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Volumn 10, Issue 4, 2013, Pages 451-468

Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy

Author keywords

Antibody drug conjugates; Cancer therapy; EpCAM; Novel binding proteins; Tumor targeting

Indexed keywords

ADECATUMUMAB; ADENOVIRUS VECTOR; ANTIBODY; CATUMAXOMAB; DIPHTHERIA TOXIN; EPITHELIAL CELL ADHESION MOLECULE; EPITHELIAL CELL ADHESION MOLECULE ANTIBODY; IMMUNOGLOBULIN; IMMUNOLIPOSOME; METHOTREXATE; NANOPARTICLE; OPORTUZUMAB MONATOX; PSEUDOMONAS EXOTOXIN; RANPIRNASE; UNCLASSIFIED DRUG;

EID: 84875129950     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2013.759938     Document Type: Review
Times cited : (79)

References (146)
  • 1
    • 49449119098 scopus 로고    scopus 로고
    • Antibody-drug conjugates for cancer therapy
    • Carter PJ, Senter PD. Antibody-drug conjugates for cancer therapy. Cancer J 2008;14(3):154-69
    • (2008) Cancer J , vol.14 , Issue.3 , pp. 154-169
    • Carter, P.J.1    Senter, P.D.2
  • 4
    • 8744295088 scopus 로고    scopus 로고
    • Antibody-directed enzyme prodrug therapy (ADEPT) for cancer
    • Bagshawe KD, Sharma SK, Begent RH. Antibody-directed enzyme prodrug therapy (ADEPT) for cancer. Expert Opin Biol Ther 2004;4(11):1777-89
    • (2004) Expert Opin Biol Ther , vol.4 , Issue.11 , pp. 1777-1789
    • Bagshawe, K.D.1    Sharma, S.K.2    Begent, R.H.3
  • 6
    • 27144511241 scopus 로고    scopus 로고
    • Engineering novel binding proteins from nonimmunoglobulin domains
    • Binz HK, Amstutz P, Plückthun A. Engineering novel binding proteins from nonimmunoglobulin domains. Nat Biotechnol 2005;23(10):1257-68
    • (2005) Nat Biotechnol , vol.23 , Issue.10 , pp. 1257-1268
    • Binz, H.K.1    Amstutz, P.2    Plückthun, A.3
  • 7
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington AD, Szostak JW. In vitro selection of RNA molecules that bind specific ligands. Nature 1990;346(6287):818-22
    • (1990) Nature , vol.346 , Issue.6287 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 8
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk C, Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 1990;249(4968):505-10
    • (1990) Science , vol.249 , Issue.4968 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 9
    • 77954914696 scopus 로고    scopus 로고
    • Aptamers for targeted drug delivery
    • Ray P, White RR. Aptamers for targeted drug delivery. Pharmaceuticals 2010;3(6):1761-78
    • (2010) Pharmaceuticals , vol.3 , Issue.6 , pp. 1761-1778
    • Ray, P.1    White, R.R.2
  • 10
    • 79955111547 scopus 로고    scopus 로고
    • EpCAM expression in primary tumour tissues and metastases: An immunohistochemical analysis
    • Spizzo G, Fong D, Wurm M, et al. EpCAM expression in primary tumour tissues and metastases: An immunohistochemical analysis. J Clin Pathol 2011;64(5):415-20
    • (2011) J Clin Pathol , vol.64 , Issue.5 , pp. 415-420
    • Spizzo, G.1    Fong, D.2    Wurm, M.3
  • 11
    • 1642580506 scopus 로고    scopus 로고
    • Frequent EpCAM protein expression in human carcinomas
    • Went P, Lugli A, Meier S, et al. Frequent EpCAM protein expression in human carcinomas. Hum Pathol 2004;35(1):122-8
    • (2004) Hum Pathol , vol.35 , Issue.1 , pp. 122-128
    • Went, P.1    Lugli, A.2    Meier, S.3
  • 12
    • 0028350104 scopus 로고
    • Ep-CAM: A human epithelial antigen is a homophilic cell-cell adhesion molecule
    • Litvinov SV, Velders MP, Bakker HA, et al. Ep-CAM: A human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol 1994;125(2):437-46
    • (1994) J Cell Biol , vol.125 , Issue.2 , pp. 437-446
    • Litvinov, S.V.1    Velders, M.P.2    Bakker, H.A.3
  • 13
    • 36348991571 scopus 로고    scopus 로고
    • Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma
    • Yamashita T, Budhu A, Forgues M, et al. Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res 2007;67(22):10831-9
    • (2007) Cancer Res , vol.67 , Issue.22 , pp. 10831-10839
    • Yamashita, T.1    Budhu, A.2    Forgues, M.3
  • 14
    • 4143065769 scopus 로고    scopus 로고
    • The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation
    • Münz M, Kieu C, Mack B, et al. The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 2004;23(34):5748-58
    • (2004) Oncogene , vol.23 , Issue.34 , pp. 5748-5758
    • Münz, M.1    Kieu, C.2    Mack, B.3
  • 15
    • 59749103834 scopus 로고    scopus 로고
    • Nuclear signalling by tumour-associated antigen EpCAM
    • Maetzel D, Denzel S, Mack B, et al. Nuclear signalling by tumour-associated antigen EpCAM. Nat Cell Biol 2009;11(2):162-71
    • (2009) Nat Cell Biol , vol.11 , Issue.2 , pp. 162-171
    • Maetzel, D.1    Denzel, S.2    Mack, B.3
  • 16
    • 71549145616 scopus 로고    scopus 로고
    • Initial activation of EpCAM cleavage via cell-to-cell contact
    • Denzel S, Maetzel D, Mack B, et al. Initial activation of EpCAM cleavage via cell-to-cell contact. BMC Cancer 2009;9:402
    • (2009) BMC Cancer , vol.9 , pp. 402
    • Denzel, S.1    Maetzel, D.2    Mack, B.3
  • 17
    • 84873409026 scopus 로고    scopus 로고
    • EpCAM regulates cell cycle progression via control of cyclin d1 expression
    • doi:10.1038/onc.2012.75
    • Chaves-Perez A, Mack B, Maetzel D, et al. EpCAM regulates cell cycle progression via control of cyclin D1 expression. Oncogene 2012; doi:10.1038/onc.2012.75
    • (2012) Oncogene
    • Chaves-Perez, A.1    Mack, B.2    Maetzel, D.3
  • 18
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: Models and concepts
    • Dalerba P, Cho RW, Clarke MF. Cancer stem cells: Models and concepts. Annu Rev Med 2007;58:267-84
    • (2007) Annu Rev Med , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 19
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003;100(7):3983-8
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.7 , pp. 3983-3988
    • Al-Hajj, M.1    Wicha, M.S.2    Benito-Hernandez, A.3
  • 20
    • 6044259206 scopus 로고    scopus 로고
    • Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
    • Allard WJ, Matera J, Miller MC, et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res 2004;10(20):6897-904
    • (2004) Clin Cancer Res , vol.10 , Issue.20 , pp. 6897-6904
    • Allard, W.J.1    Matera, J.2    Miller, M.C.3
  • 21
    • 42649100970 scopus 로고    scopus 로고
    • Detection, clinical relevance and specific biological properties of disseminating tumour cells
    • Pantel K, Brakenhoff RH, Brandt B. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer 2008;8(5):329-40
    • (2008) Nat Rev Cancer , vol.8 , Issue.5 , pp. 329-340
    • Pantel, K.1    Brakenhoff, R.H.2    Brandt, B.3
  • 22
    • 38449106597 scopus 로고    scopus 로고
    • EpCAM expression in normal, non-pathological tissues
    • Schmelzer E, Reid LM. EpCAM expression in normal, non-pathological tissues. Frontiers Biosci 2008;13:3096-100
    • (2008) Frontiers Biosci , vol.13 , pp. 3096-3100
    • Schmelzer, E.1    Reid, L.M.2
  • 23
    • 0343839113 scopus 로고
    • Colorectal carcinoma-specific antigen: Detection by means of monoclonal antibodies
