00963     Document Type: Article

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