메뉴 건너뛰기




Volumn 6, Issue 11, 2007, Pages 3019-3027

Antitumor activity of an epithelial cell adhesion molecule-targeted nanovesicular drug delivery system

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; EPITHELIAL CELL ADHESION MOLECULE; IMMUNOLIPOSOME;

EID: 36749016236     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0615     Document Type: Article
Times cited : (88)

References (52)
  • 2
    • 0036781811 scopus 로고    scopus 로고
    • Ligand-targeted therapeutics in anticancer therapy
    • Allen TM. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2002;2:750-63.
    • (2002) Nat Rev Cancer , vol.2 , pp. 750-763
    • Allen, T.M.1
  • 3
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • Adams GP, Weiner LM. Monoclonal antibody therapy of cancer. Nat Biotechnol 2005;23:1147-57.
    • (2005) Nat Biotechnol , vol.23 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 4
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: Entering the mainstream
    • Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science 2004;303:1818-22.
    • (2004) Science , vol.303 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 5
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005;4:145-60.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 145-160
    • Torchilin, V.P.1
  • 6
    • 0025731906 scopus 로고
    • Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
    • Allen TM, Hansen C, Martin F, Redemann C, Yau-Young A. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta 1991;1066:29-36.
    • (1991) Biochim Biophys Acta , vol.1066 , pp. 29-36
    • Allen, T.M.1    Hansen, C.2    Martin, F.3    Redemann, C.4    Yau-Young, A.5
  • 7
    • 1842478453 scopus 로고    scopus 로고
    • Improved outcome when B-cell lymphoma is treated with combinations of immunoliposomal anticancer drugs targeted to both the CD19 and CD20 epitopes
    • Sapra P, Allen TM. Improved outcome when B-cell lymphoma is treated with combinations of immunoliposomal anticancer drugs targeted to both the CD19 and CD20 epitopes. Clin Cancer Res 2004;10:2530-7.
    • (2004) Clin Cancer Res , vol.10 , pp. 2530-2537
    • Sapra, P.1    Allen, T.M.2
  • 8
    • 0036554863 scopus 로고    scopus 로고
    • Anti-HER2 immunoliposomes: Enhanced efficacy attributable to targeted delivery
    • Park JW, Hong K, Kirpotin DB, et al. Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery. Clin Cancer Res 2002;8:1172-81.
    • (2002) Clin Cancer Res , vol.8 , pp. 1172-1181
    • Park, J.W.1    Hong, K.2    Kirpotin, D.B.3
  • 9
    • 0034671316 scopus 로고    scopus 로고
    • Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice
    • Sugano M, Egilmez NK, Yokota SJ, et al. Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice. Cancer Res 2000;60:6942-9.
    • (2000) Cancer Res , vol.60 , pp. 6942-6949
    • Sugano, M.1    Egilmez, N.K.2    Yokota, S.J.3
  • 10
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986;46:6387-92.
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 11
    • 0027630475 scopus 로고
    • Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes
    • Zalipsky S. Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes. Bioconjug Chem 1993;4:296-9.
    • (1993) Bioconjug Chem , vol.4 , pp. 296-299
    • Zalipsky, S.1
  • 12
    • 0029120094 scopus 로고
    • A new strategy for attachment of antibodies to sterically stabilized liposomes resulting in efficient targeting to cancer cells
    • Allen TM, Brandeis E, Hansen CB, Kao GY, Zalipsky S. A new strategy for attachment of antibodies to sterically stabilized liposomes resulting in efficient targeting to cancer cells. Biochim Biophys Acta 1995;1237:99-108.
    • (1995) Biochim Biophys Acta , vol.1237 , pp. 99-108
    • Allen, T.M.1    Brandeis, E.2    Hansen, C.B.3    Kao, G.Y.4    Zalipsky, S.5
  • 13
    • 0035817346 scopus 로고    scopus 로고
    • In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniques with those made by a new post-insertion approach
    • Iden DL, Allen TM. In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniques with those made by a new post-insertion approach. Biochim Biophys Acta 2001;1513:207-16.