    • Herlyn M, Steplewski Z, Herlyn D, et al. Colorectal carcinoma-specific antigen: Detection by means of monoclonal antibodies. Proc Natl Acad Sci USA 1979;76(3):1438-42
    • (1979) Proc Natl Acad Sci USA , vol.76 , Issue.3 , pp. 1438-1442
    • Herlyn, M.1    Steplewski, Z.2    Herlyn, D.3
  • 24
    • 33846804010 scopus 로고    scopus 로고
    • EpCAM (CD326) finding its role in cancer
    • Baeuerle PA, Gires O. EpCAM (CD326) finding its role in cancer. Br J Cancer 2007;96(3):417-23
    • (2007) Br J Cancer , vol.96 , Issue.3 , pp. 417-423
    • Baeuerle, P.A.1    Gires, O.2
  • 25
    • 84855952224 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule expression (CD326) in cancer: A short review
    • Patriarca C, Macchi RM, Marschner AK, et al. Epithelial cell adhesion molecule expression (CD326) in cancer: A short review. Cancer Treat Rev 2012;38(1):68-75
    • (2012) Cancer Treat Rev , vol.38 , Issue.1 , pp. 68-75
    • Patriarca, C.1    Macchi, R.M.2    Marschner, A.K.3
  • 26
    • 0035105519 scopus 로고    scopus 로고
    • Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions
    • Balzar M, Briaire-de Bruijn I, Rees-Bakker H, et al. Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions. Mol Cell Biol 2001;21(7):2570-80
    • (2001) Mol Cell Biol , vol.21 , Issue.7 , pp. 2570-2580
    • Balzar, M.1    Briaire-De Bruijn, I.2    Rees-Bakker, H.3
  • 27
    • 0035937123 scopus 로고    scopus 로고
    • Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)
    • Chong JM, Speicher DW. Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM). J Biol Chem 2001;276(8):5804-13
    • (2001) J Biol Chem , vol.276 , Issue.8 , pp. 5804-5813
    • Chong, J.M.1    Speicher, D.W.2
  • 28
    • 34250792850 scopus 로고    scopus 로고
    • A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression
    • Kuhn S, Koch M, Nubel T, et al. A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression. Mol Cancer Res 2007;5(6):553-67
    • (2007) Mol Cancer Res , vol.5 , Issue.6 , pp. 553-567
    • Kuhn, S.1    Koch, M.2    Nubel, T.3
  • 29
    • 0032749197 scopus 로고    scopus 로고
    • The biology of the 17-1A antigen (Ep-CAM)
    • Balzar M, Winter M, de Boer C, et al. The biology of the 17-1A antigen (Ep-CAM). J Mol Med 1999;77(10):699-712
    • (1999) J Mol Med , vol.77 , Issue.10 , pp. 699-712
    • Balzar, M.1    Winter, M.2    De Boer, C.3
  • 30
    • 0035020015 scopus 로고    scopus 로고
    • Anti-self antibodies selected from a human IgD heavy chain repertoire: A novel approach to generate therapeutic human antibodies against tumor-associated differentiation antigens
    • Raum T, Gruber R, Riethmüller G, et al. Anti-self antibodies selected from a human IgD heavy chain repertoire: A novel approach to generate therapeutic human antibodies against tumor-associated differentiation antigens. Cancer Immunol Immunother 2001;50(3):141-50
    • (2001) Cancer Immunol Immunother , vol.50 , Issue.3 , pp. 141-150
    • Raum, T.1    Gruber, R.2    Riethmüller, G.3
  • 31
    • 77958616420 scopus 로고    scopus 로고
    • Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies
    • Münz M, Murr A, Kvesic M, et al. Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies. Cancer Cell Int 2010;10:44
    • (2010) Cancer Cell Int , vol.10 , pp. 44
    • Münz, M.1    Murr, A.2    Kvesic, M.3
  • 32
    • 80054870896 scopus 로고    scopus 로고
    • DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency
    • Stefan N, Martin-Killias P, Wyss-Stoeckle S, et al. DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency. J Mol Biol 2011;413(4):826-43
    • (2011) J Mol Biol , vol.413 , Issue.4 , pp. 826-843
    • Stefan, N.1    Martin-Killias, P.2    Wyss-Stoeckle, S.3
  • 33
    • 67651003100 scopus 로고    scopus 로고
    • The emerging role of EpCAM in cancer and stem cell signaling
    • Münz M, Baeuerle PA, Gires O. The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res 2009;69(14):5627-9
    • (2009) Cancer Res , vol.69 , Issue.14 , pp. 5627-5629
    • Münz, M.1    Baeuerle, P.A.2    Gires, O.3
  • 34
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414(6859):105-11
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3
  • 35
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nat Rev Cancer 2008;8(10):755-68
    • (2008) Nat Rev Cancer , vol.8 , Issue.10 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 36
    • 58849093242 scopus 로고    scopus 로고
    • On the abundance of EpCAM on cancer stem cells
    • author rely 43
    • Gires O, Klein CA, Baeuerle PA. On the abundance of EpCAM on cancer stem cells. Nat Rev Cancer 2009;9(2):143; author reply 43
    • (2009) Nat Rev Cancer , vol.9 , Issue.2 , pp. 143
    • Gires, O.1    Klein, C.A.2    Baeuerle, P.A.3
  • 37
    • 0038236533 scopus 로고    scopus 로고
    • Adenocarcinoma cells exposed in vitro to Navelbine or Taxol increase Ep-CAM expression through a novel mechanism
    • Thurmond LM, Stimmel JB, Ingram AC, et al. Adenocarcinoma cells exposed in vitro to Navelbine or Taxol increase Ep-CAM expression through a novel mechanism. Cancer Immunol Immunother 2003;52(7):429-37
    • (2003) Cancer Immunol Immunother , vol.52 , Issue.7 , pp. 429-437
    • Thurmond, L.M.1    Stimmel, J.B.2    Ingram, A.C.3
  • 38
    • 0033540282 scopus 로고    scopus 로고
    • The structural analysis of adhesions mediated by Ep-CAM
    • Balzar M, Prins FA, Bakker HA, et al. The structural analysis of adhesions mediated by Ep-CAM. Exp Cell Res 1999;246(1):108-21
    • (1999) Exp Cell Res , vol.246 , Issue.1 , pp. 108-121
    • Balzar, M.1    Prins, F.A.2    Bakker, H.A.3
  • 39
    • 0035872406 scopus 로고    scopus 로고
    • The epithelial glycoprotein 2 (EGP-2) promoter-driven epithelial-specific expression of EGP-2 in transgenic mice: A new model to study carcinoma-directed immunotherapy
    • McLaughlin P, Harmsen MC, Dokter W, et al. The epithelial glycoprotein 2 (EGP-2) promoter-driven epithelial-specific expression of EGP-2 in transgenic mice: A new model to study carcinoma-directed immunotherapy. Cancer Res 2001;61(10):4105-11
    • (2001) Cancer Res , vol.61 , Issue.10 , pp. 4105-4111
    • McLaughlin, P.1    Harmsen, M.C.2    Dokter, W.3
  • 40
    • 0038718522 scopus 로고    scopus 로고
    • Developing inhibitors of the epidermal growth factor receptor for cancer treatment
    • Grünwald V, Hidalgo M. Developing inhibitors of the epidermal growth factor receptor for cancer treatment. J Natl Cancer Inst 2003;95(12):851-67
    • (2003) J Natl Cancer Inst , vol.95 , Issue.12 , pp. 851-867
    • Grünwald, V.1    Hidalgo, M.2
  • 41
    • 63749086305 scopus 로고    scopus 로고
    • ErbB receptors and signaling pathways in cancer
    • Hynes NE, MacDonald G. ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 2009;21(2):177-84
    • (2009) Curr Opin Cell Biol , vol.21 , Issue.2 , pp. 177-184
    • Hynes, N.E.1    MacDonald, G.2
  • 43
    • 82355168570 scopus 로고    scopus 로고
    • Activator protein 1 (AP-1) contributes to EpCAM-dependent breast cancer invasion
    • Sankpal NV, Mayfield JD, Willman MW, et al. Activator protein 1 (AP-1) contributes to EpCAM-dependent breast cancer invasion. Breast Cancer Res 2011;13(6):R124
    • (2011) Breast Cancer Res , vol.13 , Issue.6
    • Sankpal, N.V.1    Mayfield, J.D.2    Willman, M.W.3
  • 44
    • 79960395521 scopus 로고    scopus 로고
    • Pivotal role of epithelial cell adhesion molecule in the survival of lung cancer cells
    • Hase T, Sato M, Yoshida K, et al. Pivotal role of epithelial cell adhesion molecule in the survival of lung cancer cells. Cancer Sci 2011;102(8):1493-500
    • (2011) Cancer Sci , vol.102 , Issue.8 , pp. 1493-1500
    • Hase, T.1    Sato, M.2    Yoshida, K.3
  • 45
    • 4143074922 scopus 로고    scopus 로고
    • EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy
    • Osta WA, Chen Y, Mikhitarian K, et al. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 2004;64(16):5818-24
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5818-5824
    • Osta, W.A.1    Chen, Y.2    Mikhitarian, K.3
  • 46
    • 78049307486 scopus 로고    scopus 로고
    • H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM
    • Chen MW, Hua KT, Kao HJ, et al. H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res 2010;70(20):7830-40
    • (2010) Cancer Res , vol.70 , Issue.20 , pp. 7830-7840
    • Chen, M.W.1    Hua, K.T.2    Kao, H.J.3
  • 47
    • 79954858874 scopus 로고    scopus 로고
    • An RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule (EpCAM)
    • Shigdar S, Lin J, Yu Y, et al. An RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule (EpCAM). Cancer Sci 2011;102(5):991-8
    • (2011) Cancer Sci , vol.102 , Issue.5 , pp. 991-998
    • Shigdar, S.1    Lin, J.2    Yu, Y.3
  • 48
    • 83055198567 scopus 로고    scopus 로고
    • Enhanced in vitro antiproliferative effects of EpCAM antibody- functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells
    • Mitra M, Misra R, Harilal A, et al. Enhanced in vitro antiproliferative effects of EpCAM antibody-functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells. Mol Vis 2011;17:2724-37
    • (2011) Mol Vis , vol.17 , pp. 2724-2737
    • Mitra, M.1    Misra, R.2    Harilal, A.3
  • 49
    • 0033844659 scopus 로고    scopus 로고
    • Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin
    • Selbo PK, Sivam G, Fodstad O, et al. Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin. Int J Cancer 2000;87(6):853-9
    • (2000) Int J Cancer , vol.87 , Issue.6 , pp. 853-859
    • Selbo, P.K.1    Sivam, G.2    Fodstad, O.3
  • 50
    • 0034627152 scopus 로고    scopus 로고
    • Ep-CAM overexpression in breast cancer as a predictor of survival
    • Gastl G, Spizzo G, Obrist P, et al. Ep-CAM overexpression in breast cancer as a predictor of survival. Lancet 2000;356(9246):1981-2
    • (2000) Lancet , vol.356 , Issue.9246 , pp. 1981-1982
    • Gastl, G.1    Spizzo, G.2    Obrist, P.3
  • 51
    • 2442474077 scopus 로고    scopus 로고
    • Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival
    • Varga M, Obrist P, Schneeberger S, et al. Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival. Clin Cancer Res 2004;10(9):3131-6
    • (2004) Clin Cancer Res , vol.10 , Issue.9 , pp. 3131-3136
    • Varga, M.1    Obrist, P.2    Schneeberger, S.3
  • 52
    • 53249097862 scopus 로고    scopus 로고
    • Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer
    • Schmidt M, Hasenclever D, Schaeffer M, et al. Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer. Clin Cancer Res 2008;14(18):5849-55
    • (2008) Clin Cancer Res , vol.14 , Issue.18 , pp. 5849-5855
    • Schmidt, M.1    Hasenclever, D.2    Schaeffer, M.3
  • 53
    • 11144358272 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule (KSA) expression: Pathobiology and its role as an independent predictor of survival in renal cell carcinoma
    • Seligson DB, Pantuck AJ, Liu X, et al. Epithelial cell adhesion molecule (KSA) expression: Pathobiology and its role as an independent predictor of survival in renal cell carcinoma. Clin Cancer Res 2004;10(8):2659-69
    • (2004) Clin Cancer Res , vol.10 , Issue.8 , pp. 2659-2669
    • Seligson, D.B.1    Pantuck, A.J.2    Liu, X.3
  • 54
    • 79961166877 scopus 로고    scopus 로고
    • Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity
    • Akita H, Nagano H, Takeda Y, et al. Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity. Oncogene 2011;30(31):3468-76
    • (2011) Oncogene , vol.30 , Issue.31 , pp. 3468-3476
    • Akita, H.1    Nagano, H.2    Takeda, Y.3
  • 55
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann PC, Huber SL, Herrler T, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007;1(3):313-23
    • (2007) Cell Stem Cell , vol.1 , Issue.3 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3
  • 56
    • 77952144984 scopus 로고    scopus 로고
    • Adecatumumab: An anti-EpCAM monoclonal antibody, from the bench to the bedside
    • Kurtz JE, Dufour P. Adecatumumab: An anti-EpCAM monoclonal antibody, from the bench to the bedside. Expert Opin Biol Ther 2010;10(6):951-8
    • (2010) Expert Opin Biol Ther , vol.10 , Issue.6 , pp. 951-958
    • Kurtz, J.E.1    Dufour, P.2
  • 57
    • 0034032007 scopus 로고    scopus 로고
    • The human antimouse immunoglobulin response and the anti-idiotypic network have no influence on clinical outcome in patients with minimal residual colorectal cancer treated with monoclonal antibody CO17-1A
    • Gruber R, van Haarlem LJ, Warnaar SO, et al. The human antimouse immunoglobulin response and the anti-idiotypic network have no influence on clinical outcome in patients with minimal residual colorectal cancer treated with monoclonal antibody CO17-1A. Cancer Res 2000;60(7):1921-6
    • (2000) Cancer Res , vol.60 , Issue.7 , pp. 1921-1926
    • Gruber, R.1    Van Haarlem, L.J.2    Warnaar, S.O.3
  • 58
    • 0023280724 scopus 로고
    • Tumor-associated antigen expression of primary and metastatic colon carcinomas detected by monoclonal antibody 17-1A
    • Goodwin RA, Tuttle SE, Bucci DM, et al. Tumor-associated antigen expression of primary and metastatic colon carcinomas detected by monoclonal antibody 17-1A. Am J Clin Pathol 1987;88(4):462-7
    • (1987) Am J Clin Pathol , vol.88 , Issue.4 , pp. 462-467
    • Goodwin, R.A.1    Tuttle, S.E.2    Bucci, D.M.3
  • 59
    • 0026056113 scopus 로고
    • Initial clinical evaluation of two murine IgG2a monoclonal antibodies for immunotherapy of gastrointestinal carcinoma
    • Herlyn D, Sears HF, Ernst CS, et al. Initial clinical evaluation of two murine IgG2a monoclonal antibodies for immunotherapy of gastrointestinal carcinoma. Am J Clin Oncol 1991;14(5):371-8
    • (1991) Am J Clin Oncol , vol.14 , Issue.5 , pp. 371-378
    • Herlyn, D.1    Sears, H.F.2    Ernst, C.S.3
  • 60
    • 0034812866 scopus 로고    scopus 로고
    • Clinical experience with edrecolomab: A monoclonal antibody therapy for colorectal carcinoma
    • Schwartzberg LS. Clinical experience with edrecolomab: A monoclonal antibody therapy for colorectal carcinoma. Crit Rev Oncol Hematol 2001;40(1):17-24