    • (2001) Biochim Biophys Acta , vol.1513 , pp. 207-216
    • Iden, D.L.1    Allen, T.M.2
  • 14
    • 11144300731 scopus 로고    scopus 로고
    • Future directions of liposome- and immunoliposome-based cancer therapeutics
    • Park JW, Benz CC, Martin FJ. Future directions of liposome- and immunoliposome-based cancer therapeutics. Semin Oncol 2004;31:196-205.
    • (2004) Semin Oncol , vol.31 , pp. 196-205
    • Park, J.W.1    Benz, C.C.2    Martin, F.J.3
  • 15
    • 33645465742 scopus 로고    scopus 로고
    • Antibodies for targeted cancer therapy - technical aspects and clinical perspectives
    • Zangemeister-Wittke U. Antibodies for targeted cancer therapy - technical aspects and clinical perspectives. Pathobiology 2005;72:279-86.
    • (2005) Pathobiology , vol.72 , pp. 279-286
    • Zangemeister-Wittke, U.1
  • 16
    • 0037224431 scopus 로고    scopus 로고
    • Doxorubicin-loaded Fab′ fragments of anti-disialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice
    • Pastorino F, Brignole C, Marimpietri D, et al. Doxorubicin-loaded Fab′ fragments of anti-disialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice. Cancer Res 2003;63:86-92.
    • (2003) Cancer Res , vol.63 , pp. 86-92
    • Pastorino, F.1    Brignole, C.2    Marimpietri, D.3
  • 17
    • 1042290308 scopus 로고    scopus 로고
    • Improved therapeutic responses in a xenograft model of human B lymphoma (Namalwa) for liposomal vincristine versus liposomal doxorubicin targeted via anti-CD19 IgG2a or Fab′ fragments
    • Sapra P, Moase EH, Ma J, Allen TM. Improved therapeutic responses in a xenograft model of human B lymphoma (Namalwa) for liposomal vincristine versus liposomal doxorubicin targeted via anti-CD19 IgG2a or Fab′ fragments. Clin Cancer Res 2004;10:1100-11.
    • (2004) Clin Cancer Res , vol.10 , pp. 1100-1111
    • Sapra, P.1    Moase, E.H.2    Ma, J.3    Allen, T.M.4
  • 18
    • 29244489232 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo
    • Mamot C, Drummond DC, Noble CO, et al. Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo. Cancer Res 2005;65:11631-8.
    • (2005) Cancer Res , vol.65 , pp. 11631-11638
    • Mamot, C.1    Drummond, D.C.2    Noble, C.O.3
  • 19
    • 13544268486 scopus 로고    scopus 로고
    • Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification
    • Nellis DF, Ekstrom DL, Kirpotin DB, et al. Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification. Biotechnol Prog 2005;21:205-20.
    • (2005) Biotechnol Prog , vol.21 , pp. 205-220
    • Nellis, D.F.1    Ekstrom, D.L.2    Kirpotin, D.B.3
  • 21
    • 0030731464 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins
    • Litvinov SV, Balzar M, Winter MJ, et al. Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins. J Cell Biol 1997;139:1337-48.
    • (1997) J Cell Biol , vol.139 , pp. 1337-1348
    • Litvinov, S.V.1    Balzar, M.2    Winter, M.J.3
  • 22
    • 4143065769 scopus 로고    scopus 로고
    • The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation
    • Munz M, Kieu C, Mack B, et al. The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 2004;23:5748-58.
    • (2004) Oncogene , vol.23 , pp. 5748-5758
    • Munz, M.1    Kieu, C.2    Mack, B.3
  • 23
    • 1642580506 scopus 로고    scopus 로고
    • Frequent EpCam protein expression in human carcinomas
    • Went PT, Lugli A, Meier S, et al. Frequent EpCam protein expression in human carcinomas. Hum Pathol 2004;35:122-8.