    • (2001) Crit Rev Oncol Hematol , vol.40 , Issue.1 , pp. 17-24
    • Schwartzberg, L.S.1
  • 61
    • 0028224082 scopus 로고
    • Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group
    • Riethmüller G, Schneider-Gadicke E, Schlimok G, et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet 1994;343(8907):1177-83
    • (1994) Lancet , vol.343 , Issue.8907 , pp. 1177-1183
    • Riethmüller, G.1    Schneider-Gadicke, E.2    Schlimok, G.3
  • 62
    • 0343965762 scopus 로고    scopus 로고
    • Monoclonal antibody therapy for resected Dukes' C colorectal cancer: Seven-year outcome of a multicenter randomized trial
    • Riethmüller G, Holz E, Schlimok G, et al. Monoclonal antibody therapy for resected Dukes' C colorectal cancer: Seven-year outcome of a multicenter randomized trial. J Clin Oncol 1998;16(5):1788-94
    • (1998) J Clin Oncol , vol.16 , Issue.5 , pp. 1788-1794
    • Riethmüller, G.1    Holz, E.2    Schlimok, G.3
  • 63
    • 65349172418 scopus 로고    scopus 로고
    • Adjuvant therapy with the monoclonal antibody Edrecolomab plus fluorouracil-based therapy does not improve overall survival of patients with stage III colon cancer
    • Fields AL, Keller A, Schwartzberg L, et al. Adjuvant therapy with the monoclonal antibody Edrecolomab plus fluorouracil-based therapy does not improve overall survival of patients with stage III colon cancer. J Clin Oncol 2009;27(12):1941-7
    • (2009) J Clin Oncol , vol.27 , Issue.12 , pp. 1941-1947
    • Fields, A.L.1    Keller, A.2    Schwartzberg, L.3
  • 64
    • 65349124782 scopus 로고    scopus 로고
    • When wishful thinking leads to a misty-eyed appraisal: The story of the adjuvant colon cancer trials with edrecolomab
    • Schmoll HJ, Arnold D. When wishful thinking leads to a misty-eyed appraisal: The story of the adjuvant colon cancer trials with edrecolomab. J Clin Oncol 2009;27(12):1926-9
    • (2009) J Clin Oncol , vol.27 , Issue.12 , pp. 1926-1929
    • Schmoll, H.J.1    Arnold, D.2
  • 65
    • 23844452159 scopus 로고    scopus 로고
    • Lessons learned from the edrecolomab story: How a checkered past became a checkered flag for monoclonal antibodies in colorectal cancer therapy
    • Goldberg RM. Lessons learned from the edrecolomab story: How a checkered past became a checkered flag for monoclonal antibodies in colorectal cancer therapy. Onkologie 2005;28(6-7):311-12
    • (2005) Onkologie , vol.28 , Issue.6-7 , pp. 311-312
    • Goldberg, R.M.1
  • 66
    • 0009450939 scopus 로고    scopus 로고
    • A phase I trial of the humanized anti-EGP40 monoclonal antibody 3622W94 (Abstr. 1562)
    • LoBuglio A, Saleh M, Braddock J, et al. A phase I trial of the humanized anti-EGP40 monoclonal antibody 3622W94 (Abstr. 1562). Proc Am Soc Clin Oncol 1997;16:436
    • (1997) Proc Am Soc Clin Oncol , vol.16 , pp. 436
    • LoBuglio, A.1    Saleh, M.2    Braddock, J.3
  • 67
    • 9344222778 scopus 로고    scopus 로고
    • ING-1, a monoclonal antibody targeting Ep-CAM in patients with advanced adenocarcinomas
    • de Bono JS, Tolcher AW, Forero A, et al. ING-1, a monoclonal antibody targeting Ep-CAM in patients with advanced adenocarcinomas. Clin Cancer Res 2004;10(22):7555-65
    • (2004) Clin Cancer Res , vol.10 , Issue.22 , pp. 7555-7565
    • De Bono, J.S.1    Tolcher, A.W.2    Forero, A.3
  • 68
    • 78650991636 scopus 로고    scopus 로고
    • Phase II study of the human anti-epithelial cell adhesion molecule antibody Adecatumumab in prostate cancer patients with increasing serum levels of prostate-specific antigen after radical prostatectomy
    • Marschner N, Ruettinger D, Zugmaier G, et al. Phase II study of the human anti-epithelial cell adhesion molecule antibody Adecatumumab in prostate cancer patients with increasing serum levels of prostate-specific antigen after radical prostatectomy. Urol Int 2010;85(4):386-95
    • (2010) Urol Int , vol.85 , Issue.4 , pp. 386-395
    • Marschner, N.1    Ruettinger, D.2    Zugmaier, G.3
  • 69
    • 77951881160 scopus 로고    scopus 로고
    • An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer
    • Schmidt M, Scheulen ME, Dittrich C, et al. An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer. Ann Oncol 2010;21(2):275-82
    • (2010) Ann Oncol , vol.21 , Issue.2 , pp. 275-282
    • Schmidt, M.1    Scheulen, M.E.2    Dittrich, C.3
  • 70
    • 84865535404 scopus 로고    scopus 로고
    • Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with EpCAM-positive relapsed or refractory advanced-stage breast cancer
    • Schmidt M, Ruttinger D, Sebastian M, et al. Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with EpCAM-positive relapsed or refractory advanced-stage breast cancer. Ann Oncol 2012;23(9):2306-13
    • (2012) Ann Oncol , vol.23 , Issue.9 , pp. 2306-2313
    • Schmidt, M.1    Ruttinger, D.2    Sebastian, M.3
  • 71
    • 33646843426 scopus 로고
    • SCLC-cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP-2
    • De Leij L, Helrich W, Stein R, et al. SCLC-cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP-2. Int J Cancer 1994;57(S8):60-3
    • (1994) Int J Cancer , vol.57 , Issue.S8 , pp. 60-63
    • De Leij, L.1    Helrich, W.2    Stein, R.3
  • 72
    • 0033571383 scopus 로고    scopus 로고
    • High thermal stability is essential for tumor targeting of antibody fragments: Engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment
    • Willuda J, Honegger A, Waibel R, et al. High thermal stability is essential for tumor targeting of antibody fragments: Engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment. Cancer Res 1999;59(22):5758-67
    • (1999) Cancer Res , vol.59 , Issue.22 , pp. 5758-5767
    • Willuda, J.1    Honegger, A.2    Waibel, R.3
  • 73
    • 36749016236 scopus 로고    scopus 로고
    • Antitumor activity of an epithelial cell adhesion molecule-targeted nanovesicular drug delivery system
    • Hussain S, Plückthun A, Allen TM, et al. Antitumor activity of an epithelial cell adhesion molecule-targeted nanovesicular drug delivery system. Mol Cancer Ther 2007;6(11):3019-27
    • (2007) Mol Cancer Ther , vol.6 , Issue.11 , pp. 3019-3027
    • Hussain, S.1    Plückthun, A.2    Allen, T.M.3
  • 74
    • 33846199148 scopus 로고    scopus 로고
    • Chemosensitization of carcinoma cells using epithelial cell adhesion molecule-targeted liposomal antisense against bcl-2/bcl-xL
    • Hussain S, Plückthun A, Allen TM, et al. Chemosensitization of carcinoma cells using epithelial cell adhesion molecule-targeted liposomal antisense against bcl-2/bcl-xL. Mol Cancer Ther 2006;5(12):3170-80
    • (2006) Mol Cancer Ther , vol.5 , Issue.12 , pp. 3170-3180
    • Hussain, S.1    Plückthun, A.2    Allen, T.M.3
  • 75
    • 84868270670 scopus 로고    scopus 로고
    • Preclinical evaluation of VB6-845: An anti-EpCAM immunotoxin with reduced immunogenic potential
    • Entwistle J, Brown JG, Chooniedass S, et al. Preclinical evaluation of VB6-845: An anti-EpCAM immunotoxin with reduced immunogenic potential. Cancer Biother Radiopharm 2012;27(9):582-92
    • (2012) Cancer Biother Radiopharm , vol.27 , Issue.9 , pp. 582-592
    • Entwistle, J.1    Brown, J.G.2    Chooniedass, S.3
  • 76
    • 0037478897 scopus 로고    scopus 로고
    • A recombinant immunotoxin derived from a humanized epithelial cell adhesion molecule-specific single-chain antibody fragment has potent and selective antitumor activity
    • Di Paolo C, Willuda J, Kubetzko S, et al. A recombinant immunotoxin derived from a humanized epithelial cell adhesion molecule-specific single-chain antibody fragment has potent and selective antitumor activity. Clin Cancer Res 2003;9(7):2837-48
    • (2003) Clin Cancer Res , vol.9 , Issue.7 , pp. 2837-2848
    • Di Paolo, C.1    Willuda, J.2    Kubetzko, S.3
  • 77
    • 0034917310 scopus 로고    scopus 로고
    • Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors
    • Heideman DAM, Snijders PJF, Craanen ME, et al. Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors. Cancer Gene Ther 2001;8(5):342-51
    • (2001) Cancer Gene Ther , vol.8 , Issue.5 , pp. 342-351
    • Heideman, D.A.M.1    Snijders, P.J.F.2    Craanen, M.E.3
  • 78
    • 84862825933 scopus 로고    scopus 로고
    • Sustained and cancer cell targeted cytosolic delivery of Onconase results in potent antitumor effects
    • Zhao HL, Xue C, Du JL, et al. Sustained and cancer cell targeted cytosolic delivery of Onconase results in potent antitumor effects. J Control Release 2012;159(3):346-52
    • (2012) J Control Release , vol.159 , Issue.3 , pp. 346-352
    • Zhao, H.L.1    Xue, C.2    Du, J.L.3
  • 79
    • 0033178740 scopus 로고    scopus 로고
    • Simultaneous activation of T cells and accessory cells by a new class of intact bispecific antibody results in efficient tumor cell killing
    • Zeidler R, Reisbach G, Wollenberg B, et al. Simultaneous activation of T cells and accessory cells by a new class of intact bispecific antibody results in efficient tumor cell killing. J Immunol 1999;163(3):1246-52
    • (1999) J Immunol , vol.163 , Issue.3 , pp. 1246-1252
    • Zeidler, R.1    Reisbach, G.2    Wollenberg, B.3
  • 80
    • 34447642376 scopus 로고    scopus 로고
    • Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM x anti-CD3): A phase I study
    • Sebastian M, Passlick B, Friccius-Quecke H, et al. Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM x anti-CD3): A phase I study. Cancer Immunoly Immunother 2007;56(10):1637-44
    • (2007) Cancer Immunoly Immunother , vol.56 , Issue.10 , pp. 1637-1644
    • Sebastian, M.1    Passlick, B.2    Friccius-Quecke, H.3
  • 81
    • 77952078636 scopus 로고    scopus 로고
    • Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients
    • Ruf P, Kluge M, Jager M, et al. Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients. Br J Clin Pharmacol 2010;69(6):617-25
    • (2010) Br J Clin Pharmacol , vol.69 , Issue.6 , pp. 617-625
    • Ruf, P.1    Kluge, M.2    Jager, M.3
  • 82
    • 28744445538 scopus 로고    scopus 로고
    • MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors
    • Brischwein K, Schlereth B, Guller B, et al. MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors. Mol Immunol 2006;43(8):1129-43
    • (2006) Mol Immunol , vol.43 , Issue.8 , pp. 1129-1143
    • Brischwein, K.1    Schlereth, B.2    Guller, B.3
  • 83
    • 84856007019 scopus 로고    scopus 로고
    • EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells
    • Cioffi M, Dorado J, Baeuerle PA, et al. EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res 2012;18(2):465-74
    • (2012) Clin Cancer Res , vol.18 , Issue.2 , pp. 465-474
    • Cioffi, M.1    Dorado, J.2    Baeuerle, P.A.3
  • 84
    • 0042780350 scopus 로고    scopus 로고
    • Designing repeat proteins: Well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins
    • Binz HK, Stumpp MT, Forrer P, et al. Designing repeat proteins: Well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins. J Mol Biol 2003;332(2):489-503
    • (2003) J Mol Biol , vol.332 , Issue.2 , pp. 489-503
    • Binz, H.K.1    Stumpp, M.T.2    Forrer, P.3
  • 85
    • 80054856259 scopus 로고    scopus 로고
    • DARPins and other repeat protein scaffolds: Advances in engineering and applications
    • Boersma YL, Plückthun A. DARPins and other repeat protein scaffolds: Advances in engineering and applications. Curr Opin Biotechnol 2011;22(6):849-57
    • (2011) Curr Opin Biotechnol , vol.22 , Issue.6 , pp. 849-857
    • Boersma, Y.L.1    Plückthun, A.2
  • 86
    • 2342624119 scopus 로고    scopus 로고
    • High-affinity binders selected from designed ankyrin repeat protein libraries
    • Binz HK, Amstutz P, Kohl A, et al. High-affinity binders selected from designed ankyrin repeat protein libraries. Nat Biotechnol 2004;22(5):575-82
    • (2004) Nat Biotechnol , vol.22 , Issue.5 , pp. 575-582
    • Binz, H.K.1    Amstutz, P.2    Kohl, A.3
  • 87
    • 84855591894 scopus 로고    scopus 로고
    • Facile double-functionalization of designed ankyrin repeat proteins using click and thiol chemistries
    • Simon M, Zangemeister-Wittke U, Plückthun A. Facile double-functionalization of designed ankyrin repeat proteins using click and thiol chemistries. Bioconj Chem 2012;23(2):279-86
    • (2012) Bioconj Chem , vol.23 , Issue.2 , pp. 279-286
    • Simon, M.1    Zangemeister-Wittke, U.2    Plückthun, A.3
  • 88
    • 84855599223 scopus 로고    scopus 로고
    • Designed Ankyrin Repeat Proteins (DARPins) from research to therapy
    • Tamaskovic R, Simon M, Stefan N, et al. Designed Ankyrin Repeat Proteins (DARPins) from research to therapy. Methods Enzymol 2011;503:101-34
    • (2011) Methods Enzymol , vol.503 , pp. 101-134
    • Tamaskovic, R.1    Simon, M.2    Stefan, N.3
  • 89
    • 79951818184 scopus 로고    scopus 로고
    • Cell-specific aptamer-mediated targeted drug delivery
    • Zhou J, Rossi JJ. Cell-specific aptamer-mediated targeted drug delivery. Oligonucleotides 2011;21(1):1-10
    • (2011) Oligonucleotides , vol.21 , Issue.1 , pp. 1-10
    • Zhou, J.1    Rossi, J.J.2
  • 90
    • 74049140005 scopus 로고    scopus 로고
    • In vivo selection of tumor-targeting RNA motifs
    • Mi J, Liu Y, Rabbani ZN, et al. In vivo selection of tumor-targeting RNA motifs. Nat Chem Biol 2010;6(1):22-4
    • (2010) Nat Chem Biol , vol.6 , Issue.1 , pp. 22-24
    • Mi, J.1    Liu, Y.2    Rabbani, Z.N.3
  • 91
    • 64149094557 scopus 로고    scopus 로고
    • Generating aptamers for recognition of virus-infected cells
    • Tang Z, Parekh P, Turner P, et al. Generating aptamers for recognition of virus-infected cells. Clin Chem 2009;55(4):813-22
    • (2009) Clin Chem , vol.55 , Issue.4 , pp. 813-822
    • Tang, Z.1    Parekh, P.2    Turner, P.3
  • 92
    • 27144550160 scopus 로고    scopus 로고
    • Arming antibodies: Prospects and challenges for immunoconjugates
    • Wu AM, Senter PD. Arming antibodies: Prospects and challenges for immunoconjugates. Nat Biotechnol 2005;23(9):1137-46
    • (2005) Nat Biotechnol , vol.23 , Issue.9 , pp. 1137-1146
    • Wu, A.M.1    Senter, P.D.2
  • 93