    • (2004) Hum Pathol , vol.35 , pp. 122-128
    • Went, P.T.1    Lugli, A.2    Meier, S.3
  • 24
    • 0034627152 scopus 로고    scopus 로고
    • Ep-CAM overexpression in breast cancer as a predictor of survival
    • Gastl G, Spizzo G, Obrist P, Dunser M, Mikuz G. Ep-CAM overexpression in breast cancer as a predictor of survival. Lancet 2000;356:1981-2.
    • (2000) Lancet , vol.356 , pp. 1981-1982
    • Gastl, G.1    Spizzo, G.2    Obrist, P.3    Dunser, M.4    Mikuz, G.5
  • 25
    • 4043147142 scopus 로고    scopus 로고
    • High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer
    • Spizzo G, Went P, Dirnhofer S, et al. High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer. Breast Cancer Res Treat 2004;86:207-13.
    • (2004) Breast Cancer Res Treat , vol.86 , pp. 207-213
    • Spizzo, G.1    Went, P.2    Dirnhofer, S.3
  • 26
    • 34547193404 scopus 로고    scopus 로고
    • Phenotypic characterization of human colorectal cancer stem cells
    • Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A 2007;104:10158-63.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10158-10163
    • Dalerba, P.1    Dylla, S.J.2    Park, I.K.3
  • 27
    • 0037478897 scopus 로고    scopus 로고
    • A recombinant immunotoxin derived from a humanized epithelial cell adhesion molecule-specific single-chain antibody fragment has potent and selective antitumor activity
    • Di Paolo C, Willuda J, Kubetzko S, et al. A recombinant immunotoxin derived from a humanized epithelial cell adhesion molecule-specific single-chain antibody fragment has potent and selective antitumor activity. Clin Cancer Res 2003;9:2837-48.
    • (2003) Clin Cancer Res , vol.9 , pp. 2837-2848
    • Di Paolo, C.1    Willuda, J.2    Kubetzko, S.3
  • 28
    • 36749053185 scopus 로고    scopus 로고
    • A phase I study of VB4-845 in patients with advanced, recurrent head and neck cancer on a weekly dosing scheme
    • Fitsialos D, Quenneville J, Rasamoelisolo M, et al. A phase I study of VB4-845 in patients with advanced, recurrent head and neck cancer on a weekly dosing scheme. Proc Am Soc Clin Oncol 2005;23:5569.
    • (2005) Proc Am Soc Clin Oncol , vol.23 , pp. 5569
    • Fitsialos, D.1    Quenneville, J.2    Rasamoelisolo, M.3
  • 29
    • 33846199148 scopus 로고    scopus 로고
    • Chemosensitization of carcinoma cells using epithelial cell adhesion molecule-targeted liposomal antisense against bcl-2/bcl-xL
    • Hussain S, Pluckthun A, Allen TM, Zangemeister-Wittke U. Chemosensitization of carcinoma cells using epithelial cell adhesion molecule-targeted liposomal antisense against bcl-2/bcl-xL. Mol Cancer Ther 2006;5:3170-80.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3170-3180
    • Hussain, S.1    Pluckthun, A.2    Allen, T.M.3    Zangemeister-Wittke, U.4
  • 30
    • 0033571383 scopus 로고    scopus 로고
    • High thermal stability is essential for tumor targeting of antibody fragments: Engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment
    • Willuda J, Honegger A, Waibel R, et al. High thermal stability is essential for tumor targeting of antibody fragments: engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment. Cancer Res 1999;59:5758-67.
    • (1999) Cancer Res , vol.59 , pp. 5758-5767
    • Willuda, J.1    Honegger, A.2    Waibel, R.3
  • 31
    • 0001160175 scopus 로고    scopus 로고
    • In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma
    • Lopes de Menezes DE, Pilarski LM, Allen TM. In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma. Cancer Res 1998;58:3320-30.
    • (1998) Cancer Res , vol.58 , pp. 3320-3330
    • Lopes de Menezes, D.E.1    Pilarski, L.M.2    Allen, T.M.3
  • 32
    • 0018719041 scopus 로고
    • Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes
    • Olson F, Hunt CA, Szoka FC, Vail WJ, Papahadjopoulos D. Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim Biophys Acta 1979;557:9-23.