    • 39049128340 scopus 로고    scopus 로고
    • Trends in immunoconjugate and ligand-receptor based targeting development for cancer therapy
    • Brumlik MJ, Daniel BJ, Waehler R, et al. Trends in immunoconjugate and ligand-receptor based targeting development for cancer therapy. Expert Opin Drug Deliv 2008;5(1):87-103
    • (2008) Expert Opin Drug Deliv , vol.5 , Issue.1 , pp. 87-103
    • Brumlik, M.J.1    Daniel, B.J.2    Waehler, R.3
  • 94
    • 31544441685 scopus 로고    scopus 로고
    • Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: Effects of linker technology on efficacy and toxicity
    • Doronina SO, Mendelsohn BA, Bovee TD, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: Effects of linker technology on efficacy and toxicity. Bioconj Chem 2006;17(1):114-24
    • (2006) Bioconj Chem , vol.17 , Issue.1 , pp. 114-124
    • Doronina, S.O.1    Mendelsohn, B.A.2    Bovee, T.D.3
  • 95
    • 77955312203 scopus 로고    scopus 로고
    • Antibody-drug conjugates: Targeted drug delivery for cancer
    • Alley SC, Okeley NM, Senter PD. Antibody-drug conjugates: Targeted drug delivery for cancer. Curr Opin Chem Biol 2010;14(4):529-37
    • (2010) Curr Opin Chem Biol , vol.14 , Issue.4 , pp. 529-537
    • Alley, S.C.1    Okeley, N.M.2    Senter, P.D.3
  • 96
    • 0025288274 scopus 로고
    • Phase I clinical comparative study of monoclonal antibody KS1/4 and KS1/4-methotrexate immunconjugate in patients with non-small cell lung carcinoma
    • Elias DJ, Hirschowitz L, Kline LE, et al. Phase I clinical comparative study of monoclonal antibody KS1/4 and KS1/4-methotrexate immunconjugate in patients with non-small cell lung carcinoma. Cancer Res 1990;50(13):4154-9
    • (1990) Cancer Res , vol.50 , Issue.13 , pp. 4154-4159
    • Elias, D.J.1    Hirschowitz, L.2    Kline, L.E.3
  • 97
    • 0028172671 scopus 로고
    • Monoclonal antibody KS1/4-methotrexate immunoconjugate studies in non-small cell lung carcinoma
    • Elias DJ, Kline LE, Robbins BA, et al. Monoclonal antibody KS1/4-methotrexate immunoconjugate studies in non-small cell lung carcinoma. Am J Respir Crit Care Med 1994;150(4):1114-22
    • (1994) Am J Respir Crit Care Med , vol.150 , Issue.4 , pp. 1114-1122
    • Elias, D.J.1    Kline, L.E.2    Robbins, B.A.3
  • 98
    • 0030050856 scopus 로고    scopus 로고
    • Preparation and functional evaluation of new doxorubicin immunoconjugates containing an acid-sensitive linker on small-cell lung cancer cells
    • Froesch BA, Stahel RA, Zangemeister-Wittke U. Preparation and functional evaluation of new doxorubicin immunoconjugates containing an acid-sensitive linker on small-cell lung cancer cells. Cancer Immunol Immunother 1996;42(1):55-63
    • (1996) Cancer Immunol Immunother , vol.42 , Issue.1 , pp. 55-63
    • Froesch, B.A.1    Stahel, R.A.2    Zangemeister-Wittke, U.3
  • 99
    • 0027218284 scopus 로고
    • Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates
    • Trail PA, Willner D, Lasch SJ, et al. Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science 1993;261(5118):212-15
    • (1993) Science , vol.261 , Issue.5118 , pp. 212-215
    • Trail, P.A.1    Willner, D.2    Lasch, S.J.3
  • 100
    • 79960356302 scopus 로고    scopus 로고
    • Investigational antibody drug conjugates for solid tumors
    • Sapra P, Hooper AT, O'Donnell CJ, et al. Investigational antibody drug conjugates for solid tumors. Expert Opin Inv Drug 2011;20(8):1131-49
    • (2011) Expert Opin Inv Drug , vol.20 , Issue.8 , pp. 1131-1149
    • Sapra, P.1    Hooper, A.T.2    O'Donnell, C.J.3
  • 101
    • 77958043944 scopus 로고    scopus 로고
    • Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules
    • Lopus M, Oroudjev E, Wilson L, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther 2010;9(10):2689-99
    • (2010) Mol Cancer Ther , vol.9 , Issue.10 , pp. 2689-2699
    • Lopus, M.1    Oroudjev, E.2    Wilson, L.3
  • 102
    • 79952092706 scopus 로고    scopus 로고
    • Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
    • Burris HA III, Rugo HS, Vukelja SJ, et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol 2011;29(4):398-405
    • (2011) J Clin Oncol , vol.29 , Issue.4 , pp. 398-405
    • Burris III, H.A.1    Rugo, H.S.2    Vukelja, S.J.3
  • 103
    • 84863688392 scopus 로고    scopus 로고
    • A Phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine
    • Krop IE, Lorusso P, Miller KD, et al. A Phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine. J Clin Oncol 2012;30(26):3234-41
    • (2012) J Clin Oncol , vol.30 , Issue.26 , pp. 3234-3241
    • Krop, I.E.1    Lorusso, P.2    Miller, K.D.3
  • 104
    • 84868520609 scopus 로고    scopus 로고
    • Trastuzumab emtansine for HER2-positive advanced breast cancer
    • Verma S, Miles D, Gianni L, et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012
    • (2012) N Engl J Med
    • Verma, S.1    Miles, D.2    Gianni, L.3
  • 105
    • 77950224905 scopus 로고    scopus 로고
    • Antibody-maytansinoid conjugates designed to bypass multidrug resistance
    • Kovtun YVY, Audette CAC, Mayo MFM, et al. Antibody-maytansinoid conjugates designed to bypass multidrug resistance. Cancer Res 2010;70(6):2528-37
    • (2010) Cancer Res , vol.70 , Issue.6 , pp. 2528-2537
    • Kovtun, Y.V.Y.1    Audette, C.A.C.2    Mayo, M.F.M.3
  • 106
    • 84860142832 scopus 로고    scopus 로고
    • Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma
    • Moldenhauer G, Salnikov AV, Lüttgau S, et al. Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma. J Natl Cancer Inst 2012;104(8):622-34
    • (2012) J Natl Cancer Inst , vol.104 , Issue.8 , pp. 622-634
    • Moldenhauer, G.1    Salnikov, A.V.2    Lüttgau, S.3
  • 107
    • 0014959969 scopus 로고
    • Specific inhibition of nuclear RNA polymerase II by alpha-amanitin
    • Lindell TJ, Weinberg F, Morris PW, et al. Specific inhibition of nuclear RNA polymerase II by alpha-amanitin. Science 1970;170(3956):447-9
    • (1970) Science , vol.170 , Issue.3956 , pp. 447-449
    • Lindell, T.J.1    Weinberg, F.2    Morris, P.W.3
  • 108
    • 0035866038 scopus 로고    scopus 로고
    • Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate
    • Houba PH, Boven E, van der Meulen-Muileman IH, et al. Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate. Int J Cancer 2001;91(4):550-4
    • (2001) Int J Cancer , vol.91 , Issue.4 , pp. 550-554
    • Houba, P.H.1    Boven, E.2    Van Der Meulen-Muileman, I.H.3
  • 109
    • 0037017864 scopus 로고    scopus 로고
    • A fully human anti-Ep-CAM scFvbeta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug
    • de Graaf M, Boven E, Oosterhoff D, et al. A fully human anti-Ep-CAM scFvbeta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug. Br J Cancer 2002;86(5):811-18
    • (2002) Br J Cancer , vol.86 , Issue.5 , pp. 811-818
    • De Graaf, M.1    Boven, E.2    Oosterhoff, D.3
  • 110
    • 0037048309 scopus 로고    scopus 로고
    • Secreted and tumour targeted human carboxylesterase for activation of irinotecan
    • Oosterhoff D, Pinedo HM, van der Meulen IH, et al. Secreted and tumour targeted human carboxylesterase for activation of irinotecan. Br J Cancer 2002;87(6):659-64
    • (2002) Br J Cancer , vol.87 , Issue.6 , pp. 659-664
    • Oosterhoff, D.1    Pinedo, H.M.2    Van Der Meulen, I.H.3
  • 111
    • 16244373666 scopus 로고    scopus 로고
    • Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11
    • Oosterhoff D, Overmeer RM, de Graaf M, et al. Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11. Br J Cancer 2005;92(5):882-7
    • (2005) Br J Cancer , vol.92 , Issue.5 , pp. 882-887
    • Oosterhoff, D.1    Overmeer, R.M.2    De Graaf, M.3
  • 112
    • 0034682480 scopus 로고    scopus 로고
    • Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity
    • Tsutsumi Y, Onda M, Nagata S, et al. Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity. Proc Natl Acad Sci USA 2000;97(15):8548-53
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.15 , pp. 8548-8553
    • Tsutsumi, Y.1    Onda, M.2    Nagata, S.3
  • 113
    • 49649091350 scopus 로고    scopus 로고
    • An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes
    • Onda M, Beers R, Xiang L, et al. An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proc Natl Acad Sci USA 2008;105(32):11311-16
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.32 , pp. 11311-11316
    • Onda, M.1    Beers, R.2    Xiang, L.3
  • 114
    • 81555214408 scopus 로고    scopus 로고
    • A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer
    • Weldon JE, Pastan I. A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. FEBS 2011;278(23):4683-700
    • (2011) FEBS , vol.278 , Issue.23 , pp. 4683-4700
    • Weldon, J.E.1    Pastan, I.2
  • 115
    • 0038290547 scopus 로고    scopus 로고
    • Immunotoxins containing Pseudomonas exotoxin A: A short history
    • Pastan II. Immunotoxins containing Pseudomonas exotoxin A: A short history. Cancer Immunol Immunother 2003;52(5):338-41
    • (2003) Cancer Immunol Immunother , vol.52 , Issue.5 , pp. 338-341
    • Pastan, I.I.1
  • 116
    • 0034672415 scopus 로고    scopus 로고
    • Systemic immunotoxin treatment inhibits formation of human breast cancer metastasis and tumor growth in nude rats
    • Engebraaten O, Sivam G, Juell S, et al. Systemic immunotoxin treatment inhibits formation of human breast cancer metastasis and tumor growth in nude rats. Int J Cancer 2000;88(6):970-6
    • (2000) Int J Cancer , vol.88 , Issue.6 , pp. 970-976
    • Engebraaten, O.1    Sivam, G.2    Juell, S.3
  • 117
    • 0030936041 scopus 로고    scopus 로고
    • A novel immunotoxin recognising the epithelial glycoprotein-2 has potent antitumoural activity on chemotherapy-resistant lung cancer
    • Zimmermann S, Wels W, Froesch BA, et al. A novel immunotoxin recognising the epithelial glycoprotein-2 has potent antitumoural activity on chemotherapy-resistant lung cancer. Cancer Immunol Immunother 1997;44(1):1-9
    • (1997) Cancer Immunol Immunother , vol.44 , Issue.1 , pp. 1-9
    • Zimmermann, S.1    Wels, W.2    Froesch, B.A.3
  • 118
    • 84860693680 scopus 로고    scopus 로고
    • High interstitial fluid pressure is associated with low tumour penetration of diagnostic monoclonal antibodies applied for molecular imaging purposes
    • Heine M, Freund B, Nielsen P, et al. High interstitial fluid pressure is associated with low tumour penetration of diagnostic monoclonal antibodies applied for molecular imaging purposes. PLoS ONE 2011;7(5):e36258-e58
    • (2011) PLoS ONE , vol.7 , Issue.5
    • Heine, M.1    Freund, B.2    Nielsen, P.3
  • 119
    • 79955593880 scopus 로고    scopus 로고
    • Development of a GMP Phase III purification process for VB4-845, an immunotoxin expressed in E. coli using high cell density fermentation
    • Premsukh A, Lavoie JM, Cizeau J, et al. Development of a GMP Phase III purification process for VB4-845, an immunotoxin expressed in E. coli using high cell density fermentation. Protein Expr Purif 2011;78(1):27-37
    • (2011) Protein Expr Purif , vol.78 , Issue.1 , pp. 27-37
    • Premsukh, A.1    Lavoie, J.M.2    Cizeau, J.3
  • 120
    • 67651163873 scopus 로고    scopus 로고
    • Engineering and biological characterization of VB6-845, an anti-EpCAM immunotoxin containing a T-cell epitope-depleted variant of the plant toxin bouganin
    • Cizeau JJ, Grenkow DMD, Brown JGJ, et al. Engineering and biological characterization of VB6-845, an anti-EpCAM immunotoxin containing a T-cell epitope-depleted variant of the plant toxin bouganin. J Immunother 2009;32(6):574-84
    • (2009) J Immunother , vol.32 , Issue.6 , pp. 574-584
    • Cizeau, J.J.1    Grenkow, D.M.D.2    Brown, J.G.J.3
  • 121
    • 4143110187 scopus 로고    scopus 로고
    • Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering
    • Ewert S, Honegger A, Plückthun A. Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering. Methods 2004;34(2):184-99
    • (2004) Methods , vol.34 , Issue.2 , pp. 184-199
    • Ewert, S.1    Honegger, A.2    Plückthun, A.3
  • 122
    • 78751503899 scopus 로고    scopus 로고
    • A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity
    • Martin-Killias P, Stefan N, Rothschild S, et al. A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity. Clin Cancer Res 2011;17(1):100-10
    • (2011) Clin Cancer Res , vol.17 , Issue.1 , pp. 100-110
    • Martin-Killias, P.1    Stefan, N.2    Rothschild, S.3
  • 123
    • 6944243903 scopus 로고    scopus 로고
    • Exceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells
    • Bremer E, Samplonius D, Kroesen BJ, et al. Exceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells. Neoplasia 2004;6(5):636-45
    • (2004) Neoplasia , vol.6 , Issue.5 , pp. 636-645
    • Bremer, E.1    Samplonius, D.2    Kroesen, B.J.3
  • 124
    • 1242296922 scopus 로고    scopus 로고
    • Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2
    • Bremer EE, Kuijlen JJ, Samplonius DD, et al. Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2. Int J Cancer 2004;109(2):281-90
    • (2004) Int J Cancer , vol.109 , Issue.2 , pp. 281-290
    • Bremer, E.E.1    Kuijlen, J.J.2    Samplonius, D.D.3
  • 125
    • 34248187996 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
    • Tolcher AW, Mita M, Meropol NJ, et al. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J Clin Oncol 2007;25(11):1390-5
    • (2007) J Clin Oncol , vol.25 , Issue.11 , pp. 1390-1395
    • Tolcher, A.W.1    Mita, M.2    Meropol, N.J.3
  • 126
    • 45649084324 scopus 로고    scopus 로고
    • Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer
    • Greco FA, Bonomi P, Crawford J, et al. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer 2008;61(1):82-90
    • (2008) Lung Cancer , vol.61 , Issue.1 , pp. 82-90
    • Greco, F.A.1    Bonomi, P.2    Crawford, J.3
  • 127
    • 14644437742 scopus 로고    scopus 로고
    • Mechanisms of resistance to TRAIL-induced apoptosis in cancer
    • Zhang L, Fang B. Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther 2005;12(3):228-37
    • (2005) Cancer Gene Ther , vol.12 , Issue.3 , pp. 228-237