    • (1979) Biochim Biophys Acta , vol.557 , pp. 9-23
    • Olson, F.1    Hunt, C.A.2    Szoka, F.C.3    Vail, W.J.4    Papahadjopoulos, D.5
  • 33
    • 0020143776 scopus 로고
    • Use of radiolabeled hexadecyl cholesteryl ether as a liposome marker
    • Pool GL, French ME, Edwards RA, Huang L, Lumb RH. Use of radiolabeled hexadecyl cholesteryl ether as a liposome marker. Lipids 1982;17:448-52.
    • (1982) Lipids , vol.17 , pp. 448-452
    • Pool, G.L.1    French, M.E.2    Edwards, R.A.3    Huang, L.4    Lumb, R.H.5
  • 34
    • 0027514941 scopus 로고
    • Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases
    • Haran G, Cohen R, Bar LK, Barenholz Y. Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim Biophys Acta 1993;1151:201-15.
    • (1993) Biochim Biophys Acta , vol.1151 , pp. 201-215
    • Haran, G.1    Cohen, R.2    Bar, L.K.3    Barenholz, Y.4
  • 35
    • 18244362593 scopus 로고    scopus 로고
    • Anti-CD19-targeted liposomal doxorubicin improves the therapeutic efficacy in murine B-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates
    • Allen TM, Mumbengegwi DR, Charrois GJ. Anti-CD19-targeted liposomal doxorubicin improves the therapeutic efficacy in murine B-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates. Clin Cancer Res 2005;11:3567-73.
    • (2005) Clin Cancer Res , vol.11 , pp. 3567-3573
    • Allen, T.M.1    Mumbengegwi, D.R.2    Charrois, G.J.3
  • 36
    • 0031021149 scopus 로고    scopus 로고
    • Sterically stabilized anti-HER2 immunoliposomes: Design and targeting to human breast cancer cells in vitro
    • Kirpotin D, Park JW, Hong K, et al. Sterically stabilized anti-HER2 immunoliposomes: design and targeting to human breast cancer cells in vitro. Biochemistry 1997;36:66-75.
    • (1997) Biochemistry , vol.36 , pp. 66-75
    • Kirpotin, D.1    Park, J.W.2    Hong, K.3
  • 37
    • 0025346213 scopus 로고
    • Lipid composition is important for highly efficient target binding and retention of immunoliposomes
    • Maruyama K, Kennel SJ, Huang L. Lipid composition is important for highly efficient target binding and retention of immunoliposomes. Proc Natl Acad Sci U S A 1990;87:5744-8.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 5744-5748
    • Maruyama, K.1    Kennel, S.J.2    Huang, L.3
  • 38
    • 10744233861 scopus 로고    scopus 로고
    • Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy
    • Pastorino F, Brignole C, Marimpietri D, et al. Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy. Cancer Res 2003;63:7400-9.
    • (2003) Cancer Res , vol.63 , pp. 7400-7409
    • Pastorino, F.1    Brignole, C.2    Marimpietri, D.3
  • 39
    • 0024468809 scopus 로고
    • Pharmacokinetics and tissue distribution of doxorubicin encapsulated in stable liposomes with long circulation times
    • Gabizon A, Shiota R, Papahadjopoulos D. Pharmacokinetics and tissue distribution of doxorubicin encapsulated in stable liposomes with long circulation times. J Natl Cancer Inst 1989;81:1484-8.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 1484-1488
    • Gabizon, A.1    Shiota, R.2    Papahadjopoulos, D.3
  • 40
    • 33746172167 scopus 로고    scopus 로고
    • Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
    • Kirpotin DB, Drummond DC, Shao Y, et al. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 2006;66:6732-40.
    • (2006) Cancer Res , vol.66 , pp. 6732-6740
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3
  • 41
    • 0030024958 scopus 로고    scopus 로고
    • Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: Pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma
    • Northfelt DW, Martin FJ, Working P, et al. Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma. J Clin Pharmacol 1996;36:55-63.