    • Zhang, L.1    Fang, B.2
  • 128
    • 0025960523 scopus 로고
    • Amino acid sequence of an anti-tumor protein from Rana pipiens oocytes and early embryos. Homology to pancreatic ribonucleases
    • Ardelt W, Mikulski SM, Shogen K. Amino acid sequence of an anti-tumor protein from Rana pipiens oocytes and early embryos. Homology to pancreatic ribonucleases. J Biol Chem 1991;266(1):245-51
    • (1991) J Biol Chem , vol.266 , Issue.1 , pp. 245-251
    • Ardelt, W.1    Mikulski, S.M.2    Shogen, K.3
  • 129
    • 78650394311 scopus 로고    scopus 로고
    • Cellular uptake of ribonuclease A relies on anionic glycans
    • Chao TY, Lavis LD, Raines RT. Cellular uptake of ribonuclease A relies on anionic glycans. Biochemistry 2010;49(50):10666-73
    • (2010) Biochemistry , vol.49 , Issue.50 , pp. 10666-10673
    • Chao, T.Y.1    Lavis, L.D.2    Raines, R.T.3
  • 130
    • 47749114193 scopus 로고    scopus 로고
    • Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity
    • Rutkoski TJ, Raines RT. Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity. Curr Pharm Biotechnol 2008;9(3):185-9
    • (2008) Curr Pharm Biotechnol , vol.9 , Issue.3 , pp. 185-189
    • Rutkoski, T.J.1    Raines, R.T.2
  • 131
    • 0027256672 scopus 로고
    • A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity
    • Wu Y, Mikulski SM, Ardelt W, et al. A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity. J Biol Chem 1993;268(14):10686-93
    • (1993) J Biol Chem , vol.268 , Issue.14 , pp. 10686-10693
    • Wu, Y.1    Mikulski, S.M.2    Ardelt, W.3
  • 132
    • 34249093093 scopus 로고    scopus 로고
    • Intracellular pathway of Onconase that enables its delivery to the cytosol
    • Rodríguez M, Torrent G, Bosch M, et al. Intracellular pathway of Onconase that enables its delivery to the cytosol. J Cell Sci 2007;120(8):1405-11
    • (2007) J Cell Sci , vol.120 , Issue.8 , pp. 1405-1411
    • Rodríguez, M.1    Torrent, G.2    Bosch, M.3
  • 133
  • 134
    • 77951156788 scopus 로고    scopus 로고
    • Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding
    • Andersen JT, Daba MB, Berntzen G, et al. Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding. J Biol Chem 2010;285(7):4826
    • (2010) J Biol Chem , vol.285 , Issue.7 , pp. 4826
    • Andersen, J.T.1    Daba, M.B.2    Berntzen, G.3
  • 135
    • 4344630984 scopus 로고    scopus 로고
    • Ex vivo evaluation of anti-EpCAM immunocytokine huKS-IL2 in ovarian cancer
    • Connor J, Felder M, Hank J, et al. Ex vivo evaluation of anti-EpCAM immunocytokine huKS-IL2 in ovarian cancer. J Immunother 2004;27(3):211-19
    • (2004) J Immunother , vol.27 , Issue.3 , pp. 211-219
    • Connor, J.1    Felder, M.2    Hank, J.3
  • 136
    • 4344569693 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and biological pharmacodynamics of the immunocytokine EMD 273066 (huKSIL2): Results of a phase I trial in patients with prostate cancer
    • Ko YJ, Bubley GJ, Weber R, et al. Safety, pharmacokinetics, and biological pharmacodynamics of the immunocytokine EMD 273066 (huKSIL2): Results of a phase I trial in patients with prostate cancer. J Immunother 2004;27(3):232-9
    • (2004) J Immunother , vol.27 , Issue.3 , pp. 232-239
    • Ko, Y.J.1    Bubley, G.J.2    Weber, R.3
  • 137
    • 68049129857 scopus 로고    scopus 로고
    • Radiofrequency ablation combined with KS-IL2 immunocytokine (EMD 273066) results in an enhanced antitumor effect against murine colon adenocarcinoma
    • Johnson EE, Yamane BH, Buhtoiarov IN, et al. Radiofrequency ablation combined with KS-IL2 immunocytokine (EMD 273066) results in an enhanced antitumor effect against murine colon adenocarcinoma. Clin Cancer Res 2009;15(15):4875-84
    • (2009) Clin Cancer Res , vol.15 , Issue.15 , pp. 4875-4884
    • Johnson, E.E.1    Yamane, B.H.2    Buhtoiarov, I.N.3
  • 138
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: Entering the mainstream
    • Allen TM, Cullis PR. Drug delivery systems: Entering the mainstream. Science 2004;303(5665):1818-22
    • (2004) Science , vol.303 , Issue.5665 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 139
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • Maeda H, Wu J, Sawa T, et al. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review. J Control Release 2000;65(1-2):271-84
    • (2000) J Control Release , vol.65 , Issue.1-2 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3
  • 140
    • 70350234894 scopus 로고    scopus 로고
    • A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
    • Schmidt MM, Wittrup KD. A modeling analysis of the effects of molecular size and binding affinity on tumor targeting. Mol Cancer Ther 2009;8(10):2861-71
    • (2009) Mol Cancer Ther , vol.8 , Issue.10 , pp. 2861-2871
    • Schmidt, M.M.1    Wittrup, K.D.2
  • 141
    • 0942279603 scopus 로고    scopus 로고
    • A nonviral carrier for targeted gene delivery to tumor cells
    • van Zanten J, Doornbos-Van der Meer B, Audouy S, et al. A nonviral carrier for targeted gene delivery to tumor cells. Cancer Gene Ther 2004;11(2):156-64
    • (2004) Cancer Gene Ther , vol.11 , Issue.2 , pp. 156-164
    • Van Zanten, J.1    Doornbos-Van Der Meer, B.2    Audouy, S.3
  • 142
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • Song E, Zhu P, Lee SK, et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol 2005;23(6):709-17
    • (2005) Nat Biotechnol , vol.23 , Issue.6 , pp. 709-717
    • Song, E.1    Zhu, P.2    Lee, S.K.3
  • 143
    • 70349512496 scopus 로고    scopus 로고
    • EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins
    • Winkler J, Martin-Killias P, Plückthun A, et al. EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins. Mol Cancer Ther 2009;8(9):2674-83
    • (2009) Mol Cancer Ther , vol.8 , Issue.9 , pp. 2674-2683
    • Winkler, J.1    Martin-Killias, P.2    Plückthun, A.3
  • 144
    • 0032858151 scopus 로고    scopus 로고
    • Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM
    • Haisma HJ, Pinedo HM, Rijswijk A, et al. Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM. Gene Ther 1999;6(8):1469-74
    • (1999) Gene Ther , vol.6 , Issue.8 , pp. 1469-1474
    • Haisma, H.J.1    Pinedo, H.M.2    Rijswijk, A.3
  • 145
    • 78650875585 scopus 로고    scopus 로고
    • Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targeting
    • Dreier B, Mikheeva G, Belousova N, et al. Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targeting. J Mol Biol 2011;405(2):410-26
    • (2011) J Mol Biol , vol.405 , Issue.2 , pp. 410-426
    • Dreier, B.1    Mikheeva, G.2    Belousova, N.3
  • 146
    • 79959708509 scopus 로고    scopus 로고
    • EpCAM- and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber-modified adenovirus
    • Kawashima R, Abei M, Fukuda K, et al. EpCAM- and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber-modified adenovirus. Int J Cancer 2011;129(5):1244-53
    • (2011) Int J Cancer , vol.129 , Issue.5 , pp. 1244-1253
    • Kawashima, R.1    Abei, M.2    Fukuda, K.3


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