    • (1996) J Clin Pharmacol , vol.36 , pp. 55-63
    • Northfelt, D.W.1    Martin, F.J.2    Working, P.3
  • 42
    • 0035676563 scopus 로고    scopus 로고
    • Phase III data on Caelyx in ovarian cancer
    • Muggia F, Hamilton A. Phase III data on Caelyx in ovarian cancer. Eur J Cancer 2001;37 Suppl 9:15-8.
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 9 , pp. 15-18
    • Muggia, F.1    Hamilton, A.2
  • 43
    • 0026733476 scopus 로고
    • Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice
    • Huang SK, Lee KD, Hong K, Friend DS, Papahadjopoulos D. Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice. Cancer Res 1992;52:5135-43.
    • (1992) Cancer Res , vol.52 , pp. 5135-5143
    • Huang, S.K.1    Lee, K.D.2    Hong, K.3    Friend, D.S.4    Papahadjopoulos, D.5
  • 45
    • 33846804010 scopus 로고    scopus 로고
    • EpCAM (CD326) finding its role in cancer
    • Baeuerle PA, Gires O. EpCAM (CD326) finding its role in cancer. Br J Cancer 2007;96:1491.
    • (2007) Br J Cancer , vol.96 , pp. 1491
    • Baeuerle, P.A.1    Gires, O.2
  • 46
    • 34147115929 scopus 로고    scopus 로고
    • A phase I open-label study to evaluate safety, tolerability and pharmacokinetic (PK) profile of VB4-845, an anti-EpCAM immunotoxin, in subjects with SCCHN
    • Quenneville J, Fitsialos D, Rasamoelisolo M, et al. A phase I open-label study to evaluate safety, tolerability and pharmacokinetic (PK) profile of VB4-845, an anti-EpCAM immunotoxin, in subjects with SCCHN. Proc Am Soc Clin Oncol 2005;23:55539.
    • (2005) Proc Am Soc Clin Oncol , vol.23 , pp. 55539
    • Quenneville, J.1    Fitsialos, D.2    Rasamoelisolo, M.3
  • 47
    • 0028986610 scopus 로고
    • Development of anti-p185HER2 immunoliposomes for cancer therapy
    • Park JW, Hong K, Carter P, et al. Development of anti-p185HER2 immunoliposomes for cancer therapy. Proc Natl Acad Sci U S A 1995;92:1327-31.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 1327-1331
    • Park, J.W.1    Hong, K.2    Carter, P.3
  • 48
    • 0030876540 scopus 로고    scopus 로고
    • Immunoliposomes bearing polyethyleneglycol-coupled Fab′ fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo
    • Maruyama K, Takahashi N, Tagawa T, Nagaike K, Iwatsuru M. Immunoliposomes bearing polyethyleneglycol-coupled Fab′ fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo. FEBS Lett 1997;413:177-80.
    • (1997) FEBS Lett , vol.413 , pp. 177-180
    • Maruyama, K.1    Takahashi, N.2    Tagawa, T.3    Nagaike, K.4    Iwatsuru, M.5
  • 49
    • 0028349925 scopus 로고
    • Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes
    • Gabizon A, Catane R, Uziely B, et al. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res 1994;54:987-92.
    • (1994) Cancer Res , vol.54 , pp. 987-992
    • Gabizon, A.1    Catane, R.2    Uziely, B.3
  • 50
    • 0026352832 scopus 로고
    • Sterically stabilized liposomes: Improvements in pharmacokinetics and antitumor therapeutic efficacy
    • Papahadjopoulos D, Allen TM, Gabizon A, et al. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc Natl Acad Sci U S A 1991;88:11460-4.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 11460-11464
    • Papahadjopoulos, D.1    Allen, T.M.2    Gabizon, A.3
  • 51
    • 0029828939 scopus 로고    scopus 로고
    • Targeting of stealth liposomes to erbB-2 (Her/2) receptor: In vitro and in vivo studies
    • Goren D, Horowitz AT, Zalipsky S, et al. Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro and in vivo studies. Br J Cancer 1996;74:1749-56.
    • (1996) Br J Cancer , vol.74 , pp. 1749-1756
    • Goren, D.1    Horowitz, A.T.2    Zalipsky, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.